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Volumn 56, Issue 23, 2013, Pages 9471-9481

Developing bivalent ligands to target CUG triplet repeats, the causative agent of myotonic dystrophy type 1

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; RNA;

EID: 84890468828     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400794z     Document Type: Article
Times cited : (48)

References (70)
  • 1
    • 79960512053 scopus 로고    scopus 로고
    • Therapeutics development in myotonic dystrophy type 1
    • Foff, E. P.; Mahadevan, M. S. Therapeutics development in myotonic dystrophy type 1 Muscle Nerve 2011, 44, 160-169
    • (2011) Muscle Nerve , vol.44 , pp. 160-169
    • Foff, E.P.1    Mahadevan, M.S.2
  • 3
    • 28044432118 scopus 로고    scopus 로고
    • The structural basis of myotonic dystrophy from the crystal structure of CUG repeats
    • Mooers, B. H. M.; Logue, J. S.; Berglund, J. A. The structural basis of myotonic dystrophy from the crystal structure of CUG repeats Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 16626-16631
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 16626-16631
    • Mooers, B.H.M.1    Logue, J.S.2    Berglund, J.A.3
  • 4
    • 67651162116 scopus 로고    scopus 로고
    • Structural insights into CUG repeats containing the 'stretched U-U wobble': Implications for myotonic dystrophy
    • Kiliszek, A.; Kierzek, R.; Krzyzosiak, W. J.; Rypniewski, W. Structural insights into CUG repeats containing the 'stretched U-U wobble': Implications for myotonic dystrophy Nucleic Acids Res. 2009, 37, 4149-4156
    • (2009) Nucleic Acids Res. , vol.37 , pp. 4149-4156
    • Kiliszek, A.1    Kierzek, R.2    Krzyzosiak, W.J.3    Rypniewski, W.4
  • 5
    • 79954597554 scopus 로고    scopus 로고
    • Identification of MBNL1 and MBNL3 domains required for splicing activation and repression
    • Grammatikakis, I.; Goo, Y. H.; Echeverria, G. V.; Cooper, T. A. Identification of MBNL1 and MBNL3 domains required for splicing activation and repression Nucleic Acids Res. 2011, 39, 2769-2780
    • (2011) Nucleic Acids Res. , vol.39 , pp. 2769-2780
    • Grammatikakis, I.1    Goo, Y.H.2    Echeverria, G.V.3    Cooper, T.A.4
  • 6
    • 33746796393 scopus 로고    scopus 로고
    • Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy
    • Kanadia, R. N.; Shin, J.; Yuan, Y.; Beattie, S. G.; Wheeler, T. M.; Thornton, C. A.; Swanson, M. S. Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 11748-11753
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 11748-11753
    • Kanadia, R.N.1    Shin, J.2    Yuan, Y.3    Beattie, S.G.4    Wheeler, T.M.5    Thornton, C.A.6    Swanson, M.S.7
  • 7
    • 65549105556 scopus 로고    scopus 로고
    • Mechanisms of RNA-mediated disease
    • O'Rourke, J. R.; Swanson, M. S. Mechanisms of RNA-mediated disease J. Biol. Chem. 2009, 284, 7419-7423
    • (2009) J. Biol. Chem. , vol.284 , pp. 7419-7423
    • O'Rourke, J.R.1    Swanson, M.S.2
  • 8
  • 9
    • 70450203364 scopus 로고    scopus 로고
    • Pathogenic mechanisms of myotonic dystrophy
    • Lee, J. E.; Cooper, T. A. Pathogenic mechanisms of myotonic dystrophy Biochem. Soc. Trans. 2009, 37, 1281-1286
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 1281-1286
    • Lee, J.E.1    Cooper, T.A.2
  • 10
    • 33750303909 scopus 로고    scopus 로고
    • A reversal of misfortune for myotonic dystrophy?
