The organizing potential of sphingolipids in intracellular membrane transport

Physiological Reviews

Volumn 81, Issue 4, 2001, Pages 1689-1723

  Holthuis, J C M ^a   Pomorski, T ^a   Raggers, R J ^a   Sprong, H ^a   Van Meer, G ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCEROLIPID; SPHINGOLIPID; STEROL;

CELL MEMBRANE; CELL MEMBRANE TRANSPORT; CELL SELECTION; EUKARYOTE; GOLGI COMPLEX; LIPOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW;

EID: 0034789931     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.2001.81.4.1689     Document Type: Review

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214. Inhibition of serine palmitoyl-transferase activity by lipoxamycin
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216. The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporormiella australis producing organism, fermentation, isolation, and biological activity
217. Viridiofungins, novel inhibitors of sphingolipid synthesis
218. Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase
219. Khafrefungin, a novel inhibitor of sphingolipid synthesis
220. Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver
221. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase
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223. Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide
224. Oligomerization and topology of the Golgi membrane protein glucosylceramide synthase
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226. Internalization and sorting of a fluorescent analogue of glucosylceramide to the Golgi apparatus of human skin fibroblasts: Utilization of endocytic and nonendocytic transport mechanisms
227. The MAL proteolipid is necessary for the overall apical delivery of membrane proteins in the polarized epithelial Madin-Darby canine kidney and Fischer rat thyroid cell lines
228. Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion from COPI-coated vesicles
229. Mutational analysis of the Golgi retention signal of bovine beta-1,4-galactosyl-transferase
230. Sorting of endogenous plasma membrane proteins occurs from two sites in cultured human intestinal epithelial cells (Caco-2)
231. Subcellular distribution and biosynthesis of rat liver gangliosides
232. Interactions of N-stearoyl sphingomyelin with cholesterol and dipalmitoylphosphatidylcholine in bilayer membranes
233. Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells
234. The fraction of the lipid in a biological membrane that is in a fluid state: A spin label assay
235. Structure and cohesive properties of sphingomyelin/cholesterol bilayers
236. Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
237. Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated
238. Scale formation in algae
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243. Soluble gangliosides in cultured neurotumor cells
244. Effect of drugs and temperature on biosynthesis and transport of glycosphingolipids in cultured neurotumor cells
245. Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin
246. Intracellular distribution of a biotin-labeled ganglioside, GM1, by immunoelectron microscopy after endocytosis in fibroblasts
247. Renal cortical brush-border and basolateral membranes: Cholesterol and phospholipid composition and relative turnover
248. Perspectives on Golgi apparatus form and function
249. Ceramide excluded from cell-free vesicular lipid transfer from endoplasmic reticulum to Golgi apparatus: Evidence for lipid sorting
250. Membrane organization at low cholesterol concentrations: A study using 7-nitrobenz-2-oxa-1,3-diazol-4-yl-labeled cholesterol
251. Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails
252. Intracellular transport of GPI-anchored proteins
253. Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention
254. An investigation of the role of transmembrane domains in Golgi protein retention
255. Localization of proteins to the Golgi apparatus
256. VIP21/caveolin is a cholesterol-binding protein
257. Transport of vesicular stomatitis virus G protein to the cell surface is signal mediated in polarized and nonpolarized cells
258. The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis
259. Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene
260. The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases
261. A suppressor gene that enables Saccharomyces cerevisiae to grow without making sphingolipids encodes a protein that resembles an Escherichia coli fatty acyltransferase
262. Combined influence of cholesterol and synthetic amphiphillic peptides upon bilayer thickness in model membranes
263. Enzyme and phospholipid asymmetry in liver microsomal membranes
264. Transverse asymmetry of phospholipids in subcellular membranes of rat liver
265. Retention and retrieval in the endoplasmic reticulum and the Golgi apparatus
266. Phytosphingosine is a characteristic component of the glycolipids in the vertebrate intestine
267. Purification, cDNA cloning, and expression of UDP-Gal: Glucosylceramide beta-1,4-galactosyltransferase from rat brain
268. Lipid composition of myelin from the peripheral nervous system. Intradural spinal roots
269. ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation
270. Dissection of a single round of vesicular transport: Sequential intermediates for intercistemal movement in the Golgi stack
271. Heterogeneous distribution of filipin-cholesterol complexes across the cistemae of the Golgi apparatus
272. Anterograde flow of cargo across the Golgi stack potentially mediated via bidirectional "percolating" COPI vesicles
273. Interleaflet clear space is reduced in the membrane of COP I and COP II-coated buds/vesicles
274. Bidirectional transport by distinct populations of COPI-coated vesicles
275. Stepwise assembly of functionally active transport vesicles
276. Ultrastructural localization of gangliosides; GM1 is concentrated in caveolae
277. Caveolae and caveolins
278. Molecular arrangements in sphingolipids. Conformation and hydrogen bonding of ceramide and their implication on membrane stability and permeability
279. Model for the structure of the lipid bilayer
280. The phosphoinositol sphingolipids of Saccharomyces cerevisiae are highly localized in the plasma membrane
281. Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae
282. A mutant cytochrome b5 with a lengthened membrane anchor escapes from the endoplasmic reticulum and reaches the plasma membrane
