-
1
-
-
0030026679
-
Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase
-
Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, et al. (1996) Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 379: 91-96.
-
(1996)
Nature
, vol.379
, pp. 91-96
-
-
Hannigan, G.E.1
Leung-Hagesteijn, C.2
Fitz-Gibbon, L.3
Coppolino, M.G.4
Radeva, G.5
-
2
-
-
0033378656
-
Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats
-
Li F, Zhang Y, Wu C, (1999) Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats. J Cell Sci 112 (Pt 24):: 4589-4599.
-
(1999)
J Cell Sci
, vol.112
, Issue.Pt 24
, pp. 4589-4599
-
-
Li, F.1
Zhang, Y.2
Wu, C.3
-
3
-
-
33644848599
-
ILK, PINCH and parvin: the tIPP of integrin signalling
-
Legate KR, Montanez E, Kudlacek O, Fassler R, (2006) ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol 7: 20-31.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 20-31
-
-
Legate, K.R.1
Montanez, E.2
Kudlacek, O.3
Fassler, R.4
-
4
-
-
11144225205
-
Integrin-linked kinase: a cancer therapeutic target unique among its ILK
-
Hannigan G, Troussard AA, Dedhar S, (2005) Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 5: 51-63.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 51-63
-
-
Hannigan, G.1
Troussard, A.A.2
Dedhar, S.3
-
5
-
-
47749087950
-
Integrin-linked kinase-essential roles in physiology and cancer biology
-
McDonald PC, Fielding AB, Dedhar S, (2008) Integrin-linked kinase-essential roles in physiology and cancer biology. J Cell Sci 121: 3121-3132.
-
(2008)
J Cell Sci
, vol.121
, pp. 3121-3132
-
-
McDonald, P.C.1
Fielding, A.B.2
Dedhar, S.3
-
6
-
-
31544439674
-
Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival
-
Troussard AA, McDonald PC, Wederell ED, Mawji NM, Filipenko NR, et al. (2006) Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival. Cancer research 66: 393-403.
-
(2006)
Cancer Research
, vol.66
, pp. 393-403
-
-
Troussard, A.A.1
McDonald, P.C.2
Wederell, E.D.3
Mawji, N.M.4
Filipenko, N.R.5
-
7
-
-
23844530846
-
Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer
-
Younes MN, Kim S, Yigitbasi OG, Mandal M, Jasser SA, et al. (2005) Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer. Molecular cancer therapeutics 4: 1146-1156.
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, pp. 1146-1156
-
-
Younes, M.N.1
Kim, S.2
Yigitbasi, O.G.3
Mandal, M.4
Jasser, S.A.5
-
8
-
-
77957859815
-
Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3beta (GSK-3beta) phosphorylation
-
Maydan M, McDonald PC, Sanghera J, Yan J, Rallis C, et al. (2010) Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3beta (GSK-3beta) phosphorylation. PLoS One 5: e12356.
-
(2010)
PLoS One
, vol.5
-
-
Maydan, M.1
McDonald, P.C.2
Sanghera, J.3
Yan, J.4
Rallis, C.5
-
9
-
-
40849108777
-
Mapping the integrin-linked kinase interactome using SILAC
-
Dobreva I, Fielding A, Foster LJ, Dedhar S, (2008) Mapping the integrin-linked kinase interactome using SILAC. Journal of proteome research 7: 1740-1749.
-
(2008)
Journal of Proteome Research
, vol.7
, pp. 1740-1749
-
-
Dobreva, I.1
Fielding, A.2
Foster, L.J.3
Dedhar, S.4
-
10
-
-
40849088170
-
Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization
-
Fielding AB, Dobreva I, McDonald PC, Foster LJ, Dedhar S, (2008) Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization. J Cell Biol 180: 681-689.
-
(2008)
J Cell Biol
, vol.180
, pp. 681-689
-
-
Fielding, A.B.1
Dobreva, I.2
McDonald, P.C.3
Foster, L.J.4
Dedhar, S.5
-
11
-
-
79551638786
-
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells
-
Fielding AB, Lim S, Montgomery K, Dobreva I, Dedhar S, (2011) A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells. Oncogene 30: 521-534.
