Myor/ABF-1 mrna expression marks follicular helper T cells but is dispensable for Tfh cell differentiation and function in vivo

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Debuisson, Delphine ^a   Mari, Nathalie ^a   Denanglaire, Sébastien ^a   Leo, Oberdan ^a   Andris, Fabienne ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; STAT3 PROTEIN; MSC PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; GENE; HELPER CELL; HUMORAL IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MOUSE; MYOR GENE; NONHUMAN; T LYMPHOCYTE SUBPOPULATION; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; CELL DIFFERENTIATION; CYTOLOGY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; MICE; MICE, KNOCKOUT; RNA, MESSENGER; T-LYMPHOCYTES, HELPER-INDUCER; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84891291693     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084415     Document Type: Article

References (86)

1. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, et al. (2000) A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669. Available: http://www.ncbi.nlm.nih.gov/pubmed/10761931.
2. Szabo SJ, Sullivan BM, Peng SL, Glimcher LH (2003) Molecular mechanisms regulating Th1 immune responses. Annual review of immunology 21: 713-758. Available: http://www.ncbi.nlm.nih.gov/pubmed/12500979. Accessed 2013 Aug 21. (Pubitemid 37174546)
3. Kaplan MH, Schindler U, Smiley ST, Grusby MJ (1996) Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4: 313- 319. Available: http://www.ncbi.nlm.nih.gov/pubmed/8624821. (Pubitemid 26132509)
4. Glimcher LH, Murphy KM (2000) lymphocyte grows up Lineage commitment in the immune system: the T helper lymphocyte grows up: 1693-1711. doi:10.1101/gad.14.14.1693.
5. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, et al. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133. Available: http://www.ncbi.nlm.nih.gov/pubmed/16990136. Accessed 2013 Aug 13. (Pubitemid 44380299)
6. Crotty S (2011) Follicular helper CD4 T cells (TFH). Annual review of immunology 29: 621-663. Available: http://www.ncbi.nlm.nih.gov/pubmed/21314428. Accessed 2013 Aug 12.
7. Cannons JL, Lu KT, Schwartzberg PL (2013) T follicular helper cell diversity and plasticity. Trends in immunology 34: 200-207. Available: http://www.ncbi.nlm.nih.gov/pubmed/23395212. Accessed 2013 Aug 21.
8. Schaerli P, Willimann K, Lang a B, Lipp M, Loetscher P, et al. (2000) CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. The Journal of experimental medicine 192: 1553-1562. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=219 3097&tool=pmcentrez&rendertype=abstract.
9. Tangye SG, Ma CS, Brink R, Deenick EK (2013) The good, the bad and the ugly - TFH cells in human health and disease. 13: 412-426. doi:10.1038/nri3447.
10. King C (2009) New insights into the differentiation and function of T follicular helper cells. Nature reviews Immunology 9: 757-766. Available: http://www.ncbi.nlm.nih.gov/pubmed/19855402. Accessed 2013 Aug 9.
11. Ma CS, Deenick EK, Batten M, Tangye SG (2012) The origins, function, and regulation of T follicular helper cells. The Journal of experimental medicine 209: 1241-1253. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi? artid=3405510&tool=pmcentrez&rendertype=abstract. Accessed 2013 Aug 12.
12. Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, et al. (2008) Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29: 138-149. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2556461&tool= pmcentrez&rendertype=abstract. Accessed 2013 Sept 11.
13. Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, et al. (2009) Bcl6 mediates the development of T follicular helper cells. Science (New York, NY) 325: 1001-1005. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi? artid=2857334&tool=pmcentrez&rendertype=abstract. Accessed 2013 Sept 4.
14. Eddahri F, Bureau F, Spolski R, Leonard WJ, Leo O, et al. (2009) Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. 113: 2426-2433. doi:10.1182/blood-2008-04-154682.
15. Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, et al. (2009) Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (New York, NY) 325: 1006-1010. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2766560&tool= pmcentrez&rendertype=abstract. Accessed 2013 Sept 4.
