Gangliosides influence EGFR/ErbB2 heterodimer stability but they do not modify EGF-dependent ErbB2 phosphorylation

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1801, Issue 6, 2010, Pages 617-624

  Milani, Simona ^a   Sottocornola, Elena ^a   Zava, Stefania ^a   Galbiati, Mariarita ^a   Berra, Bruno ^a   Colombo, Irma ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

D PDMP; EGFR; ErbB2; Gangliosides; HC11 cell line

Indexed keywords

2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; BETA CASEIN; CERAMIDE GLUCOSYLTRANSFERASE; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GANGLIOSIDE; GANGLIOSIDE GM3; HETERODIMER; INSULIN; MESSENGER RNA; PROLACTIN;

ARTICLE; BREAST CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

BASE SEQUENCE; CELL DIVISION; CELL LINE; DIMERIZATION; DNA PRIMERS; EPIDERMAL GROWTH FACTOR; GANGLIOSIDES; HUMANS; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2;

EID: 77950627388     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2010.02.006     Document Type: Article

References (40)

1. Rampersaud A.A., Oblinger J.L., Ponnappan R.K., Burry R.W., and Yates A.J. Gangliosides and growth factor receptor regulation. Biochem. Soc. Trans. 27 (1999) 415-422
2. Miljan E.A., and Bremer E.G. Regulation of growth factor receptors by gangliosides. Sci. STKE 160 (2002) RE15
3. Hakomori S.I. Structure and function of glycosphingolipids and sphingolipids: recollections and future trends. Biochim. Biophys. Acta 1780 (2008) 325-346
4. Regina Todeschini A., and Hakomori S.I. Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains. Biochim. Biophys. Acta 1780 (2008) 421-433
5. Hynes N.E., and Stern D.F. The biology of erbB-2/neu/HER-2 and its role in cancer. Biochim. Biophys. Acta 1198 (1994) 165-184
6. Stern D.F. ErbBs in mammary development. Exp. Cell Res. 284 (2003) 89-98
7. Holbro T., and Hynes N.E. ErbB receptors: directing key signaling networks throughout life. Annu. Rev. Pharmacol. Toxicol. 44 (2004) 195-217
8. Ross J.S., and Fletcher J.A. The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy. Stem Cells 16 (1998) 413-428
9. Yarden Y., and Sliwkowski M.X. Untangling the ErbB signalling network. Nat. Mol. Cell Biol. 2 (2001) 127-137
10. Lemmon M.A. Ligand-induced ErbB receptor dimerization. Exp. Cell Res. 315 (2009) 638-648
11. Qian X., LeVea C.M., Freeman J.K., Dougall W.C., and Greene M.I. Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 1500-1504
12. Landgraf R. HER2 (ErbB2): functional diversity from structurally conserved building blocks. Breast Cancer Res. 9 (2007) 202
13. Spivak-Kroizmzn T., Rotin D., Pinchasi D., Ullrich A., Schlessinger J., and Lax I. Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses. J. Biol. Chem. 267 (1992) 8056-8063
14. Gulliford T.J., Huang G.C., Ouyang X., and Epstein R.J. Reduced ability of transforming growth factor-alpha to induce EGF receptor heterodimerization and downregulation suggests a mechanism of oncogenic synergy with ErbB2. Oncogene 15 (1997) 2219-2223
15. Kokai Y., Myers J.N., Wada T., Brown V.I., LeVea C.M., Davis J.G., Dobashi K., and Greene M.I. Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts. Cell 58 (1989) 287-292
16. 3 on tyrosine phosphorylation of the epidermal growth factor receptor. J. Biol. Chem. 261 (1986) 2434-2440
17. Meuillet E.J., Mania-Farnell B., George D., Inokuchi J.I., and Bremer E.G. Modulation of EGF receptor activity by changes in the GM3 content in a human epidermoid carcinoma cell line, A431. Exp. Cell Res. 256 (2000) 74-82
18. Zurita A.R., Maccioni H.J., and Daniotti J.L. Modulation of EGFR phosphorylation by endogenously expressed gangliosides. Biochem. J. 335 (2001) 465-472
19. Wang X.Q., Sun P., O'Gorman M., Tai T., and Paller A.S. Epidermal growth factor receptor glycosylation is required for ganglioside GM3 binding and GM3-mediated suppression of activation. Glycobiology 11 (2001) 515-522
20. Yoon S.J., Nakayama K., Hikita T., Handa K., and Hakomori S.I. Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptor. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 18987-18991
