메뉴 건너뛰기




Volumn 33, Issue 12, 2013, Pages 717-727

The biology of leptin and its implications in breast cancer: A general view

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 6; LEPTIN; LEPTIN RECEPTOR; STAT3 PROTEIN; VASCULOTROPIN;

EID: 84890087045     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2012.0168     Document Type: Review
Times cited : (19)

References (95)
  • 3
    • 0034640508 scopus 로고    scopus 로고
    • Activation of downstream signals by the long form of the leptin receptor
    • Banks AS, Davis SM, Bates SH, Myers MG. 2000. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 275(19): 14563-14572.
    • (2000) J Biol Chem , vol.275 , Issue.19 , pp. 14563-14572
    • Banks, A.S.1    Davis, S.M.2    Bates, S.H.3    Myers, M.G.4
  • 4
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. 1996. Leptin enters the brain by a saturable system independent of insulin. Peptides 17(2): 305-311.
    • (1996) Peptides , vol.17 , Issue.2 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W.3    Jaspan, J.B.4    Maness, L.M.5
  • 5
    • 0033597897 scopus 로고    scopus 로고
    • Subcellular localization and internalization of the four human leptin receptor isoforms
    • Barr VA, Lane K, Taylor SI. 1999. Subcellular localization and internalization of the four human leptin receptor isoforms. J Biol Chem 274(30): 21416-21424.
    • (1999) J Biol Chem , vol.274 , Issue.30 , pp. 21416-21424
    • Barr, V.A.1    Lane, K.2    Taylor, S.I.3
  • 8
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjørbæk C, Uotani S, da Silva B, Flier JS. 1997. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 272(51): 32686-32695.
    • (1997) J Biol Chem , vol.272 , Issue.51 , pp. 32686-32695
    • Bjørbæk, C.1    Uotani, S.2    Da Silva, B.3    Flier, J.S.4
  • 9
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: A simple pathway becomes complex
    • Bray SJ. 2006. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7(9): 678-689.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , Issue.9 , pp. 678-689
    • Bray, S.J.1
  • 10
    • 37048998927 scopus 로고    scopus 로고
    • Adiposity and cancer
    • Fantuzzi G, Mazzone T, eds., Totowa, New Jersey: Humana Press, Inc
    • Calle EE. 2007. Adiposity and cancer. In: Fantuzzi G, Mazzone T, eds. Adipose tissue and adipokines in health and disease. Totowa, New Jersey: Humana Press, Inc. pp. 307-339.
    • (2007) Adipose Tissue and Adipokines in Health and Disease , pp. 307-339
    • Calle, E.E.1
  • 11
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269(5223): 546-549.
    • (1995) Science , vol.269 , Issue.5223 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 17
    • 0742287956 scopus 로고    scopus 로고
    • Leptin receptor-deficient MMTV-TGF - A/LeprdbLeprdb female mice do not develop oncogene-induced mammary tumors
    • Cleary MP, Juneja SC, Phillips FC, Hu X, Grande JP, Maihle NJ. 2004. Leptin receptor-deficient MMTV-TGF-a/LeprdbLeprdb female mice do not develop oncogene-induced mammary tumors. Exp Biol Med 229(2): 182-193.
    • (2004) Exp Biol Med , vol.229 , Issue.2 , pp. 182-193
    • Cleary, M.P.1    Juneja, S.C.2    Phillips, F.C.3    Hu, X.4    Grande, J.P.5    Maihle, N.J.6
  • 20
    • 33947653911 scopus 로고    scopus 로고
    • The metabolic syndrome: A high-risk state for cancer?
    • Cowey S, Hardy RW. 2006. The metabolic syndrome: a high-risk state for cancer? Am J Pathol 169(5): 1505-1522.
    • (2006) Am J Pathol , vol.169 , Issue.5 , pp. 1505-1522
    • Cowey, S.1    Hardy, R.W.2
  • 21
    • 0032130090 scopus 로고    scopus 로고
    • Localization of leptin receptor splice variants in mouse peripheral tissues by immunohistochemistry
    • De Matteis R, Dashtipour K, Ognibene A, Cinti S. 1998. Localization of leptin receptor splice variants in mouse peripheral tissues by immunohistochemistry. Proc Nutr Soc 57(03): 441-448.
