Protection from pulmonary fibrosis in leukotriene-deficient mice

American Journal of Respiratory and Critical Care Medicine

Volumn 165, Issue 2, 2002, Pages 229-235

  Peters Golden, Marc ^a   Bailie, Marc ^a   Marshall, Teresa ^a   Wilke, Carol ^a   Phan, Sem H ^a   Toews, Galen B ^a   Moore, Bethany B ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

5 lipoxygenase; Bleomycin; Eicosanoids; Interferon ; Interleukin 10

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; BLEOMYCIN; COLLAGEN; CYTOKINE; GAMMA INTERFERON; HYDROXYPROLINE; LEUKOTRIENE; PEPTIDOLEUKOTRIENE; PROSTAGLANDIN E2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INTERFERON PRODUCTION; LUNG COMPLIANCE; LUNG FIBROSIS; LUNG LAVAGE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0037080719     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.165.2.2104050     Document Type: Article

References (47)

1. NHLBI workshop summary. Pharmacological therapy for idiopathic pulmonary fibrosis: Past, present, and future
2. Treatment of asthma with drugs modifying the leukotriene pathway
3. Effect of leukotriene B4 in the human lung: Recruitment of neutrophils into the alveolar spaces without a change in protein permeability
4. Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis
5. Leukotrienes, LTC4 and LTB4, in bronchoalveolar lavage in bronchial asthma and other respiratory diseases
6. Neutrophil chemotactic factor in the respiratory tract of patients with chronic airway diseases or idiopathic pulmonary fibrosis
7. Alveolar macrophages from patients with asbestos exposure release increased levels of leukotriene B4
8. Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin
9. Bleomycin-induced pulmonary fibrosis in the rat; inhibition by indomethacin
10. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene
11. GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism
12. Regulation of 5-lipoxygenase metabolism in mononuclear phagocytes by CD4 T lymphocytes
13. Different patterns of arachidonate metabolism in autologous human blood monocytes and alveolar macrophages
14. Bleomycin-induced lung injury in the rabbit; analysis and correlation of bronchoalveolar lavage, morphometrics, and fibroblast stimulating activity
15. Inhibition of bleomycin-induced pulmonary fibrosis by nordihydroguiaretic acid. The role of alveolar macrophage activation and mediator production
16. Gamma-linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters
17. Macrophages are a significant source of type 1 cytokines during mycobacterial infection
18. Comparison of antioxidant and nonantioxidant lipoxygenase inhibitors on neutrophil function: Implications for pathogenesis of myocardial reperfusion injury
19. Dietary fish oil and fish and borage oil suppress intrapulmonary proinflammatory eicosanoid biosynthesis and attenuate pulmonary neutrophil accumulation in endotoxic rats
20. Peroxisome proliferator activated receptor-gamma mediates the action of gamma linolenic acid in breast cancer cells
21. Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities
22. The monocyte-derived neutrophil activating peptide (NAP/interleukin-8) stimulates human neutrophil arachidonate-5-lipoxygenase, but not the release of cellular arachidonate
23. IL-4 renders mast cells functionally responsive to endothelin-1
24. Transforming growth factor β upregulates 5-lipoxygenase activity during myeloid maturation
25. Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo
26. Leukotriene E4 and granulocyte infiltration into asthmatic airways
27. Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids
28. Leukotriene receptor antagonists and synthesis inhibitors reverse survival in eosinophils of asthmatic individuals
29. Regulation of alveolar macrophage production of chemoattractants by leukotriene B4 and prostaglandin E2
30. Asbestos fibers and silica particles stimulate rat alveolar macrophages to release tumor necrosis factor. Autoregulatory role of leukotriene B4
31. Altered inflammatory responses in leukotriene-deficient mice
32. The intensity of chronic lung inflammation and fibrosis after bleomycin is directly related to the severity of acute injury
33. In vivo levels and in vitro production of interferon-gamma in fibrosing interstitial lung diseases
34. Increased expression of the interleukin-10 gene by alveolar macrophages in interstitial lung disease
35. A preliminary study of long-term treatment with interferon gamma-1b and low dose prednisolone in patients with idiopathic pulmonary fibrosis
36. Allergic lung responses are increased in prostaglandin H synthase-deficient mice
37. Investigation of the inhibitory effects of PGE2 and selective EP agonists on chemotaxis of human neutrophils
38. Regulation of human alveolar macrophage- and blood monocyte-derived interleukin-8 by prostaglandin E2 and dexamethasone
39. Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression
40. Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators
41. The effect and interaction of bradykinin and prostaglandins on protein and collagen production by lung fibroblasts
42. 2
43. Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E
44. 2 and to express cyclooxygenase-2
45. Leukotriene B4 induces in vitro fibroblast chemotaxis
46. Modulation of fibroblast proliferation by sulfidopeptide leukotrienes: Effect of indomethacin
47. Binding of leukotriene C4 to rat lung fibroblasts and stimulation of collagen synthesis in vitro