283. Getting stuck in the Golgi
284. Sorting and retrieval between the endoplasmic reticulure and Golgi apparatus
285. Getting through the Golgi complex
286. The debate about transport in the Golgi. Two sides of the same coin?
287. Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin
288. Correlative light-electron microscopy reveals the tubular-saccular ultrastructure of carriers operating between Golgi apparatus and plasma membrane
289. Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells
290. Three-dimensional high-resolution particle tracking for optical tweezers by forward scattered light
291. The MAL proteolipid is necessary for normal apical transport and accurate sorting of the influenza virus hemagglutinin in Madin-Darby canine kidney cells
292. Biosynthesis of mannosylinositolphosphoceramide in Saccharomyces cerevisiae is dependent on genes controlling the flow of secretory vesicles from the endoplasmic reticulum to the Golgi
293. Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases
294. Condensed complexes, rafts, and the chemical activity of cholesterol in membranes
295. Lipid traffic: The ABC of transbilayer movement
296. Interaction of cholesterol with sphingomyelins and acyl-chain-matched phosphatidylcholines: A comparative study of the effect of the chain length
297. Isolation and characterization of plasma membranes from Friend erythroleukaemic cells. A study with sphingomyelinase C
298. Transmembrane domain-dependent sorting of proteins to the ER and plasma membrane in yeast
299. Phase equilibria in binary mixtures of phosphatidylcholine and cholesterol
300. Structure of liquid-crystalline phases of different phospholipids, monoglycerides, sphingolipids in the absence or presence of water
301. Mitochondrial and microsomal phospholipids of Morris hepatoma 7777
302. The lipids of the plasma membranes and endoplasmic reticulum from cultured baby hamster kidney cells (BHK21)
303. Characterization of a new gene family developing pleiotropic phenotypes upon mutation in Saccharomyces cerevisiae
304. Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains
305. The differential miscibility of lipids as the basis for the formation of functional membrane rafts
306. Glycans in post-Golgi apical targeting: Sorting signals or structural props?
307. Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane
308. Effects of brefeldin A on synthesis and intracellular transport of ganglioside GT3 by chick embryo retina cells
309. Mechanism of intracellular protein transport
310. The protein machinery of vesicle budding and fusion
311. Throttles and dampers: Controlling the engine of membrane fusion
312. Protein sorting by transport vesicles
313. 1 epithelial cells
314. Role of vesicle-associated syntaxin 5 in the assembly of pre-Golgi intermediates
315. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase
316. Action of monensin, a monovalent cationophore, on cultured human fibroblasts: Evidence that it induces high cellular accumulation of glucosyl- and lactosylceramide (gluco- and lactocerebroside)
317. Influence of monovalent cation transport on anabolism of glycosphingolipids in cultured human fibroblasts
318. Evidence for association of glycosphingolipid with a colchicine-sensitive microtubule-like cytoskeletal structure of cultured cells
319. Cholesterol-induced fluid-phase immiscibility in membranes
320. Identification of ISC1 (YERO19w) as inositol phosphosphingolipid phospholipase C in Soccharomyces cerevisiae
321. N-glycans as apical sorting signals in epithelial cells
322. Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane donmin
323. Infusion of alpha-galactosidase A reduces tissue globotriaosylceramide storage in patients with fabry disease
324. Monolayer coupling in sphingomyelin bilayer systems
325. Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membrane
326. Separation of caveolae from associated microdomains of GPI-anchored proteins
327. Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs
328. Ceramide UDPgalactosyltransferase from myelinating rat brain: Purification, cloning, and expression
329. Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy
330. Characterization of rat kidney proximal tubule brush border membrane-associated phosphatidylinositol phosphodiesterase
331. Transient confinement of a glycosylphosphatidylinositol-anchored protein in the plasma membrane
332. Mice lacking complex ganghosides develop Wallerian degeneration and myelination defects
333. Brefeldin A induced inhibition of de novo globo- and neolacto-series glycolipid core chain biosynthesis in human cells. Evidence for an effect on beta 1→4 galactosyltransferase activity
334. Sphingomyelin transport to the cell surface occurs independently of protein secretion in rat hepatocytes
335. Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons
336. Assays for transmembrane movement of sphingolipids
337. Cholesterol modulation of lipid intermixing in phospholipid and glycosphingolipid mixtures. Evaluation using fluorescent lipid probes and brominated lipid quenchers
338. Cholesterol at different bilayer concentrations can promote or antagonize lateral segregation of phospholipids of differing acyl chain length
339. Functional rafts in cell membranes
340. Lipid rafts and signal transduction
341. Lipid sorting in epithelial cells
342. Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains
343. The fluid mosaic model of the structure of cell membranes
344. Differential extractability of influenza virus hemagglutinin during intracellular transport in polarized epithelial cells and non-polar fibroblasts
345. Suppressor gene analysis reveals an essential role for sphingolipids in transport of glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae
346. Analysis of phosphorylated sphingolipid long-chain bases reveals potential roles in heat stress and growth control in Saccharomyces
347. Rapid turn-over of plasma membrane sphingomyelin and cholesterol in baby hamster kidney cells after exposure to sphingomyelinase
348. A detergent-free method for purifying caveolae membrane from tissue culture cells
349. Lateral organisation of membrane lipids. The superlattice view
350. 1-Palmitoyl-2-pyrenedecanoyl glycerophospholipids as membrane probes: Evidence for regular distribution in liquid-crystalline phosphatidylcholine bilayers
351. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae membranes
352. Cytosolic gangliosides of rat brain: Their fractionation into
353. Cytosolic gangliosides: Occurrence in calf brain as ganglioside-protein complexes
354. Evidence for the existence of ganglioside-enriched plasma membrane domains in human peripheral lymphocytes
355. Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes
356. Sphingosine 1-phosphate: A prototype of a new class of second messengers
357. Direct visualization of redistribution and capping of fluorescent gangliosides on lymphocytes
358. Asymmetric distribution of gangliosides in rat renal brush-border and basolateral membranes
359. UDP-galactose: Ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum
360. Isolation, characterization, and expression of cDNA clones that encode rat UDP-galactose: Ceramide galactosyltransferase
361. Immunoisolation and partial characterization of endothelial plasmalemmal vesicles (caveolae)
362. 2+)-ATPase
363. Calorimetric evidence for the liquid-crystalline state of lipids in a biomembrane
364. Spill labels as enzyme substrates. Heterogeneous lipid distribution in liver microsomal membranes
365. Studies on the asymmetric arrangement of membrane-lipid-enveloped virions as a model system
366. Myelin glycolipids and their functions
367. Asymmetry of the lipid-bilayer of Sindbis virus
368. Recycling of Golgi-resident glycosyltransferases through the ER reveals a novel pathway and provides an explanation for nocodazole-induced Golgi scattering
369. The isolation and analysis of the luminal plasma membrane of calf urinary bladder epithelium
370. Outer membrane monolayer domains from two-dimensional surface scanning resistance measurements
371. Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system
372. E/M dips: Evidence for lipids regularly distributed into hexagonal super-lattices in pyrene-PC/DMPC binary mixtures at specific concentrations
373. Topography of cerebroside sulfotransferase in Golgi-enriched vesicles from rat brain
374. Protein and lipid sorting from the trans-Golgi network to secretory granules. Recent developments
375. Molecular organization of glycosphingolipids in phosphatidylcholine bilayers and biological membranes
376. Localization of globoside and Forssman glycolipids on erythrocyte membranes
377. Cloned mammalian neutral sphingomyelinase. Functions in sphingolipid signaling
378. Dual-color visualization of trans-Golgi network to plasma membrane traffic along microtubules in living cells
379. Two glycosphingolipid sialyltransferases are localized in different sub-Golgi compartments in rat liver
380. Sub-Golgi distribution in rat liver of CMP-NeuAc GM3- and CMP-NeuAc:GT1bα2→8 sialyltransferases and comparison with the distribution of the other glycosyltransferase activities involved in ganglioside biosynthesis
381. Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue
382. Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids
383. Uncoupling of ganglioside biosynthesis by Brefeldin A
384. Modulation of ganglioside biosynthesis in primary cultured neurons
