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Volumn 20, Issue 6, 2013, Pages 155-169

A skin-depth analysis of integrins: Role of the integrin network in health and disease

Author keywords

Adhesion; Blistering diseases; Cancer; Integrins; Signaling; Skin; Therapeutics

Indexed keywords

ABCIXIMAB; ANGIOSTATIN; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARBOPLATIN; CILENGITIDE; COLLAGEN TYPE 17; COLLAGEN TYPE 7; DACARBAZINE; ENDOSTATIN; EPTIFIBATIDE; FIBRINOGEN; FLUCICLATIDE F 18; GALACTO ARGINYLGLYCYLASPARTIC ACID F 18; GRANULOCYTE COLONY STIMULATING FACTOR; HP 802 247; INTEGRIN; INTEGRIN LINKED KINASE; INTEGRIN RECEPTOR; JSM 6427; LAMININ; PACLITAXEL; PLECTIN; RADIOPHARMACEUTICAL AGENT; SIMVASTATIN; SMALL INTERFERING RNA; TIROFIBAN; TUMSTATIN; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; VOLOCIXIMAB;

EID: 84890354799     PISSN: 15419061     EISSN: 15435180     Source Type: Journal    
DOI: 10.3109/15419061.2013.854334     Document Type: Review
Times cited : (38)

References (127)
  • 1
    • 84887212399 scopus 로고    scopus 로고
    • The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells
    • Alghisi GC, Ponsonnet L, Ruegg C (2009). The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells. PLoS One. 4: E4449
    • (2009) PLoS One , vol.4
    • Alghisi, G.C.1    Ponsonnet, L.2    Ruegg, C.3
  • 2
    • 84873385587 scopus 로고    scopus 로고
    • Integrin signaling in cancer cell survival and chemoresistance
    • Aoudjit F, Vuori K (2012). Integrin signaling in cancer cell survival and chemoresistance. Chemother Res Pract. 2012: 283181
    • (2012) Chemother Res Pract 2012 , pp. 283181
    • Aoudjit, F.1    Vuori, K.2
  • 5
    • 14944348752 scopus 로고    scopus 로고
    • Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defi nes a novel prognostic indicator of aggressive colon carcinoma
    • Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM (2005). Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defi nes a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest. 115: 339-347
    • (2005) J Clin Invest , vol.115 , pp. 339-347
    • Bates, R.C.1    Bellovin, D.I.2    Brown, C.3    Maynard, E.4    Wu, B.5    Kawakatsu, H.6    Sheppard, D.7    Oettgen, P.8    Mercurio, A.M.9
  • 6
    • 60749125436 scopus 로고    scopus 로고
    • Epidermal homeostasis: A balancing act of stem cells in the skin
    • Blanpain C, Fuchs E (2009). Epidermal homeostasis: A balancing act of stem cells in the skin. Nat Rev Mol Cell Biol. 10 : 207-217
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 207-217
    • Blanpain, C.1    Fuchs, E.2
  • 7
    • 84879421363 scopus 로고    scopus 로고
    • Integrin inactivators: Balancing cellular functions in vitro and in vivo
    • Bouvard D, Pouwels J, De Franceschi N, Ivaska J (2013). Integrin inactivators: Balancing cellular functions in vitro and in vivo. Nat Rev Mol Cell Biol. 14: 430-442
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 430-442
    • Bouvard, D.1    Pouwels, J.2    De Franceschi, N.3    Ivaska, J.4
  • 9
    • 84894226869 scopus 로고    scopus 로고
    • Disorders of the cutaneous basement membrane zone-The paradigm of epidermolysis bullosa
    • Epub ahead of print
    • Bruckner-Tuderman L, Has C (2013). Disorders of the cutaneous basement membrane zone-The paradigm of epidermolysis bullosa. Matrix Biol. (Epub ahead of print
    • (2013) Matrix Biol
    • Bruckner-Tuderman, L.1    Has, C.2
  • 10
    • 84906940380 scopus 로고    scopus 로고
    • Signaling events mediated by alpha3beta1 integrin are essential for mammary tumorigenesis
    • Epub ahead of print
    • Cagnet S, Faraldo MM, Kreft M, Sonnenberg A, Raymond K, Glukhova MA (2013). Signaling events mediated by alpha3beta1 integrin are essential for mammary tumorigenesis. Oncogene. (Epub ahead of print
    • (2013) Oncogene
    • Cagnet, S.1    Faraldo, M.M.2    Kreft, M.3    Sonnenberg, A.4    Raymond, K.5    Glukhova, M.A.6
  • 13
    • 0029565083 scopus 로고
    • Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis
    • Carroll JM, Romero MR, Watt FM (1995). Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell. 83: 957-968
    • (1995) Cell , vol.83 , pp. 957-968
    • Carroll, J.M.1    Romero, M.R.2    Watt, F.M.3
  • 14
    • 0346363880 scopus 로고    scopus 로고