    • (1998) Proc Nutr Soc , vol.57 , Issue.3 , pp. 441-448
    • De Matteis, R.1    Dashtipour, K.2    Ognibene, A.3    Cinti, S.4
  • 22
    • 79959526395 scopus 로고    scopus 로고
    • TGF-b signaling in breast cancer cell invasion and bone metastasis
    • Drabsch Y, Dijke Pt. 2011. TGF-b signaling in breast cancer cell invasion and bone metastasis. J Mammary Gland Biol Neoplasia 16(2):97108.
    • (2011) J Mammary Gland Biol Neoplasia , vol.16 , Issue.2 , pp. 97108
    • Drabsch, Y.1    Pt, D.2
  • 23
    • 0031010408 scopus 로고    scopus 로고
    • Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
    • Fei H, Okano HJ, Li C, Lee G-H, Zhao C, Darnell R, Friedman JM. 1997. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A 94(13): 7001-7005.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.13 , pp. 7001-7005
    • Fei, H.1    Okano, H.J.2    Li, C.3    Lee, G.-H.4    Zhao, C.5    Darnell, R.6    Friedman, J.M.7
  • 24
    • 79960561552 scopus 로고    scopus 로고
    • Glioblastomaderived leptin induces tube formation and growth of endothelial cells: Comparison with VEGF effects
    • Ferla R, Bonomi M, Otvos L, Surmacz E. 2011. Glioblastomaderived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer 11(1):303.
    • (2011) BMC Cancer , vol.11 , Issue.1 , pp. 303
    • Ferla, R.1    Bonomi, M.2    Otvos, L.3    Surmacz, E.4
  • 28
    • 5144229540 scopus 로고    scopus 로고
    • Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells
    • Garofalo C, Sisci D, Surmacz E. 2004. Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells. Clin Cancer Res 10(19): 6466-6475.
    • (2004) Clin Cancer Res , vol.10 , Issue.19 , pp. 6466-6475
    • Garofalo, C.1    Sisci, D.2    Surmacz, E.3
  • 30
    • 0031017561 scopus 로고    scopus 로고
    • Human bloodbrain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels
    • Golden PL, Maccagnan TJ, Pardridge WM. 1997. Human bloodbrain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J Clin Invest 99(1): 14-18.
    • (1997) J Clin Invest , vol.99 , Issue.1 , pp. 14-18
    • Golden, P.L.1    Maccagnan, T.J.2    Pardridge, W.M.3
  • 32
    • 70349741579 scopus 로고    scopus 로고
    • Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer
    • Gonzalez RR, Watters A, Xu Y, iSingh U, Mann D, Rueda B, Penichet M. 2009. Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer. Breast Cancer Res 11(3):R36.
    • (2009) Breast Cancer Res , vol.11 , Issue.3
    • Gonzalez, R.R.1    Watters, A.2    Xu, Y.3    Isingh, U.4    Mann, D.5    Rueda, B.6    Penichet, M.7
  • 33
    • 77953704226 scopus 로고    scopus 로고
    • Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFkB/HIF-1a activation
    • Gonzalez-Perez RR, Xu Y, Guo S, Watters A, Zhou W, Leibovich SJ. 2010. Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFkB/HIF-1a activation. Cell Signal 22(9): 1350-1362.
    • (2010) Cell Signal , vol.22 , Issue.9 , pp. 1350-1362
    • Gonzalez-Perez, R.R.1    Xu, Y.2    Guo, S.3    Watters, A.4    Zhou, W.5    Leibovich, S.J.6
  • 34
    • 79959570695 scopus 로고    scopus 로고
    • Notch, IL-1 and leptin crosstalk outcome (NILCO) Is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer
    • Guo S, Gonzalez-Perez RR. 2011. Notch, IL-1 and leptin crosstalk outcome (NILCO) Is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer. PLoS One 6(6):e21467.
