Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 23, 2009, Pages 9483-9488

  Yoshikawa, Misato ^a,b   Go, Shinji ^a   Takasaki, Kotaro ^c   Kakazu, Yasuhiro ^d   Ohashi, Mitsuru ^d   Nagafuku, Masakazu ^a,b   Kabayama, Kazuya ^a   Sekimoto, Junji ^a   Suzuki, Shun Ichi ^a   Takaiwa, Kazutaka ^d   Kimitsuki, Takashi ^d   Matsumoto, Nozomu ^d   Komune, Shizuo ^d   Kamei, Daisuke ^e   Saito, Masaki ^f   Fujiwara, Michihiro ^c   Iwasaki, Katsunori ^b,c   Inokuchi, Jin Ichi ^a,b  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c FUKUOKA UNIVERSITY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e YOKOHAMA CITY UNIVERSITY   (Japan)

^f MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Auditory system; Cochlea; Deafness; Knockout mice; Sialyltransferase

Indexed keywords

GANGLIOSIDE GM3; GANGLIOSIDE GM3 SYNTHASE; GLYCOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COCHLEA; COCHLEA POTENTIAL; CONTROLLED STUDY; CORTI ORGAN; DEGENERATION; ENDOLYMPH; EVOKED BRAIN STEM AUDITORY RESPONSE; HEARING; HEARING LOSS; KNOCKOUT MOUSE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SPIRAL GANGLION; STRIA VASCULARIS; VESTIBULE;

ANIMALS; DEAFNESS; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MUTATION; ORGAN OF CORTI; SIALYLTRANSFERASES; STARTLE REACTION; STRIA VASCULARIS;

MUS;

EID: 67249121549     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903279106     Document Type: Article

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