Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5467-5480

  Goodell, John R ^a   Madhok, Avni A ^a   Hiasa, Hiroshi ^b   Ferguson, David M ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Acalrubicin; Acridine; Acridone; Amsacrine; Antiviral; DNA binding; Herpes virus; Heterocycle; HSV 1; HSV 2; Intercalator; Topoisomerase; Topoisomerase catalytic inhibitor; Topoisomerase poison; Xanthone

Indexed keywords

2 (4 METHYLPIPERAZINE 1 CARBONYL)ACRIDIN 9(10H) ONE; 2 (MORPHOLINE 4 CARBONYL)ACRIDIN 9(10H) ONE; 2 PHENOXYTEREPHTHALIC ACID; 2 PHENYLAMINO TEREPHTHALIC ACID; 3 (4 METHYLPIPERAZINE 1 CARBONYL)ACRIDIN 9(10H) ONE; 3 (4 METHYLPIPERAZINE 1 CARBONYL)XANTHEN 9 ONE; 3 (MORPHOLINE 4 CARBONYL) 9H XANTHEN 9 ONE; 3 (MORPHOLINE 4 CARBONYL)ACRIDIN 9(10H) ONE; 4 (4 METHYLPIPERAZINE 1 CARBONYL) 9 PHENOXY (10H) ACRIDINE; 4 (4 METHYLPIPERAZINE 1 CARBONYL)ACRIDIN 9(10H) ONE; 4 (MORPHOLINE 4 CARBONYL) 9 PHENOXY (10H) ACRIDINE; 4 (MORPHOLINE 4 CARBONYL)ACRIDINE 9(10H) ONE; 9 OXO 9,10 DIHYDROACRIDINE 2 CARBOXYLIC ACID; 9 OXO 9,10 DIHYDROACRIDINE 3 CARBOXYLIC ACID; 9 OXO 9,10 DIHYDROACRIDINE 4 CARBOXYLIC ACID; 9 OXO 9H XANTHENE 3 CARBOXYLIC ACID; ACRIDINE DERIVATIVE; ACRIDONE DERIVATIVE; AMINOACRIDINE; AMSACRINE; ANTIVIRUS AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); N (2 CARBOXYPHNYL)ANTHRANILIC ACID; N (4 CARBOXYPHENYL)ANTHRANILIC ACID; N,N DIETHYL 2 ACRIDIN 9(10H) ONE CARBOXAMIDE; N,N DIETHYL 3 ACRIDIN 9(10H) ONE CARBOXAMIDE; N,N DIETHYL 4 ACRIDIN 9(10H) ONE CARBOXAMIDE; N,N DIETHYL 9H XANTHEN 9 ONE 3 CARBOXAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANTHONE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DNA CLEAVAGE; DNA DETERMINATION; DNA SUPERCOILING; DRUG BINDING; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG DNA BINDING; DRUG MECHANISM; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; EVALUATION; HERPES; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; INFECTION CONTROL; NONHUMAN; PROTEIN DNA BINDING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ACRIDINES; ANTIVIRAL AGENTS; DNA TOPOISOMERASES; DNA TOPOISOMERASES, TYPE II; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; MICROBIAL SENSITIVITY TESTS; VIRUS REPLICATION;

HERPES; HERPESVIRIDAE;

EID: 33745601106     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.044     Document Type: Article

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