    • (2011) PLoS One , vol.6 , Issue.6
    • Guo, S.1    Gonzalez-Perez, R.R.2
  • 36
    • 0036168190 scopus 로고    scopus 로고
    • Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity
    • Hileman SM, Pierroz DD, Masuzaki H, Bjørbæk C, El-Haschimii K, Banks WA, Flier JS. 2002. Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 143(3): 775-783.
    • (2002) Endocrinology , vol.143 , Issue.3 , pp. 775-783
    • Hileman, S.M.1    Pierroz, D.D.2    Masuzaki, H.3    Bjørbæk, C.4    El-Haschimii, K.5    Banks, W.A.6    Flier, J.S.7
  • 37
    • 17744388106 scopus 로고    scopus 로고
    • Transcellular transport of leptin by the short leptin receptor isoform obra in madin-darby canine kidney cells
    • Hileman SM, Tornøe J, Flier JS, Bjørbæk C. 2000. Transcellular transport of leptin by the short leptin receptor isoform obra in madin-darby canine kidney cells. Endocrinology 141(6):1955- 1961.
    • (2000) Endocrinology , vol.141 , Issue.6 , pp. 1955-1961
    • Hileman, S.M.1    Tornøe, J.2    Flier, J.S.3    Bjørbæk, C.4
  • 39
    • 0037146224 scopus 로고    scopus 로고
    • Leptin-A growth factor in normal and malignant breast cells and for normal mammary gland development
    • Hu X, Juneja SC, Maihle NJ, Cleary MP. 2002. Leptin-A growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst 94(22):1704- 1711.
    • (2002) J Natl Cancer Inst , vol.94 , Issue.22 , pp. 1704-1711
    • Hu, X.1    Juneja, S.C.2    Maihle, N.J.3    Cleary, M.P.4
  • 40
    • 0014004384 scopus 로고
    • Diabetes, a new mutafton in the mouse
    • Hummel KP, Dickie MM, Coleman DL. 1966. Diabetes, a new mutafton in the mouse. Science 153(3740): 1127-1128.
    • (1966) Science , vol.153 , Issue.3740 , pp. 1127-1128
    • Hummel, K.P.1    Dickie, M.M.2    Coleman, D.L.3
  • 42
    • 0000736325 scopus 로고
    • Obese, a new mutation in the house mouse
    • Ingalls AM, Dickie MM, Snell GD. 1950. Obese, a new mutation in the house mouse. J Hered 41: 317-318.
    • (1950) J Hered , vol.41 , pp. 317-318
    • Ingalls, A.M.1    Dickie, M.M.2    Snell, G.D.3
  • 43
    • 3042817487 scopus 로고    scopus 로고
    • Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer
    • Ishikawa M, Kitayama J, Nagawa H. 2004. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 10(13): 4325-4331.
    • (2004) Clin Cancer Res , vol.10 , Issue.13 , pp. 4325-4331
    • Ishikawa, M.1    Kitayama, J.2    Nagawa, H.3
  • 44
    • 0030037734 scopus 로고    scopus 로고
    • Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas
    • Iwata H, Iwase H, Toyama T, Hara Y, Omoto Y, Okada Y, Kobayashi S. 1996. Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas. Jpn J Cancer Res 20(5): 602-611.
    • (1996) Jpn J Cancer Res , vol.20 , Issue.5 , pp. 602-611
    • Iwata, H.1    Iwase, H.2    Toyama, T.3    Hara, Y.4    Omoto, Y.5    Okada, Y.6    Kobayashi, S.7
  • 47
    • 2942650969 scopus 로고    scopus 로고
    • Adipose tissue as an endocrine organ
    • Kershaw EE, Flier JS. 2004. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89(6): 2548-2556.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.6 , pp. 2548-2556
    • Kershaw, E.E.1    Flier, J.S.2
  • 48
    • 0034457883 scopus 로고    scopus 로고
    • In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
    • Kim Y-B, Uotani S, Pierroz DD, Flier JS, Kahn BB. 2000. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 141(7): 2328-2339.