-
(2011)
Oncogene
, vol.30
, pp. 521-534
-
-
Fielding, A.B.1
Lim, S.2
Montgomery, K.3
Dobreva, I.4
Dedhar, S.5
-
12
-
-
67749113756
-
TOGp regulates microtubule assembly and density during mitosis and contributes to chromosome directional instability
-
Cassimeris L, Becker B, Carney B, (2009) TOGp regulates microtubule assembly and density during mitosis and contributes to chromosome directional instability. Cell motility and the cytoskeleton 66: 535-545.
-
(2009)
Cell Motility and the Cytoskeleton
, vol.66
, pp. 535-545
-
-
Cassimeris, L.1
Becker, B.2
Carney, B.3
-
13
-
-
0037314330
-
The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells
-
Gergely F, Draviam VM, Raff JW, (2003) The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes & development 17: 336-341.
-
(2003)
Genes & Development
, vol.17
, pp. 336-341
-
-
Gergely, F.1
Draviam, V.M.2
Raff, J.W.3
-
14
-
-
4143066950
-
Mitotic spindle assembly and chromosome segregation: refocusing on microtubule dynamics
-
Kline-Smith SL, Walczak CE, (2004) Mitotic spindle assembly and chromosome segregation: refocusing on microtubule dynamics. Mol Cell 15: 317-327.
-
(2004)
Mol Cell
, vol.15
, pp. 317-327
-
-
Kline-Smith, S.L.1
Walczak, C.E.2
-
15
-
-
0029115509
-
Vinblastine suppresses dynamics of individual microtubules in living interphase cells
-
Dhamodharan R, Jordan MA, Thrower D, Wilson L, Wadsworth P, (1995) Vinblastine suppresses dynamics of individual microtubules in living interphase cells. Mol Biol Cell 6: 1215-1229.
-
(1995)
Mol Biol Cell
, vol.6
, pp. 1215-1229
-
-
Dhamodharan, R.1
Jordan, M.A.2
Thrower, D.3
Wilson, L.4
Wadsworth, P.5
-
16
-
-
0025824979
-
Mechanism of inhibition of cell proliferation by Vinca alkaloids
-
Jordan MA, Thrower D, Wilson L, (1991) Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res 51: 2212-2222.
-
(1991)
Cancer Res
, vol.51
, pp. 2212-2222
-
-
Jordan, M.A.1
Thrower, D.2
Wilson, L.3
-
17
-
-
0027360552
-
Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations
-
Jordan MA, Toso RJ, Thrower D, Wilson L, (1993) Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc Natl Acad Sci U S A 90: 9552-9556.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 9552-9556
-
-
Jordan, M.A.1
Toso, R.J.2
Thrower, D.3
Wilson, L.4
-
18
-
-
0034960408
-
Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine
-
Ngan VK, Bellman K, Hill BT, Wilson L, Jordan MA, (2001) Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol 60: 225-232.
-
(2001)
Mol Pharmacol
, vol.60
, pp. 225-232
-
-
Ngan, V.K.1
Bellman, K.2
Hill, B.T.3
Wilson, L.4
Jordan, M.A.5
-
19
-
-
0032933622
-
Taxol suppresses dynamics of individual microtubules in living human tumor cells
-
Yvon AM, Wadsworth P, Jordan MA, (1999) Taxol suppresses dynamics of individual microtubules in living human tumor cells. Mol Biol Cell 10: 947-959.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 947-959
-
-
Yvon, A.M.1
Wadsworth, P.2
Jordan, M.A.3
-
20
-
-
0032516094
-
Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways
-
Novak A, Hsu SC, Leung-Hagesteijn C, Radeva G, Papkoff J, et al. (1998) Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proceedings of the National Academy of Sciences of the United States of America 95: 4374-4379.
