Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling

EMBO Reports

Volumn 13, Issue 8, 2012, Pages 750-758

  Yu, Yu ^a,b   Wu, Junzhou ^a,b   Wang, Yunling ^a,c   Zhao, Ting ^a,b   Ma, Bo ^a,b   Liu, Yuqing ^a,b   Fang, Weigang ^a,b   Zhu, Wei Guo ^a,b   Zhang, Hongquan ^a,b,c  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

catenin; Kindlins; protein complex; Wnt signalling

Indexed keywords

BETA CATENIN; FOCAL ADHESION KINASE; KINDLIN 2; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CANCER INVASION; CELL INVASION; COMPLEX FORMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; TUMOR CELL; WNT SIGNALING PATHWAY;

AXIN PROTEIN; BETA CATENIN; BLOTTING, WESTERN; CELL LINE; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; MEMBRANE PROTEINS; MULTIPROTEIN COMPLEXES; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PROTEIN BINDING; PROTEIN STABILITY; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN; TRANSCRIPTION, GENETIC; WNT SIGNALING PATHWAY;

GASTROPODA;

EID: 84864884471     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2012.88     Document Type: Article

References (19)

1. Lu Z, Ghosh S, Wang Z, Hunter T (2003) Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of b-catenin, and enhanced tumor cell invasion. Cancer Cell 4: 499-515
2. Clevers H (2006) Wnt/b-catenin signaling in development and disease. Cell 127: 469-480
3. Damalas A, Kahan S, Shtutman M, Ben-Ze'ev A, Oren M (2001) Deregulated b-catenin induces a p53-and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J 20: 4912-4922
4. Moon RT, Kohn AD, De Ferrari GV, Kaykas A (2004) WNT and b-catenin signalling: diseases and therapies. Nat Rev Genet 5: 691-701
5. Howe LR, Brown AM (2004) Wnt signaling and breast cancer. Cancer Biol Ther 3: 36-41
6. Sin S et al (2011) Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis. J Natl Cancer Inst 103: 1323-1337
7. Kato K, Shiozawa T, Mitsushita J, Toda A, Horiuchi A, Nikaido T, Fujii S, Konishi I (2004) Expression of the mitogen-inducible gene-2 (mig-2) is elevated in human uterine leiomyomas but not in leiomyosarcomas. Hum Pathol 35: 55-60
8. An Z, Dobra K, Lock JG, Stromblad S, Hjerpe A, Zhang H (2010) Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration. Int J Cancer 127: 1999-2008
9. Shi X, Ma YQ, Tu Y, Chen K, Wu S, Fukuda K, Qin J, Plow EF, Wu C (2007) The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility. J Biol Chem 282: 20455-20466
10. Staal FJ, Noort Mv M, Strous GJ, Clevers HC (2002) Wnt signals are transmitted through N-terminally dephosphorylated b-catenin. EMBO Rep 3: 63-68
11. Etienne-Manneville S, Hall A (2001) Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCz. Cell 106: 489-498
12. Bottomly D, Kyler SL, McWeeney SK, Yochum GS (2010) Identification of {b}-catenin binding regions in colon cancer cells using ChIP-Seq. Nucleic Acids Res 38: 5735-5745
13. Yook JI et al (2006) A Wnt-Axin2-GSK3b cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol 8: 1398-1406
14. Gozgit JM, Pentecost BT, Marconi SA, Otis CN, Wu C, Arcaro KF (2006) Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer. Mol Cancer Res 4: 905-913
15. Shi X, Wu C (2008) A suppressive role of mitogen inducible gene-2 in mesenchymal cancer cell invasion. Mol Cancer Res 6: 715-724
16. Gong X, An Z, Wang Y, Guan L, Fang W, Stromblad S, Jiang Y, Zhang H (2010) Kindlin-2 controls sensitivity of prostate cancer cells to cisplatininduced cell death. Cancer Lett 299: 54-62
17. Zhang M, Wang M, Tan X, Li TF, Zhang YE, Chen D (2010) Smad3 prevents b-catenin degradation and facilitates b-catenin nuclear translocation in chondrocytes. J Biol Chem 285: 8703-8710
18. Zhang N et al (2011) FoxM1 promotes b-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell 20: 427-442
19. Veeman MT, Slusarski DC, Kaykas A, Louie SH, Moon RT (2003) Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol 13: 680-685