    • (2000) Endocrinology , vol.141 , Issue.7 , pp. 2328-2339
    • Kim, Y.-B.1    Uotani, S.2    Pierroz, D.D.3    Flier, J.S.4    Kahn, B.B.5
  • 49
    • 77953672808 scopus 로고    scopus 로고
    • Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: Effects of preoperative chemotherapy
    • Koda M, Kanczuga-Koda L, Sulkowska M, Surmacz E, Sulkowski S. 2010. Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effects of preoperative chemotherapy. BMC Cancer 10(1):320.
    • (2010) BMC Cancer , vol.10 , Issue.1 , pp. 320
    • Koda, M.1    Kanczuga-Koda, L.2    Sulkowska, M.3    Surmacz, E.4    Sulkowski, S.5
  • 50
    • 44949122559 scopus 로고    scopus 로고
    • Expression of leptin and its receptor in female breast cancer in relation with selected apoptotic markers
    • Koda M, Sulkowska M, Kanczuga-Koda L, Jarzabek K, Sulkowski S. 2007. Expression of leptin and its receptor in female breast cancer in relation with selected apoptotic markers. Folia Histochem Cytobiol 45(1): 187-191.
    • (2007) Folia Histochem Cytobiol , vol.45 , Issue.1 , pp. 187-191
    • Koda, M.1    Sulkowska, M.2    Kanczuga-Koda, L.3    Jarzabek, K.4    Sulkowski, S.5
  • 52
    • 0033578334 scopus 로고    scopus 로고
    • Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction
    • Li C, Friedman JM. 1999. Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc Natl Acad Sci U S A 96(17): 9677-9682.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.17 , pp. 9677-9682
    • Li, C.1    Friedman, J.M.2
  • 53
    • 0029050937 scopus 로고
    • Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
    • Lonnqvist F, Arner P, Nordfors L, Schalling M. 1995. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1(9): 950-953.
    • (1995) Nat Med , vol.1 , Issue.9 , pp. 950-953
    • Lonnqvist, F.1    Arner, P.2    Nordfors, L.3    Schalling, M.4
  • 54
    • 0034801977 scopus 로고    scopus 로고
    • Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors
    • Maamra M, Bidlingmaier M, Postel-Vinay M-C, Wu Z, Strasburger CJ, Ross RJM. 2001. Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology 142(10): 4389-4393.
    • (2001) Endocrinology , vol.142 , Issue.10 , pp. 4389-4393
    • Maamra, M.1    Bidlingmaier, M.2    Postel-Vinay, M.-C.3    Wu, Z.4    Strasburger, C.J.5    Ross, R.J.M.6
  • 55
    • 0029086473 scopus 로고
    • Threading analysis suggests that the obese gene product may be a helical cytokine
    • Madej T, Boguski MS, Bryant SH. 1995. Threading analysis suggests that the obese gene product may be a helical cytokine. FEBS Lett 373(1): 13-18.
    • (1995) FEBS Lett , vol.373 , Issue.1 , pp. 13-18
    • Madej, T.1    Boguski, M.S.2    Bryant, S.H.3
  • 59
    • 61449148370 scopus 로고    scopus 로고
    • Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells
    • McMurtry V, Simeone A-M, Nieves-Alicea R, Tari A. 2009. Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells. Clin Exp Metastasis 26(3): 197-204.
    • (2009) Clin Exp Metastasis , vol.26 , Issue.3 , pp. 197-204
    • McMurtry, V.1    Simeone, A.-M.2    Nieves-Alicea, R.3    Tari, A.4
  • 60
    • 0029895233 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
    • Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. 1996. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 387(2-3): 113-116.
    • (1996) FEBS Lett , vol.387 , Issue.2-3 , pp. 113-116
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3    Lawrence, C.B.4    Hannah, L.T.5    Trayhurn, P.6
  • 61
    • 33644527562 scopus 로고    scopus 로고
    • High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels
    • Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I, Noguchi S. 2006. High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. Int J Cancer 118(6): 1414-1419.
    • (2006) Int J Cancer , vol.118 , Issue.6 , pp. 1414-1419
    • Miyoshi, Y.1    Funahashi, T.2    Tanaka, S.3    Taguchi, T.4    Tamaki, Y.5    Shimomura, I.6    Noguchi, S.7
  • 62
    • 0038747134 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin
    • Münzberg H, Huo L, Nillni EA, Hollenberg AN, Bjørbæk C. 2003. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 144(5): 2121-2131.