    • Identifi cation of a lethal form of epidermolysis bullosa simplex associated with a homozygous genetic mutation in plectin
    • Charlesworth A, Gagnoux-Palacios L, Bonduelle M, Ortonne JP, De Raeve L, Meneguzzi G (2003). Identifi cation of a lethal form of epidermolysis bullosa simplex associated with a homozygous genetic mutation in plectin. J Invest Dermatol. 121: 1344-1348
    • (2003) J Invest Dermatol , vol.121 , pp. 1344-1348
    • Charlesworth, A.1    Gagnoux-Palacios, L.2    Bonduelle, M.3    Ortonne, J.P.4    De Raeve, L.5    Meneguzzi, G.6
  • 15
    • 41449114840 scopus 로고    scopus 로고
    • PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells
    • Chen K, Tu Y, Zhang Y, Blair HC, Zhang L, Wu C (2008). PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells. J Biol Chem. 283: 2508-2517
    • (2008) J Biol Chem , vol.283 , pp. 2508-2517
    • Chen, K.1    Tu, Y.2    Zhang, Y.3    Blair, H.C.4    Zhang, L.5    Wu, C.6
  • 16
    • 33645220951 scopus 로고    scopus 로고
    • Dissociation of the complex between cd151 and laminin-binding integrins permits migration of epithelial cells
    • Chometon G, Zhang ZG, Rubinstein E, Boucheix C, Mauch C, Aumailley M (2006). Dissociation of the complex between CD151 and laminin-binding integrins permits migration of epithelial cells. Exp Cell Res. 312: 983-995
    • (2006) Exp Cell Res , vol.312 , pp. 983-995
    • Chometon, G.1    Zhang, Z.G.2    Rubinstein, E.3    Boucheix, C.4    Mauch, C.5    Aumailley, M.6
  • 18
    • 77950577869 scopus 로고    scopus 로고
    • Replenishment of type VII collagen and re-epithelialization of chronically ulcerated skin after intradermal administration of allogeneic mesenchymal stromal cells in two patients with recessive dystrophic epidermolysis bullosa
    • Conget P, Rodriguez F, Kramer S, Allers C, Simon V, Palisson F, Gonzalez S, Yubero MJ (2010). Replenishment of type VII collagen and re-epithelialization of chronically ulcerated skin after intradermal administration of allogeneic mesenchymal stromal cells in two patients with recessive dystrophic epidermolysis bullosa. Cytotherapy. 12: 429-431
    • (2010) Cytotherapy , vol.12 , pp. 429-431
    • Conget, P.1    Rodriguez, F.2    Kramer, S.3    Allers, C.4    Simon, V.5    Palisson, F.6    Gonzalez, S.7    Yubero, M.J.8
  • 19
    • 70649105588 scopus 로고    scopus 로고
    • Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2
    • Crampton SP, Wu B, Park EJ, Kim JH, Solomon C, Waterman ML, Hughes CC (2009). Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2. PLoS One. 4: E7841
    • (2009) PLoS One , vol.4
    • Crampton, S.P.1    Wu, B.2    Park, E.J.3    Kim, J.H.4    Solomon, C.5    Waterman, M.L.6    Hughes, C.C.7
  • 20
    • 4444265587 scopus 로고    scopus 로고
    • Functional improvement of mutant keratin cells on addition of desmin: An alternative approach to gene therapy for dominant diseases
    • D'Alessandro M, Morley SM, Ogden PH, Liovic M, Porter RM, Lane EB (2004). Functional improvement of mutant keratin cells on addition of desmin: An alternative approach to gene therapy for dominant diseases. Gene Ther. 11: 1290-1295
    • (2004) Gene Ther , vol.11 , pp. 1290-1295
    • D'Alessandro, M.1    Morley, S.M.2    Ogden, P.H.3    Liovic, M.4    Porter, R.M.5    Lane, E.B.6
  • 22
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: Biological implications and therapeutic opportunities
    • Desgrosellier JS, Cheresh DA (2010). Integrins in cancer: Biological implications and therapeutic opportunities. Nat Rev Cancer. 10: 9-22
    • (2010) Nat Rev Cancer , vol.10 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 24
    • 49249096493 scopus 로고    scopus 로고
    • The rsu-1-pinch1-ilk complex is regulated by ras activation in tumor cells
    • Dougherty GW, Jose C, Gimona M, Cutler ML (2008). The Rsu-1-PINCH1-ILK complex is regulated by Ras activation in tumor cells. Eur J Cell Biol. 87: 721-734
    • (2008) Eur J Cell Biol , vol.87 , pp. 721-734
    • Dougherty, G.W.1    Jose, C.2    Gimona, M.3    Cutler, M.L.4
  • 25
    • 0036547696 scopus 로고    scopus 로고
    • Urokinase-Type plasminogen activator: A potent marker of metastatic potential in human cancers
    • Duffy MJ (2002). Urokinase-Type plasminogen activator: A potent marker of metastatic potential in human cancers. Biochem Soc Trans. 30: 207-210