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, pp. 4374-4379
-
-
Novak, A.1
Hsu, S.C.2
Leung-Hagesteijn, C.3
Radeva, G.4
Papkoff, J.5
-
21
-
-
0031962084
-
Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity
-
Wu C, Keightley SY, Leung-Hagesteijn C, Radeva G, Coppolino M, et al. (1998) Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. The Journal of biological chemistry 273: 528-536.
-
(1998)
The Journal of Biological Chemistry
, vol.273
, pp. 528-536
-
-
Wu, C.1
Keightley, S.Y.2
Leung-Hagesteijn, C.3
Radeva, G.4
Coppolino, M.5
-
22
-
-
0031040149
-
The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents
-
Rowinsky EK, (1997) The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents. Annu Rev Med 48: 353-374.
-
(1997)
Annu Rev Med
, vol.48
, pp. 353-374
-
-
Rowinsky, E.K.1
-
23
-
-
0037586498
-
AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
-
Anand S, Penrhyn-Lowe S, Venkitaraman AR, (2003) AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3: 51-62.
-
(2003)
Cancer Cell
, vol.3
, pp. 51-62
-
-
Anand, S.1
Penrhyn-Lowe, S.2
Venkitaraman, A.R.3
-
24
-
-
0036168948
-
Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models
-
Hu L, Hofmann J, Lu Y, Mills GB, Jaffe RB, (2002) Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Cancer research 62: 1087-1092.
-
(2002)
Cancer Research
, vol.62
, pp. 1087-1092
-
-
Hu, L.1
Hofmann, J.2
Lu, Y.3
Mills, G.B.4
Jaffe, R.B.5
-
25
-
-
0032530482
-
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
-
Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, et al. (1998) Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proceedings of the National Academy of Sciences of the United States of America 95: 11211-11216.
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, pp. 11211-11216
-
-
Delcommenne, M.1
Tan, C.2
Gray, V.3
Rue, L.4
Woodgett, J.5
-
26
-
-
77957883339
-
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae
-
Wickstrom SA, Lange A, Hess MW, Polleux J, Spatz JP, et al. (2010) Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Developmental cell 19: 574-588.
-
(2010)
Developmental Cell
, vol.19
, pp. 574-588
-
-
Wickstrom, S.A.1
Lange, A.2
Hess, M.W.3
Polleux, J.4
Spatz, J.P.5
-
28
-
-
0035949576
-
Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics
-
Goncalves A, Braguer D, Kamath K, Martello L, Briand C, et al. (2001) Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics. Proceedings of the National Academy of Sciences of the United States of America 98: 11737-11742.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, pp. 11737-11742
-
-
Goncalves, A.1
Braguer, D.2
Kamath, K.3
Martello, L.4
Briand, C.5
-
29
-
-
74049103772
-
QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model
-
Kalra J, Warburton C, Fang K, Edwards L, Daynard T, et al. (2009) QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model. Breast cancer research: BCR 11: R25.
-
(2009)
Breast Cancer Research: BCR
, vol.11
-
-
Kalra, J.1
Warburton, C.2
Fang, K.3
Edwards, L.4
Daynard, T.5
-
30
-
-
79955517624
-
Validating the use of a luciferase labeled breast cancer cell line, MDA435LCC6, as a means to monitor tumor progression and to assess the therapeutic activity of an established anticancer drug, docetaxel (Dt) alone or in combination with the ILK inhibitor, QLT0267
-
Kalra J, Anantha M, Warburton C, Waterhouse D, Yan H, et al. (2011) Validating the use of a luciferase labeled breast cancer cell line, MDA435LCC6, as a means to monitor tumor progression and to assess the therapeutic activity of an established anticancer drug, docetaxel (Dt) alone or in combination with the ILK inhibitor, QLT0267. Cancer biology & therapy 11: 826-838.
-
(2011)
Cancer Biology & Therapy
, vol.11
, pp. 826-838
-
-
Kalra, J.1
Anantha, M.2
Warburton, C.3
Waterhouse, D.4
Yan, H.5
-
31
-
-
62149130798
-
Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells
-
Muranyi AL, Dedhar S, Hogge DE, (2009) Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells. Exp Hematol 37: 450-460.
