The role of bacterial infection in the pathogenesis of inflammatory bowel disease

Internal Medicine

Volumn 43, Issue 7, 2004, Pages 534-539

  Ohkusa, Toshifumi ^a   Nomura, Tetsuya ^a   Sato, Nobuhiro ^a  

^a JUNTENDO UNIVERSITY   (Japan)

Author keywords

Bacteria; Crohn's disease; Inflammatory bowel disease; Innate immunity; Ulcerative colitis

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOENZYME; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR;

BACTERIAL GROWTH; BACTERIAL INFECTION; BACTERIAL STRAIN; COMORBIDITY; CROHN DISEASE; DUODENUM DISEASE; ENTERITIS; GENETIC SUSCEPTIBILITY; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; IMMUNE RESPONSE; IMMUNITY; INTESTINE FLORA; INTESTINE ULCER; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; REVIEW; STOMACH ACID; STOMACH DISEASE; ULCERATIVE COLITIS;

ANIMALS; AUTOIMMUNE DISEASES; COLITIS, ULCERATIVE; CROHN DISEASE; DISEASE MODELS, ANIMAL; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNITY, NATURAL; INFLAMMATION MEDIATORS; INFLAMMATORY BOWEL DISEASES; MALE; PROGNOSIS; RISK ASSESSMENT;

EID: 4444256383     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.43.534     Document Type: Review

References (67)