    • (2002) Biochem Soc Trans , vol.30 , pp. 207-210
    • Duffy, M.J.1
  • 28
    • 58149345037 scopus 로고    scopus 로고
    • Epidermolysis bullosa and the risk of life-Threatening cancers: The national eb registry experience, 1986
    • Fine JD, Johnson LB, Weiner M, Li KP, Suchindran C (2009). Epidermolysis bullosa and the risk of life-Threatening cancers: The National EB Registry experience, 1986-2006. J Am Acad Dermatol. 60: 203-211
    • (2009) J Am Acad Dermatol , vol.60 , pp. 203-211
    • Fine, J.D.1    Johnson, L.B.2    Weiner, M.3    Li, K.P.4    Suchindran, C.5
  • 29
    • 0036245242 scopus 로고    scopus 로고
    • Getting under the skin of epidermal morphogenesis
    • Fuchs E, Raghavan S (2002). Getting under the skin of epidermal morphogenesis. Nat Rev Genet. 3: 199-209
    • (2002) Nat Rev Genet , vol.3 , pp. 199-209
    • Fuchs, E.1    Raghavan, S.2
  • 31
    • 0025214421 scopus 로고
    • Elevated levels of the alpha 5 beta 1 fi bronectin receptor suppress the transformed phenotype of chinese hamster ovary cells
    • Giancotti FG, Ruoslahti E (1990). Elevated levels of the alpha 5 beta 1 fi bronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell. 60: 849-859
    • (1990) Cell , vol.60 , pp. 849-859
    • Giancotti, F.G.1    Ruoslahti, E.2
  • 32
    • 33846274992 scopus 로고    scopus 로고
    • Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer
    • Gozgit JM, Pentecost BT, Marconi SA, Otis CN, Wu C, Arcaro KF (2006). Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer. Mol Cancer Res. 4: 905-913
    • (2006) Mol Cancer Res , vol.4 , pp. 905-913
    • Gozgit, J.M.1    Pentecost, B.T.2    Marconi, S.A.3    Otis, C.N.4    Wu, C.5    Arcaro, K.F.6
  • 33
    • 0029066406 scopus 로고
    • Gene targeting of BPAG1: Abnormalities in mechanical strength and cell migration in stratifi ed epithelia and neurologic degeneration
    • Guo L, Degenstein L, Dowling J, Yu QC, Wollmann R, Perman B, Fuchs E (1995). Gene targeting of BPAG1: Abnormalities in mechanical strength and cell migration in stratifi ed epithelia and neurologic degeneration. Cell. 81: 233-243
    • (1995) Cell , vol.81 , pp. 233-243
    • Guo, L.1    Degenstein, L.2    Dowling, J.3    Yu, Q.C.4    Wollmann, R.5    Perman, B.6    Fuchs, E.7
  • 37
    • 33845990287 scopus 로고    scopus 로고
    • Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes
    • Herz C, Aumailley M, Schulte C, Schlotzer-Schrehardt U, Bruckner-Tuderman L, Has C (2006). Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes. J Biol Chem. 281: 36082-36090
    • (2006) J Biol Chem , vol.281 , pp. 36082-36090
    • Herz, C.1    Aumailley, M.2    Schulte, C.3    Schlotzer-Schrehardt, U.4    Bruckner-Tuderman, L.5    Has, C.6
  • 38
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes RO (2002). Integrins: Bidirectional, allosteric signaling machines. Cell. 110: 673-687
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 39
    • 79957696056 scopus 로고    scopus 로고
    • Generation of keratinocytes from normal and recessive dystrophic epidermolysis bullosa-induced pluripotent stem cells
    • Itoh M, Kiuru M, Cairo MS, Christiano AM (2011). Generation of keratinocytes from normal and recessive dystrophic epidermolysis bullosa-induced pluripotent stem cells. Proc Natl Acad Sci U S A. 108: 8797-8802
    • (2011) Proc Natl Acad Sci U S A. , vol.108 , pp. 8797-8802
    • Itoh, M.1    Kiuru, M.2    Cairo, M.S.3    Christiano, A.M.4
  • 40
    • 33644522372 scopus 로고    scopus 로고
    • New roles for integrins in squamouscell carcinoma
    • Janes SM, Watt FM (2006). New roles for integrins in squamouscell carcinoma. Nat Rev Cancer. 6: 175-183
    • (2006) Nat Rev Cancer , vol.6 , pp. 175-183
    • Janes, S.M.1    Watt, F.M.2
  • 41
    • 4944239350 scopus 로고    scopus 로고
    • CD151, the fi rst member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin
    • Karamatic Crew V, Burton N, Kagan A, Green CA, Levene C, Flinter F, Brady RL, Daniels G, Anstee DJ (2004). CD151, the fi rst member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin. Blood. 104: 2217-2223
    • (2004) Blood , vol.104 , pp. 2217-2223