-
(2009)
Exp Hematol
, vol.37
, pp. 450-460
-
-
Muranyi, A.L.1
Dedhar, S.2
Hogge, D.E.3
-
33
-
-
62849085547
-
Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity
-
Maresca TJ, Salmon ED, (2009) Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity. J Cell Biol 184: 373-381.
-
(2009)
J Cell Biol
, vol.184
, pp. 373-381
-
-
Maresca, T.J.1
Salmon, E.D.2
-
34
-
-
0030479048
-
Oscillating mitotic newt lung cell kinetochores are, on average, under tension and rarely push
-
Waters JC, Skibbens RV, Salmon ED, (1996) Oscillating mitotic newt lung cell kinetochores are, on average, under tension and rarely push. J Cell Sci 109 (Pt 12):: 2823-2831.
-
(1996)
J Cell Sci
, vol.109
, Issue.Pt 12
, pp. 2823-2831
-
-
Waters, J.C.1
Skibbens, R.V.2
Salmon, E.D.3
-
35
-
-
0037601739
-
Suppression of centromere dynamics by Taxol in living osteosarcoma cells
-
Kelling J, Sullivan K, Wilson L, Jordan MA, (2003) Suppression of centromere dynamics by Taxol in living osteosarcoma cells. Cancer Res 63: 2794-2801.
-
(2003)
Cancer Res
, vol.63
, pp. 2794-2801
-
-
Kelling, J.1
Sullivan, K.2
Wilson, L.3
Jordan, M.A.4
-
36
-
-
18844475127
-
Microtubules are acetylated in domains that turn over slowly
-
Webster DR, Borisy GG, (1989) Microtubules are acetylated in domains that turn over slowly. J Cell Sci 92 (Pt 1):: 57-65.
-
(1989)
J Cell Sci
, vol.92
, Issue.Pt 1
, pp. 57-65
-
-
Webster, D.R.1
Borisy, G.G.2
-
37
-
-
0028004566
-
Evidence that kinetochore microtubules in crane-fly spermatocytes disassemble during anaphase primarily at the poleward end
-
Wilson PJ, Forer A, Leggiadro C, (1994) Evidence that kinetochore microtubules in crane-fly spermatocytes disassemble during anaphase primarily at the poleward end. J Cell Sci 107 (Pt 11):: 3015-3027.
-
(1994)
J Cell Sci
, vol.107
, Issue.Pt 11
, pp. 3015-3027
-
-
Wilson, P.J.1
Forer, A.2
Leggiadro, C.3
-
38
-
-
57349190213
-
MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics
-
Barr AR, Gergely F, (2008) MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics. Molecular and cellular biology 28: 7199-7211.
-
(2008)
Molecular and Cellular Biology
, vol.28
, pp. 7199-7211
-
-
Barr, A.R.1
Gergely, F.2
-
39
-
-
1642442739
-
Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle
-
Kaplan DD, Meigs TE, Kelly P, Casey PJ, (2004) Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. J Biol Chem 279: 10829-10832.
-
(2004)
J Biol Chem
, vol.279
, pp. 10829-10832
-
-
Kaplan, D.D.1
Meigs, T.E.2
Kelly, P.3
Casey, P.J.4
-
40
-
-
34347364625
-
A novel role of phospho-beta-catenin in microtubule regrowth at centrosome
-
Huang P, Senga T, Hamaguchi M, (2007) A novel role of phospho-beta-catenin in microtubule regrowth at centrosome. Oncogene 26: 4357-4371.
-
(2007)
Oncogene
, vol.26
, pp. 4357-4371
-
-
Huang, P.1
Senga, T.2
Hamaguchi, M.3
-
41
-
-
77955621504
-
Determination of microtubule dynamic instability in living cells
-
Kamath K, Oroudjev E, Jordan MA, (2010) Determination of microtubule dynamic instability in living cells. Methods in cell biology 97: 1-14.
-
(2010)
Methods in Cell Biology
, vol.97
, pp. 1-14
-
-
Kamath, K.1
Oroudjev, E.2
Jordan, M.A.3
|