Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involves suppression of oxidative stress and inflammatory cytokines

Carcinogenesis

Volumn 34, Issue 12, 2013, Pages 2833-2841

  Fang, Jun ^a,b   Seki, Takahiro ^a,c,f   Tsukamoto, Tetsuya ^d   Qin, Haibo ^a   Yin, Hongzhuan ^a,e   Liao, Long ^a   Nakamura, Hideaki ^a   Maeda, Hiroshi ^a  

^a SOJO UNIVERSITY   (Japan)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c KUMAMOTO UNIVERSITY   (Japan)

^d FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e CHINA MEDICAL UNIVERSITY   (China)

^f KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; AZOXYMETHANE; CANOLA OIL; CANOLOL; CYCLOOXYGENASE 2; DEXTRAN SULFATE; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER INHIBITION; CELL STRAIN HEK293; CHEMOPROPHYLAXIS; COLITIS; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIARRHEA; DRUG EFFECT; DRUG SAFETY; ENTERITIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LARGE INTESTINE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM HEMORRHAGE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CARCINOGENESIS; COLITIS; CYCLOOXYGENASE 2; CYTOKINES; DEXTRAN SULFATE; FEMALE; HEK293 CELLS; HEME OXYGENASE-1; HUMANS; INFLAMMATORY BOWEL DISEASES; MACROPHAGE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PHENOLS; TUMOR NECROSIS FACTOR-ALPHA; VINYL COMPOUNDS;

EID: 84889005044     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt309     Document Type: Article

References (51)