    • Karamatic Crew, V.1    Burton, N.2    Kagan, A.3    Green, C.A.4    Levene, C.5    Flinter, F.6    Brady, R.L.7    Daniels, G.8    Anstee, D.J.9
  • 44
    • 77952483707 scopus 로고    scopus 로고
    • Bone marrow stem cell therapy for recessive dystrophic epidermolysis bullosa
    • xii-xiii
    • Kiuru M, Itoh M, Cairo MS, Christiano AM (2010). Bone marrow stem cell therapy for recessive dystrophic epidermolysis bullosa. Dermatol Clin. 28: 371-382, xii-xiii
    • (2010) Dermatol Clin , vol.28 , pp. 371-382
    • Kiuru, M.1    Itoh, M.2    Cairo, M.S.3    Christiano, A.M.4
  • 45
    • 1342346591 scopus 로고    scopus 로고
    • The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion
    • Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC (2004). The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem. 279: 6824-6833
    • (2004) J Biol Chem , vol.279 , pp. 6824-6833
    • Kloeker, S.1    Major, M.B.2    Calderwood, D.A.3    Ginsberg, M.H.4    Jones, D.A.5    Beckerle, M.C.6
  • 49
    • 49549083034 scopus 로고    scopus 로고
    • Colocalization of kindlin-1, kindlin-2, and migfi lin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome
    • Lai-Cheong JE, Ussar S, Arita K, Hart IR, McGrath JA (2008). Colocalization of kindlin-1, kindlin-2, and migfi lin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome. J Invest Dermatol. 128: 2156-2165
    • (2008) J Invest Dermatol , vol.128 , pp. 2156-2165
    • Lai-Cheong, J.E.1    Ussar, S.2    Arita, K.3    Hart, I.R.4    McGrath, J.A.5
  • 51
    • 77649181584 scopus 로고    scopus 로고
    • The role of kindlins in cell biology and relevance to human disease
    • Lai-Cheong JE, Parsons M, McGrath JA (2010). The role of kindlins in cell biology and relevance to human disease. Int J Biochem Cell Biol. 42: 595-603
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 595-603
    • Lai-Cheong, J.E.1    Parsons, M.2    McGrath, J.A.3
  • 54
    • 34248593729 scopus 로고    scopus 로고
    • Antisense integrin alphaV and beta3 gene therapy suppresses subcutaneously implanted hepatocellular carcinomas
    • Li J, Tan H, Dong X, Xu Z, Shi C, Han X, Jiang H, Krissansen GW, Sun X (2007). Antisense integrin alphaV and beta3 gene therapy suppresses subcutaneously implanted hepatocellular carcinomas. Dig Liver Dis. 39: 557-565
    • (2007) Dig Liver Dis , vol.39 , pp. 557-565
    • Li, J.1    Tan, H.2    Dong, X.3    Xu, Z.4    Shi, C.5    Han, X.6    Jiang, H.7    Krissansen, G.W.8    Sun, X.9
  • 55
    • 84873203417 scopus 로고    scopus 로고
    • Silencing of integrin-linked kinase suppresses in vivo tumorigenesis of human ovarian carcinoma cells
    • Li Q, Li C, Zhang YY, Chen W, Lv JL, Sun J, You QS (2013). Silencing of integrin-linked kinase suppresses in vivo tumorigenesis of human ovarian carcinoma cells. Mol Med Rep. 7: 1050-1054
    • (2013) Mol Med Rep , vol.7 , pp. 1050-1054
    • Li, Q.1    Li, C.2    Zhang, Y.Y.3    Chen, W.4    Lv, J.L.5    Sun, J.6    You, Q.S.7
  • 56
    • 84896400729 scopus 로고    scopus 로고
    • Overexpression of integrin-linked kinase (ILK) promotes glioma cell invasion and migration and down-regulates E-cadherin via the NF-kappaB pathway
    • Epub ahead of print
    • Liang F, Zhang S, Wang B, Qiu J, Wang Y (2013). Overexpression of integrin-linked kinase (ILK) promotes glioma cell invasion and migration and down-regulates E-cadherin via the NF-kappaB pathway. J Mol Histol. (Epub ahead of print
    • (2013) J Mol Histol
    • Liang, F.1    Zhang, S.2    Wang, B.3    Qiu, J.4    Wang, Y.5
  • 57
    • 84885600726 scopus 로고    scopus 로고
    • Human cord blood derived unrestricted somatic stem cells promote wound healing and have therapeutic potential for patients with recessive dystrophic epidermolysis bullosa
    • Epub ahead of print
    • Liao Y, Itoh M, Yang A, Zhu H, Roberts S, Highet AM, Latshaw S, Mitchell K, van de Ven C, Christiano A, Cairo MS (2013). Human cord blood derived unrestricted somatic stem cells promote wound healing and have therapeutic potential for patients with recessive dystrophic epidermolysis bullosa. Cell Transplant. (Epub ahead of print
    • (2013) Cell Transplant
    • Liao, Y.1    Itoh, M.2    Yang, A.3    Zhu, H.4    Roberts, S.5    Highet, A.M.6    Latshaw, S.7    Mitchell, K.8    Van De Ven, C.9    Christiano, A.10    Cairo, M.S.11
  • 58
    • 84872656003 scopus 로고    scopus 로고