16. Yu D, Rao S, Tsai LM, Lee SK, He Y, et al. (2009) The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31: 457- 468. Available: http://www.ncbi.nlm.nih.gov/pubmed/19631565. Accessed 2013 Aug 26.
17. Eto D, Lao C, DiToro D, Barnett B, Escobar TC, et al. (2011) IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PloS one 6: e17739. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=305 6724&tool=pmcentrez&rendertype=abstract. Accessed Accessed 2013 Aug 22.
18. Ozaki K, Spolski R, Feng CG, Qi C-F, Cheng J, et al. (2002) A critical role for IL-21 in regulating immunoglobulin production. Science (New York, NY) 298: 1630-1634. Available: http://www.ncbi.nlm.nih.gov/pubmed/12446913. Accessed 2013 Sept 4. (Pubitemid 35387203)
19. Zotos D, Coquet JM, Zhang Y, Light A, D'Costa K, et al. (2010) IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. The Journal of experimental medicine 207: 365-378. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 2822601&tool=pmcentrez&rendertype=abstract. Accessed 2013 Aug 12.
20. Spolski R, Leonard WJ (2010) IL-21 and T follicular helper cells. International immunology 22: 7-12. Available: http://www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=2795365&tool=pmcentrez&rendertype=abstract. Accessed Accessed 2013 Aug 30.
21. Wei L, Laurence A, Elias KM, Shea JJO (2007) IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner. doi:10.1074/jbc.M705100200. (Pubitemid 350232469)
22. Crotty S (2012) The 1-1-1 fallacy. Immunological reviews 247: 133-142. Available: http://www.ncbi.nlm.nih.gov/pubmed/22500837.
23. Massari ME, Murre C (2000) Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Molecular and cellular biology 20: 429- 440. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 85097&tool=pmcentrez&rendertype=abstract. Accessed 2013 Sept 5. (Pubitemid 30023084)
24. Murre C (2005) Helix-loop-helix proteins and lymphocyte development. Nature immunology 6: 1079-1086. Available: http://www.ncbi.nlm.nih.gov/pubmed/ 16239924. Accessed Accessed 2013 Aug 21. (Pubitemid 41541785)
25. Lu J, Webb R, Richardson J a, Olson EN (1999) MyoR: a muscle-restricted basic helix-loop-helix transcription factor that antagonizes the actions of MyoD. Proceedings of the National Academy of Sciences of the United States of America 96: 552-557. Available: http://www.pubmedcentral.nih.gov/articlerender. fcgi?artid=15174&tool=pmcentrez&rendertype=abstract. (Pubitemid 29061246)
26. Robb L, Hartley L, Wang CC, Harvey RP, Begley CG (1998) Musculin: a Murine Basic Helix-Loop-Helix Transcription Factor Gene Expressed in Embryonic Skeletal Muscle. Mechanisms of development 76: 197-201. Available: http://www.ncbi.nlm.nih.gov/pubmed/9767165. (Pubitemid 28467920)
27. Lu J-R, Bassel-Duby R, Hawkins A, Chang P, Valdez R, et al. (2002) Control of facial muscle development by MyoR and capsulin. Science (New York, NY) 298: 2378-2381. Available: http://www.ncbi.nlm.nih.gov/pubmed/12493912. Accessed 2013 June 4. (Pubitemid 36014208)
28. Massari ME, Rivera RR, Voland JR, Quong MW, Breit TM, et al. (1998) Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes. Molecular and cellular biology 18: 3130- 3139. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 108895&tool=pmcentrez&rendertype=abstract. (Pubitemid 28240486)
29. Mathas S, Janz M, Hummel F, Hummel M, Wollert-Wulf B, et al. (2006) Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma. Nature immunology 7: 207-215. Available: http://www.ncbi.nlm.nih.gov/pubmed/16369535. Accessed 2013 June 11. (Pubitemid 43135887)
30. Küppers R, Klein U, Schwering I, Distler V, Bräuninger A, et al. (2003) Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling. The Journal of clinical investigation 111: 529-537. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=151 925&tool=pmcentrez&rendertype=abstract. Accessed 2013 Sept 5. (Pubitemid 36228010)
31. Lu KT, Kanno Y, Cannons JL, Handon R, Bible P, et al. (2011) Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitrogenerated and in vivo-derived follicular T helper cells. Immunity 35: 622-632. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 3235 706&tool=pmcentrez&rendertype=abstract. Accessed 2013 Aug 6.
32. Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, et al. (2008) A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29: 127-137. Available: http://www.ncbi.nlm.nih.gov/pubmed/ 18602282. Accessed Accessed 2013 Aug 26.
33. Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho I-C, et al. (2009) The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nature immunology 10: 167-175. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 2742982&tool=pmcentrez&rendertype=abstract. Accessed 2013 Aug 11.
34. Kroenke MA, Eto D, Locci M, Cho M, Davidson T, et al. (2012) Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. Journal of immunology (Baltimore, Md.: 1950) 188: 3734-3744. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3324673&tool= pmcentrez&rendertype=abstract. Accessed 2013 Aug 29.
35. Chtanova T, Tangye SG, Newton R, Frank N, Hodge MR, et al. (2004) T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. Journal of immunology (Baltimore, Md.: 1950) 173: 68-78. Available: http://www.ncbi.nlm.nih.gov/pubmed/15210760. (Pubitemid 38797327)
36. Rasheed A-U, Rahn H-P, Sallusto F, Lipp M, Mü ller G (2006) Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression. European journal of immunology 36: 1892- 1903. Available: http://www.ncbi.nlm.nih.gov/pubmed/16791882. Accessed 2013 Sept 4. (Pubitemid 44089055)
37. Haynes NM, Allen CDC, Lesley R, Ansel KM, Killeen N, et al. (2007) Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. Journal of immunology (Baltimore, Md.: 1950) 179: 5099-5108. Available: http://www.ncbi.nlm.nih.gov/pubmed/17911595. Accessed 2013 Sept 5.
38. Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ, et al. (2011) ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 34: 932-946. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=312 4577&tool=pmcentrez&rendertype=abstract. Accessed 2013 Aug 17.
39. Eddahri F, Oldenhove G, Denanglaire S, Urbain J, Leo O, et al. (2006) CD4+ CD25+ regulatory T cells control the magnitude of T-dependent humoral immune responses to exogenous antigens. European journal of immunology 36: 855-863. Available: http://www.ncbi.nlm.nih.gov/pubmed/16511897. Accessed 2013 Aug 12.
40. Lu B, Zagouras P, Fischer JE, Lu J, Li B, et al. (2004) Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation. Proceedings of the National Academy of Sciences of the United States of America 101: 3023-3028. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=365738&tool= pmcentrez&rendertype=abstract. (Pubitemid 38327728)
41. Youngblood B, Hale JS, Ahmed R (2013) T-cell memory differentiation: insights from transcriptional signatures and epigenetics. Immunology 139: 277-284. Available: http://www.ncbi.nlm.nih.gov/pubmed/23347146. Accessed 2013 Aug 6.
42. Zhu J (2010) Transcriptional regulation of Th2 cell differentiation. Immunology and cell biology 88: 244-249. Available: http://www.pubmedcentral. nih.gov/articlerender.fcgi?artid=3477614&tool=pmcentrez&rendertype= abstract. Accessed 2013 Sept 5.
43. O'Shea JJ, Lahesmaa R, Vahedi G, Laurence A, Kanno Y (2011) Genomic views of STAT function in CD4+ T helper cell differentiation. Nature reviews Immunology 11: 239-250. Available: http://www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=3070307&tool=pmcentrez&rendertype=abstract. Accessed 2013 Aug 8.
44. De Pooter RF, Kee BL (2010) E proteins and the regulation of early lymphocyte development. Immunological reviews 238: 93-109. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2992984&tool= pmcentrez&rendertype=abstract. Accessed 2013 Sept 5.
45. Roberts VJ, Steenbergen R, Murre C (1993) Localization of E2A mRNA expression in developing and adult rat tissues. Proceedings of the National Academy of Sciences of the United States of America 90: 7583-7587. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=47186&tool=pm centrez&rendertype=abstract. (Pubitemid 23249994)
46. Sawada S, Littman DR (1993) A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Molecular and cellular biology 13: 5620-5628. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=360288&tool= pmcentrez&rendertype=abstract. (Pubitemid 23260664)
47. Bain G, Quong MW, Soloff RS, Hedrick SM, Murre C (1999) Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47. The Journal of experimental medicine 190: 1605-1616. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2195738&tool= pmcentrez&rendertype=abstract. (Pubitemid 30002342)
48. Barndt RJ, Dai M, Zhuang Y (2000) Functions of E2A-HEB heterodimers in Tcell development revealed by a dominant negative mutation of HEB. Molecular and cellular biology 20: 6677-6685. Available: http://www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=86175&tool=pmcentrez&rendertype=abstract.
49. Bain G, Engel I, Robanus Maandag EC, Te Riele HP, Voland JR, et al. (1997) E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. Molecular and cellular biology 17: 4782-4791. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 232330&tool=pmcentrez&rendertype=abstract. (Pubitemid 27318153)
50. Liu Z, Li Z, Mao K, Zou J, Wang Y, et al. (2009) Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling. Journal of immunology (Baltimore, Md.: 1950) 183: 6320-6329. Available: http://www.ncbi.nlm.nih.gov/pubmed/ 19880450. Accessed 2013 Aug 26.
51. Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, et al. (2008) Autoregulation of Th1-mediated inflammation by twist1. The Journal of experimental medicine 205: 1889-1901. Available: http://www.pubmedcentral.nih. gov/articlerender.fcgi?artid=2525589&tool=pmcentrez&rendertype=abstract. Accessed 2013 Aug 20.
52. Pham D, Vincentz JW, Firulli AB, Kaplan MH (2012) Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function. Journal of immunology (Baltimore, Md.: 1950) 189: 832-840. Available: http://www. pubmedcentral.nih.gov/articlerender.fcgi?artid=3392532&tool= pmcentrez&rendertype=abstract. Accessed 2013 Sept 4.
53. Pham D, Walline CC, Hollister K, Dent AL, Blum JS, et al. (2013) The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor alpha chain. The Journal of biological chemistry. Available: http://www.ncbi.nlm.nih. gov/pubmed/23935104. Accessed 2013 Aug 26.
54. Hishikawa K, Marumo T, Miura S, Nakanishi A, Matsuzaki Y, et al. (2005) Musculin/MyoR is expressed in kidney side population cells and can regulate their function. The Journal of cell biology 169: 921-928. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2171631&tool= pmcentrez&rendertype=abstract. Accessed 2013 Sept 5. (Pubitemid 41002868)
55. Kamiura N, Hirahashi J, Matsuzaki Y, Idei M, Takase O, et al. (2013) Basic helix-loop-helix transcriptional factor MyoR regulates BMP-7 in acute kidney injury. American journal of physiology Renal physiology 304: F1159-66. Available: http://www.ncbi.nlm.nih.gov/pubmed/23515721. Accessed 2013 July 4.
56. Yu L (2003) MyoR is expressed in nonmyogenic cells and can inhibit their differentiation. Experimental Cell Research 289: 162-173. Available: http://linkinghub.elsevier.com/retrieve/pii/S0014482703002520. Accessed 2013 July 4. (Pubitemid 36993846)
57. Li Q, Agno JE, Edson M a, Nagaraja AK, Nagashima T, et al. (2011) Transforming growth factor b receptor type 1 is essential for female reproductive tract integrity and function. PLoS genetics 7: e1002320. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3197682&tool= pmcentrez&rendertype=abstract. Accessed 2013 May 27.
58. Hale JS, Youngblood B, Latner DR, Mohammed AUR, Ye L, et al. (2013) Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection. Immunity 38: 805-817. Available: http://www.ncbi.nlm.nih.gov/pubmed/23583644. Accessed 2013 Aug 6.
