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Volumn 18, Issue 1, 2014, Pages 79-93

Targeting leukotriene B4 in inflammation

Author keywords

5 lipoxygenase; Arachidonic acid; Inflammatory diseases; Leukotriene A4 hydrolase

Indexed keywords

1 [3 (4 BIPHENYLYLMETHYL) 4 HYDROXYCHROMAN 7 YL]CYCLOPENTANECARBOXYLIC ACID; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 5 [2 (2 CARBOXYETHYL) 3 [6 (4 METHOXYPHENYL) 5 HEXENYLOXY]PHENOXY]VALERIC ACID; 5 ETHYL 2 HYDROXY 4 [6 METHYL 6 (1H TETRAZOL 5 YL)HEPTYLOXY]ACETOPHENONE; ADENYLATE CYCLASE; AMELUBANT; ARACHIDONATE 5 LIPOXYGENASE; ATRELEUTON; BESTATIN; CAPTOPRIL; ETALOCIB; FIBOFLAPON; HYDROLASE; JNJ 26993135; LEUKOTRIENE B4 RECEPTOR; PHOSPHOLIPASE A2; QUIFLAPON; SC 57461A; SETILEUTON; UNCLASSIFIED DRUG; ZILEUTON;

EID: 84890324535     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2013.843671     Document Type: Review
Times cited : (37)

References (126)
  • 1
    • 80054052917 scopus 로고    scopus 로고
    • Lipoxygenase and leukotriene pathways: Biochemistry biology and roles in disease
    • Haeggstrom JZ, Funk CD. Lipoxygenase and leukotriene pathways: Biochemistry, biology, and roles in disease. Chem Rev 2011;111(10):5866-98
    • (2011) Chem Rev , vol.111 , Issue.10 , pp. 5866-5898
    • Haeggstrom, J.Z.1    Funk, C.D.2
  • 2
    • 80054079339 scopus 로고    scopus 로고
    • Leukotriene receptors
    • Nakamura M, Shimizu T. Leukotriene receptors. Chem Rev 2011;111(10):6231-98
    • (2011) Chem Rev , vol.111 , Issue.10 , pp. 6231-6298
    • Nakamura, M.1    Shimizu, T.2
  • 3
    • 0019254822 scopus 로고
    • Leukotrienes are potent constrictors of human bronchi
    • Dahlen SE, Hedqvist P, Hammarstrom S, Samuelsson B. Leukotrienes are potent constrictors of human bronchi. Nature 1980;288(5790):484-6
    • (1980) Nature , vol.288 , Issue.5790 , pp. 484-486
    • Dahlen, S.E.1    Hedqvist, P.2    Hammarstrom, S.3    Samuelsson, B.4
  • 4
    • 0019311062 scopus 로고
    • Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes
    • Ford-Hutchinson AW, Bray MA, Doig MV, et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 1980;286(5770):264-5
    • (1980) Nature , vol.286 , Issue.5770 , pp. 264-265
    • Ford-Hutchinson, A.W.1    Bray, M.A.2    Doig, M.V.3
  • 5
    • 0019390289 scopus 로고
    • Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence
    • Palmblad J, Malmsten CL, Uden AM, et al. Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence. Blood 1981;58(3):658-61
    • (1981) Blood , vol.58 , Issue.3 , pp. 658-661
    • Palmblad, J.1    Malmsten, C.L.2    Uden, A.M.3
  • 6
    • 0023177955 scopus 로고
    • Leukotrienes And Lipoxins: Structures Biosyn thesis and biological effects
    • Samuelsson B, Dahlen SE, Lindgren JA, et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 1987;237(4819):1171-6
    • (1987) Science , vol.237 , Issue.4819 , pp. 1171-1176
    • Samuelsson, B.1    Dahlen, S.E.2    Lindgren, J.A.3
  • 7
    • 77949773229 scopus 로고    scopus 로고
    • Lipoxins: Regulators of resolution
    • Ryan A, Godson C. Lipoxins: Regulators of resolution. Curr Opin Pharmacol 2010;10(2):166-72
    • (2010) Curr Opin Pharmacol , vol.10 , Issue.2 , pp. 166-172
    • Ryan, A.1    Godson, C.2
  • 8
    • 79955670124 scopus 로고    scopus 로고
    • Resolvins and protectins in inflammation resolution
    • Serhan CN, Petasis NA. Resolvins and protectins in inflammation resolution. Chem Rev 2011;111(10):5922-43
    • Chem Rev 2011 , vol.111 , Issue.10 , pp. 5922-5943
    • Serhan, C.N.1    Petasis, N.A.2
  • 9
    • 0018710244 scopus 로고
    • Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds
    • Borgeat P, Samuelsson B. Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds. J Biol Chem 1979;254(16):7865-9
    • (1979) J Biol Chem , vol.254 , Issue.16 , pp. 7865-7869
    • Borgeat, P.1    Samuelsson, B.2
  • 10
    • 0009582144 scopus 로고
    • Arachidonic acid metabolism in polymorphonuclear leukocytes: Unstable intermediate in formation of dihydroxy acids
    • Borgeat P, Samuelsson B. Arachidonic acid metabolism in polymorphonuclear leukocytes: Unstable intermediate in formation of dihydroxy acids. Proc Natl Acad Sci USA 1979;76(7):3213-17
    • (1979) Proc Natl Acad Sci USA , vol.76 , Issue.7 , pp. 3213-3217
    • Borgeat, P.1    Samuelsson, B.2
  • 11
    • 59849118736 scopus 로고    scopus 로고
    • Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP
    • Lee SP, Serezani CH, Medeiros AI, et al. Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. J Immunol 2009;182(1):530-7
    • (2009) J Immunol , vol.182 , Issue.1 , pp. 530-537
    • Lee, S.P.1    Serezani, C.H.2    Medeiros, A.I.3
  • 12
    • 78650316623 scopus 로고    scopus 로고
    • Leukotriene B4 augments and restores FcgRs-dependent phagocytosis in macrophages
    • Okamoto F, Saeki K, Sumimoto H, et al. Leukotriene B4 augments and restores FcgRs-dependent phagocytosis in macrophages. J Biol Chem 2010;285(52):41113-21
    • (2010) J Biol Chem , vol.285 , Issue.52 , pp. 41113-41121
    • Okamoto, F.1    Saeki, K.2    Sumimoto, H.3
  • 13
    • 84863622602 scopus 로고    scopus 로고
    • Macrophage dectin-1 expression is controlled by leukotriene B4 via a GMCSF/ PU.1 axis
    • Serezani CH, Kane S, Collins L, et al. Macrophage dectin-1 expression is controlled by leukotriene B4 via a GMCSF/ PU.1 axis. J Immunol 2012;189(2):906-15
    • (2012) J Immunol , vol.189 , Issue.2 , pp. 906-915
    • Serezani, C.H.1    Kane, S.2    Collins, L.3
  • 14
    • 34250177883 scopus 로고    scopus 로고
    • Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents
    • Flamand L, Tremblay MJ, Borgeat P. Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents. J Immunol 2007;178(12):8036-45
    • (2007) J Immunol , vol.178 , Issue.12 , pp. 8036-8045
    • Flamand, L.1    Tremblay, M.J.2    Borgeat, P.3
  • 15
    • 44449122937 scopus 로고    scopus 로고
    • Leukotriene B4 induces release of antimicrobial peptides in lungs of virally infected mice
    • Gaudreault E, Gosselin J. Leukotriene B4 induces release of antimicrobial peptides in lungs of virally infected mice. J Immunol 2008;180(9):6211-21
    • (2008) J Immunol , vol.180 , Issue.9 , pp. 6211-6221
    • Gaudreault, E.1    Gosselin, J.2
  • 16
    • 34548476951 scopus 로고    scopus 로고
    • Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: Novel lipid-peptide interactions in innate immune responses
    • Wan M, Sabirsh A, Wetterholm A, et al. Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: Novel lipid-peptide interactions in innate immune responses. Faseb J 2007;21(11):2897-905
    • (2007) Faseb J , vol.21 , Issue.11 , pp. 2897-2905
    • Wan, M.1    Sabirsh, A.2    Wetterholm, A.3
  • 17
    • 79957485585 scopus 로고    scopus 로고
    • LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects
    • Widegren H, Andersson M, Borgeat P, et al. LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects. Respir Med 2011;105(7):997-1006
    • (2011) Respir Med , vol.105 , Issue.7 , pp. 997-1006
    • Widegren, H.1    Andersson, M.2    Borgeat, P.3
  • 18
    • 76149145665 scopus 로고    scopus 로고
    • Leukotriene B4 mediates gd T lymphocyte migration in response to diverse stimuli
    • Costa MF, de Souza-Martins R, de Souza MC, et al. Leukotriene B4 mediates gd T lymphocyte migration in response to diverse stimuli. J Leukoc Biol 2009;87(2):323-32
    • (2009) J Leukoc Biol , vol.87 , Issue.2 , pp. 323-332
    • Costa, M.F.1    De Souza-Martins, R.2    De Souza, M.C.3
  • 19
    • 0142092620 scopus 로고    scopus 로고
    • Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues
    • Goodarzi K, Goodarzi M, Tager AM, et al. Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues. Nat Immunol 2003;4(10):965-73
    • (2003) Nat Immunol , vol.4 , Issue.10 , pp. 965-973
    • Goodarzi, K.1    Goodarzi, M.2    Tager, A.M.3
  • 20
    • 30444451040 scopus 로고    scopus 로고
    • The leukotriene b4 lipid chemoattractant receptor blt1 defines antigen-primed t cells in humans
    • Islam SA, Thomas SY, Hess C, et al. The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans. Blood 2006;107(2):444-53
    • (2006) Blood , vol.107 , Issue.2 , pp. 444-453
    • Islam, S.A.1    Thomas, S.Y.2    Hess, C.3
  • 21
    • 77950521044 scopus 로고    scopus 로고
    • The Leukotriene B4 Receptor BLT1 Is Required For The Induction Of Experimental Autoimmune Encephalomyelitis
    • Kihara Y, Yokomizo T, Kunita A, et al. The leukotriene B4 receptor, BLT1, is required for the induction of experimental autoimmune encephalomyelitis. Biochem Biophys Res Commun 2010;394(3):673-8
    • (2010) Biochem Biophys Res Commun , vol.394 , Issue.3 , pp. 673-678
    • Kihara, Y.1    Yokomizo, T.2    Kunita, A.3
  • 22
    • 40149107407 scopus 로고    scopus 로고
    • Activation of innate immunity by the leukotriene B4 inhibits EBV induced B-cell transformation in cord-blood derived mononuclear cultures
    • Klein E, Liu A, Claesson HE. Activation of innate immunity by the leukotriene B4 inhibits EBV induced B-cell transformation in cord-blood derived mononuclear cultures. Immunol Lett 2008;116(2):174-7
    • (2008) Immunol Lett , vol.116 , Issue.2 , pp. 174-177
    • Klein, E.1    Liu, A.2    Claesson, H.E.3
  • 23
    • 40149111807 scopus 로고    scopus 로고
    • Leukotriene B4 activates T cells that inhibit B-cell proliferation in EBV-infected cord blood-derived mononuclear cell cultures
    • Liu A, Claesson HE, Mahshid Y, et al. Leukotriene B4 activates T cells that inhibit B-cell proliferation in EBV-infected cord blood-derived mononuclear cell cultures. Blood 2008;111(5):2693-703
    • (2008) Blood , vol.111 , Issue.5 , pp. 2693-2703
    • Liu, A.1    Claesson, H.E.2    Mahshid, Y.3
  • 24
    • 0142124327 scopus 로고    scopus 로고
    • Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
    • Tager AM, Bromley SK, Medoff BD, et al. Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. Nat Immunol 2003;4(10):982-90
    • (2003) Nat Immunol , vol.4 , Issue.10 , pp. 982-990
    • Tager, A.M.1    Bromley, S.K.2    Medoff, B.D.3
  • 25
    • 0029661982 scopus 로고    scopus 로고
    • The PPARa-leukotriene B4 pathway to inflammation control
    • Devchand PR, Keller H, Peters JM, et al. The PPARa-leukotriene B4 pathway to inflammation control. Nature 1996;384(6604):39-43
    • (1996) Nature , vol.384 , Issue.6604 , pp. 39-43
    • Devchand, P.R.1    Keller, H.2    Peters, J.M.3
  • 26
    • 49849086021 scopus 로고    scopus 로고
    • The peroxisome proliferator-Activated receptor-g agonist pioglitazone represses inflammation in a peroxisome proliferator-Activated receptor-A-dependent manner in vitro and in vivo in mice
    • Orasanu G, Ziouzenkova O, Devchand PR, et al. The peroxisome proliferator-Activated receptor-g agonist pioglitazone represses inflammation in a peroxisome proliferator-Activated receptor-A-dependent manner in vitro and in vivo in mice. J Am Coll Cardiol 2008;52(10):869-81
    • (2008) J Am Coll Cardiol , vol.52 , Issue.10 , pp. 869-881
    • Orasanu, G.1    Ziouzenkova, O.2    Devchand, P.R.3
  • 28
    • 0025917868 scopus 로고
    • Relationship between leukotriene B4 and immunological parameters in rheumatoid synovial fluids
    • Ahmadzadeh N, Shingu M, Nobunaga M, Tawara T. Relationship between leukotriene B4 and immunological parameters in rheumatoid synovial fluids. Inflammation 1991;15(6):497-503
    • (1991) Inflammation , vol.15 , Issue.6 , pp. 497-503
    • Ahmadzadeh, N.1    Shingu, M.2    Nobunaga, M.3    Tawara, T.4
  • 29
    • 67649666621 scopus 로고    scopus 로고
    • Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
    • Gheorghe KR, Korotkova M, Catrina AI, et al. Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids. Arthritis Res Ther 2009;11(3):R83
    • (2009) Arthritis Res Ther , vol.11 , Issue.3
    • Gheorghe, K.R.1    Korotkova, M.2    Catrina, A.I.3
  • 30
    • 0019217271 scopus 로고
    • Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis
    • Klickstein LB, Shapleigh C, Goetzl EJ. Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis. J Clin Invest 1980;66(5):1166-70
    • (1980) J Clin Invest , vol.66 , Issue.5 , pp. 1166-1170
    • Klickstein, L.B.1    Shapleigh, C.2    Goetzl, E.J.3
  • 31
    • 0020334434 scopus 로고
    • Leukotriene B4, an inflammatory mediator in gout
    • Rae SA, Davidson EM, Smith MJ. Leukotriene B4, an inflammatory mediator in gout. Lancet 1982;2(8308):1122-4
    • (1982) Lancet , vol.2 , Issue.8308 , pp. 1122-1124
    • Rae, S.A.1    Davidson, E.M.2    Smith, M.J.3
  • 32
    • 77955900056 scopus 로고    scopus 로고
    • Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis
    • Chou RC, Kim ND, Sadik CD, et al. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity 2010;33(2):266-78
    • (2010) Immunity , vol.33 , Issue.2 , pp. 266-278
    • Chou, R.C.1    Kim, N.D.2    Sadik, C.D.3
  • 33
    • 33645859604 scopus 로고    scopus 로고
    • A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis
    • Kim ND, Chou RC, Seung E, et al. A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis. J Exp Med 2006;203(4):829-35
    • (2006) J Exp Med , vol.203 , Issue.4 , pp. 829-835
    • Kim, N.D.1    Chou, R.C.2    Seung, E.3
  • 34
    • 84869228804 scopus 로고    scopus 로고
    • Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcgR signaling
    • Sadik CD, Kim ND, Iwakura Y, Luster AD. Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcgR signaling. Proc Natl Acad Sci USA 2012;109(46):E3177-85
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.46
    • Sadik, C.D.1    Kim, N.D.2    Iwakura, Y.3    Luster, A.D.4
  • 35
    • 59049103619 scopus 로고    scopus 로고
    • Combination therapies that inhibit cyclooxygenase-2 and leukotriene synthesis prevent disease in murine collagen induced arthritis
    • Anderson GD, Keys KL, De Ciechi PA, Masferrer JL. Combination therapies that inhibit cyclooxygenase-2 and leukotriene synthesis prevent disease in murine collagen induced arthritis. Inflamm Res 2009;58(2):109-17
    • (2009) Inflamm Res , vol.58 , Issue.2 , pp. 109-117
    • Anderson, G.D.1    Keys, K.L.2    De Ciechi, P.A.3    Masferrer, J.L.4
  • 36
    • 78149489303 scopus 로고    scopus 로고
    • Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis
    • Chen M, Lam BK, Luster AD, et al. Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis. J Immunol 2010;185(9):5503-11
    • (2010) J Immunol , vol.185 , Issue.9 , pp. 5503-5511
    • Chen, M.1    Lam, B.K.2    Luster, A.D.3
  • 37
    • 33646484781 scopus 로고    scopus 로고
    • Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: A critical role for BLT1 in collagen-induced arthritis in mice
    • Shao WH, Del Prete A, Bock CB, Haribabu B. Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: A critical role for BLT1 in collagen-induced arthritis in mice. J Immunol 2006;176(10):6254-61
    • (2006) J Immunol , vol.176 , Issue.10 , pp. 6254-6261
    • Shao, W.H.1    Del Prete, A.2    Bock, C.B.3    Haribabu, B.4
  • 38
    • 77649179672 scopus 로고    scopus 로고
    • Eicosanoids and cancer
    • Wang D, Dubois RN. Eicosanoids and cancer. Nat Rev Cancer 2010;10(3):181-93
    • (2010) Nat Rev Cancer , vol.10 , Issue.3 , pp. 181-193
    • Wang, D.1    Dubois, R.N.2
  • 39
    • 0036795009 scopus 로고    scopus 로고
    • Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells
    • Tong WG, Ding XZ, Hennig R, et al. Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Clin Cancer Res 2002;8(10):3232-42
    • (2002) Clin Cancer Res , vol.8 , Issue.10 , pp. 3232-3242
    • Tong, W.G.1    Ding, X.Z.2    Hennig, R.3
  • 40
    • 20244363504 scopus 로고    scopus 로고
    • Increased 5-lipoxygenase expression and induction of apoptosis by its inhibitors in esophageal cancer: A potential target for prevention
    • Hoque A, Lippman SM, Wu TT, et al. Increased 5-lipoxygenase expression and induction of apoptosis by its inhibitors in esophageal cancer: A potential target for prevention. Carcinogenesis 2005;26(4):785-91
    • (2005) Carcinogenesis , vol.26 , Issue.4 , pp. 785-791
    • Hoque, A.1    Lippman, S.M.2    Wu, T.T.3
  • 41
    • 1842841717 scopus 로고    scopus 로고
    • Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors
    • Matsuyama M, Yoshimura R, Mitsuhashi M, et al. Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors. Int J Oncol 2004;24(4):821-7
    • (2004) Int J Oncol , vol.24 , Issue.4 , pp. 821-827
    • Matsuyama, M.1    Yoshimura, R.2    Mitsuhashi, M.3
  • 42
    • 0024211197 scopus 로고
    • Leukotriene B4 production in human atherosclerotic plaques
    • De Caterina R, Mazzone A, Giannessi D, et al. Leukotriene B4 production in human atherosclerotic plaques. Biomed Biochim Acta 1988;47(10-11):S182-5
    • (1988) Biomed Biochim Acta , vol.47 , Issue.10-11
    • De Caterina, R.1    Mazzone, A.2    Giannessi, D.3
  • 43
    • 0032560647 scopus 로고    scopus 로고
    • Differential leukotriene constrictor responses in human atherosclerotic coronary arteries
    • Allen S, Dashwood M, Morrison K, Yacoub M. Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. Circulation 1998;97(24):2406-13
    • (1998) Circulation , vol.97 , Issue.24 , pp. 2406-2413
    • Allen, S.1    Dashwood, M.2    Morrison, K.3    Yacoub, M.4
  • 44
    • 0037417973 scopus 로고    scopus 로고
    • Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis
    • Spanbroek R, Grabner R, Lotzer K, et al. Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proc Natl Acad Sci USA 2003;100(3):1238-43
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.3 , pp. 1238-1243
    • Spanbroek, R.1    Grabner, R.2    Lotzer, K.3
  • 45
    • 33744497551 scopus 로고    scopus 로고
    • Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability
    • Qiu H, Gabrielsen A, Agardh HE, et al. Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Proc Natl Acad Sci USA 2006;103(21):8161-6
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.21 , pp. 8161-8166
    • Qiu, H.1    Gabrielsen, A.2    Agardh, H.E.3
  • 46
    • 23844530173 scopus 로고    scopus 로고
    • Leukotriene modifiers as potential therapeutics for cardiovascular disease
    • Funk CD. Leukotriene modifiers as potential therapeutics for cardiovascular disease. Nat Rev Drug Discov 2005;4(8):664-72
    • (2005) Nat Rev Drug Discov , vol.4 , Issue.8 , pp. 664-672
    • Funk, C.D.1
  • 47
    • 62649157212 scopus 로고    scopus 로고
    • Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice
    • Cao RY, St Amand T, Grabner R, et al. Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice. Atherosclerosis 2009;203(2):395-400
    • (2009) Atherosclerosis , vol.203 , Issue.2 , pp. 395-400
    • Cao, R.Y.1    St Amand, T.2    Grabner, R.3
  • 48
    • 84860205401 scopus 로고    scopus 로고
    • Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to cox-2 deletion in mice
    • Yu Z, Crichton I, Tang SY, et al. Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. Proc Natl Acad Sci USA 2012;109(17):6727-32
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.17 , pp. 6727-6732
