Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors

Journal of Neuroscience

Volumn 24, Issue 19, 2004, Pages 4605-4613

  Iwata, Akira ^a   Stys, Peter K ^c   Wolf, John A ^a   Chen, Xiao Han ^a   Taylor, Andrew G ^b   Meaney, David F ^b   Smith, Douglas H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Axon trauma; Calcium; Diffuse axonal injury; Noninactivation; Protease inhibitors; Proteolysis; Sodium channels; Tetrodotoxin; Traumatic brain injury

Indexed keywords

CALCIUM; PROTEINASE INHIBITOR; TETRODOTOXIN; VOLTAGE GATED SODIUM CHANNEL;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; AXONAL INJURY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; EMBRYO; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEINASE INHIBITION; RAT; SODIUM TRANSPORT;

ANIMALS; AXONS; CALCIUM; CELLS, CULTURED; FLUORESCENT DYES; NEURONS; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STRESS, MECHANICAL; TETRODOTOXIN; TRAUMA, NERVOUS SYSTEM;

EID: 2442662940     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0515-03.2004     Document Type: Article

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