    • Integrin-linked kinase regulates interphase and mitotic microtubule dynamics
    • Lim S, Kawamura E, Fielding AB, Maydan M, Dedhar S (2013). Integrin-linked kinase regulates interphase and mitotic microtubule dynamics. PLoS One. 8: E53702
    • (2013) PLoS One , vol.8
    • Lim, S.1    Kawamura, E.2    Fielding, A.B.3    Maydan, M.4    Dedhar, S.5
  • 59
    • 84863273857 scopus 로고    scopus 로고
    • Silencing of the integrin-linked kinase gene induces the apoptosis in ovarian carcinoma
    • Liu Q, Xiao L, Yuan D, Shi X, Li P (2012). Silencing of the integrin-linked kinase gene induces the apoptosis in ovarian carcinoma. J Recept Signal Transduct Res. 32: 120-127
    • (2012) J Recept Signal Transduct Res , vol.32 , pp. 120-127
    • Liu, Q.1    Xiao, L.2    Yuan, D.3    Shi, X.4    Li, P.5
  • 62
    • 78649867535 scopus 로고    scopus 로고
    • Unique and redundant functions of integrins in the epidermis
    • Margadant C, Charafeddine RA, Sonnenberg A (2010). Unique and redundant functions of integrins in the epidermis. FASEB J. 24: 4133-4152
    • (2010) FASEB J. , vol.24 , pp. 4133-4152
    • Margadant, C.1    Charafeddine, R.A.2    Sonnenberg, A.3
  • 64
    • 44849100858 scopus 로고    scopus 로고
    • Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma
    • McCarty JH, Barry M, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO (2008). Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am J Pathol. 172: 1740-1747
    • (2008) Am J Pathol , vol.172 , pp. 1740-1747
    • McCarty, J.H.1    Barry, M.2    Crowley, D.3    Bronson, R.T.4    Lacy-Hulbert, A.5    Hynes, R.O.6
  • 66
  • 67
    • 0030453194 scopus 로고    scopus 로고
    • Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors
    • Miyamoto S, Teramoto H, Gutkind JS, Yamada KM (1996). Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors. J Cell Biol. 135: 1633-1642
    • (1996) J Cell Biol , vol.135 , pp. 1633-1642
    • Miyamoto, S.1    Teramoto, H.2    Gutkind, J.S.3    Yamada, K.M.4
  • 68
    • 40449133970 scopus 로고    scopus 로고
    • Kindlin-3 is essential for integrin activation and platelet aggregation
    • Moser M, Nieswandt B, Ussar S, Pozgajova M, Fassler R (2008). Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med. 14: 325-330
    • (2008) Nat Med , vol.14 , pp. 325-330
    • Moser, M.1    Nieswandt, B.2    Ussar, S.3    Pozgajova, M.4    Fassler, R.5
  • 70
    • 44949237149 scopus 로고    scopus 로고
    • Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis
    • Nakrieko KA, Welch I, Dupuis H, Bryce D, Pajak A, St Arnaud R, Dedhar S, D'Souza SJ, Dagnino L (2008). Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. Mol Biol Cell. 19 : 1462-1473
    • (2008) Mol Biol Cell , vol.19 , pp. 1462-1473
    • Nakrieko, K.A.1    Welch, I.2    Dupuis, H.3    Bryce, D.4    Pajak, A.5    St Arnaud, R.6    Dedhar, S.7    D'Souza, S.J.8    Dagnino, L.9
  • 71
    • 84866452621 scopus 로고    scopus 로고
    • SiRNA-mediated silencing of integrin beta3 expression inhibits the metastatic potential of B16 melanoma cells
    • Nasulewicz-Goldeman A, Uszczynska B, Szczaurska-Nowak K, Wietrzyk J (2012). siRNA-mediated silencing of integrin beta3 expression inhibits the metastatic potential of B16 melanoma cells. Oncol Rep. 28: 1567-1573
    • (2012) Oncol Rep , vol.28 , pp. 1567-1573
    • Nasulewicz-Goldeman, A.1    Uszczynska, B.2    Szczaurska-Nowak, K.3    Wietrzyk, J.4
  • 74
    • 49049111187 scopus 로고    scopus 로고
    • Bullous pemphigoid and related subepidermal autoimmune blistering diseases
    • Olasz EB, Yancey KB (2008). Bullous pemphigoid and related subepidermal autoimmune blistering diseases. Curr Dir Autoimmun. 10: 141-166
    • (2008) Curr Dir Autoimmun , vol.10 , pp. 141-166
    • Olasz, E.B.1    Yancey, K.B.2
  • 75
    • 1642587815 scopus 로고    scopus 로고
    • Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase
    • Oloumi A, McPhee T, Dedhar S (2004). Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochim Biophys Acta. 1691: 1-15
    • (2004) Biochim Biophys Acta , vol.1691 , pp. 1-15
    • Oloumi, A.1    McPhee, T.2    Dedhar, S.3
  • 77
    • 77951707634 scopus 로고    scopus 로고
    • ILK expression in human basal cell carcinoma correlates with epithelial-mesenchymal transition markers and tumour invasion