1. Baumgart,D.C. et al. (2007) Inflammatory bowel disease: cause and immunobiology. Lancet, 369, 1627-1640.
2. Baumgart,D.C. et al. (2007) Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet, 369, 1641-1657.
3. Xavier,R.J. et al. (2007) Unravelling the pathogenesis of inflammatory bowel disease. Nature, 448, 427-434.
4. Khor,B. et al. (2011) Genetics and pathogenesis of inflammatory bowel disease. Nature, 474, 307-317.
5. Ohkusa,T. et al. (2004) The role of bacterial infection in the pathogenesis of inflammatory bowel disease. Intern. Med., 43, 534-539.
6. Arthur,J.C. et al. (2012) Intestinal inflammation targets cancer-inducing activity of the microbiota. Science, 338, 120-123.
7. Ohkusa,T. et al. (2005) Effectiveness of antibiotic combination therapy in patients with active ulcerative colitis: a randomized, controlled pilot trial with long-term follow-up. Scand. J. Gastroenterol., 40, 1334-1342.
8. Ohkusa,T. et al. (2010) Newly developed antibiotic combination therapy for ulcerative colitis: a double-blind placebo-controlled multicenter trial. Am. J. Gastroenterol., 105, 1820-1829.
9. Rezaie,A. et al. (2007) Oxidative stress and pathogenesis of inflammatory bowel disease: an epiphenomenon or the cause? Dig. Dis. Sci., 52, 2015-2021.
10. Pavlick,K.P. et al. (2002) Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease. Free Radic. Biol. Med., 33, 311-322.
11. Yukitake,H. et al. (2011) BTZO-15, an ARE-activator, ameliorates DSSand TNBS-induced colitis in rats. PLoS One, 6, e23256.
12. Wakamatsu,D. et al. (2005) Isolation, identification, and structure of a potent alkyl-peroxyl radical scavenger in crude canola oil, canolol. Biosci. Biotechnol. Biochem., 69, 1568-1574.
13. Shrestha,K. et al. (2012) Isolation and identification of a potent radical scavenger (canolol) from roasted high erucic mustard seed oil from Nepal and its formation during roasting. J. Agric. Food Chem., 60, 7506-7512.
14. Kuwahara,H. et al. (2004) Antioxidative and antimutagenic activities of 4-vinyl-2,6-dimethoxyphenol (canolol) isolated from canola oil. J. Agric. Food Chem., 52, 4380-4387.
15. Kuwahara,H. et al. (2009) Generation of drug-resistant mutants of Helicobacter pylori in the presence of peroxynitrite, a derivative of nitric oxide, at pathophysiological concentration. Microbiol. Immunol., 53, 1-7.
16. Cao,X. et al. (2008) 4-Vinyl-2,6-dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils. Int. J. Cancer, 122, 1445-1454.
17. Wirtz,S. et al. (2007) Chemically induced mouse models of intestinal inflammation. Nat. Protoc., 2, 541-546.
18. Neufert,C. et al. (2007) An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression. Nat. Protoc., 2, 1998-2004.
19. Takagi,T. et al. (2011) Carbon monoxide liberated from carbon monoxidereleasing molecule exerts an anti-inflammatory effect on dextran sulfate sodium-induced colitis in mice. Dig. Dis. Sci., 56, 1663-1671.
20. Akaike,T. et al. (2000) Nitric oxide and virus infection. Immunology, 101, 300-308.
21. Beckman,J.S. et al. (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol., 271(5 Pt 1), C1424-C1437.
22. Akaike,T. et al. (1996) Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. Proc. Natl Acad. Sci. USA, 93, 2448-2453.
23. Niles,J.C. et al. (2006) Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation. Nitric Oxide, 14, 109-121.
24. Sawa,T. et al. (2006) Nitrative DNA damage in inflammation and its possible role in carcinogenesis. Nitric Oxide, 14, 91-100.
25. Fang,J. et al. (2004) Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment. Apoptosis, 9, 27-35.
26. McCord,J.M. (2000) The evolution of free radicals and oxidative stress. Am. J. Med., 108, 652-659.
27. Maeda,H. et al. (1991) Oxygen free radicals as pathogenic molecules in viral diseases. Proc. Soc. Exp. Biol. Med., 198, 721-727.
28. Maeda,H. et al. (1998) Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Mosc)., 63, 854-865.
29. Akaike,T. et al. (1990) Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice. J. Clin. Invest., 85, 739-745.
30. Fang,J. et al. (2010) Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate of (styrene-maleic acid copolymer) and (4-amino- 6-hydroxypyrazolo[3,4-d]pyrimidine), on hepatic ischemia-reperfusion injury. Exp. Biol. Med. (Maywood), 235, 487-496.
31. Oda,T. et al. (1989) Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD. Science, 244, 974-976.
32. Davies,K.J. (1993) Protein modification by oxidants and the role of proteolytic enzymes. Biochem. Soc. Trans., 21, 346-353.
33. Lindahl,T. (1993) Instability and decay of the primary structure of DNA. Nature, 362, 709-715.
34. Wagner,B.A. et al. (1994) Free radical-mediated lipid peroxidation in cells: oxidizability is a function of cell lipid bis-allylic hydrogen content. Biochemistry, 33, 4449-4453.
35. Dong,X. et al. (2011) Protective effect of canolol from oxidative stressinduced cell damage in ARPE-19 cells via an ERK mediated antioxidative pathway. Mol. Vis., 17, 2040-2048.
36. Was,H. et al. (2011) Effects of heme oxygenase-1 on induction and development of chemically induced squamous cell carcinoma in mice. Free Radic. Biol. Med., 51, 1717-1726.
37. Dubois,R.N. et al. (1998) Cyclooxygenase in biology and disease. FASEB J., 12, 1063-1073.
38. Hawcroft,G. et al. (2012) The omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of PGE2-dependent cell motility. Br. J. Pharmacol., 166, 1724-1737.
39. Miyamoto,S. et al. (2008) A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies. Carcinogenesis, 29, 418-426.
40. Nathan,C. (2006) Neutrophils and immunity: challenges and opportunities. Nat. Rev. Immunol., 6, 173-182.
41. Mosser,D.M. et al. (2008) Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol., 8, 958-969.
42. Bulua,A.C. et al. (2011) Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1- associated periodic syndrome (TRAPS). J. Exp. Med., 208, 519-533.
43. Matsuzawa,A. et al. (2005) ROS-dependent activation of the TRAF6- ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat. Immunol., 6, 587-592.
44. Warren,J.S. et al. (1988) Macrophage-derived cytokines amplify immune complex-triggered O2-. responses by rat alveolar macrophages. Am. J. Pathol., 130, 489-495.
45. Szefler,S.J. et al. (1989) IFN-gamma and LPS overcome glucocorticoid inhibition of priming for superoxide release in human monocytes. Evidence that secretion of IL-1 and tumor necrosis factor-alpha is not essential for monocyte priming. J. Immunol., 142, 3985-3992.
46. Galano,A. et al. (2011) Canolol: a promising chemical agent against oxidative stress. J. Phys. Chem. B, 115, 8590-8596.
47. Jemal,A. et al. (2010) Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol. Biomarkers Prev., 19, 1893-1907.
48. Strate,L.L. et al. (2005) Hereditary colorectal cancer syndromes. Cancer Causes Control, 16, 201-213.
49. Ullman,T.A. et al. (2011) Intestinal inflammation and cancer. Gastroenterology, 140, 1807-1816.
50. Sawa,T. et al. (1998) Lipid peroxyl radicals from oxidized oils and heme-iron: implication of a high-fat diet in colon carcinogenesis. Cancer Epidemiol. Biomarkers Prev., 7, 1007-1012.
51. Chao,A. et al. (2005) Meat consumption and risk of colorectal cancer. JAMA, 293, 172-182.