    • (2003) Endocrinology , vol.144 , Issue.5 , pp. 2121-2131
    • Münzberg, H.1    Huo, L.2    Nillni, E.A.3    Hollenberg, A.N.4    Bjørbæk, C.5
  • 63
    • 20444424617 scopus 로고    scopus 로고
    • Epidermal growth factor receptor family and its role in cancer progression
    • Nair P. 2005. Epidermal growth factor receptor family and its role in cancer progression. Curr Sci 88(6): 890-898.
    • (2005) Curr Sci , vol.88 , Issue.6 , pp. 890-898
    • Nair, P.1
  • 64
    • 0037152340 scopus 로고    scopus 로고
    • Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: Reciprocal involvement of PKC-alpha and PPAR expression
    • Okumura M, Yamamoto M, Sakuma H, Kojima T, Maruyama T, Jamali M, Cooper DR, Yasuda K. 2002. Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression. Biochim Biophys Acta 1592(2): 107-116.
    • (2002) Biochim Biophys Acta , vol.1592 , Issue.2 , pp. 107-116
    • Okumura, M.1    Yamamoto, M.2    Sakuma, H.3    Kojima, T.4    Maruyama, T.5    Jamali, M.6    Cooper, D.R.7    Yasuda, K.8
  • 66
    • 80052331618 scopus 로고    scopus 로고
    • Targeting the leptin receptor: A potential new mode of treatment for breast cancer
    • Otvos L, Surmacz E. 2011. Targeting the leptin receptor: a potential new mode of treatment for breast cancer. Expert Rev Anticancer Ther 11(8): 1147-1150.
    • (2011) Expert Rev Anticancer Ther , vol.11 , Issue.8 , pp. 1147-1150
    • Otvos, L.1    Surmacz, E.2
  • 67
    • 78650187530 scopus 로고    scopus 로고
    • Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo
    • Park J, Kusminski CM, Chua SC, Scherer PE. 2010. Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo. Am J Pathol 177(6): 3133-3144.
    • (2010) Am J Pathol , vol.177 , Issue.6 , pp. 3133-3144
    • Park, J.1    Kusminski, C.M.2    Chua, S.C.3    Scherer, P.E.4
  • 68
    • 56849130281 scopus 로고    scopus 로고
    • Leptinregulated gene expression in MCF-7 breast cancer cells: Mechanistic insights into leptin-regulated mammary tumor growth and progression
    • Perera CN, Chin HG, Duru N, Camarillo IG. 2008a. Leptinregulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression. J Endocrinol 199(2): 221-233.
    • (2008) J Endocrinol , vol.199 , Issue.2 , pp. 221-233
    • Perera, C.N.1    Chin, H.G.2    Duru, N.3    Camarillo, I.G.4
  • 69
    • 46449136776 scopus 로고    scopus 로고
    • Identification of proteins secreted from leptin stimulated MCF-7 breast cancer cells: A dual proteomic approach
    • Perera CN, Spalding HS, Mohammed SI, Camarillo IG. 2008b. Identification of proteins secreted from leptin stimulated MCF-7 breast cancer cells: a dual proteomic approach. Exp Biol Med 233(6): 708-720.
    • (2008) Exp Biol Med , vol.233 , Issue.6 , pp. 708-720
    • Perera, C.N.1    Spalding, H.S.2    Mohammed, S.I.3    Camarillo, I.G.4
  • 71
    • 77950861428 scopus 로고    scopus 로고
    • Interaction between menopausal status and obesity in affecting breast cancer risk
    • Rose DP, Vona-Davis L. 2010. Interaction between menopausal status and obesity in affecting breast cancer risk. Maturitas 66(1): 33-38.
    • (2010) Maturitas , vol.66 , Issue.1 , pp. 33-38
    • Rose, D.P.1    Vona-Davis, L.2
  • 72
    • 0034788985 scopus 로고    scopus 로고
    • The IGF system and breast cancer
    • Sachdev D, Yee D. 2001. The IGF system and breast cancer. Endoc-Relat Cancer 8(3): 197-209.