    • Cooper, T. A. A reversal of misfortune for myotonic dystrophy? New Engl. J. Med. 2006, 355, 1825-1827
    • (2006) New Engl. J. Med. , vol.355 , pp. 1825-1827
    • Cooper, T.A.1
  • 11
    • 77956108781 scopus 로고    scopus 로고
    • CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1
    • Ward, A. J.; Rimer, M.; Killian, J. M.; Dowling, J. J.; Cooper, T. A. CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1 Hum. Mol. Genet. 2010, 19, 3614-3622
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 3614-3622
    • Ward, A.J.1    Rimer, M.2    Killian, J.M.3    Dowling, J.J.4    Cooper, T.A.5
  • 12
    • 53049095405 scopus 로고    scopus 로고
    • The RNA-binding protein CUGBP1 regulates stability of tumor necrosis factor mRNA in muscle cells: Implications for myotonic dystrophy
    • Zhang, L.; Lee, J. E.; Wilusz, J.; Wilusz, C. J. The RNA-binding protein CUGBP1 regulates stability of tumor necrosis factor mRNA in muscle cells: Implications for myotonic dystrophy J. Biol. Chem. 2008, 283, 22457-22463
    • (2008) J. Biol. Chem. , vol.283 , pp. 22457-22463
    • Zhang, L.1    Lee, J.E.2    Wilusz, J.3    Wilusz, C.J.4
  • 13
    • 34948834723 scopus 로고    scopus 로고
    • Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation
    • Kuyumcu-Martinez, N. M.; Wang, G. S.; Cooper, T. A. Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation Mol. Cell 2007, 28, 68-78
    • (2007) Mol. Cell , vol.28 , pp. 68-78
    • Kuyumcu-Martinez, N.M.1    Wang, G.S.2    Cooper, T.A.3
  • 16
    • 73249146284 scopus 로고    scopus 로고
    • Chemical reversal of the RNA gain of function in myotonic dystrophy
    • Cooper, T. a. Chemical reversal of the RNA gain of function in myotonic dystrophy Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 18433-18434
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 18433-18434
    • Cooper, T.A.1
  • 17
    • 84863270094 scopus 로고    scopus 로고
    • RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1
    • Lee, J. E.; Bennett, C. F.; Cooper, T. A. RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1 Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 4221-4226
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 4221-4226
    • Lee, J.E.1    Bennett, C.F.2    Cooper, T.A.3
  • 18
    • 84873414139 scopus 로고    scopus 로고
    • RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy
    • Sobczak, K.; Wheeler, T. M.; Wang, W.; Thornton, C. A. RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy Mol. Ther. 2013, 21, 380-387
    • (2013) Mol. Ther. , vol.21 , pp. 380-387
    • Sobczak, K.1    Wheeler, T.M.2    Wang, W.3    Thornton, C.A.4
  • 20
    • 79961062490 scopus 로고    scopus 로고
    • In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models
    • García-López, A.; Llamusí, B.; Orzáez, M.; Pérez-Payá, E.; Artero, R. D. In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 11866-11871
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 11866-11871
    • García-López, A.1    Llamusí, B.2    Orzáez, M.3    Pérez-Payá, E.4    Artero, R.D.5
  • 22
    • 84864446995 scopus 로고    scopus 로고
    • From dynamic combinatorial 'hit' to lead: In vitro and in vivo activity of compounds targeting the pathogenic RNAs that cause myotonic dystrophy
    • Ofori, L. O.; Hoskins, J.; Nakamori, M.; Thornton, C. A.; Miller, B. L. From dynamic combinatorial 'hit' to lead: In vitro and in vivo activity of compounds targeting the pathogenic RNAs that cause myotonic dystrophy Nucleic Acids Res. 2012, 40, 6380-6390
    • (2012) Nucleic Acids Res. , vol.40 , pp. 6380-6390
    • Ofori, L.O.1    Hoskins, J.2    Nakamori, M.3    Thornton, C.A.4    Miller, B.L.5
  • 24
    • 67650506996 scopus 로고    scopus 로고
    • Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: Application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3
    • Pushechnikov, A.; Lee, M. M.; Childs-Disney, J. L.; Sobczak, K.; French, J. M.; Thornton, C. A.; Disney, M. D. Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: Application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3 J. Am. Chem. Soc. 2009, 131, 9767-9779
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 9767-9779
    • Pushechnikov, A.1    Lee, M.M.2    Childs-Disney, J.L.3    Sobczak, K.4    French, J.M.5    Thornton, C.A.6    Disney, M.D.7
  • 25
    • 84862105985 scopus 로고    scopus 로고
    • Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive
    • Childs-Disney, J. L.; Hoskins, J.; Rzuczek, S. G.; Thornton, C. A.; Disney, M. D. Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive ACS Chem. Biol. 2012, 7, 856-862
    • (2012) ACS Chem. Biol. , vol.7 , pp. 856-862
    • Childs-Disney, J.L.1    Hoskins, J.2    Rzuczek, S.G.3    Thornton, C.A.4    Disney, M.D.5
  • 26
    • 70349493012 scopus 로고    scopus 로고
    • A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding
    • Arambula, J. F.; Ramisetty, S. R.; Baranger, A. M.; Zimmerman, S. C. A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 16068-16073
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 16068-16073
    • Arambula, J.F.1    Ramisetty, S.R.2    Baranger, A.M.3    Zimmerman, S.C.4
  • 29
    • 0032476812 scopus 로고    scopus 로고
    • Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
    • Mammen, M.; Choi, S. K.; Whitesides, G. M. Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors Angew. Chem., Int. Ed. 1998, 37, 2755-2794
    • (1998) Angew. Chem., Int. Ed. , vol.37 , pp. 2755-2794
    • Mammen, M.1    Choi, S.K.2    Whitesides, G.M.3
  • 30
    • 0028028246 scopus 로고
    • Polyacrylamides bearing pendant alpha-sialoside groups strongly inhibit agglutination of erythrocytes by influenza A virus: Multivalency and steric stabilization of particulate biological systems
    • Lees, W. J.; Spaltenstein, A.; Kingery-Wood, J. E.; Whitesides, G. M. Polyacrylamides bearing pendant alpha-sialoside groups strongly inhibit agglutination of erythrocytes by influenza A virus: multivalency and steric stabilization of particulate biological systems J. Med. Chem. 1994, 37, 3419-3433
    • (1994) J. Med. Chem. , vol.37 , pp. 3419-3433
    • Lees, W.J.1    Spaltenstein, A.2    Kingery-Wood, J.E.3    Whitesides, G.M.4
  • 31
    • 84862326827 scopus 로고    scopus 로고
    • Towards multivalent CD1d ligands: Synthesis and biological activity of homodimeric alpha-galactosyl ceramide analogues
    • Jervis, P. J.; Moulis, M.; Jukes, J. P.; Ghadbane, H.; Cox, L. R.; Cerundolo, V.; Besra, G. S. Towards multivalent CD1d ligands: Synthesis and biological activity of homodimeric alpha-galactosyl ceramide analogues Carbohydr. Res. 2012, 356, 152-162
    • (2012) Carbohydr. Res. , vol.356 , pp. 152-162
    • Jervis, P.J.1    Moulis, M.2    Jukes, J.P.3    Ghadbane, H.4    Cox, L.R.5    Cerundolo, V.6    Besra, G.S.7
  • 33
    • 0034616880 scopus 로고    scopus 로고
    • Application of the bivalent ligand approach to the design of novel dimeric serotonin reuptake inhibitors
    • Tamiz, A. P.; Zhang, J.; Zhang, M.; Wang, C. Z.; Johnson, K. M.; Kozikowski, A. P. Application of the bivalent ligand approach to the design of novel dimeric serotonin reuptake inhibitors J. Am. Chem. Soc. 2000, 122, 5393-5394
    • (2000) J. Am. Chem. Soc. , vol.122 , pp. 5393-5394
    • Tamiz, A.P.1    Zhang, J.2    Zhang, M.3    Wang, C.Z.4    Johnson, K.M.5    Kozikowski, A.P.6
  • 34
    • 0346981999 scopus 로고    scopus 로고
    • Influencing receptor-ligand binding mechanisms with multivalent ligand architecture
