Towards multivalent CD1d ligands: Synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

Carbohydrate Research

Volumn 356, Issue , 2012, Pages 152-162

  Jervis, Peter J ^a   Moulis, Marie ^a   Jukes, John Paul ^b   Ghadbane, Hemza ^b   Cox, Liam R ^a   Cerundolo, Vincenzo ^b   Besra, Gurdyal S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

GalCer; CD1d; Click chemistry; Dimer; iNKT cells; Multivalency

Indexed keywords

CD1D; CERAMIDES; CLICK CHEMISTRY; CLICK REACTION; MULTIVALENCY;

AMIDES; BIOACTIVITY; CHELATION; DIMERS;

LIGANDS;

ALPHA GALACTOSYLCERAMIDE; ASCORBIC ACID; CD1D ANTIGEN; CERAMIDE DERIVATIVE; GALACTOSE; HOMODIMER; MACROGOL; SULFATE; T LYMPHOCYTE RECEPTOR; TETRABUTYLAMMONIUM;

BIOLOGICAL ACTIVITY; CONFERENCE PAPER; CRYSTAL STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HYDROGEN BOND; MAJOR HISTOCOMPATIBILITY COMPLEX; NATURAL KILLER T CELL; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SYNTHESIS; TH1 CELL; TH2 CELL;

ANIMALS; ANTIGENS, CD1D; CARBOHYDRATE CONFORMATION; CATALYSIS; CELLS, CULTURED; CLICK CHEMISTRY; DIMERIZATION; GALACTOSYLCERAMIDES; INJECTIONS, INTRAVENOUS; INTERFERON-GAMMA; LIGANDS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; NATURAL KILLER T-CELLS; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; SPLEEN;

EID: 84862326827     PISSN: 00086215     EISSN: 1873426X     Source Type: Journal    
DOI: 10.1016/j.carres.2012.02.034     Document Type: Conference Paper

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