    • (2001) Endoc-Relat Cancer , vol.8 , Issue.3 , pp. 197-209
    • Sachdev, D.1    Yee, D.2
  • 73
    • 78649369742 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition (EMT) phenomenon
    • Savagner P. 2010. The epithelial-mesenchymal transition (EMT) phenomenon. Ann Oncol 21(suppl 7):vii89-vii92.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 7
    • Savagner, P.1
  • 74
    • 34250315764 scopus 로고    scopus 로고
    • Leptininduced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3
    • Saxena NK, Vertino PM, Anania FA, Sharma D. 2007. Leptininduced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J Biol Chem 282(18): 13316-13325.
    • (2007) J Biol Chem , vol.282 , Issue.18 , pp. 13316-13325
    • Saxena, N.K.1    Vertino, P.M.2    Anania, F.A.3    Sharma, D.4
  • 76
    • 27644465299 scopus 로고    scopus 로고
    • Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: Evidence that tumor necrosis factor-alpha- and interleukin-1betatreated human preadipocytes are potent leptin producers
    • Simons PJ, van den Pangaart PS, van Roomen CPAA, Aerts JMFG, Boon L. 2005. Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: evidence that tumor necrosis factor-alpha- and interleukin-1betatreated human preadipocytes are potent leptin producers. Cytokine 32(2): 94-103.
    • (2005) Cytokine , vol.32 , Issue.2 , pp. 94-103
    • Simons, P.J.1    Van Den Pangaart, P.S.2    Van Roomen, C.P.A.A.3    Aerts, J.M.F.G.4    Boon, L.5
  • 77
    • 4544326176 scopus 로고    scopus 로고
    • Evidence for the notch signaling pathway on the role of estrogen in angiogenesis
    • Soares R, Balogh G, Guo S, Gärtner F, Russo J, Schmitt F. 2004. Evidence for the notch signaling pathway on the role of estrogen in angiogenesis. Mol Endocrinol 18(9): 2333-2343.
    • (2004) Mol Endocrinol , vol.18 , Issue.9 , pp. 2333-2343
    • Soares, R.1    Balogh, G.2    Guo, S.3    Gärtner, F.4    Russo, J.5    Schmitt, F.6
  • 78
    • 48949091209 scopus 로고    scopus 로고
    • Leptin augments proliferation of breast cancer cells via transactivation of HER2
    • Soma D, Kitayama J, Yamashita H, Miyato H, Ishikawa M, Nagawa H. 2008. Leptin augments proliferation of breast cancer cells via transactivation of HER2. J Surg Res 149(1): 9-14.
    • (2008) J Surg Res , vol.149 , Issue.1 , pp. 9-14
    • Soma, D.1    Kitayama, J.2    Yamashita, H.3    Miyato, H.4    Ishikawa, M.5    Nagawa, H.6
  • 80
    • 36849035772 scopus 로고    scopus 로고
    • Mammary cancer susceptibility: Human genes and rodent models
    • Szpirer C, Szpirer J. 2007. Mammary cancer susceptibility: human genes and rodent models. Mamm Genome 18(12): 817-831.
    • (2007) Mamm Genome , vol.18 , Issue.12 , pp. 817-831
    • Szpirer, C.1    Szpirer, J.2
  • 81
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia LA. 1997. The leptin receptor. J Biol Chem 272(10): 6093-6096.
    • (1997) J Biol Chem , vol.272 , Issue.10 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 83
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: Inflammation and the pleiotropic role of white adipose tissue
    • Trayhurn P, Wood IS. 2004. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92: 347-355.
    • (2004) Br J Nutr , vol.92 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 84
    • 0025887329 scopus 로고
    • Rat obesity gene fatty (fa) maps to chromosome 5: Evidence for homology with the mouse gene diabetes (db)
    • Truett GE, Bahary N, Friedman JM, Leibel RL. 1991. Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db). Proc Natl Acad Sci U S A 88(17): 7806-7809.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , Issue.17 , pp. 7806-7809
    • Truett, G.E.1    Bahary, N.2    Friedman, J.M.3    Leibel, R.L.4
  • 85
    • 75149170979 scopus 로고    scopus 로고
    • Fibroblast growth factor signalling: From development to cancer
    • Turner N, Grose R. 2010. Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer 10(2): 116-129.
    • (2010) Nat Rev Cancer , vol.10 , Issue.2 , pp. 116-129
    • Turner, N.1    Grose, R.2
  • 86
    • 0033008075 scopus 로고    scopus 로고
    • Functional properties of leptin receptor isoforms: Internalization and degradation of leptin and ligand-induced receptor downregulation
    • Uotani S, Bjørbaek C, Tornøe J, Flier JS. 1999. Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes 48(2): 279-286.
    • (1999) Diabetes , vol.48 , Issue.2 , pp. 279-286
    • Uotani, S.1    Bjørbaek, C.2    Tornøe, J.3    Flier, J.S.4
  • 90
    • 35648965654 scopus 로고    scopus 로고
    • Mechanistic insights from structural studies of b-catenin and its binding partners
    • Xu W, Kimelman D. 2007. Mechanistic insights from structural studies of b-catenin and its binding partners. J Cell Sci 120(19): 3337-3344.
    • (2007) J Cell Sci , vol.120 , Issue.19 , pp. 3337-3344
    • Xu, W.1    Kimelman, D.2
  • 91
    • 84858019563 scopus 로고    scopus 로고
    • Leptininduced epithelial-mesenchymal transition in breast cancer cells requires b-catenin activation via Akt/GSK3- and MTA1/ Wnt1 protein-dependent pathways
    • Yan D, Avtanski D, Saxena NK, Sharma D. 2012. Leptininduced epithelial-mesenchymal transition in breast cancer cells requires b-catenin activation via Akt/GSK3- and MTA1/ Wnt1 protein-dependent pathways. J Biol Chem 287(11):8598- 8612.
    • (2012) J Biol Chem , vol.287 , Issue.11 , pp. 8598-8612
    • Yan, D.1    Avtanski, D.2    Saxena, N.K.3    Sharma, D.4
  • 92
    • 4143118039 scopus 로고    scopus 로고
    • Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin
    • Yin N, Wang D, Zhang H, Yi X, Sun X, Shi B, Wu H, Wu G, Wang X, Shang Y. 2004. Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin. Cancer Res 64(16): 5870-5875.
    • (2004) Cancer Res , vol.64 , Issue.16 , pp. 5870-5875
    • Yin, N.1    Wang, D.2    Zhang, H.3    Yi, X.4    Sun, X.5    Shi, B.6    Wu, H.7    Wu, G.8    Wang, X.9    Shang, Y.10
  • 93
    • 0028946288 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1995. Positional cloning of the mouse obese gene and its human homologue. Nature 374(6521): 479-479.
    • (1995) Nature , vol.374 , Issue.6521 , pp. 479-479
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 94
    • 80052155796 scopus 로고    scopus 로고
    • Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival
    • Zheng Q, Dunlap SM, Zhu J, Downs-Kelly E, Rich J, Hursting SD, Berger NA, Reizes O. 2011. Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival. Endoc-Relat Cancer 18(4): 491-503.
    • (2011) Endoc-Relat Cancer , vol.18 , Issue.4 , pp. 491-503
    • Zheng, Q.1    Dunlap, S.M.2    Zhu, J.3    Downs-Kelly, E.4    Rich, J.5    Hursting, S.D.6    Berger, N.A.7    Reizes, O.8
  • 95
    • 78650908647 scopus 로고    scopus 로고
    • Leptin proangiogenic signature in breast cancer is linked to IL-1 signalling
    • Zhou W, Guo S, Gonzalez-Perez RR. 2011. Leptin proangiogenic signature in breast cancer is linked to IL-1 signalling. Br J Cancer, 104: 128-137.
    • (2011) Br J Cancer , vol.104 , pp. 128-137
    • Zhou, W.1    Guo, S.2    Gonzalez-Perez, R.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.