    • Gestwicki, J. E.; Cairo, C. W.; Strong, L. E.; Oetjen, K. a.; Kiessling, L. L. Influencing receptor-ligand binding mechanisms with multivalent ligand architecture J. Am. Chem. Soc. 2002, 124, 14922-14933
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 14922-14933
    • Gestwicki, J.E.1    Cairo, C.W.2    Strong, L.E.3    Oetjen, K.A.4    Kiessling, L.L.5
  • 36
    • 65749087933 scopus 로고    scopus 로고
    • Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2
    • Lee, M. M.; Pushechnikov, A.; Disney, M. D. Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2 ACS Chem. Biol. 2009, 4, 345-355
    • (2009) ACS Chem. Biol. , vol.4 , pp. 345-355
    • Lee, M.M.1    Pushechnikov, A.2    Disney, M.D.3
  • 37
    • 80052775251 scopus 로고    scopus 로고
    • Using modularly assembled ligands to bind RNA internal loops separated by different distances
    • Childs-Disney, J. L.; Tsitovich, P. B.; Disney, M. D. Using modularly assembled ligands to bind RNA internal loops separated by different distances ChemBioChem 2011, 12, 2143-2146
    • (2011) ChemBioChem , vol.12 , pp. 2143-2146
    • Childs-Disney, J.L.1    Tsitovich, P.B.2    Disney, M.D.3
  • 38
    • 79957596498 scopus 로고    scopus 로고
    • Design strategies for bivalent ligands targeting GPCRs
    • Shonberg, J.; Scammells, P. J.; Capuano, B. Design strategies for bivalent ligands targeting GPCRs ChemMedChem 2011, 6, 963-974
    • (2011) ChemMedChem , vol.6 , pp. 963-974
    • Shonberg, J.1    Scammells, P.J.2    Capuano, B.3
  • 39
    • 0347694971 scopus 로고    scopus 로고
    • On the nature of the multivalency effect: A thermodynamic model
    • Kitov, P. I.; Bundle, D. R. On the nature of the multivalency effect: A thermodynamic model J. Am. Chem. Soc. 2003, 125, 16271-16284
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 16271-16284
    • Kitov, P.I.1    Bundle, D.R.2
  • 43
    • 79960172993 scopus 로고    scopus 로고
    • Bivalent dopamine D2 receptor ligands: Synthesis and binding properties
    • Kühhorn, J.; Hübner, H.; Gmeiner, P. Bivalent dopamine D2 receptor ligands: Synthesis and binding properties J. Med. Chem. 2011, 54, 4896-4903
    • (2011) J. Med. Chem. , vol.54 , pp. 4896-4903
    • Kühhorn, J.1    Hübner, H.2    Gmeiner, P.3
  • 44
    • 84862944463 scopus 로고    scopus 로고
    • Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents
    • Peng, Y.; Sun, H.; Lu, J.; Liu, L.; Cai, Q.; Shen, R.; Yang, C. Y.; Yi, H.; Wang, S. Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents J. Med. Chem. 2012, 55, 106-114
    • (2012) J. Med. Chem. , vol.55 , pp. 106-114
    • Peng, Y.1    Sun, H.2    Lu, J.3    Liu, L.4    Cai, Q.5    Shen, R.6    Yang, C.Y.7    Yi, H.8    Wang, S.9
  • 45
    • 77954346851 scopus 로고    scopus 로고
    • Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists
    • Liu, J.; Brahimi, F.; Saragovi, H. U.; Burgess, K. Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists J. Med. Chem. 2010, 53, 5044-5048
    • (2010) J. Med. Chem. , vol.53 , pp. 5044-5048
    • Liu, J.1    Brahimi, F.2    Saragovi, H.U.3    Burgess, K.4
  • 46
    • 84880523180 scopus 로고    scopus 로고
    • Single-molecule study of the CUG repeat-MBNL1 interaction and its inhibition by small molecules
    • Haghighat Jahromi, A.; Honda, M.; Zimmerman, S. C.; Spies, M. Single-molecule study of the CUG repeat-MBNL1 interaction and its inhibition by small molecules Nucleic Acids Res. 2013, 41, 6687-6697
    • (2013) Nucleic Acids Res. , vol.41 , pp. 6687-6697
    • Haghighat Jahromi, A.1    Honda, M.2    Zimmerman, S.C.3    Spies, M.4
  • 47
    • 84869411946 scopus 로고    scopus 로고
    • Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder
    • Wong, C. H.; Richardson, S. L.; Ho, Y. J.; Lucas, A. M.; Tuccinardi, T.; Baranger, A. M.; Zimmerman, S. C. Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder ChemBioChem 2012, 13, 2505-2509
