Conditional ablation of β1 integrin in skin: Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination

Journal of Cell Biology

Volumn 150, Issue 5, 2000, Pages 1149-1160

  Raghavan, Srikala ^a   Bauer, Christoph ^a   Mundschau, Gina ^a   Li, Qingqin ^a   Fuchs, Elaine ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Conditional knockout; Epidermis; Integrins; Proliferation; Skin

Indexed keywords

INTEGRIN; KALININ; ALPHA3 INTEGRIN; BETA1 INTEGRIN; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL MIGRATION; CELL POLARITY; CELL PROLIFERATION; CONTROLLED STUDY; EPIDERMIS; HAIR FOLLICLE; HEMIDESMOSOME; KERATINOCYTE; MEMBRANE FORMATION; MEMBRANE STRUCTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN; ANIMAL; BASEMENT MEMBRANE; CONGENITAL SKIN DISEASE; GENE DELETION; GENETICS; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; ULTRASTRUCTURE;

ANIMALIA;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD29; BASEMENT MEMBRANE; EPIDERMIS; GENE DELETION; HAIR FOLLICLE; INTEGRIN ALPHA3; INTEGRINS; MICE; MICE, KNOCKOUT; SKIN; SKIN ABNORMALITIES;

EID: 0034604845     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.150.5.1149     Document Type: Article

References (38)

1. Differentiation of embryonal stem cells into keratinocytes: Comparison of wild-type and beta 1 integrin-deficient cells
2. The dermal-epidermal junction
3. Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis
4. Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes
5. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
6. Alpha 3 beta 1 integrin is required for normal development of the epidermal basement membrane
7. Beta4 integrin is required for hemidesmosome formation, cell adhesion, and cell survival
8. Consequences of lack of beta 1 integrin gene expression in mice
9. Beauty is skin deep: Biology and genetics of the epidermis
10. Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice
11. Integrin signaling
12. Novel roles for alpha3beta1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes
13. Regulation of cell surface beta 1 integrin levels during keratinocyte terminal differentiation
14. Integrin signaling and cell growth control
15. Structure and assembly of hemidesmosomes
16. Stem cell patterning and fate in human epidermis
17. Evidence that B1 integrins in keratinocyte cell-cell junctions are not in the ligand-occupied conformation
18. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis
19. Beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms
20. Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype
21. The intracellular functions of alpha 6 beta 4 integrin are regulated by EGF
22. Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development
23. Fibronectin and integrins in cell adhesion, signaling, and morphogenesis
24. Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain
25. Biology and function of hemidesmosomes
26. Type XVII collagen (BP180) and LAD-1 are present as separate trimeric complexes
27. Mutation analysis and molecular genetics of epidermolysis bullosa
28. Kalinin: An epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments
29. Deficiency of β1 integrins in teratoma interferes with basement membrane assembly and laminin-1 expression
30. Bidirectional signaling between the cytoskeleton and integrins
31. Klf4 is a transcription factor required for establishing the barrier function of the skin
32. Targeted deletion of β1 integrins in F9 embryonal carcinomas cells affects morphological differentiation, but not tissue-specific gene expression
33. Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality
34. Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice
35. The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin
36. Regulation of keratinocyte terminal differentiation by integrin-extracellular matrix interactions
37. Beta 1 integrin-dependent and -independent polymerization of fibronectin
38. Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro