Circulating levels of leptin, adiposity and breast cancer risk

British Journal of Cancer

Volumn 100, Issue 4, 2009, Pages 578-582

  Wu, M H ^a   Chou, Y C ^a   Chou, W Y ^b   Hsu, G C ^c   Chu, C H ^c   Yu, C P ^c   Yu, J C ^c   Sun, C A ^b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Adiposity; Breast cancer; Leptin

Indexed keywords

LEPTIN;

ADULT; AGED; ANTHROPOMETRIC PARAMETERS; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; BREAST CANCER; CANCER RISK; CARCINOGENESIS; CASE CONTROL STUDY; CONCENTRATION (PARAMETERS); CONTROL GROUP; CONTROLLED STUDY; FEMALE; GENERAL HOSPITAL; HOSPITAL ADMISSION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MOLECULAR MECHANICS; OBESITY; POSTMENOPAUSE; PRIORITY JOURNAL; QUESTIONNAIRE; TAIWAN; WAIST CIRCUMFERENCE;

ADIPOSITY; ADULT; AGED; BODY MASS INDEX; BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; HUMANS; LEPTIN; MIDDLE AGED; QUESTIONNAIRES; RISK FACTORS; TAIWAN; WAIST CIRCUMFERENCE;

EID: 60349122497     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604913     Document Type: Article

References (39)

