In vivo discovery of a peptide that prevents CUG-RNA hairpin formation and reverses RNA toxicity in myotonic dystrophy models

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 29, 2011, Pages 11866-11871

  García López, Amparo ^a   Llamusí, Beatriz ^a   Orzáez, Mar ^b   Pérez Payá, Enrique ^b,c   Artero, Ruben D ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^c INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

Author keywords

Disease model; Drug discovery; Medicinal chemistry; Non coding RNA disease; RNA secondary structure

Indexed keywords

CUG RNA HAIRPIN; DEXTRO AMINO ACID HEXAPEPTIDE 1; HEXAPEPTIDE; MUSCLEBLIND LIKE 1 PROTEIN; PEPTIDE LIBRARY; PROTEIN; RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; EYE TOXICITY; FEMALE; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MOUSE; MUSCLE ATROPHY; MUSCLE DISEASE; MUSCLE TOXICITY; MYOTONIC DYSTROPHY; MYOTONIC DYSTROPHY TYPE 1; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RNA SPLICING; RNA TOXICITY; SINGLE STRAND CONFORMATION POLYMORPHISM; TRANSGENE;

ANIMALS; DNA-BINDING PROTEINS; DROSOPHILA; DRUG DISCOVERY; MICE; MUSCLES; MYOTONIC DYSTROPHY; OLIGOPEPTIDES; PEPTIDE LIBRARY; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; RNA-BINDING PROTEINS; TRINUCLEOTIDE REPEAT EXPANSION;

MUS;

EID: 79961062490     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1018213108     Document Type: Article

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