    • Yu, Z.1    Crichton, I.2    Tang, S.Y.3
  • 49
    • 4644301666 scopus 로고    scopus 로고
    • The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia- dependent aortic aneurysm
    • Zhao L, Moos MP, Grabner R, et al. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med 2004;10(9):966-73
    • (2004) Nat Med , vol.10 , Issue.9 , pp. 966-973
    • Zhao, L.1    Moos, M.P.2    Grabner, R.3
  • 50
    • 70349303279 scopus 로고    scopus 로고
    • Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus
    • Houard X, Ollivier V, Louedec L, et al. Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus. Faseb J 2009;23(5):1376-83
    • (2009) Faseb J , vol.23 , Issue.5 , pp. 1376-1383
    • Houard, X.1    Ollivier, V.2    Louedec, L.3
  • 51
    • 34250835541 scopus 로고    scopus 로고
    • Inhibited aortic aneurysm formation in BLT1-deficient mice
    • Ahluwalia N, Lin AY, Tager AM, et al. Inhibited aortic aneurysm formation in BLT1-deficient mice. J Immunol 2007;179(1):691-7
    • (2007) J Immunol , vol.179 , Issue.1 , pp. 691-697
    • Ahluwalia, N.1    Lin, A.Y.2    Tager, A.M.3
  • 52
    • 77952424069 scopus 로고    scopus 로고
    • Pharmacological Inhibition Of BLT1 Diminishes Early Abdominal Aneurysm Formation
    • Kristo F, Hardy GJ, Anderson TJ, et al. Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation. Atherosclerosis 2010;210(1):107-13
    • (2010) Atherosclerosis , vol.210 , Issue.1 , pp. 107-113
    • Kristo, F.1    Hardy, G.J.2    Anderson, T.J.3
  • 53
    • 33748684386 scopus 로고    scopus 로고
    • Eicosanoid Transcellular Biosynthesis from cell-cell interactions to in vivo tissue responses
    • Folco G, Murphy RC. Eicosanoid transcellular biosynthesis: From cell-cell interactions to in vivo tissue responses. Pharmacol Rev 2006;58(3):375-88
    • (2006) Pharmacol Rev , vol.58 , Issue.3 , pp. 375-388
    • Folco, G.1    Murphy, R.C.2
  • 54
    • 66349090778 scopus 로고    scopus 로고
    • Phospholipase A2 structure/function, mechanism, and signaling
    • Suppl
    • Burke JE, Dennis EA. Phospholipase A2 structure/function, mechanism, and signaling. J Lipid Res 2009;50(Suppl):S237-42
    • (2009) J Lipid Res , vol.50
    • Burke, J.E.1    Dennis, E.A.2
  • 56
    • 78651453239 scopus 로고    scopus 로고
    • The Structure Of Human 5-lipoxygenase
    • Gilbert NC, Bartlett SG, Waight MT, et al. The structure of human 5-lipoxygenase. Science 2011;331(6014):217-19
    • (2011) Science , vol.331 , Issue.6014 , pp. 217-219
    • Gilbert, N.C.1    Bartlett, S.G.2    Waight, M.T.3
  • 57
    • 4744375385 scopus 로고    scopus 로고
    • Protein kinase a inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523
    • Luo M, Jones SM, Phare SM, et al. Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523. J Biol Chem 2004;279(40):41512-20
    • (2004) J Biol Chem , vol.279 , Issue.40 , pp. 41512-41520
    • Luo, M.1    Jones, S.M.2    Phare, S.M.3
  • 58
    • 0034625136 scopus 로고    scopus 로고
    • 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
    • Werz O, Klemm J, Samuelsson B, Radmark O. 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases. Proc Natl Acad Sci USA 2000;97(10):5261-6
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.10 , pp. 5261-5266
    • Werz, O.1    Klemm, J.2    Samuelsson, B.3    Radmark, O.4
  • 59
    • 0037177904 scopus 로고    scopus 로고
    • Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-Activated protein kinase 2 (MK2)
    • Werz O, Szellas D, Steinhilber D, Radmark O. Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-Activated protein kinase 2 (MK2). J Biol Chem 2002;277(17):14793-800
    • (2002) J Biol Chem , vol.277 , Issue.17 , pp. 14793-14800
    • Werz, O.1    Szellas, D.2    Steinhilber, D.3    Radmark, O.4
  • 60
    • 28844492469 scopus 로고    scopus 로고
    • Phosphorylation by protein kinase a inhibits nuclear import of 5-lipoxygenase
    • Luo M, Jones SM, Flamand N, et al. Phosphorylation by protein kinase a inhibits nuclear import of 5-lipoxygenase. J Biol Chem 2005;280(49):40609-16
    • (2005) J Biol Chem , vol.280 , Issue.49 , pp. 40609-40616
    • Luo, M.1    Jones, S.M.2    Flamand, N.3
  • 61
    • 80053925891 scopus 로고    scopus 로고
    • Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes
    • Pergola C, Rogge A, Dodt G, et al. Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes. Faseb J 2011;25(10):3377-87
    • (2011) Faseb J. , vol.25 , Issue.10 , pp. 3377-3387
    • Pergola, C.1    Rogge, A.2    Dodt, G.3
  • 62
    • 38749113897 scopus 로고    scopus 로고
    • What's all the FLAP about? 5-lipoxygenase-Activating protein inhibitors for inflammatory diseases
    • Evans JF, Ferguson AD, Mosley RT, Hutchinson JH. What's all the FLAP about?: 5-lipoxygenase-Activating protein inhibitors for inflammatory diseases. Trends Pharmacol Sci 2008;29(2):72-8
    • (2008) Trends Pharmacol Sci , vol.29 , Issue.2 , pp. 72-78
    • Evans, J.F.1    Ferguson, A.D.2    Mosley, R.T.3    Hutchinson, J.H.4
  • 63
    • 33748348405 scopus 로고    scopus 로고
    • Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production
    • Rakonjac M, Fischer L, Provost P, et al. Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. Proc Natl Acad Sci USA 2006;103(35):13150-5
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.35 , pp. 13150-13155
    • Rakonjac, M.1    Fischer, L.2    Provost, P.3
  • 64
    • 0037059334 scopus 로고    scopus 로고
    • Leukotriene A4 hydrolase/ aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms
    • Rudberg PC, Tholander F, Thunnissen MM, Haeggstrom JZ. Leukotriene A4 hydrolase/ aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms. J Biol Chem 2002;277(2):1398-404
    • (2002) J Biol Chem , vol.277 , Issue.2 , pp. 1398-1404
    • Rudberg, P.C.1    Tholander, F.2    Thunnissen, M.M.3    Haeggstrom, J.Z.4
  • 65
    • 0029664901 scopus 로고    scopus 로고
    • Leukotriene A4 hydrolase: Protection from mechanism-based inactivation by mutation of tyrosine-378
    • Mueller MJ, Blomster M, Oppermann UC, et al. Leukotriene A4 hydrolase: Protection from mechanism-based inactivation by mutation of tyrosine-378. Proc Natl Acad Sci USA 1996;93(12):5931-5
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.12 , pp. 5931-5935
    • Mueller, M.J.1    Blomster, M.2    Oppermann, U.C.3
  • 66
    • 0026759504 scopus 로고
    • Opioid peptides are substrates for the bifunctional enzyme LTA4 hydrolase/aminopeptidase
    • Griffin KJ, Gierse J, Krivi G, Fitzpatrick FA. Opioid peptides are substrates for the bifunctional enzyme LTA4 hydrolase/aminopeptidase. Prostaglandins 1992;44(3):251-7
    • (1992) Prostaglandins , vol.44 , Issue.3 , pp. 251-257
    • Griffin, K.J.1    Gierse, J.2    Krivi, G.3    Fitzpatrick, F.A.4
  • 67
    • 77957344556 scopus 로고    scopus 로고
    • A critical role for lta4h in limiting chronic pulmonary neutrophilic inflammation
    • Snelgrove RJ, Jackson PL, Hardison MT, et al. A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation. Science 2010;330(6000):90-4
    • (2010) Science , vol.330 , Issue.6000 , pp. 90-94
    • Snelgrove, R.J.1    Jackson, P.L.2    Hardison, M.T.3
  • 68
    • 0030976460 scopus 로고    scopus 로고
    • A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
    • Yokomizo T, Izumi T, Chang K, et al. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 1997;387(6633):620-4
    • (1997) Nature , vol.387 , Issue.6633 , pp. 620-624
    • Yokomizo, T.1    Izumi, T.2    Chang, K.3
  • 69
    • 0142061071 scopus 로고    scopus 로고
    • Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4
    • Ott VL, Cambier JC, Kappler J, et al. Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4. Nat Immunol 2003;4(10):974-81
    • (2003) Nat Immunol , vol.4 , Issue.10 , pp. 974-981
    • Ott, V.L.1    Cambier, J.C.2    Kappler, J.3
  • 70
    • 23044443692 scopus 로고    scopus 로고
    • Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment
    • Heller EA, Liu E, Tager AM, et al. Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation 2005;112(4):578-86
    • (2005) Circulation , vol.112 , Issue.4 , pp. 578-586
    • Heller, E.A.1    Liu, E.2    Tager, A.M.3
  • 71
    • 33646473075 scopus 로고    scopus 로고
    • Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4
    • Qiu H, Johansson AS, Sjostrom M, et al. Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4. Proc Natl Acad Sci USA 2006;103(18):6913-18
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.18 , pp. 6913-6918
    • Qiu, H.1    Johansson, A.S.2    Sjostrom, M.3
  • 72
    • 33748521513 scopus 로고    scopus 로고
    • Role of 5-lipoxygenase pathway in the regulation of RAW 264.7 macrophage proliferation
    • Nieves D, Moreno JJ. Role of 5-lipoxygenase pathway in the regulation of RAW 264.7 macrophage proliferation. Biochem Pharmacol 2006;72(8):1022-30
    • (2006) Biochem Pharmacol , vol.72 , Issue.8 , pp. 1022-1030
    • Nieves, D.1    Moreno, J.J.2
  • 73
    • 67649220653 scopus 로고    scopus 로고
    • Expression of functional leukotriene B4 receptors on human airway smooth muscle cells
    • e1-3
    • Watanabe S, Yamasaki A, Hashimoto K, et al. Expression of functional leukotriene B4 receptors on human airway smooth muscle cells. J Allergy Clin Immunol 2009;124(1):59-65; e1-3
    • (2009) J Allergy Clin Immunol , vol.124 , Issue.1 , pp. 59-65
    • Watanabe, S.1    Yamasaki, A.2    Hashimoto, K.3
  • 74
    • 0034618068 scopus 로고    scopus 로고
    • A second leukotriene B4 receptor, BLT2. A new therapeutic target in inflammation and immunological disorders
    • Yokomizo T, Kato K, Terawaki K, et al. A second leukotriene B4 receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med 2000;192(3):421-32
    • (2000) J Exp Med , vol.192 , Issue.3 , pp. 421-432
    • Yokomizo, T.1    Kato, K.2    Terawaki, K.3
  • 75
    • 0035853806 scopus 로고    scopus 로고
    • Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2
    • Yokomizo T, Kato K, Hagiya H, et al. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem 2001;276(15):12454-9
    • (2001) J Biol Chem , vol.276 , Issue.15 , pp. 12454-12459
    • Yokomizo, T.1    Kato, K.2    Hagiya, H.3
  • 76
    • 42249115644 scopus 로고    scopus 로고
    • 12 (S). -Hydroxyheptadeca-5Z, 8E, 10E-Trienoic acid is a natural ligand for leukotriene B4 receptor 2
    • Okuno T, Iizuka Y, Okazaki H, et al. 12 (S)-Hydroxyheptadeca-5Z, 8E, 10E-Trienoic acid is a natural ligand for leukotriene B4 receptor 2. J Exp Med 2008;205(4):759-66
    • (2008) J Exp Med , vol.205 , Issue.4 , pp. 759-766
    • Okuno, T.1    Iizuka, Y.2    Okazaki, H.3
  • 77
    • 78649726409 scopus 로고    scopus 로고
    • Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis
    • Iizuka Y, Okuno T, Saeki K, et al. Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis. Faseb J 2010;24(12):4678-90
    • (2010) Faseb J , vol.24 , Issue.12 , pp. 4678-4690
    • Iizuka, Y.1    Okuno, T.2    Saeki, K.3
  • 78
    • 84881160011 scopus 로고    scopus 로고
    • Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia
    • Matsunaga Y, Fukuyama S, Okuno T, et al. Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. Faseb J 2013;27(8):3306-14
    • (2013) Faseb J , vol.27 , Issue.8 , pp. 3306-3314
    • Matsunaga, Y.1    Fukuyama, S.2    Okuno, T.3
  • 79
    • 0037561999 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2a-deficient mice are resistant to collagen-induced arthritis
    • Hegen M, Sun L, Uozumi N, et al. Cytosolic phospholipase A2a-deficient mice are resistant to collagen-induced arthritis. J Exp Med 2003;197(10):1297- 302
    • (2003) J Exp Med , vol.197 , Issue.10 , pp. 1297-1302
    • Hegen, M.1    Sun, L.2    Uozumi, N.3
  • 80
    • 25144519259 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2a-deficient mice are resistant to experimental autoimmune encephalomyelitis
    • Marusic S, Leach MW, Pelker JW, et al. Cytosolic phospholipase A2a-deficient mice are resistant to experimental autoimmune encephalomyelitis. J Exp Med 2005;202(6):841-51
    • (2005) J Exp Med , vol.202 , Issue.6 , pp. 841-851
    • Marusic, S.1    Leach, M.W.2    Pelker, J.W.3
  • 81
    • 0031445523 scopus 로고    scopus 로고
    • Role of cytosolic phospholipase A2 in allergic response and parturition
    • Uozumi N, Kume K, Nagase T, et al. Role of cytosolic phospholipase A2 in allergic response and parturition. Nature 1997;390(6660):618-22
    • (1997) Nature , vol.390 , Issue.6660 , pp. 618-622
    • Uozumi, N.1    Kume, K.2    Nagase, T.3
  • 82
    • 77649104362 scopus 로고    scopus 로고
    • Cytosolic Phospholipase A2a Inhibitor Pyrroxyphene Displays Anti-Arthritic And Anti-bone Destructive Action In A Murine Arthritis Model
    • Tai N, Kuwabara K, Kobayashi M, et al. Cytosolic phospholipase A2a inhibitor, pyrroxyphene, displays anti-Arthritic and anti-bone destructive action in a murine arthritis model. Inflamm Res 2010;59(1):53-62
    • (2010) Inflamm Res , vol.59 , Issue.1 , pp. 53-62
    • Tai, N.1    Kuwabara, K.2    Kobayashi, M.3
  • 83
    • 0141785825 scopus 로고    scopus 로고
    • A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates. LPS-induced lung injury in mice
    • Nagase T, Uozumi N, Aoki-Nagase T, et al. A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates. LPS-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol 2003;284(5):L720-6
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284 , Issue.5
    • Nagase, T.1    Uozumi, N.2    Aoki-Nagase, T.3
  • 84
    • 33745458476 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 inhibition attenuates ischemia-reperfusion injury in an isolated rat lung model
    • Bellido-Reyes YA, Akamatsu H, Kojima K, et al. Cytosolic phospholipase A2 inhibition attenuates ischemia-reperfusion injury in an isolated rat lung model. Transplantation 2006;81(12):1700-7
    • (2006) Transplantation , vol.81 , Issue.12 , pp. 1700-1707
    • Bellido-Reyes, Y.A.1    Akamatsu, H.2    Kojima, K.3
  • 85
    • 0027945466 scopus 로고
    • Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene
    • Chen XS, Sheller JR, Johnson EN, Funk CD. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature 1994;372(6502):179-82
    • (1994) Nature , vol.372 , Issue.6502 , pp. 179-182
    • Chen, X.S.1    Sheller, J.R.2    Johnson, E.N.3    Funk, C.D.4
  • 86
    • 0034745137 scopus 로고    scopus 로고
    • Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumoniae
    • Mancuso P, Nana-Sinkam P, Peters-Golden M. Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumoniae. Infect Immun 2001;69(4):2011-16
    • (2001) Infect Immun , vol.69 , Issue.4 , pp. 2011-2016
    • Mancuso, P.1    Nana-Sinkam, P.2    Peters-Golden, M.3
  • 87
    • 0030835266 scopus 로고    scopus 로고
    • 5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice
    • Pt 1
    • Irvin CG, Tu YP, Sheller JR, Funk CD. 5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice. Am J Physiol 1997;272(6 Pt 1):L1053-8
    • (1997) Am J Physiol , vol.272 , Issue.6
    • Irvin, C.G.1    Tu, Y.P.2    Sheller, J.R.3    Funk, C.D.4
  • 88
    • 0037080719 scopus 로고    scopus 로고
    • Protection from pulmonary fibrosis in leukotriene-deficient mice
    • Peters-Golden M, Bailie M, Marshall T, et al. Protection from pulmonary fibrosis in leukotriene-deficient mice. Am J Respir Crit Care Med 2002;165(2):229-35
    • (2002) Am J Respir Crit Care Med , vol.165 , Issue.2 , pp. 229-235
    • Peters-Golden, M.1    Bailie, M.2    Marshall, T.3
  • 89
    • 34548051403 scopus 로고    scopus 로고
    • Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice
    • Adamek A, Jung S, Dienesch C, et al. Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice. Eur J Pharmacol 2007;571(1):51-4
    • (2007) Eur J Pharmacol , vol.571 , Issue.1 , pp. 51-54
    • Adamek, A.1    Jung, S.2    Dienesch, C.3
  • 90
    • 84873414539 scopus 로고    scopus 로고
    • Myeloid Cell 5-lipoxygenase Activating Protein Modulates The Response To Vascular Injury
    • Yu Z, Ricciotti E, Miwa T, et al. Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury. Circ Res 2013;112(3):432-40
    • (2013) Circ Res , vol.112 , Issue.3 , pp. 432-440
    • Yu, Z.1    Ricciotti, E.2    Miwa, T.3
  • 91
    • 77649172085 scopus 로고    scopus 로고
    • 5-Lipoxygenase inhibitors: A review of recent developments and patents
    • Pergola C, Werz O. 5-Lipoxygenase inhibitors: A review of recent developments and patents. Expert Opin Ther Patent 2010;20(3):355-75
    • (2010) Expert Opin Ther Patent , vol.20 , Issue.3 , pp. 355-375
    • Pergola, C.1    Werz, O.2
  • 92
    • 0033590513 scopus 로고    scopus 로고
    • Treatment of asthma with drugs modifying the leukotriene pathway
    • Drazen JM, Israel E, O'Byrne PM. Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med 1999;340(3):197-206
    • (1999) N Engl J Med , vol.340 , Issue.3 , pp. 197-206
    • Drazen, J.M.1    Israel, E.2    O'Byrne, P.M.3
  • 93
    • 84879363415 scopus 로고    scopus 로고
    • 5-Lipoxygenase inhibitors: A review of recent patents (2010 - 2012)
    • Patent 2013
    • Hofmann B, Steinhilber D. 5-Lipoxygenase inhibitors: A review of recent patents (2010 - 2012). Expert Opin Ther Patent 2013;23(7):895-909
    • Expert Opin Ther , vol.23 , Issue.7 , pp. 895-909
    • Hofmann, B.1    Steinhilber, D.2
  • 94
    • 77953642757 scopus 로고    scopus 로고
    • Treatment with 5-lipoxygenase inhibitor via-2291 (atreleuton) in patients with recent acute coronary syndrome
    • Tardif JC, L'Allier P L, Ibrahim R, et al. Treatment with 5-lipoxygenase inhibitor VIA-2291 (Atreleuton) in patients with recent acute coronary syndrome. Circ Cardiovasc Imaging 2010;3(3):298-307
    • (2010) Circ Cardiovasc Imaging , vol.3 , Issue.3 , pp. 298-307
    • Tardif, J.C.1    L'Allier P, L.2    Ibrahim, R.3
  • 95
    • 79151482943 scopus 로고    scopus 로고
    • MK-0633 a potent 5-lipoxygenase inhibitor in chronic obstructive pulmonary disease
    • Bernstein JA, Liu N, Knorr BA, et al. MK-0633, a potent 5-lipoxygenase inhibitor, in chronic obstructive pulmonary disease. Respir Med 2011;105(3):392-401
    • (2011) Respir Med , vol.105 , Issue.3 , pp. 392-401
    • Bernstein, J.A.1    Liu, N.2    Knorr, B.A.3
  • 96
    • 0030898073 scopus 로고    scopus 로고
    • Role of the 5-lipoxygenase-Activating protein (FLAP) in murine acute inflammatory responses
    • Byrum RS, Goulet JL, Griffiths RJ, Koller BH. Role of the 5-lipoxygenase-Activating protein (FLAP) in murine acute inflammatory responses. J Exp Med 1997;185(6):1065-75
    • (1997) J Exp Med , vol.185 , Issue.6 , pp. 1065-1075
    • Byrum, R.S.1    Goulet, J.L.2    Griffiths, R.J.3    Koller, B.H.4
  • 97
    • 0026760732 scopus 로고
    • Pharmacology of MK-0591 (3-[1-(4- chlorobenzyl)-3-(t-butylthio)-5- (quinolin- 2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor
    • Brideau C, Chan C, Charleson S, et al. Pharmacology of MK-0591 (3-[1-(4- chlorobenzyl)-3-(t-butylthio)-5-(quinolin- 2-yl-methoxy)- indol-2-yl]-2,2- dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol 1992;70(6):799-807
