Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 6, 2007, Pages 2164-2172

  Caffrey, Conor R ^a   Steverding, Dietmar ^b,h   Swenerton, Ryan K ^a   Kelly, Ben ^a   Walshe, Deirdre ^a   Debnath, Anjan ^a   Zhou, Yuan Min ^a   Doyle, Patricia S ^a   Fafarman, Aaron T ^c   Zorn, Julie A ^c   Land, Kirkwood M ^d   Beauchene, Jessica ^d   Schreiber, Kimberly ^d   Moll, Heidrun ^e   Ponte Sucre, Alicia ^e,f   Schirmeister, Tanja ^e   Saravanamuthu, Ahilan ^g   Fairlamb, Alan H ^g   Cohen, Fred E ^a   McKerrow, James H ^a   Weisman, Jennifer L ^c   May, Barnaby C H ^a   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF THE PACIFIC   (United States)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^g UNIVERSITY OF DUNDEE   (United Kingdom)

^h UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE DERIVATIVE; BIS 6 DICHLORO2 METHOXYACRIDINE; BIS 7 DICHLORO 2 METHOXYBENZO[B][1,5]NAPHTHYRIDINE; UNCLASSIFIED DRUG;

ACYLATION; ALKYLATION; ANTHELMINTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI;

ACRIDINES; ANIMALS; ANTIPARASITIC AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; HL-60 CELLS; HUMANS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; POLYAMINES; PROTOZOA; SCHISTOSOMA MANSONI; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI BRUCEI;

EID: 34250162859     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01418-06     Document Type: Article

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