Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress

Journal of Biological Chemistry

Volumn 287, Issue 14, 2012, Pages 11398-11409

  Vladykovskaya, Elena ^a,b   Sithu, Srinivas D ^a,b   Haberzettl, Petra ^a,b   Wickramasinghe, Nalinie S ^a,b   Merchant, Michael L ^b   Hill, Bradford G ^a,b   McCracken, James ^a,b   Agarwal, Abhinav ^a,b   Dougherty, Susan ^a,b   Gordon, Sharon A ^b   Schuschke, Dale A ^b   Barski, Oleg A ^a,b   O'Toole, Timothy ^a,b   D'Souza, Stanley E ^b   Bhatnagar, Aruni ^a,b   Srivastava, Sanjay ^a,b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; AMINO ACIDS; CELL DEATH; CHEMICAL ACTIVATION; ENDOTHELIAL CELLS; LIPIDS; OXIDATION; PEPTIDES; PHOSPHORYLATION;

4-HYDROXY-TRANS-2-NONENAL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC TRANSLATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; TERT-BUTYLHYDROPEROXIDE; UNFOLDED PROTEIN RESPONSE; URSODEOXYCHOLIC ACID;

ENZYMES;

4 HYDROXYNONENAL; ACTIVATING TRANSCRIPTION FACTOR 3; ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; ARYLALIPHATIC CARBOXYLIC ACID; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; GLUTATHIONE; HOMOCYSTEINE INDUCIBLE ENDOPLASMIC RETICULUM PROTEIN; INITIATION FACTOR 2ALPHA; INTERLEUKIN 8; PHENYLBUTYRIC ACID; PROTEIN KINASE; PROTEIN KINASE LIKE ER KINASE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TAUROURSODEOXYCHOLIC ACID; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIAL ACTIVATION; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; LEUKOCYTE ROLLING; LIPID PEROXIDATION; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PROCESSING; RAT; UMBILICAL VEIN ENDOTHELIAL CELL; UNFOLDED PROTEIN RESPONSE; VASCULITIS;

EUKARYOTA; RATTUS;

EID: 84859494099     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.320416     Document Type: Article

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