    • (1992) Can J Physiol Pharmacol , vol.70 , Issue.6 , pp. 799-807
    • Brideau, C.1    Chan, C.2    Charleson, S.3
  • 98
    • 0027241739 scopus 로고
    • Biochemical activity, pharmacokinetics, and tolerability of MK-886, a leukotriene biosynthesis inhibitor, in humans
    • Depre M, Friedman B, Tanaka W, et al. Biochemical activity, pharmacokinetics, and tolerability of MK-886, a leukotriene biosynthesis inhibitor, in humans. Clin Pharmacol Ther 1993;53(5):602-7
    • (1993) Clin Pharmacol Ther , vol.53 , Issue.5 , pp. 602-607
    • Depre, M.1    Friedman, B.2    Tanaka, W.3
  • 99
    • 84871558873 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-Activating protein inhibitor
    • Bain G, King CD, Schaab K, et al. Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-Activating protein inhibitor. Br J Clin Pharmacol 2013;75(3):779-90
    • (2013) Br J Clin Pharmacol , vol.75 , Issue.3 , pp. 779-790
    • Bain, G.1    King, C.D.2    Schaab, K.3
  • 100
    • 84872561296 scopus 로고    scopus 로고
    • The 5-lipoxygenase-Activating Protein Inhibitor GSK2190915 Attenuates The Early And Late Responses To Inhaled Allergen In Mild Asthma
    • Kent SE, Boyce M, Diamant Z, et al. The 5-lipoxygenase-Activating protein inhibitor, GSK2190915, attenuates the early and late responses to inhaled allergen in mild asthma. Clin Exp Allergy 2013;43(2):177-86
    • (2013) Clin Exp Allergy , vol.43 , Issue.2 , pp. 177-186
    • Kent, S.E.1    Boyce, M.2    Diamant, Z.3
  • 101
    • 0032715754 scopus 로고    scopus 로고
    • Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- And leukotriene A4 hydrolase-deficient mice
    • Byrum RS, Goulet JL, Snouwaert JN, et al. Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- And leukotriene A4 hydrolase-deficient mice. J Immunol 1999;163(12):6810-19
    • (1999) J Immunol , vol.163 , Issue.12 , pp. 6810-6819
    • Byrum, R.S.1    Goulet, J.L.2    Snouwaert, J.N.3
  • 102
    • 0025925182 scopus 로고
    • Inhibition of leukotriene A4 hydrolase/ aminopeptidase by captopril
    • Orning L, Krivi G, Bild G, et al. Inhibition of leukotriene A4 hydrolase/ aminopeptidase by captopril. J Biol Chem 1991;266(25):16507-11
    • (1991) J Biol Chem , vol.266 , Issue.25 , pp. 16507-16511
    • Orning, L.1    Krivi, G.2    Bild, G.3
  • 103
    • 0025924825 scopus 로고
    • Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes
    • Orning L, Krivi G, Fitzpatrick FA. Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes. J Biol Chem 1991;266(3):1375-8
    • (1991) J Biol Chem , vol.266 , Issue.3 , pp. 1375-1378
    • Orning, L.1    Krivi, G.2    Fitzpatrick, F.A.3
  • 104
    • 0026731923 scopus 로고
    • Omega-[(omegaarylalkyl) aryl]alkanoic acids: A new class of specific LTA4 hydrolase inhibitors
    • Labaudiniere R, Hilboll G, Leon-Lomeli A, et al. Omega-[(omegaarylalkyl) aryl]alkanoic acids: A new class of specific LTA4 hydrolase inhibitors. J Med Chem 1992;35(17):3156-69
    • (1992) J Med Chem , vol.35 , Issue.17 , pp. 3156-3169
    • Labaudiniere, R.1    Hilboll, G.2    Leon-Lomeli, A.3
  • 105
    • 0028895017 scopus 로고
    • Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase
    • Hogg JH, Ollmann IR, Haeggstrom JZ, et al. Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem 1995;3(10):1405-15
    • (1995) Bioorg Med Chem , vol.3 , Issue.10 , pp. 1405-1415
    • Hogg, J.H.1    Ollmann, I.R.2    Haeggstrom, J.Z.3
  • 106
    • 0027457065 scopus 로고
    • Development of selective tight-binding inhibitors of leukotriene A4 hydrolase
    • Yuan W, Munoz B, Wong CH, et al. Development of selective tight-binding inhibitors of leukotriene A4 hydrolase. J Med Chem 1993;36(2):211-20
    • (1993) J Med Chem , vol.36 , Issue.2 , pp. 211-220
    • Yuan, W.1    Munoz, B.2    Wong, C.H.3
  • 107
    • 0034744491 scopus 로고    scopus 로고
    • Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti-inflammatory agents
    • Penning TD. Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti-inflammatory agents. Curr Pharm Des 2001;7(3):163-79
    • (2001) Curr Pharm Des , vol.7 , Issue.3 , pp. 163-179
    • Penning, T.D.1
  • 108
    • 0032478676 scopus 로고    scopus 로고
    • Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis
    • Tsuji F, Miyake Y, Enomoto H, et al. Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis. Eur J Pharmacol 1998;346(1):81-5
    • (1998) Eur J Pharmacol , vol.346 , Issue.1 , pp. 81-85
    • Tsuji, F.1    Miyake, Y.2    Enomoto, H.3
  • 109
    • 0031987313 scopus 로고    scopus 로고
    • Involvement of leukotriene B4 in murine dermatitis models
    • Tsuji F, Miyake Y, Horiuchi M, Mita S. Involvement of leukotriene B4 in murine dermatitis models. Biochem Pharmacol 1998;55(3):297-304
    • (1998) Biochem Pharmacol , vol.55 , Issue.3 , pp. 297-304
    • Tsuji, F.1    Miyake, Y.2    Horiuchi, M.3    Mita, S.4
  • 110
    • 0035146853 scopus 로고    scopus 로고
    • Crystal structure of human leukotriene A4 hydrolase, a bifunctional enzyme in inflammation
    • Thunnissen MM, Nordlund P, Haeggstrom JZ. Crystal structure of human leukotriene A4 hydrolase, a bifunctional enzyme in inflammation. Nat Struct Biol 2001;8(2):131-5
    • (2001) Nat Struct Biol , vol.8 , Issue.2 , pp. 131-135
    • Thunnissen, M.M.1    Nordlund, P.2    Haeggstrom, J.Z.3
  • 111
    • 77249161707 scopus 로고    scopus 로고
    • Discovery of 4-[(2S)-2-{[4-(4- chlorophenoxy)phenoxy]methyl}-1- pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis
    • Sandanayaka V, Mamat B, Mishra RK, et al. Discovery of 4-[(2S)-2-{[4-(4- chlorophenoxy)phenoxy]methyl}-1- pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J Med Chem 2010;53(2):573-85
    • (2010) J Med Chem , vol.53 , Issue.2 , pp. 573-585
    • Sandanayaka, V.1    Mamat, B.2    Mishra, R.K.3
  • 112
    • 43049122101 scopus 로고    scopus 로고
    • Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase
    • Kirkland TA, Adler M, Bauman JG, et al. Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem 2008;16(9):4963-83
    • (2008) Bioorg Med Chem , vol.16 , Issue.9 , pp. 4963-4983
    • Kirkland, T.A.1    Adler, M.2    Bauman, J.G.3
  • 113
    • 34248570465 scopus 로고    scopus 로고
    • Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton
    • Rao NL, Dunford PJ, Xue X, et al. Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. J Pharmacol Exp Ther 2007;321(3):1154-60
