12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2

Journal of Experimental Medicine

Volumn 205, Issue 4, 2008, Pages 759-766

  Okuno, Toshiaki ^a,b   Iizuka, Yoshiko ^a   Okazaki, Hiroshi ^b   Yokomizo, Takehiko ^a,b,c   Taguchi, Ryo ^a,c   Shimizu, Takao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 1; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LEUKOTRIENE B4 RECEPTOR; LEUKOTRIENE B4 RECEPTOR 2; LIGAND; TRIENOIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BONE MARROW CELL; CELL ISOLATION; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIPID ANALYSIS; MAMMAL CELL; MASS SPECTROMETRY; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SMALL INTESTINE; THROMBOCYTE ACTIVATION; WILD TYPE;

ACETONE; ANIMALS; BLOOD PLATELETS; BONE MARROW CELLS; CELL MOVEMENT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE 1; FATTY ACIDS, UNSATURATED; FEMALE; GTP-BINDING PROTEINS; HUMANS; INTESTINE, SMALL; LIGANDS; LIPIDS; MASS SPECTROMETRY; MICE; RATS; RECEPTORS, LEUKOTRIENE B4; SIGNAL TRANSDUCTION; SOLUBILITY;

EID: 42249115644     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20072329     Document Type: Article

References (27)

1. Hamberg, M., J. Svensson, and B. Samuelsson. 1974. Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Proc. Natl. Acad. Sci. USA. 71:3824-3828.
2. Narumiya, S. 2003. Prostanoids in immunity: roles revealed by mice deficient in their receptors. Life Sci. 74:391-395.
3. Serhan, C.N., Y. Lu, S. Hong, and R. Yang. 2007. Mediator lipidomics: search algorithms for eicosanoids, resolvins, and protectins. Methods Enzymol. 432:275-317.
4. Samuelsson, B., S.E. Dahlen, J.A. Lindgren, C.A. Rouzer, and C.N. Serhan. 1987. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science. 237:1171-1176.
5. Samuelsson, B., and C.D. Funk. 1989. Enzymes involved in the biosynthesis of leukotriene B4. J. Biol. Chem. 264:19469-19472.
6. Shimizu, T., and L.S. Wolfe. 1990. Arachidonic acid cascade and signal transduction. J. Neurochem. 55:1-15.
7. Zeldin, D.C. 2001. Epoxygenase pathways of arachidonic acid metabolism. J. Biol. Chem. 276:36059-36062.
8. Haeggstrom, J.Z. 2004. Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis. J. Biol. Chem. 279:50639-50642.
9. Brink, C., S.E. Dahlen, J. Drazen, J.F. Evans, D.W. Hay, S. Nicosia, C.N. Serhan, T. Shimizu, and T. Yokomizo. 2003. International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol. Rev. 55:195-227.
10. Tager, A.M., and A.D. Luster. 2003. BLT1 and BLT2: the leukotriene B(4) receptors. Prostaglandins Leukot. Essent. Fatty Acids. 69:123-134.
11. Yokomizo, T., T. Izumi, K. Chang, Y. Takuwa, and T. Shimizu. 1997. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature. 387:620-624.
12. Yokomizo, T., K. Kato, K. Terawaki, T. Izumi, and T. Shimizu. 2000. A second leukotriene B4 receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J. Exp. Med. 192:421-432.
13. Luster, A.D., and A.M. Tager. 2004. T-cell trafficking in asthma: lipid mediators grease the way. Nat. Rev. Immunol. 4:711-724.
14. Jala, V.R., and B. Haribabu. 2004. Leukotrienes and atherosclerosis: new roles for old mediators. Trends Immunol. 25:315-322.
15. Yokomizo, T., K. Kato, H. Hagiya, T. Izumi, and T. Shimizu. 2001. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J. Biol. Chem. 276:12454-12459.
16. Iizuka, Y., T. Yokomizo, K. Terawaki, M. Komine, K. Takami, and T. Shimizu. 2005. Characterization of a mouse second leukotriene B4 receptor, mBLT2. J. Biol. Chem. 280:24816-24823.
17. Gronert, K., S.P. Colgan, and C.N. Serhan. 1998. Characterization of human neutrophil and endothelial cell ligand-operated extracellular acidification rate by microphysiometry: impact of reoxygenation. J. Pharmacol. Exp. Ther. 285:252-261.
18. Kuniyeda, K., T. Okuno, K. Terawaki, M. Miyano, T. Yokomizo, and T. Shimizu. 2007. Identification of the intracellular region of the leukotriene B4 receptor type 1 that is specifically involved in Gi activation. J. Biol. Chem. 282:3998-4006.
19. Shao, W.H., A. Del Prete, C.B. Bock, and B. Haribabu. 2006. Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: a critical role for BLT1 in collagen-induced arthritis in mice. J. Immunol. 176:6254-6261.
20. Lundeen, K.A., B. Sun, L. Karlsson, and A.M. Fourie. 2006. Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells. J. Immunol. 177:3439-3447.
21. Terawaki, K., T. Yokomizo, T. Nagase, A. Toda, M. Taniguchi, K. Hashizume, T. Yagi, and T. Shimizu. 2005. Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses. J. Immunol. 175:4217-4225.
22. Kovanen, P.T. 2007. Mast cells: multipotent local effector cells in atherothrombosis. Immunol. Rev. 217:105-122.
23. Sun, J., G.K. Sukhova, P.J. Wolters, M. Yang, S. Kitamoto, P. Libby, L.A. MacFarlane, J. Mallen-St Clair, and G.P. Shi. 2007. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat. Med. 13:719-724.
24. Kobayashi, T., Y. Tahara, M. Matsumoto, M. Iguchi, H. Sano, T. Murayama, H. Arai, H. Oida, T. Yurugi-Kobayashi, J.K. Yamashita, et al. 2004. Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice. J. Clin. Invest. 114:784-794.
25. Uchida, K. 1999. Current status of acrolein as a lipid peroxidation product. Trends Cardiovasc. Med. 9:109-113.
26. Chaudhary, A.K., M. Nokubo, G.R. Reddy, S.N. Yeola, J.D. Morrow, I.A. Blair, and L.J. Marnett. 1994. Detection of endogenous malondialdehyde- deoxyguanosine adducts in human liver. Science. 265:1580-1582.
27. Okuno, T., H. Ago, K. Terawaki, M. Miyano, T. Shimizu, and T. Yokomizo. 2003. Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low affinity state after G-protein activation. J. Biol. Chem. 278:41500-41509.