Functional differences between kindlin-1 and kindlin-2 in keratinocytes

Journal of Cell Science

Volumn 125, Issue 9, 2012, Pages 2172-2184

  Bandyopadhyay, Aditi ^a   Rothschild, Gerson ^a   Kim, Sean ^a   Calderwood, David A ^b   Raghavan, Srikala ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Integrins; Keratinocytes; Kindlins

Indexed keywords

ALPHAVBETA6 INTEGRIN; BETA1 INTEGRIN; BETA6 INTEGRIN; FIBRONECTIN; KINDLIN 1; KINDLIN 2; PAXILLIN; PROTEIN; TALIN; UNCLASSIFIED DRUG; VINCULIN;

ARTICLE; CELL ADHESION; CELL SPREADING; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; FOCAL ADHESION; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; UPREGULATION;

AMINO ACID SEQUENCE; ANTIGENS, CD29; ANTIGENS, NEOPLASM; CELL ADHESION; FIBRONECTINS; FLOW CYTOMETRY; FOCAL ADHESIONS; GENE KNOCKOUT TECHNIQUES; HUMANS; INTEGRINS; KERATINOCYTES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; SEQUENCE ALIGNMENT;

EID: 84862836115     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.096214     Document Type: Article

References (29)

1. Ashton, G. H., McLean, W. H., South, A. P., Oyama, N., Smith, F. J., Al-Suwaid, R., Al-Ismaily, A., Atherton, D. J., Harwood, C. A., Leigh, I. M. et al. (2004). Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome. J. Invest. Dermatol. 122, 78-83.
2. Brakebusch, C. and Fässler, R. (2005). beta 1 integrin function in vivo: adhesion, migration and more. Cancer Metastasis Rev. 24, 403-411.
3. Brakebusch, C., Grose, R., Quondamatteo, F., Ramirez, A., Jorcano, J. L., Pirro, A., Svensson, M., Herken, R., Sasaki, T., Timpl, R. et al. (2000). Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes. EMBO J. 19, 3990-4003.
4. Harburger, D. S. and Calderwood, D. A. (2009). Integrin signalling at a glance. J. Cell Sci. 122, 159-163.
5. Harburger, D. S., Bouaouina, M. and Calderwood, D. A. (2009). Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects. J. Biol. Chem. 284, 11485-11497.
6. He, Y., Esser, P., Heinemann, A., Bruckner-Tuderman, L. and Has, C. (2011a). Kindlin-1 and -2 have overlapping functions in epithelial cells implications for phenotype modification. Am. J. Pathol. 178, 975-982.
7. He, Y., Esser, P., Schacht, V., Bruckner-Tuderman, L. and Has, C. (2011b). Role of kindlin-2 in fibroblast functions: implications for wound healing. J. Invest. Dermatol. 131, 245-256.
8. Humphries, J. D., Byron, A. and Humphries, M. J. (2006). Integrin ligands at a glance. J. Cell Sci. 119, 3901-3903.
9. Hynes, R. O. (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.
10. Karaköse, E., Schiller, H. B. and Fässler, R. (2010). The kindlins at a glance. J. Cell Sci. 123, 2353-2356.
11. Lai-Cheong, J. E., Ussar, S., Arita, K., Hart, I. R. and McGrath, J. A. (2008). Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome. J. Invest. Dermatol. 128, 2156-2165.
12. Lai-Cheong, J. E., Parsons, M. and McGrath, J. A. (2010). The role of kindlins in cell biology and relevance to human disease. Int. J. Biochem. Cell Biol. 42, 595-603.
13. Larjava, H., Plow, E. F. and Wu, C. (2008). Kindlins: essential regulators of integrin signalling and cell-matrix adhesion. EMBO Rep. 9, 1203-1208.
14. Legate, K. R., Wickström, S. A. and Fässler, R. (2009). Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev. 23, 397-418.
15. Ma, Y. Q., Qin, J., Wu, C. and Plow, E. F. (2008). Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J. Cell Biol. 181, 439-446.
16. Malinin, N. L., Plow, E. F. and Byzova, T. V. (2010). Kindlins in FERM adhesion. Blood 115, 4011-4017.
17. Meves, A., Stremmel, C., Gottschalk, K. and Fässler, R. (2009). The Kindlin protein family: new members to the club of focal adhesion proteins. Trends Cell Biol. 19, 504-513.
18. Montanez, E., Ussar, S., Schifferer, M., Bösl, M., Zent, R., Moser, M. and Fässler, R. (2008). Kindlin-2 controls bidirectional signaling of integrins. Genes Dev. 22, 1325-1330.
19. Moser, M., Nieswandt, B., Ussar, S., Pozgajova, M. and Fässler, R. (2008). Kindlin-3 is essential for integrin activation and platelet aggregation. Nat. Med. 14, 325-330.
20. Moser, M., Legate, K. R., Zent, R. and Fässler, R. (2009). The tail of integrins, talin, and kindlins. Science 324, 895-899.
21. Plow, E. F., Qin, J. and Byzova, T. (2009). Kindling the flame of integrin activation and function with kindlins. Curr. Opin. Hematol. 16, 323-328.
22. Raghavan, S., Bauer, C., Mundschau, G., Li, Q. and Fuchs, E. (2000). Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J. Cell Biol. 150, 1149-1160.
23. Raghavan, S., Vaezi, A. and Fuchs, E. (2003). A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamics. Dev. Cell 5, 415-427.
24. Siegel, D. H., Ashton, G. H., Penagos, H. G., Lee, J. V., Feiler, H. S., Wilhelmsen, K. C., South, A. P., Smith, F. J., Prescott, A. R., Wessagowit, V. et al. (2003). Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am. J. Hum. Genet. 73, 174-187.
25. Ussar, S., Moser, M., Widmaier, M., Rognoni, E., Harrer, C., Genzel-Boroviczeny, O. and Fässler, R. (2008). Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. PLoS Genet. 4, e1000289.
26. Watt, F. M. (2002). Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J. 21, 3919-3926.
27. Wickström, S. A. and Fässler, R. (2009). Integrins anchor the invasive machinery. Dev. Cell 17, 158-160.
28. Wickström, S. A., Radovanac, K. and Fässler, R. (2011). Genetic analyses of integrin signaling. Cold Spring Harb. Perspect. Biol. 3, 3.
29. Zaidel-Bar, R., Itzkovitz, S., Ma'ayan, A., Iyengar, R. and Geiger, B. (2007). Functional atlas of the integrin adhesome. Nat. Cell Biol. 9, 858-867.