    • (2007) J Pharmacol Exp Ther , vol.321 , Issue.3 , pp. 1154-1160
    • Rao, N.L.1    Dunford, P.J.2    Xue, X.3
  • 114
    • 77952313992 scopus 로고    scopus 로고
    • Leukotriene A4 hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness
    • Rao NL, Riley JP, Banie H, et al. Leukotriene A4 hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness. Am J Respir Crit Care Med 2010;181(9):899-907
    • (2010) Am J Respir Crit Care Med , vol.181 , Issue.9 , pp. 899-907
    • Rao, N.L.1    Riley, J.P.2    Banie, H.3
  • 115
    • 84883849935 scopus 로고    scopus 로고
    • Blocking macrophage leukotriene B4 prevents endothelial injury and reverses pulmonary hypertension
    • Tian W, Jiang X, Tamosiuniene R, et al. Blocking macrophage leukotriene B4 prevents endothelial injury and reverses pulmonary hypertension. Sci Transl Med 2013;5(200):200ra117
    • (2013) Sci Transl Med , vol.5 , Issue.200
    • Tian, W.1    Jiang, X.2    Tamosiuniene, R.3
  • 116
    • 40149104966 scopus 로고    scopus 로고
    • Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase
    • Whittle BJ, Varga C, Berko A, et al. Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase. Br J Pharmacol 2008;153(5):983-91
    • (2008) Br J Pharmacol , vol.153 , Issue.5 , pp. 983-991
    • Whittle, B.J.1    Varga, C.2    Berko, A.3
  • 117
    • 39549095380 scopus 로고    scopus 로고
    • Leukotriene B4 receptor antagonists as therapeutics for inflammatory disease: Preclinical and clinical developments
    • Hicks A, Monkarsh SP, Hoffman AF, Goodnow R. Jr. Leukotriene B4 receptor antagonists as therapeutics for inflammatory disease: Preclinical and clinical developments. Expert Opin Investig Drugs 2007;16(12):1909-20
    • (2007) Expert Opin Investig Drugs , vol.16 , Issue.12 , pp. 1909-1920
    • Hicks, A.1    Monkarsh, S.P.2    Hoffman, A.F.3    Goodnow Jr., R.4
  • 118
    • 0034714372 scopus 로고    scopus 로고
    • Effects of the second-generation leukotriene B4 receptor antagonist, LY293111Na, on leukocyte infiltration and collagen-induced arthritis in mice
    • Kuwabara K, Yasui K, Jyoyama H, et al. Effects of the second-generation leukotriene B4 receptor antagonist, LY293111Na, on leukocyte infiltration and collagen-induced arthritis in mice. Eur J Pharmacol 2000;402(3):275-85
    • (2000) Eur J Pharmacol , vol.402 , Issue.3 , pp. 275-285
    • Kuwabara, K.1    Yasui, K.2    Jyoyama, H.3
  • 119
    • 0029056109 scopus 로고
    • Effect of CGS 25019C and other LTB4 antagonists in the mouse ear edema and rat neutropenia models
    • Raychaudhuri A, Kotyuk B, Pellas TC, et al. Effect of CGS 25019C and other LTB4 antagonists in the mouse ear edema and rat neutropenia models. Inflamm Res 1995;44(Suppl 2):S141-2
    • (1995) Inflamm Res , vol.44 , Issue.SUPPL. 2
    • Raychaudhuri, A.1    Kotyuk, B.2    Pellas, T.C.3
  • 120
    • 83555173421 scopus 로고    scopus 로고
    • Selective inhibition of leukotriene receptor blt-2 reduces vascular oxidative stress and improves endothelial function in apoe- mice
    • Hoyer FF, Albrecht L, Nickenig G, Muller C. Selective inhibition of leukotriene receptor BLT-2 reduces vascular oxidative stress and improves endothelial function in ApoE-/- mice. Mol Cell Biochem 2012;359(1-2):25-31
    • (2012) Mol Cell Biochem , vol.359 , Issue.1-2 , pp. 25-31
    • Hoyer, F.F.1    Albrecht, L.2    Nickenig, G.3    Muller, C.4
  • 121
    • 29144484773 scopus 로고    scopus 로고
    • Leukotriene receptor antagonists in children with cystic fibrosis lung disease : Anti-inflammatory and clinical effects
    • Schmitt-Grohe S, Zielen S. Leukotriene receptor antagonists in children with cystic fibrosis lung disease : Anti-inflammatory and clinical effects. Paediatr Drugs 2005;7(6):353-63
    • (2005) Paediatr Drugs , vol.7 , Issue.6 , pp. 353-363
    • Schmitt-Grohe, S.1    Zielen, S.2
  • 122
    • 2542467586 scopus 로고    scopus 로고
    • Release of anti-HIV mediators after administration of leukotriene B4 to humans
    • Flamand L, Borgeat P, Lalonde R, Gosselin J. Release of anti-HIV mediators after administration of leukotriene B4 to humans. J Infect Dis 2004;189(11):2001-9
    • (2004) J Infect Dis , vol.189 , Issue.11 , pp. 2001-2009
    • Flamand, L.1    Borgeat, P.2    Lalonde, R.3    Gosselin, J.4
  • 123
    • 84872964202 scopus 로고    scopus 로고
    • Conversion of pro-inflammatory murine alox5 into an anti-inflammatory 15s-lipoxygenating enzyme by multiple mutations of sequence determinants
    • Hofheinz K, Kakularam KR, Adel S, et al. Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants. Arch Biochem Biophys 2012;530(1):40-7
    • (2012) Arch Biochem Biophys , vol.530 , Issue.1 , pp. 40-47
    • Hofheinz, K.1    Kakularam, K.R.2    Adel, S.3
  • 124
    • 77956875151 scopus 로고    scopus 로고
    • Subcellular localization of leukotriene receptors in human endothelial cells
    • Johansson AS, Haeggstrom JZ, Hultenby K, Palmblad J. Subcellular localization of leukotriene receptors in human endothelial cells. Exp Cell Res 2010;316(17):2790-6
    • (2010) Exp Cell Res , vol.316 , Issue.17 , pp. 2790-2796
    • Johansson, A.S.1    Haeggstrom, J.Z.2    Hultenby, K.3    Palmblad, J.4
  • 125
    • 79151478743 scopus 로고    scopus 로고
    • Commonly used leukotriene B4 receptor antagonists possess intrinsic activity as agonists in human endothelial cells. Effects on calcium transients, adhesive events and mediator release
    • Johansson AS, Haeggstrom JZ, Palmblad J. Commonly used leukotriene B4 receptor antagonists possess intrinsic activity as agonists in human endothelial cells. Effects on calcium transients, adhesive events and mediator release. Prostaglandins Leukot Essent Fatty Acids 2011;84(3-4):109-12
    • (2011) Prostaglandins Leukot Essent Fatty Acids , vol.84 , Issue.3-4 , pp. 109-112
    • Johansson, A.S.1    Haeggstrom, J.Z.2    Palmblad, J.3
  • 126
    • 80051658642 scopus 로고    scopus 로고
    • Crystal structure of the b2 adrenergic receptor-gs protein complex
    • Rasmussen SG, DeVree BT, Zou Y, et al. Crystal structure of the b2 adrenergic receptor-Gs protein complex. Nature 2011;477(7366):549-55
    • (2011) Nature , vol.477 , Issue.7366 , pp. 549-555
    • Rasmussen, S.G.1    DeVree, B.T.2    Zou, Y.3


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