59. Rasheed MAU, Latner DR, Aubert RD, Gourley T, Spolski R, et al. (2013) Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells. Journal of virology 87: 7737-7746. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3700268&tool= pmcentrez&rendertype=abstract. Accessed 2013 Aug 22.
60. Mari N, Hercor M, Denanglaire S, Leo O, Andris F (2013) The capacity of Th2 lymphocytes to deliver B-cell help requires expression of the transcription factor STAT3. European journal of immunology 43: 1489-1498. Available: http://www.ncbi.nlm.nih.gov/pubmed/23504518. Accessed 2013 Aug 22.
61. Chtanova T, Tangye SG, Newton R, Frank N, Hodge MR, et al. (2004) T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. Journal of immunology (Baltimore, Md.: 1950) 173: 68-78. Available: http://www.ncbi.nlm.nih.gov/pubmed/15210760. (Pubitemid 38797327)
62. Rasheed A-U, Rahn H-P, Sallusto F, Lipp M, Mü ller G (2006) Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression. European journal of immunology 36: 1892- 1903. Available: http://www.ncbi.nlm.nih.gov/pubmed/16791882. Accessed 2013 Sept 4. (Pubitemid 44089055)
63. Haynes NM, Allen CDC, Lesley R, Ansel KM, Killeen N, et al. (2007) Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. Journal of immunology (Baltimore, Md.: 1950) 179: 5099-5108. Available: http://www.ncbi.nlm.nih.gov/pubmed/17911595. Accessed 2013 Sept 5.
64. Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ, et al. (2011) ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 34: 932-946. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=312 4577&tool=pmcentrez&rendertype=abstract. Accessed 2013 Aug 17.
65. Eddahri F, Oldenhove G, Denanglaire S, Urbain J, Leo O, et al. (2006) CD4+ CD25+ regulatory T cells control the magnitude of T-dependent humoral immune responses to exogenous antigens. European journal of immunology 36: 855-863. Available: http://www.ncbi.nlm.nih.gov/pubmed/16511897. Accessed 2013 Aug 12.
66. Lu B, Zagouras P, Fischer JE, Lu J, Li B, et al. (2004) Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation. Proceedings of the National Academy of Sciences of the United States of America 101: 3023-3028. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=365738&tool= pmcentrez&rendertype=abstract. (Pubitemid 38327728)
67. Youngblood B, Hale JS, Ahmed R (2013) T-cell memory differentiation: insights from transcriptional signatures and epigenetics. Immunology 139: 277-284. Available: http://www.ncbi.nlm.nih.gov/pubmed/23347146. Accessed 2013 Aug 6.
68. Zhu J (2010) Transcriptional regulation of Th2 cell differentiation. Immunology and cell biology 88: 244-249. Available: http://www.pubmedcentral. nih.gov/articlerender.fcgi?artid=3477614&tool=pmcentrez&rendertype= abstract. Accessed 2013 Sept 5.
69. O'Shea JJ, Lahesmaa R, Vahedi G, Laurence A, Kanno Y (2011) Genomic views of STAT function in CD4+ T helper cell differentiation. Nature reviews Immunology 11: 239-250. Available: http://www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=3070307&tool=pmcentrez&rendertype=abstract. Accessed 2013 Aug 8.
70. De Pooter RF, Kee BL (2010) E proteins and the regulation of early lymphocyte development. Immunological reviews 238: 93-109. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2992984&tool= pmcentrez&rendertype=abstract. Accessed 2013 Sept 5.
71. Roberts VJ, Steenbergen R, Murre C (1993) Localization of E2A mRNA expression in developing and adult rat tissues. Proceedings of the National Academy of Sciences of the United States of America 90: 7583-7587. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=47186&tool=pm centrez&rendertype=abstract. (Pubitemid 23249994)
72. Sawada S, Littman DR (1993) A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Molecular and cellular biology 13: 5620-5628. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=360288&tool= pmcentrez&rendertype=abstract. (Pubitemid 23260664)
73. Bain G, Quong MW, Soloff RS, Hedrick SM, Murre C (1999) Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47. The Journal of experimental medicine 190: 1605-1616. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2195738&tool= pmcentrez&rendertype=abstract. (Pubitemid 30002342)
74. Barndt RJ, Dai M, Zhuang Y (2000) Functions of E2A-HEB heterodimers in Tcell development revealed by a dominant negative mutation of HEB. Molecular and cellular biology 20: 6677-6685. Available: http://www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=86175&tool=pmcentrez&rendertype=abstract.
