Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels

Journal of Neuroscience

Volumn 21, Issue 6, 2001, Pages 1923-1930

  Wolf, John A ^a   Stys, Peter K ^c   Lusardi, Theresa ^b   Meaney, David ^b   Smith, Douglas H ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^d NONE   (United States)

Author keywords

Axon; Brain trauma; Calcium; Diffuse axonal injury; Injury; Mechanoporation; Mechanosensitivity; Sodium channels

Indexed keywords

BEPRIDIL; CALCIUM CHANNEL BLOCKING AGENT; MEGLUMINE; OMEGA CONOTOXIN MVIIC; SODIUM CHANNEL; TETRODOTOXIN;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM CONDUCTANCE; CALCIUM TRANSPORT; CONTROLLED STUDY; DIFFUSE AXONAL INJURY; HUMAN; HUMAN CELL; IN VITRO STUDY; NERVE FIBER; PRIORITY JOURNAL; SODIUM CALCIUM EXCHANGE;

AXONS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELL LINE; CULTURE TECHNIQUES; DIFFUSE AXONAL INJURY; FLUORESCENT DYES; HUMANS; IONOPHORES; MEGLUMINE; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; NEURONS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STRESS, MECHANICAL; TETRODOTOXIN; TUMOR STEM CELLS;

EID: 0035869473     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. 2+ exchanger
2. Stretch-induced injury alters mitochondrial membrane potential and cellular ATP in cultured astrocytes and neurons
3. The multimolecular cascade of spinal cord injury. Studies on prostanoids, calcium, and proteinases
4. Cytochrome c release and caspase activation in traumatic axonal injury
5. Axonal damage in severe traumatic brain injury: An experimental study in the cat
6. Voltage-gated calcium channels in CNS white matter: Role in anoxic injury
7. Inhibition of sodium-calcium exchange in cardiac sarcolemmal membrane vesicles 2. Mechanism of inhibition by bepridil
8. Mechanisms of brain injury
9. Diffuse axonal injury and traumatic coma in the primate
10. Axonal injury in the optic nerve: A model that simulates diffuse axonal injury in the brain
11. Diffuse axonal injury: An important form of traumatic brain injury
12. Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels
13. Real time imaging of calcium-induced localized proteolytic activity after axotomy and its relation to growth cone formation
14. Trauma
15. The nature, distribution and causes of traumatic brain injury
16. 2+ channels
17. Calcium channels: Molecular pharmacology, structure and regulation
18. Anoxic injury in the rat spinal cord: Pharmacological evidence for multiple steps in Ca(2+)-dependent injury of the dorsal columns
19. 2+ channels in anoxic injury of spinal cord white matter
20. Mechanism of calcium entry during axon injury and degeneration
21. Experimental spinal cord injury: Spatiotemporal characterization of elemental concentrations and water contents in axons and neuroglia
22. Ultrastructural evidence of axonal shearing as a result of lateral acceleration of the head in non-human primates
23. Cytochemical evidence for redistribution of membrane pump calcium-ATPase and ecto-Ca-ATPase activity, and calcium influx in myelinated nerve fibers of the optic nerve after stretch injury
24. A mechanistic analysis of nondisruptive axonal injury: A review
25. Inhibition of calcium channels in rat central and peripheral neurons by ω-conotoxin MVIIC
26. Biomechanical analysis of experimental diffuse axonal injury
27. Excitotoxic cell death and delayed rescue in human neurons derived from NT2
28. Traumatically induced altered membrane permeability: Its relationship to traumatically induced reactive axonal change
29. N Tera 2 cells: A human cell line which displays characteristics expected of a human committed neuronal progenitor cell
30. Pure, postmitotic, polarized human neurons derived from N Tera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons
31. Traumatically induced axonal injury: Pathogenesis and pathobiological implications
32. Pathobiology of traumatically induced axonal injury in animals and man
33. Are the pathobiological changes evoked by traumatic brain injury immediate and irreversible?
34. Axonal change in minor head injury
35. Effects of the sodium channel blocker tetrodotoxin on acute white matter pathology after experimental contusive spinal cord injury
36. Functional neurological recovery, preserved spinal cord tissue and integrity of descending axons following compressive spinal cord trauma
37. Voltage-dependent sodium channel function is regulated through membrane mechanics
38. Axonal damage in traumatic brain injury
39. High tolerance and delayed elastic response of cultured axons to dynamic stretch injury
40. Anoxic and ischemic injury of myelinated axons in CNS white matter: From mechanistic concepts to therapeutics
41. Mechanisms of calcium and sodium fluxes in axonic myelinated central nervous system axons
42. Effects of polyvalent cations and dihydropyridine calcium channel blockers on recovery of CNS white matter from anoxia
43. 2+ influx during anoxia in mammalian central nervous system white matter
44. 2+ exchanger
45. Membrane stretch affects gating modes of a skeletal muscle sodium channel
46. Measurement of intracellular calcium
47. Inhibition of the electrogenic Na pump underlies delayed depolarization of cortical neurons after mechanical injury or glutamate
48. Local blockade of sodium channels by tetrodotoxin ameliorates tissue loss and long-term functional deficits resulting from experimental spinal cord injury
49. Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B
50. 2+-mediated injury in myelinated CNS axons
51. Role of calcium in central nervous system injuries
52. Extracellular calcium ionic activity in experimental spinal cord contusion