21. Kawashima N., Yoon S.J., Itoh K., and Nakayama K. Tyrosine kinase activity of epidermal growth factor receptor is regulated by GM3 binding through carbohydrate to carbohydrate interactions. J. Biol. Chem. 284 (2009) 6147-6155
22. Kornilova E.S., Taverna D., Hoeck W., and Hynes N.E. Surface expression of erbB-2 protein is post-transcriptionally regulated in mammary epithelial cells by epidermal growth factor and by the culture density. Oncogene 7 (1992) 511-519
23. 3 content modulates the EGF-activated p185c-neu levels, but not those of the constitutively activated oncoprotein p185neu. Biochim. Biophys. Acta 1635 (2003) 55-66
24. Danielson K.G., Oborn C.J., Durban E.M., Butel J.S., and Medina D. Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro. Proc. Natl. Acad. Sci. U. S. A. 81 (1984) 3756-3760
25. Ball R.K., Friis R.R., Schoenenberger C.A., Doppler W., and Groner B. Prolactin regulation of beta-casein gene expression and of a cytosolic 120-kd protein in a cloned mouse mammary epithelial cell line. EMBO J. 7 (1988) 2089-2095
26. Taverna D., Groner B., and Hynes N.E. Epidermal growth factor receptor, platelet-derived growth factor receptor, and c-erbB-2 receptor activation all promote growth but have distinctive effects upon mouse mammary epithelial cell differentiation. Cell Growth Differ. 2 (1991) 145-154
27. Chammas R., Taverna D., Cella N., Santos C., and Hynes N.E. Laminin and tenascin assembly and expression regulate HC11 mouse mammary cell differentiation. J. Cell Sci. 107 (1994) 1031-1040
28. Hynes N.E., Taverna D., Harwerth I.M., Ciardiello F., Salomon D.S., Yamamoto T., and Groner B. Epidermal growth factor receptor, but not c-erbB-2, activation prevents lactogenic hormone induction of the beta-casein gene in mouse mammary epithelial cells. Mol. Cell. Biol. 10 (1990) 4027-4034
29. Milani S., Sottocornola E., Zava S., Berselli P., Berra B., and Colombo I. Ganglioside GM3 is stably associated to tyrosine-phosphorylated ErbB2/EGFR receptor complexes and EGFR monomers, but not to ErbB2. Biochim. Biophys. Acta 1771 (2007) 873-878
30. Sottocornola E., Misasi R., Mattei V., Ciarlo L., Gradini R., Garofalo T., Berra B., Colombo I., and Sorice M. Role of gangliosides in the association of ErbB2 with lipid rafts in mammary epithelial HC11 cells. FEBS J. 273 (2006) 1821-1830
31. Danielson K.G., Oborn C.J., Durban E.M., Butel J.S., and Medina D. Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro. Proc. Natl. Acad. Sci. U. S. A. 81 (1984) 3756-3760
32. Untergasser A., Nijveen H., Rao X., Bisseling T., Geurts R., and Leunissen J.A.M. Primer3Plus, an enhanced web interface to Primer3. Nucleic Acids Res. 35 (2007) W71-W74
33. Szabo A., Horvath G., Szoollosi J., and Nagy P. Quantitative characterization of the large-scale association of ErbB1 and ErbB2 by flow cytometric homo-FRET measurements. Biophys. J. 95 (2008) 2086-2096
34. Radin N.S., Shayman J.A., and Inokuchi J. Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances. Adv. Lipid Res. 26 (1993) 183-203
35. Schwarzmann G. Uptake and metabolism of exogenous glycosphingolipids by cultured cells. Semin. Cell Dev. Biol. 12 (2001) 163-171
36. Icard-Liepkalns I., Liepkalns V.A., Yates A.J., and Stephens R.E. Cell cycle phases of the novel human neural cell line and the effect of exogenous gangliosides. Biochem. Biophys. Res. Comm. 105 (1982) 225-230
37. Mutoh T., Tokuda A., Miyadai T., Hamaguchi M., and Fujuki N. Ganglioside GM1 binds to the Trk protein and regulates receptor function. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 5087-5091
38. Li R., Liu Y., and Ladisch S. Enhancement of epidermal growth factor signaling and activation of SRC kinase by gangliosides. J. Biol. Chem. 276 (2001) 42782-42792
39. Meuillet E., Mania-Farnell B., George D., Inokuchi J.I., and Bremer E.G. Modulation of EGF receptor activity by changes in the GM3 content in a human epidermoid carcinoma cell line, A431. Exp. Cell Res. 256 (2000) 74-82
40. Doppler W., Groner B., and Ball R.K. Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat β-casein gene promoter constructs in a mammary epithelial cell line. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 104-108