1. Augoulea A, Mastorakos G, Lambrinoudaki I, Christodoulakos G, George C (2005) Role of postmenopausal hormone replacement therapy on body fat gain and leptin levels. Gynecol Endocrinol 20: 227-235
2. Auwerx J, Staels B (1998) Leptin. Lancet 351: 737-742
3. Calle EE, Thun MJ (2004) Obesity and cancer. Oncogene 23: 6365-6378
4. Catalano S, Mauro L, Marsico S, Giordano C, Rizza P, Rago V, Montanaro D, Maggiolini M, Panno ML, Ando S (2004) Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor α in MCF-7 cells. J Biol Chem 279: 19908-19915
5. Chen C, Chang YC, Liu CL, Chang KJ, Guo IC (2006a) Leptin - induced growth of human ER-75-1 breast cancer cells is associated with upregulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21 WAF1/CIP1. Breast Cancer Res Treat 98: 121-132
6. Chen DC, Chung YF, Yeh YT, Chaung HC, Kuo FC, Fu OY, Chen HY, Hou MF, Yuan SF (2006b) Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer Lett 237: 109-114
7. Chio JH, Park SH, Leung PC, Chio KC (2004) Expression of leptin receptors and potential effects of leptin on the cell growth and activation of mitogen-activated protein kinases in ovarian cancer cells. J Clin Endocrinol Metab 90: 207-210
8. Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Stampfer M, Rimm EB (2001) Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis 157: 495-503
9. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 341: 913-915
10. Coskun U, Gunel N, Toruner FB, Sancak B, Onuk E, Bayram O (2003) Serum leptin, prolactin and vascular endothelial growth factor (VEGF) levels in patients with breast cancer. Neoplasma 50: 41-46
11. Dieudonne MN, Machinal-Quelin F, Serazin-Leory V, Leneveu MC, Pecquery R, Giudicelli Y (2002) Leptin mediates a proliferative response in human MCF7 breast cancer cells. Biochem Biophys Res Commun 293: 622-628
12. Garofalo C, Koda M, Cascio S, Sulkowska M, Kanczuga-Koda L, Golaszewska J, Russo A, Sulkowski S, Surmacz E (2006) Increased expression of leptin and leptin receptors as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res 12: 1447-1453
13. Garofalo C, Surmacz E (2006) Leptin and cancer. J Cell Physiol 207: 12-22
14. Han C, Zhang HT, Du L, Liu X, Jing J, Zhao X, Yang X, Tian B (2005) Serum levels of leptin, insulin, and lipids in relation to breast cancer in China. Endocrine 26: 19-24
15. Hardwick JC, van den Brink GR, Offerhaus GJ, van Deventer SJ, Peppelenbosch MP (2001) Leptin is a growth factor for colonic epithelial cells. Gastroenterology 121: 79-90
16. Hou WK, Xu YX, Yu T, Zhang L, Zhang WW, Fu CL, Sun Y, Wu Q, Chen L (2007) Adipocytokines and breast cancer risk. Chin Med J 120: 1592-1596
17. Hu X, Juneza SC, Maihle NJ, Cleary MP (2002) Leptin - a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst 94: 1704-1711
18. Ishikawa M, Kitayama J, Nagawa H (2004) Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 10: 4325-4331
19. Liu CL, Chang YC, Cheng SP, Chern SR, Yang TL, Lee JJ, Guo IC, Chen CP (2007) The roles of serum leptin concentration and polymorphism in leptin receptor gene at codon 109 in breast cancer. Oncology 72: 75-81
20. Lovejoy JC, de la Bretonne JA, Klemperer M, Tulley R (1996) Abdominal fat distribution and metabolic risk factors: effect of race. Metabolism 45: 1119-1124
21. Ma Z, Gingerich RL, Santiago JV, Klein S, Smith CH, Landt M (1996) Radioimmunoassay of leptin in human plasma. Clin Chem 42: 942-946
22. Mantzoros CS, Bolhke K, Moschos S, Cramer DW (1999) Leptin in relation to carcinoma in situ of the breast: a study of premenopausal cases and controls. Int J Cancer 380: 523-526
23. Ng EH, Gao F, Ji CY, Ho GH, Soo KC (1997) Risk factors for breast carcinoma in Singaporean Chinese women: the role of central obesity. Cancer 80: 725-731
24. Petridou E, Papadiamantis Y, Markopoulos C, Spanos E, Dessypris N, Trichopoulos D (2000) Leptin and insulin growth factor I in relation to breast cancer. Cancer Causes Control 11: 383-388
25. Rosenbaum M, Leibel RL (1999) The role of leptin in human physiology. N Engl J Med 341: 913-915
26. Sauter ER, Garofalo C, Hewett J, Hewett JE, Morelli C, Surmacz E (2004) leptin expression in breast nipple aspirate fluid (NAF) and serum is influenced by body mass index (BMI) but not by the presence of breast cancer. Horm Metab Res 36: 336-340
27. Schäffler A, Schölmerich J, Buechler C (2007) Mechanisms of disease: adipokines and breast cancer - endocrine and paracrine mechanisms that connect adiposity and breast cancer. Nat Clin Pract Endocrinol Metab 3: 345-354
28. Shimizu H, Shimomura Y, Nakanishi Y, Futawari T, Ohtani K, Sato N, Mori M (1997) Estrogen increases in vivo leptin production in rats and human subjects. J Endocrinol 154: 285-292
29. Sierra-Honignann M, Nath A, Murakami C, Garcia-Cardena G, Papapetropoulos A, Sessa W, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR (1998) Biological action of leptin as an angiogenic factor. Science 281: 1683-1686
30. Stattin P, Soderberg S, Biessy C, Lenner P, Hallmans G, Kaaka R, Olsson T (2004) Plasma leptin and breast cancer risk: a prospective study in northern Sweden. Breast Cancer Res Treat 86: 191-196
31. Stoll BA (1994) Breast cancer: the obesity connection. Br J Cancer 69: 799-801
32. Tessitore L, Vizio B, Jenkins O, De Stefano I, Ritossa C, Argiles JM, Benedetto C (2000) Leptin expression in colorectal and breast cancer patients. Int J Mol Med 5: 421-426
33. Tessitore L, Vizio B, Pesola D, Cecchini F, Mussa A, Argiles JM, Benedetto C (2004) Adipocyte expression and circulating levels of leptin increase in both gynaecological and breast cancer patients. Int J Oncol 24: 1529-1535
34. Tian YF, Chu CH, Wu MH, Chang CL, Yang T, Chou YC, Hsu GC, Yu CP, Yu JC, Sun CA (2007) Anthropometric measures, plasma adiponectin, and breast cancer risk. Endocr Relat Cancer 14: 669-677
35. van den Brandt PA, Spiegelman D, Yaun SS, Adami HO, Beeson L, Folsom AR, Fraser G, Goldbohm RA, Graham S, Kushi L, Marshall JR, Miller AB, Rohan T, Smith-Warner SA, Speizer FE, Willett WC, Wolk A, Hunter DJ (2000) Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol 152: 514-527
36. Vona-Davis L, Howard-McNatt M, Rose DP (2007) Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer. Obes Rev 8: 395-408
37. Woo HY, Park H, Ki CS, Park YL, Bae WG (2006) Relationships among serum leptin, leptin receptor gene polymorphisms, and breast cancer in Korea. Cancer Lett 237: 137-142
38. Yin N, Wang D, Zhang H, Yi X, Sun X, Shi B, Wu H, Wu G, Wang X, Shang Y (2004) Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin. Cancer Res 64: 5870-5875
39. Zhang F, Chen Y, Heiman M, Dimarchi R (2005) Leptin: structure, function and biology. Vitam Horm 71: 345-372