Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways

Toxicology

Volumn 315, Issue 1, 2014, Pages 24-37

  Lin, Meng Han ^a   Yen, Jui Hung ^b   Weng, Ching Yi ^a   Wang, Lisu ^a   Ha, Choi Lan ^a   Wu, Ming Jiuan ^a  

^a CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^b TZU CHI UNIVERSITY   (Taiwan)

Author keywords

4 HNE; ER stress; HO 1; P38 MAPK; Unfolded protein response

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 HYDROXYNONENAL; 4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; BETA ACTIN; CASPASE 3; CCAAT ENHANCER BINDING PROTEIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HEME OXYGENASE 1; INITIATION FACTOR 2ALPHA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN IRE1; PUMA PROTEIN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TIRON; TRANSCRIPTION FACTOR NRF2; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DAMAGE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE TARGETING; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PC12 CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UBIQUITINATION; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

EID: 84890138793     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.11.007     Document Type: Article

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