Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase

Experimental and Molecular Medicine

Volumn 44, Issue 3, 2012, Pages 191-201

  Chung, Byung Hee ^a   Kim, Sookon ^a   Kim, Jong Dai ^a   Lee, Jung Joon ^b   Baek, Yi Yong ^a   Jeoung, Dooil ^a   Lee, Hansoo ^a   Choe, Jongseon ^a   Ha, Kwon Soo ^a   Won, Moo Ho ^a   Kwon, Young Guen ^c   Kim, Young Myeong ^a  

^a Kangwon National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Yonsei University   (South Korea)

Author keywords

Nitric oxide synthase type III; Phosphorylation; Protein multimerization; Syringaresinol; Type C phospholipases; Vasodilation

Indexed keywords

ADENYLATE KINASE; CALCIUM CHELATING AGENT; CALMODULIN INHIBITOR; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PROTEIN KINASE B; SMALL INTERFERING RNA; SYRINGARESINOL;

ANIMAL TISSUE; ARTICLE; ATTENUATION; CALCIUM BLOOD LEVEL; CELL ISOLATION; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIMERIZATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR RING; VASODILATATION; WESTERN BLOTTING; WILD TYPE;

MUS;

EID: 84859772415     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2012.44.3.014     Document Type: Article

References (38)