    • Papanikolaou S, Bravou V, Gyftopoulos K, Nakas D, Repanti M, Papadaki H (2010). ILK expression in human basal cell carcinoma correlates with epithelial-mesenchymal transition markers and tumour invasion. Histopathology. 56: 799-809
    • (2010) Histopathology , vol.56 , pp. 799-809
    • Papanikolaou, S.1    Bravou, V.2    Gyftopoulos, K.3    Nakas, D.4    Repanti, M.5    Papadaki, H.6
  • 78
    • 34248169121 scopus 로고    scopus 로고
    • Revertant mosaicism in junctional epidermolysis bullosa due to multiple correcting second-site mutations in LAMB3
    • Pasmooij AM, Pas HH, Bolling MC, Jonkman MF (2007). Revertant mosaicism in junctional epidermolysis bullosa due to multiple correcting second-site mutations in LAMB3. J Clin Invest. 117: 1240-1248
    • (2007) J Clin Invest , vol.117 , pp. 1240-1248
    • Pasmooij, A.M.1    Pas, H.H.2    Bolling, M.C.3    Jonkman, M.F.4
  • 79
    • 38849166053 scopus 로고    scopus 로고
    • Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-infl ammatory target
    • Peer D, Park EJ, Morishita Y, Carman CV, Shimaoka M (2008). Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-infl ammatory target. Science. 319: 627-630
    • (2008) Science , vol.319 , pp. 627-630
    • Peer, D.1    Park, E.J.2    Morishita, Y.3    Carman, C.V.4    Shimaoka, M.5
  • 80
    • 77955613373 scopus 로고    scopus 로고
    • Small molecule antagonists of integrin receptors
    • Perdih A, Dolenc MS (2010). Small molecule antagonists of integrin receptors. Curr Med Chem. 17: 2371-2392
    • (2010) Curr Med Chem , vol.17 , pp. 2371-2392
    • Perdih, A.1    Dolenc, M.S.2
  • 82
    • 84887040998 scopus 로고    scopus 로고
    • Fibroblast cell therapy enhances initial healing in recessive dystrophic epidermolysis bullosa wounds: Results of a randomised, vehicle-controlled trial
    • Epub ahead of print
    • Petrof G, Martinez-Queipo M, Mellerio JE, Kemp P, McGrath JA (2013). Fibroblast cell therapy enhances initial healing in recessive dystrophic epidermolysis bullosa wounds: Results of a randomised, vehicle-controlled trial. Br J Dermatol. (Epub ahead of print
    • (2013) Br J Dermatol
    • Petrof, G.1    Martinez-Queipo, M.2    Mellerio, J.E.3    Kemp, P.4    McGrath, J.A.5
  • 84
    • 0034604845 scopus 로고    scopus 로고
    • Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination
    • Raghavan S, Bauer C, Mundschau G, Li Q, Fuchs E (2000). Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol. 150: 1149-1160
    • (2000) J Cell Biol , vol.150 , pp. 1149-1160
    • Raghavan, S.1    Bauer, C.2    Mundschau, G.3    Li, Q.4    Fuchs, E.5
  • 88
    • 58149250413 scopus 로고    scopus 로고
    • Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa
    • Remington J, Wang X, Hou Y, Zhou H, Burnett J, Muirhead T, Uitto J, Keene DR, Woodley DT, Chen M (2009). Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa. Mol Ther. 17: 26-33
    • (2009) Mol Ther , vol.17 , pp. 26-33
    • Remington, J.1    Wang, X.2    Hou, Y.3    Zhou, H.4    Burnett, J.5    Muirhead, T.6    Uitto, J.7    Keene, D.R.8    Woodley, D.T.9    Chen, M.10
  • 89
    • 0035942278 scopus 로고    scopus 로고
    • In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa
    • Robbins PB, Lin Q, Goodnough JB, Tian H, Chen X, Khavari PA (2001). In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa. Proc Natl Acad Sci U S A. 98: 5193-5198
    • (2001) Proc Natl Acad Sci U S A. , vol.98 , pp. 5193-5198
    • Robbins, P.B.1    Lin, Q.2    Goodnough, J.B.3    Tian, H.4    Chen, X.5    Khavari, P.A.6
  • 91
    • 84874334375 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces epithelial-mesenchymal transition and integrin alpha3beta1-mediated cell migration of hsc-4 human squamous cell carcinoma cells through slug
    • Saito D, Kyakumoto S, Chosa N, Ibi M, Takahashi N, Okubo N, Sawada S, Ishisaki A, Kamo M (2013). Transforming growth factor-beta1 induces epithelial-mesenchymal transition and integrin alpha3beta1-mediated cell migration of HSC-4 human squamous cell carcinoma cells through Slug. J Biochem. 153: 303-315
    • (2013) J Biochem , vol.153 , pp. 303-315
    • Saito, D.1    Kyakumoto, S.2    Chosa, N.3    Ibi, M.4    Takahashi, N.5    Okubo, N.6    Sawada, S.7    Ishisaki, A.8    Kamo, M.9
