Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 8, 2005, Pages 2725-2730

  Yamashita, Tadashi ^a,f   Wu, Yun Ping ^a   Sandhoff, Roger ^b   Werth, Norbert ^b   Mizukami, Hiroki ^a   Ellis, Jessica M ^a   Dupreell, Jeffrey L ^d   Geyer, Rudolf ^c   Sandhoff, Konrad ^e   Proia, Richard L ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^e UNIVERSITY OF BONN   (Germany)

^f THE UNIVERSITY OF TOKYO   (Japan)

Author keywords

Glycosphingolipid; Glycosyltransferase; Neurodegeneration

Indexed keywords

GANGLIOSIDE; GANGLIOSIDE GM2; GANGLIOSIDE GM3; GLYCOCONJUGATE; GLYCOSPHINGOLIPID; GLYCOSYLTRANSFERASE; SIALIC ACID; SYNTHETASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MATURATION; CELL INTERACTION; CONTROLLED STUDY; GALGT1 GENE; GENE; GENE MUTATION; GLIA CELL; LIPOGENESIS; MOUSE; NERVE FIBER; NERVE FIBER DEGENERATION; NONHUMAN; PRIORITY JOURNAL; SIAT9 GENE; WHITE MATTER;

ANIMALS; AXONS; BRAIN; BRAIN CHEMISTRY; CELL COMMUNICATION; GANGLIOSIDES; LIPIDS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; N-ACETYLGALACTOSAMINYLTRANSFERASES; NERVE DEGENERATION; NEUROGLIA; SIALYLTRANSFERASES;

EID: 20044394168     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0407785102     Document Type: Article

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