385. Differential targeting of glucosylceramide and gaiactosylceramide analogues after synthesis but not during transcytosis in Madin-Darby canine kidney cells
386. Subcellular localization of Forssman glycolipid in epithelial MDCK cells by immuno-electronmicroscopy after freeze-substitution
387. Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces
388. 6-NBD-sphingomyelin is translocated across the plasma membrane by a multidrug transporter activity
389. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
390. Sphingomyelin synthase is absent from endosomes
391. Conversion of diacylglycerol to phosphatidylcholine on the basolateral surface of epithelial (Madin-Darby canine kidney) cells. Evidence for the reverse action of a sphingomyelin synthase
392. (Glyco)sphingolipids are sorted in sub-apical compartments in HepG2 cells: A role for non-Golgi-related intracellular sites in the polarized distribution of (glyco)sphingolipids
393. Segregation of glucosylceramide and sphingomyelin occurs in the apical to basolateral transcytotic route in HepG2 cells
394. Lipid traffic in animal cells
395. Lipids of the Golgi membrane
396. Sphingolipid transport in eukaryotic cells
397. Sorting of sphingolipids in epithelial (Madin-Darby canine kidney) cells
398. Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: Evidence for the existence of a sphingosine phosphatase
399. Demonstration of the existence of a second, non-lysosomal glucocerebrosidase that is not deficient in Gaucher disease
400. GPI-anchored proteins are organized in submicron domains at the cell surface
401. Phospholipid asymmetry in renal brush-border membranes
402. Phase transitions of phospholipid bilayers and membranes of Achoteplasma laidlawii B visualized by freeze fracturing electron microscopy
403. The asymmetric distribution of phospholipids in the human red cell membrane. A combined study using phospholipases and freeze-etch electron microscopy
404. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme
405. Transport of newly synthesized glucosylceramide to the plasma membrane by a non-Golgi pathway
406. Internalization and sorting of plasma membrane sphingolipid analogues in differentiating oligodendrocytes
407. Sterol partitioning among intracellular membranes. Testing a model for cellular sterol distribution
408. Ceramide second messengers and ceranude assays
409. Anterograde transport through the Golgi complex: Do Golgi tubules hold the key?
410. The isolation and characterization of a mutant strain of Saccharomyces cerevisiae that requires a long chain base for growth and for synthesis of phosphosphingolipids
411. Covalently bound omega-hydroxyacylsphingosine in the stratum corneum
412. Aminopeptidase N is directly sorted to the apical domain in MDCK cells
413. Insect glycolipids
414. The rate of bulk flow from the endoplasmic reticulum to the cell surface
415. Neuronal polarity: Controlling the sorting and diffusion of membrane components
416. Participation of soluble liver proteins in the exchange of membrane phospholipids
417. The dynamics of Golgi protein traffic visualized in living yeast cells
418. Identification of detergent-resistant plasma membrane microdomains in Dictyostelium: Enrichment of signal transduction proteins
419. Intracellular lectins associated with N-linked glycoprotein traffic
420. A vital role for glycosphingolipid synthesis during development and differentiation
421. The transmembrane domain of a carboxyl-terminal anchored protein determines localization to the endoplasmic reticulum
422. New perspectives on mechanisms involved in generating epithelial cell polarity
423. Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice
424. Different biosynthetic transport routes to the plasma membrane in BHK and CHO cells
425. Reevaluating the effect of brefeldin A (BFA) on ganglioside synthesis: The location of GM2 synthase cannot be deduced from the inhibition of GM2 synthesis by BFA
426. Use of brefeldin A to define sites of glycosphingolipid synthesis: GA2/ GM2/GD2 synthase is trans to the brefeldin A block
427. Golgi membranes are absorbed into and reemerge from the ER during mitosis
428. Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae
429. An apparent association between glycosylphosphatidylinositol-anchored proteins and a sphingolipid in Tetrahymena mimbres
430. Kinase suppressor of Ras is ceramide-activated protein kinase
431. 2+-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity
432. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast
433. Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids
434. Correction of enzymatic and lysosomal storage defects in Fabry mice by adenovirus-mediated gene transfer
435. Characterization of a novel, potent, and specific inhibitor of serine palmitoyltransferase