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Volumn 35, Issue 2, 2012, Pages 538-544

Silencing of the integrin-linked kinase gene suppresses the proliferation, migration and invasion of pancreatic cancer cells (Panc-1)

Author keywords

E cadherin; Epithelial mesenchymal transition (EMT); Integrin linked kinase (ILK); Panc 1 cell line; RNA interference (RNAi)

Indexed keywords

INTEGRIN LINKED KINASE; MESSENGER RNA; SMALL INTERFERING RNA; UVOMORULIN;

EID: 84863652433     PISSN: 14154757     EISSN: 16784685     Source Type: Journal    
DOI: 10.1590/S1415-47572012005000028     Document Type: Article
Times cited : (15)

References (18)
  • 1
    • 1842531077 scopus 로고    scopus 로고
    • Cell-free 59 kDa immunoreactive integrin-linked kinase: A novel narker for ovarian carcinoma
    • Ahmed N, Oliva K, Rice GE and Quinn MA (2004) Cell-free 59 kDa immunoreactive integrin-linked kinase: A novel narker for ovarian carcinoma. Clin Cancer Res 10:2415-2420.
    • (2004) Clin Cancer Res , vol.10 , pp. 2415-2420
    • Ahmed, N.1    Oliva, K.2    Rice, G.E.3    Quinn, M.A.4
  • 2
    • 77957329131 scopus 로고    scopus 로고
    • Tuberin regulates e-cadherin localization: Implications in epithelial-mesenchymal transition
    • Barnes EA, Kenerson HL, Jiang XY and Yeung RS (2010) Tuberin regulates e-cadherin localization: Implications in epithelial-mesenchymal transition. Am J Pathol 177:1765-1778.
    • (2010) Am J Pathol , vol.177 , pp. 1765-1778
    • Barnes, E.A.1    Kenerson, H.L.2    Jiang, X.Y.3    Yeung, R.S.4
  • 3
    • 0037904987 scopus 로고    scopus 로고
    • The integrin-actin connection, an eternal love affair
    • Brakebusch C and Fassler R (2003) The integrin-actin connection, an eternal love affair. EMBO J 22:2324-2333.
    • (2003) EMBO J , vol.22 , pp. 2324-2333
    • Brakebusch, C.1    Fassler, R.2
  • 4
    • 77953916705 scopus 로고    scopus 로고
    • K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer
    • Chen H, Tu H, Meng ZQ, Chen Z, Wang P and Liu LM (2010) K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer. Eur J Surg Onc 36:657-662.
    • (2010) Eur J Surg Onc , vol.36 , pp. 657-662
    • Chen, H.1    Tu, H.2    Meng, Z.Q.3    Chen, Z.4    Wang, P.5    Liu, L.M.6
  • 5
    • 0035383590 scopus 로고    scopus 로고
    • Neuroectodermal and neuroendocrine tumors principally seen in children
    • David M and Parham MD (2001) Neuroectodermal and neuroendocrine tumors principally seen in children. Am J Clin Pathol 115:S113-S128.
    • (2001) Am J Clin Pathol , vol.115
    • David, M.1    Parham, M.D.2
  • 7
    • 0035464806 scopus 로고    scopus 로고
    • A prospective study of EUS-guided celiac plexus neurolysis for pancreatic cancer pain
    • Gunaratnam NT, Sarma AV, Norton MID and Wiersema MJ (2001) A prospective study of EUS-guided celiac plexus neurolysis for pancreatic cancer pain. Gastrointest Endosc 54:316-324.
    • (2001) Gastrointest Endosc , vol.54 , pp. 316-324
    • Gunaratnam, N.T.1    Sarma, A.V.2    Norton, M.I.D.3    Wiersema, M.J.4
  • 8
    • 11144225205 scopus 로고    scopus 로고
    • Integrin-linked kinase: A cancer therapeutic target unique among its ILK
    • Hannigan G, Troussard AA and Dedhar S (2005) Integrin-linked kinase: A cancer therapeutic target unique among its ILK. Nat Rev Cancer 5:51-63.
    • (2005) Nat Rev Cancer , vol.5 , pp. 51-63
    • Hannigan, G.1    Troussard, A.A.2    Dedhar, S.3
  • 9
    • 39749183343 scopus 로고    scopus 로고
    • Analysis of mortality rates for pancreatic cancer across the world
    • Hariharan D, Saied A and Kocher HM (2008) Analysis of mortality rates for pancreatic cancer across the world. HPB (Oxford) 10:58-62.
    • (2008) HPB (Oxford) , vol.10 , pp. 58-62
    • Hariharan, D.1    Saied, A.2    Kocher, H.M.3
  • 10
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Twist in development and metastasis
    • Kang YB and Massague J (2004) Epithelial-mesenchymal transitions: Twist in development and metastasis. Cell 118:277-279.
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.B.1    Massague, J.2
  • 13
    • 22244483775 scopus 로고    scopus 로고
    • Technical aspects of immunohistochemistry
    • Ramos-Vara JA (2005) Technical aspects of immunohistochemistry. Vet Pathol 42:405-426.
    • (2005) Vet Pathol , vol.42 , pp. 405-426
    • Ramos-Vara, J.A.1
  • 14
    • 33745117233 scopus 로고    scopus 로고
    • The epidemiology of pancreatic cancer in the United States: Changes below the surface
    • Shaib YH, Davila JA and El-serag HB (2006) The epidemiology of pancreatic cancer in the United States: Changes below the surface. Aliment Pharmacol Ther 24:87-94.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 87-94
    • Shaib, Y.H.1    Davila, J.A.2    El-serag, H.B.3
  • 15
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H, Staehelint T and Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelint, T.2    Gordon, J.3
  • 16
    • 0034676338 scopus 로고    scopus 로고
    • The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9)
    • Troussard AA, Costello P, Yoganathan TN, Kumagai S, Roskelley CD and Dedhar S (2000) The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Oncogene 19:5444-5452.
    • (2000) Oncogene , vol.19 , pp. 5444-5452
    • Troussard, A.A.1    Costello, P.2    Yoganathan, T.N.3    Kumagai, S.4    Roskelley, C.D.5    Dedhar, S.6
  • 17
    • 13944256944 scopus 로고    scopus 로고
    • Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts
    • Yau CY, Wheeler JJ, Sutton KL and Hedley DW (2005) Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. Cancer Res 65:1497-1504.
    • (2005) Cancer Res , vol.65 , pp. 1497-1504
    • Yau, C.Y.1    Wheeler, J.J.2    Sutton, K.L.3    Hedley, D.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.