  • 92
    • 33745253734 scopus 로고    scopus 로고
    • α-V-dependent outside-in signaling is required for the regulation of CD44 surface expression, MMP-2 secretion, and cell migration by osteopontin in human melanoma cells
    • Samanna V, Wei H, Ego-Osuala D, Chellaiah MA (2006). Alpha-V-dependent outside-in signaling is required for the regulation of CD44 surface expression, MMP-2 secretion, and cell migration by osteopontin in human melanoma cells. Exp Cell Res. 312: 2214-2230
    • (2006) Exp Cell Res , vol.312 , pp. 2214-2230
    • Samanna, V.1    Wei, H.2    Ego-Osuala, D.3    Chellaiah, M.A.4
  • 94
    • 51049108418 scopus 로고    scopus 로고
    • A suppressive role of mitogen inducible gene-2 in mesenchymal cancer cell invasion
    • Shi X, Wu C (2008). A suppressive role of mitogen inducible gene-2 in mesenchymal cancer cell invasion. Mol Cancer Res. 6: 715-724
    • (2008) Mol Cancer Res , vol.6 , pp. 715-724
    • Shi, X.1    Wu, C.2
  • 95
    • 79958859497 scopus 로고    scopus 로고
    • Ultrastructure and molecular pathogenesis of epidermolysis bullosa
    • Shinkuma S, McMillan JR, Shimizu H (2011). Ultrastructure and molecular pathogenesis of epidermolysis bullosa. Clin Dermatol. 29: 412-419
    • (2011) Clin Dermatol , vol.29 , pp. 412-419
    • Shinkuma, S.1    McMillan, J.R.2    Shimizu, H.3
  • 98
    • 69449100887 scopus 로고    scopus 로고
    • Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-Adhesion maturation
    • Stanchi F, Grashoff C, Nguemeni Yonga CF, Grall D, Fassler R, Van Obberghen-Schilling E (2009). Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-Adhesion maturation. J Cell Sci. 122: 1800-1811
    • (2009) J Cell Sci , vol.122 , pp. 1800-1811
    • Stanchi, F.1    Grashoff, C.2    Nguemeni Yonga, C.F.3    Grall, D.4    Fassler, R.5    Van Obberghen-Schilling, E.6
  • 102
    • 0030087944 scopus 로고    scopus 로고
    • Supramolecular assembly of basement membranes
    • Timpl R, Brown JC (1996). Supramolecular assembly of basement membranes. Bioessays. 18: 123-132
    • (1996) Bioessays , vol.18 , pp. 123-132
    • Timpl, R.1    Brown, J.C.2
  • 107
    • 0028979701 scopus 로고
    • Integrin alpha 5 beta 1 expression negatively regulates cell growth: Reversal by attachment to fi bronectin
    • Varner JA, Emerson DA, Juliano RL (1995). Integrin alpha 5 beta 1 expression negatively regulates cell growth: Reversal by attachment to fi bronectin. Mol Biol Cell. 6: 725-740
    • (1995) Mol Biol Cell , vol.6 , pp. 725-740
    • Varner, J.A.1    Emerson, D.A.2    Juliano, R.L.3
  • 109
    • 58349117913 scopus 로고    scopus 로고
    • Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton
    • Wang SE, Xiang B, Zent R, Quaranta V, Pozzi A, Arteaga CL (2009). Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Cancer Res. 69 : 475-482
    • (2009) Cancer Res , vol.69 , pp. 475-482
    • Wang, S.E.1    Xiang, B.2    Zent, R.3    Quaranta, V.4    Pozzi, A.5    Arteaga, C.L.6
  • 110
    • 0036683057 scopus 로고    scopus 로고
    • Role of integrins in regulating epidermal adhesion, growth and differentiation
    • Watt FM (2002). Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J. 21: 3919-3926
    • (2002) EMBO J. , vol.21 , pp. 3919-3926
    • Watt, F.M.1
  • 112
    • 0037451891 scopus 로고    scopus 로고
    • URP1: A member of a novel family of PH and FERM domain-containing membrane-Associated proteins is signifi cantly over-expressed in lung and colon carcinomas
    • Weinstein EJ, Bourner M, Head R, Zakeri H, Bauer C, Mazzarella R (2003). URP1: A member of a novel family of PH and FERM domain-containing membrane-Associated proteins is signifi cantly over-expressed in lung and colon carcinomas. Biochim Biophys Acta. 1637: 207-216
    • (2003) Biochim Biophys Acta , vol.1637 , pp. 207-216
    • Weinstein, E.J.1    Bourner, M.2    Head, R.3    Zakeri, H.4    Bauer, C.5    Mazzarella, R.6
  • 113
    • 5144235557 scopus 로고    scopus 로고
    • Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
    • White DE, Kurpios NA, Zuo D, Hassell JA, Blaess S, Mueller U, Muller WJ (2004). Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell. 6 : 159-170
    • (2004) Cancer Cell , vol.6 , pp. 159-170
    • White, D.E.1    Kurpios, N.A.2    Zuo, D.3    Hassell, J.A.4    Blaess, S.5    Mueller, U.6    Muller, W.J.7