75. Bain G, Engel I, Robanus Maandag EC, Te Riele HP, Voland JR, et al. (1997) E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. Molecular and cellular biology 17: 4782-4791. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid= 232330&tool=pmcentrez&rendertype=abstract. (Pubitemid 27318153)
76. Liu Z, Li Z, Mao K, Zou J, Wang Y, et al. (2009) Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling. Journal of immunology (Baltimore, Md.: 1950) 183: 6320-6329. Available: http://www.ncbi.nlm.nih.gov/pubmed/ 19880450. Accessed 2013 Aug 26.
77. Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, et al. (2008) Autoregulation of Th1-mediated inflammation by twist1. The Journal of experimental medicine 205: 1889-1901. Available: http://www.pubmedcentral.nih. gov/articlerender.fcgi?artid=2525589&tool=pmcentrez&rendertype=abstract. Accessed 2013 Aug 20.
78. Pham D, Vincentz JW, Firulli AB, Kaplan MH (2012) Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function. Journal of immunology (Baltimore, Md.: 1950) 189: 832-840. Available: http://www. pubmedcentral.nih.gov/articlerender.fcgi?artid=3392532&tool= pmcentrez&rendertype=abstract. Accessed 2013 Sept 4.
79. Pham D, Walline CC, Hollister K, Dent AL, Blum JS, et al. (2013) The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor alpha chain. The Journal of biological chemistry. Available: http://www.ncbi.nlm.nih. gov/pubmed/23935104. Accessed 2013 Aug 26.
80. Hishikawa K, Marumo T, Miura S, Nakanishi A, Matsuzaki Y, et al. (2005) Musculin/MyoR is expressed in kidney side population cells and can regulate their function. The Journal of cell biology 169: 921-928. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2171631&tool= pmcentrez&rendertype=abstract. Accessed 2013 Sept 5. (Pubitemid 41002868)
81. Kamiura N, Hirahashi J, Matsuzaki Y, Idei M, Takase O, et al. (2013) Basic helix-loop-helix transcriptional factor MyoR regulates BMP-7 in acute kidney injury. American journal of physiology Renal physiology 304: F1159-66. Available: http://www.ncbi.nlm.nih.gov/pubmed/23515721. Accessed 2013 July 4.
82. Yu L (2003) MyoR is expressed in nonmyogenic cells and can inhibit their differentiation. Experimental Cell Research 289: 162-173. Available: http://linkinghub.elsevier.com/retrieve/pii/S0014482703002520. Accessed 2013 July 4. (Pubitemid 36993846)
83. Li Q, Agno JE, Edson M a, Nagaraja AK, Nagashima T, et al. (2011) Transforming growth factor b receptor type 1 is essential for female reproductive tract integrity and function. PLoS genetics 7: e1002320. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3197682&tool= pmcentrez&rendertype=abstract. Accessed 2013 May 27.
84. Hale JS, Youngblood B, Latner DR, Mohammed AUR, Ye L, et al. (2013) Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection. Immunity 38: 805-817. Available: http://www.ncbi.nlm.nih.gov/pubmed/23583644. Accessed 2013 Aug 6.
85. Rasheed MAU, Latner DR, Aubert RD, Gourley T, Spolski R, et al. (2013) Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells. Journal of virology 87: 7737-7746. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3700268&tool= pmcentrez&rendertype=abstract. Accessed 2013 Aug 22.
86. Mari N, Hercor M, Denanglaire S, Leo O, Andris F (2013) The capacity of Th2 lymphocytes to deliver B-cell help requires expression of the transcription factor STAT3. European journal of immunology 43: 1489-1498. Available: http://www.ncbi.nlm.nih.gov/pubmed/23504518. Accessed 2013 Aug 22.