    • (2012) ChemBioChem , vol.13 , pp. 2505-2509
    • Wong, C.H.1    Richardson, S.L.2    Ho, Y.J.3    Lucas, A.M.4    Tuccinardi, T.5    Baranger, A.M.6    Zimmerman, S.C.7
  • 48
    • 0022445682 scopus 로고
    • Polyfunctional DNA intercalating agents
    • Wakelin, L. P. G. Polyfunctional DNA intercalating agents Med. Res. Rev. 1986, 6, 275-340
    • (1986) Med. Res. Rev. , vol.6 , pp. 275-340
    • Wakelin, L.P.G.1
  • 49
    • 0024361586 scopus 로고
    • Topologically constrained bifunctional intercalators: DNA intercalation by a macrocyclic bisacridine
    • Zimmerman, S. C.; Lamberson, C. R.; Cory, M.; Fairley, T. A. Topologically constrained bifunctional intercalators: DNA intercalation by a macrocyclic bisacridine J. Am. Chem. Soc. 1989, 111, 6805-6809
    • (1989) J. Am. Chem. Soc. , vol.111 , pp. 6805-6809
    • Zimmerman, S.C.1    Lamberson, C.R.2    Cory, M.3    Fairley, T.A.4
  • 51
    • 0036024720 scopus 로고    scopus 로고
    • Acridine derivatives as chemotherapeutic agents
    • Denny, W. A. Acridine derivatives as chemotherapeutic agents Curr. Med. Chem. 2002, 9, 1655-1665
    • (2002) Curr. Med. Chem. , vol.9 , pp. 1655-1665
    • Denny, W.A.1
  • 53
    • 33745601106 scopus 로고    scopus 로고
    • Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity
    • Goodell, J. R.; Madhok, A. A.; Hiasa, H.; Ferguson, D. M. Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity Bioorg. Med. Chem. 2006, 14, 5467-5480
    • (2006) Bioorg. Med. Chem. , vol.14 , pp. 5467-5480
    • Goodell, J.R.1    Madhok, A.A.2    Hiasa, H.3    Ferguson, D.M.4
  • 54
    • 84883300162 scopus 로고    scopus 로고
    • Threading polyintercalators with extremely slow dissociation rates and extended DNA binding sites
    • Rhoden Smith, A.; Iverson, B. L. Threading polyintercalators with extremely slow dissociation rates and extended DNA binding sites J. Am. Chem. Soc. 2013, 135, 12783-12789
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 12783-12789
    • Rhoden Smith, A.1    Iverson, B.L.2
  • 57
    • 34948842517 scopus 로고    scopus 로고
    • The influence of rigid or flexible linkage between two ligands on the effective affinity and avidity for reversible interactions with bivalent receptors
    • Bobrovnik, S. A. The influence of rigid or flexible linkage between two ligands on the effective affinity and avidity for reversible interactions with bivalent receptors J. Mol. Recognit. 2007, 20, 253-262
    • (2007) J. Mol. Recognit. , vol.20 , pp. 253-262
    • Bobrovnik, S.A.1
  • 58
    • 0242576079 scopus 로고    scopus 로고
    • Preparation of discrete oligoethers: Synthesis of pentabutylene glycol and hexapropylene glycol by two complementary methods
    • Knuf, E. C.; Jiang, J.-K.; Gin, M. S. Preparation of discrete oligoethers: synthesis of pentabutylene glycol and hexapropylene glycol by two complementary methods J. Org. Chem. 2003, 68, 9166-9169
    • (2003) J. Org. Chem. , vol.68 , pp. 9166-9169
    • Knuf, E.C.1    Jiang, J.-K.2    Gin, M.S.3
  • 59
    • 77956629693 scopus 로고    scopus 로고
    • Synthesis of linear polyamines with different amine spacings and their ability to form dsDNA/siRNA complexes suitable for transfection
    • Fischer, W.; Brissault, B.; Prévost, S.; Kopaczynska, M.; Andreou, I.; Janosch, A.; Gradzielski, M.; Haag, R. Synthesis of linear polyamines with different amine spacings and their ability to form dsDNA/siRNA complexes suitable for transfection Macromol. Biosci. 2010, 10, 1073-1083
    • (2010) Macromol. Biosci. , vol.10 , pp. 1073-1083
    • Fischer, W.1    Brissault, B.2    Prévost, S.3    Kopaczynska, M.4    Andreou, I.5    Janosch, A.6    Gradzielski, M.7    Haag, R.8