1. Adlercreutz H. Phytoestrogens: Epidemiology and a possible role in cancer protection. Environ Health Perspect 1995;103:103-112
2. Albrecht EW, Stegeman CA, Heeringa P, Henning RH, Goor H. Protective role of endothelial nitric oxide synthase. J Pathol 2003;199:8-17
3. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87:1620-1624
4. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000;87:840-844
5. Chataigneau T, Félétou M, Huang PL, Fishman MC, Duhault J, Vanhoutte PM. Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockoutmice. Br J Pharmacol 1999;126:219-226
6. Chung BH, Lee JJ, Kim JD, Jeoung D, Lee H, Choe J, Ha KS, Kwon YG, Kim YM. Angiogenic activity of sesamin through the activation of multiple signal pathways. Biochem Biophys Res Commun 2010;391:254-260
7. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999;399: 601-605
8. Dudzinski DM, Michel T. Life history of eNOS: partners and pathways. Cardiovasc Res 2007;75:247-260
9. Fisslthaler B, Fleming I. Activation and signaling by the AMP-activated protein kinase in endothelial cells. Circ Res 2009;105:114-127
10. Fujikawa T, Yamaguchi A, Morita I, Takeda H, Nishibe S. Protective effects of Acanthopanax senticosus harms from Hokkaido and its components on gastric ulcer in restrainedcold water stressed rat. Biol Pharm Bull 1996;19:1227-1230
11. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999;399:597-601
12. Fulton D, Gratton JP, Sessa WC. Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough? J Pharmacol Exp Ther 2001;299: 818-824
13. Hambrecht R, Adams V, Erbs S, Linke A, Kränkel N, Shu Y, Baither Y, Gielen S, Thiele H, Gummert JF, Mohr FW, Schuler G. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 2003;107:3152-3158
14. Harris MB, Blackstone MA, Sood SG, Li C, Goolsby JM, Venema VJ, Kemp BE, Venema RC. Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors. Am J Physiol Heart Circ Physiol 2004;287:H560-H566
15. Hellermann GR, Solomonson LP. Calmodulin promotes dimerization of the oxygenase domain of human endothelial nitric-oxide synthase. J Biol Chem 1997;272:12030-12034
16. Hobbs AJ, Higgs A, Moncada S. Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol 1999;39:191-220
17. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84:9265-9269
18. Jung HJ, Park HJ, Kim RG, Shin KM, Ha JH, Choi JW, Kim HJ, Lee YS, Lee KT. In vivo anti-inflammatory and antinociceptive effects of liriodendrin isolated from the stembark of Acanthopanax senticousus. Planta Med 2003;69: 610-616
19. Lantin-Hermoso RL, Rosenfeld CR, Yuhanna IS, German Z, Chen Z, Shaul PW. Estrogen acutely stimulates nitric oxide synthase activity in fetal pulmonary artery endothelium. Am J Physiol 1997;273:L119-L126
20. Lee SJ, Yun YS, Lee IK, Ryoo IJ, Yun BS, Yoo ID. An antioxidant lignan and other constituents from the root bark of Hibiscus syriacus. Planta Med 1999;65:658-660
21. Lee SJ, Kim KM, Namkoong S, Kim CK, Kang YC, Lee H, Ha KS, Han JA, Chung HT, Kwon YG, Kim YM. Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine. J Biol Chem 2005;280:5781-5788
22. Lee SJ, Namkoong S, Kim YM, Kim CK, Lee H, Ha KS, Chung HT, Kwon YG, Kim YM. Fractalkine stimulates angiogenesis by activating the Raf-1/MEK/ERK- and PI3K/Akt/eNOSdependent signal pathways. Am J Physiol Heart Circ Physiol 2006;291:2836-2846
23. Lee SJ, Namkoong S, Ha KS, Nam WD, Kwon YG, Lee H, Yoon EY, Chang DJ, Kim SO, Kim YM. Colchicine-derived compound CT20126 promotes skin allograft survival by regulating the balance of Th1 and Th2 cytokine production. Exp Mol Med 2007;39:230-238
24. List BM, Klosch B, Volker C, Gorren AC, Sessa WC, Werner ER, Kukovetz WR, Schmidt K, Mayer B. Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization. Biochem J 1997;323:159-165
25. Liu C, Zhong SM, Chen RY, Wu Y, Zhu XJ. Two new compounds from the dried tender stems of Cinnamomum cassia. J Asian Nat Prod Res 2009;11:845-849
26. MacRitchie AN, Jun SS, Chen Z, German Z, Yuhanna IS, Sherman TS, Shaul PW. Estrogen upregulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium. Circ Res 1997;81:355-362
27. Mashimo H, Goyal RK. Lessons from genetically engineered animal models. IV. Nitric oxide synthase gene knockout mice. Am J Physiol Gastrointest Liver Physiol 1999;277:G745-G750
28. Michell BJ, Chen ZP, Tiganis T, Stapleton D, Katsis F, Power DA, Sim AT, Kemp BE. Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 2001;276:17625-17628
29. Moncada S, Korbut R, Bunting S, Vane JR. Prostacyclin is a circulating hormone. Nature 1978;273:767-768
30. Namkoong S, Chung BH, Ha KS, Lee H, Kwon YG, Kim YM. Microscopic technique for the detection of nitric oxidedependent angiogenesis in an animal model. Methods Enzymol 2008;441:393-402
31. Oury TD, Day BJ, Crapo JD. Extracellular superoxide dismutase: a regulator of nitric oxide bioavailability. Lab Invest 1996;75:617-636
32. Ramirez-Sanchez I, Maya L, Ceballos G, Villarreal F. (-)-epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways. Hypertension 2010;55:1398-1405
33. Scotland RS, Morales-Ruiz M, Chen Y, Yu J, Rudic RD, Fulton D, Gratton JP, Sessa WC. Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circ Res 2002;90:904-910
34. 2+/calmodulin-dependent protein kinase kinase β. Mol Cell Biol 2006;26:5933-5945
35. Venema RC, Ju H, Zou R, Ryan JW, Venema VJ. Subunit interactions of endothelial nitric-oxide synthase, Comparisons to the neuronal and inducible nitric-oxide synthase isoforms. J Biol Chem 1997;272:1276-1282
36. Woo A, Min B, Ryoo S. Piceatannol-3'-O-beta-Dglucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity. Exp Mol Med 2010;42:524-532
37. Wu HM, Yuan Y, Zawieja DC, Tinsley J, Granger HJ. Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability. Am J Physiol 1999;276:H535-H542
38. Yang YM, Huang A, Kaley G, Sun D. ENOS uncoupling and endothelial dysfunction in aged vessels. Am J Physiol Heart Circ Physiol 2009;297:H1829-H1836