  • 114
    • 20344408503 scopus 로고    scopus 로고
    • Kindler surprise: Mutations in a novel actin-Associated protein cause Kindler syndrome
    • White SJ, McLean WH (2005). Kindler surprise: Mutations in a novel actin-Associated protein cause Kindler syndrome. J Dermatol Sci. 38: 169-175
    • (2005) J Dermatol Sci , vol.38 , pp. 169-175
    • White, S.J.1    McLean, W.H.2
  • 115
    • 75049085759 scopus 로고    scopus 로고
    • The ilk/pinch/parvin complex: The kinase is dead, long live the pseudokinase
    • Wickstrom SA, Lange A, Montanez E, Fassler R (2010). The ILK/PINCH/parvin complex: The kinase is dead, long live the pseudokinase! EMBO J 29: 281-291
    • (2010) EMBO J , vol.29 , pp. 281-291
    • Wickstrom, S.A.1    Lange, A.2    Montanez, E.3    Fassler, R.4
  • 117
    • 84875273788 scopus 로고    scopus 로고
    • Dynamic regulation of the structure and functions of integrin adhesions
    • Wolfenson H, Lavelin I, Geiger B (2013). Dynamic regulation of the structure and functions of integrin adhesions. Dev Cell. 24: 447-458
    • (2013) Dev Cell , vol.24 , pp. 447-458
    • Wolfenson, H.1    Lavelin, I.2    Geiger, B.3
  • 119
    • 3042708179 scopus 로고    scopus 로고
    • The pinch-ilk-parvin complexes: Assembly, functions and regulation
    • Wu C (2004). The PINCH-ILK-parvin complexes: Assembly, functions and regulation. Biochim Biophys Acta. 1692: 55-62
    • (2004) Biochim Biophys Acta , vol.1692 , pp. 55-62
    • Wu, C.1
  • 120
    • 33845628019 scopus 로고    scopus 로고
    • Effect of the angiogenesis inhibitor Cilengitide (EMD 121974) on glioblastoma growth in nude mice
    • discussion 1312
    • Yamada S, Bu XY, Khankaldyyan V, Gonzales-Gomez I, McComb JG, Laug WE (2006). Effect of the angiogenesis inhibitor Cilengitide (EMD 121974) on glioblastoma growth in nude mice. Neurosurgery. 59: 1304-1312 ; discussion 1312
    • (2006) Neurosurgery , vol.59 , pp. 1304-1312
    • Yamada, S.1    Bu, X.Y.2    Khankaldyyan, V.3    Gonzales-Gomez, I.4    McComb, J.G.5    Laug, W.E.6
  • 121
    • 70450240957 scopus 로고    scopus 로고
    • Non-herlitz junctional epidermolysis bullosa
    • Yancey KB, Hintner H (2010). Non-herlitz junctional epidermolysis bullosa. Dermatol Clin. 28: 67-77
    • (2010) Dermatol Clin , vol.28 , pp. 67-77
    • Yancey, K.B.1    Hintner, H.2
  • 122
    • 84864884471 scopus 로고    scopus 로고
    • Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling
    • Yu Y, Wu J, Wang Y, Zhao T, Ma B, Liu Y, Fang W, Zhu WG, Zhang H (2012). Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling. EMBO Rep. 13: 750-758
    • (2012) EMBO Rep , vol.13 , pp. 750-758
    • Yu, Y.1    Wu, J.2    Wang, Y.3    Zhao, T.4    Ma, B.5    Liu, Y.6    Fang, W.7    Zhu, W.G.8    Zhang, H.9
  • 123
    • 79953203957 scopus 로고    scopus 로고
    • Structure-function analysis of tetraspanin CD151 reveals distinct requirements for tumor cell behaviors mediated by alpha3beta1 versus alpha6beta4 integrin
    • Zevian S, Winterwood NE, Stipp CS (2011). Structure-function analysis of tetraspanin CD151 reveals distinct requirements for tumor cell behaviors mediated by alpha3beta1 versus alpha6beta4 integrin. J Biol Chem. 286: 7496-7506
    • (2011) J Biol Chem , vol.286 , pp. 7496-7506
    • Zevian, S.1    Winterwood, N.E.2    Stipp, C.S.3
  • 124
    • 14844317695 scopus 로고    scopus 로고
    • Unoccupied alpha v) beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal
    • Zhao H, Ross FP, Teitelbaum SL (2005). Unoccupied alpha(v) beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal. Mol Endocrinol. 19: 771-780
    • (2005) Mol Endocrinol , vol.19 , pp. 771-780
    • Zhao, H.1    Ross, F.P.2    Teitelbaum, S.L.3
  • 127
    • 84863652433 scopus 로고    scopus 로고
    • Silencing of the integrin-linked kinase gene suppresses the proliferation, migration and invasion of pancreatic cancer cells (Panc-1
    • Zhu XY, Liu N, Liu W, Song SW, Guo KJ (2012). Silencing of the integrin-linked kinase gene suppresses the proliferation, migration and invasion of pancreatic cancer cells (Panc-1). Genet Mol Biol. 35: 538-544
    • (2012) Genet Mol Biol , vol.35 , pp. 538-544
    • Zhu, X.Y.1    Liu, N.2    Liu, W.3    Song, S.W.4    Guo, K.J.5


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