  • 61
    • 0014273261 scopus 로고
    • Calculation of binding isotherms for heterogenous polymers
    • Crothers, D. M. Calculation of binding isotherms for heterogenous polymers Biopolymers 1968, 6, 575-584
    • (1968) Biopolymers , vol.6 , pp. 575-584
    • Crothers, D.M.1
  • 62
  • 63
    • 84155178069 scopus 로고    scopus 로고
    • MBNL1-RNA recognition: Contributions of MBNL1 sequence and RNA conformation
    • Fu, Y.; Ramisetty, S. R.; Hussain, N.; Baranger, A. M. MBNL1-RNA recognition: Contributions of MBNL1 sequence and RNA conformation ChemBioChem 2012, 13, 112-119
    • (2012) ChemBioChem , vol.13 , pp. 112-119
    • Fu, Y.1    Ramisetty, S.R.2    Hussain, N.3    Baranger, A.M.4
  • 64
    • 27744525384 scopus 로고    scopus 로고
    • Helical and coil conformations of poly(ethylene glycol) in isobutyric acid and water
    • Alessi, M. L.; Norman, A. I.; Knowlton, S. E.; Ho, D. L.; Greer, S. C. Helical and coil conformations of poly(ethylene glycol) in isobutyric acid and water Macromolecules 2005, 38, 9333-9340
    • (2005) Macromolecules , vol.38 , pp. 9333-9340
    • Alessi, M.L.1    Norman, A.I.2    Knowlton, S.E.3    Ho, D.L.4    Greer, S.C.5
  • 65
    • 0029737547 scopus 로고    scopus 로고
    • Fluorescence characteristics of 5-carboxytetramethylrhodamine linked covalently to the 5′ end of oligonucleotides: Multiple conformers of single-stranded and double-stranded dye-DNA complexes
    • Vámosi, G.; Gohlke, C.; Clegg, R. M. Fluorescence characteristics of 5-carboxytetramethylrhodamine linked covalently to the 5′ end of oligonucleotides: Multiple conformers of single-stranded and double-stranded dye-DNA complexes Biophys. J. 1996, 71, 972-994
    • (1996) Biophys. J. , vol.71 , pp. 972-994
    • Vámosi, G.1    Gohlke, C.2    Clegg, R.M.3
  • 66
    • 70350241481 scopus 로고    scopus 로고
    • Fluorescence quenching of TMR by guanosine in oligonucleotides
    • Qu, P.; Chen, X. D.; Zhou, X. X.; Li, X.; Zhao, X. S. Fluorescence quenching of TMR by guanosine in oligonucleotides Sci. China, Ser. B: Chem. 2009, 52, 1653-1659
    • (2009) Sci. China, Ser. B: Chem. , vol.52 , pp. 1653-1659
    • Qu, P.1    Chen, X.D.2    Zhou, X.X.3    Li, X.4    Zhao, X.S.5
  • 67
    • 33751321865 scopus 로고    scopus 로고
    • A detergent-based assay for the detection of promiscuous inhibitors
    • Feng, B. Y.; Shoichet, B. K. A detergent-based assay for the detection of promiscuous inhibitors Nat. Protoc. 2006, 1, 550-553
    • (2006) Nat. Protoc. , vol.1 , pp. 550-553
    • Feng, B.Y.1    Shoichet, B.K.2
  • 68
    • 34347230544 scopus 로고    scopus 로고
    • Sulforhodamine B colorimetric assay for cytotoxicity screening
    • Vichai, V.; Kirtikara, K. Sulforhodamine B colorimetric assay for cytotoxicity screening Nat. Protoc. 2006, 1, 1112-1116
    • (2006) Nat. Protoc. , vol.1 , pp. 1112-1116
    • Vichai, V.1    Kirtikara, K.2
  • 69
    • 84862147242 scopus 로고    scopus 로고
    • RNA-binding proteins in microsatellite expansion disorders: Mediators of RNA toxicity
    • Echeverria, G. V.; Cooper, T. A. RNA-binding proteins in microsatellite expansion disorders: mediators of RNA toxicity Brain Res. 2012, 1462, 100-111
    • (2012) Brain Res. , vol.1462 , pp. 100-111
    • Echeverria, G.V.1    Cooper, T.A.2
  • 70
    • 23744450059 scopus 로고    scopus 로고
    • Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy
    • Ho, T. H.; Savkur, R. S.; Poulos, M. G.; Mancini, M. A.; Swanson, M. S.; Cooper, T. A. Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy J. Cell Sci. 2005, 118, 2923-2933
    • (2005) J. Cell Sci. , vol.118 , pp. 2923-2933
    • Ho, T.H.1    Savkur, R.S.2    Poulos, M.G.3    Mancini, M.A.4    Swanson, M.S.5    Cooper, T.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.