1. Sartor RB. Review article: How relevant to human inflammatory bowel disease are current animal models of intestinal inflammation? Aliment Pharmacol Ther 11 (Suppl 3): 89-96, 1997.
2. Sartor RB. Review article: Role of the enteric microflora in the pathogenesis of intestinal inflammation and arthritis. Aliment Pharmacol Ther 11 (Suppl 3): 17-22, 1997.
3. Rath HC, Herfarth HH, Ikeda JS, et al. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest 98: 945-953, 1996.
4. Robert A, Asano T. Resistance of germfree rats to indomethacin-induced intestinal lesions. Prostaglandins 14: 333-341, 1977.
5. Panwala CM, Jones JC, Viney JL. A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdrIa, spontaneously develop colitis. J Immunol 161: 5733-5744, 1998.
6. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261, 1993.
7. Sellon RK, Tonkonogy S, Schultz M, et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in IL-10-deficient mice. Infect Immun 66: 5224-5231, 1998.
8. Dianda L, Hanby AM, Wright NA, Sebesteny A, Hayday AC, Owen MJ. T cell receptor-αβ-deficient mice fail to develop colitis in the absence of a microbial environment. Am J Pathol 150: 91-97, 1997.
9. Jex-Blake AJ, Higgs FW. Statistics of ulcerative colitis. Pros Soc Med. 2: 119-124, 1908-1909.
10. Bassler A. The bacteriology of ulcerative colitis. Med J Rec 138: 427-428, 1933.
11. Bargen JA. Experimental studies on the etiology of chronic ulcerative colitis (preliminary report). JAMA 83: 332-336, 1924.
12. Hurst AF. Ulcerative Colitis. Guy's Hosp Rep 85: 317-355, 1935.
13. Paulson M. Chronic ulcerative colitis with reference to a bacterial etiology. Experimental studies. Arch Intern Med 41: 75-96, 1928.
14. Sartor RB. Microbial factors in the pathogenesis of Crohn's disease, ulcerative colitis, and experimental intestinal inflammation. in: Inflammatory Bowel Disease. 4th ed. Kirsner JB, Shorter RG, Eds. Williams & Wilkins, Baltimore, 1995: 96-124.
15. Dragstedt LR, Dack GM, Kirsner JB. Chronic ulcerative colitis. Ann Surg 114: 653-662, 1941.
16. Burke DA, Axon AT. Adhesive Escherichia coli in inflammatory bowel disease and infective diarrhoea. Br Med J 297: 102-107, 1988.
17. von Wulffen H, Russman H, Karch H, et al. Verocytotoxin-producing Escherichia coli O2: H5 isolated from patients with ulcerative colitis. Lancet 1: 1449-1450, 1989.
18. Olusanya O, Steinruck H, Aleljung P, et al. Surface properties, connective tissue protein binding and Shiga-like toxin production of Escherichia coli isolated from patients with ulcerative colitis. Zentralbl Bakteriol (Int J Med Microbiol) 276: 254-263, 1992.
19. Giaffer MH, Holdsworth CD, Duerden BI. Virulence properties of Escherichia coli strains isolated from patients with inflammatory bowel disease. Gut 33: 646-650, 1992.
20. Mann BJ, Petri WA Jr. The role of microbial adherence factors in gastrointestinal disease. in: Infections of the Gastrointestinal Tract. Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant RL, Eds. Raven Press, New York, 1995: 99-105.
21. Matsuda H, Fujiyama Y, Andoh A, Ushijima T, Kajinami T, Bamba T. Characterization of antibody responses against rectal mucosa-associated bacterial flora in patients with ulcerative colitis. J Gastroenterol Hepatol 15: 61-68, 2000.
22. Ohkusa T, Sato N, Ogihara T, Morita K, Ogawa M, Okayasu I. Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody. J Gastroenterol Hepatol 17: 849-853, 2002.
23. Ohkusa T, Okayasu I, Ogihara T, Morita K, Ogawa M, Sato N. Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis. Gut 52: 79-83, 2003.
24. Singer RE, Buckner BA. Butyrate and propionate: important components of toxic dental plaque extracts. Infect Immun 32: 458-463, 1981.
25. Touw JJA, van Steenbergen TJ, de Graaff J. Butyrate: a cytotoxin for Vero cells produced by Bacteroides gingivalis and Bacteroides asaccharolyticus. Antonie van Leeuwenhoek 48: 315-325, 1982.
26. van Steenbergen TJ, den Ouden MD, Touw JJA, de Graaff J. Cytotoxic activity of Bacteroides gingivalis and Bacteroides asaccharolyticus. J Med Microbiol 5: 253-258, 1982.
27. Popoff MR, Szylit O, Ravisse P, Dabard J, Ohayon H. Experimental cecitis in gnotoxenic chickens monoassociated with Clostridium butyricum strains isolated from patients with neonatal necrotizing enterocolitis. Infect Immun 47: 697-703, 1985.
28. Bousseboua H, Le Coz Y, Dabard J, et al. Experimental cecitis in gnotobiotic quails monoassociated with Clostridium butyricum strains isolated from patients with neonatal necrotizing enterocolitis and from healthy newborns. Infect Immun 57: 932-936, 1989.
29. Burnham WR, Lennard-Jones JE, Stanford JL, Bird RG. Mycobacteria as a possible cause of inflammatory bowel disease. Lancet 2: 693-696, 1978.
30. Chiodini RJ, Van Kruiningen HJ, Thayer WR, Merkal RS, Coutu JA. Possible role of mycobacteria in inflammatory bowel disease. I. An unclassified Mycobacterium species isolated from patients with Crohn's disease. Dig Dis Sci 29: 1073-1079, 1984.
31. Parent K, Mitchel P. Cell wall defective variants of pseudomonas-like (Group Va) bacteria in Crohn's disease. Gastroenterology 75: 368-372, 1978.
32. Liu Y, van Kruiningen HJ, West AB, Cartun RW, Cortot A, Colombel JF. Immunocytochemical evidence of Listeria, Escherichia coli, and Streptococcus antigens in Crohn's disease. Gastroenterology 108: 1396-1404, 1995.
33. Dalziel TK. Chronic intestinal enteritis. Br Med J 2: 1068-1070, 1913.
34. Chiodini RJ. Crohn's disease and the mycobacterioses: a review and comparison of two disease entities. Clin Microbiol Rev 2: 90-117, 1989.
35. Engstrand L. Mycobacterium paratuberculosis and Crohn's disease. Scand J Infect Dis 98: 27-29, 1995.
36. Hubbard J, Surawicz CM. Etiological role of mycobacterium in Crohn's disease: An assessment of the literature. Dig Dis 17: 6-13, 1999.
37. Thompson DE. The role of mycobacteria in Crohn's disease. J Med Microbiol 41: 74-94, 1994.
38. Thomas GA, Swift GL, Green JT, et al. Controlled trial of antituberculous chemotherapy in Crohn's disease: a five year follow up study. Gut 42: 497-500, 1998.
39. Van Kruiningen HJ. Lack of support for a common etiology in Johne's disease of animals and Crohn's disease in humans. Inflamm Bowel Dis 5: 183-191, 1999.
40. Ryan P, Bennett MW, Aarons S, et al. PCR detection of Mycobacterium paratuberculosis in Crohn's disease granulomas isolated by laser capture microdissection. Gut 51: 665-670, 2002.
41. Suenaga K, Yokoyama Y, Okazaki K, Yamamoto Y. Mycobacteria in the intestine of Japanese patients with inflammatory bowel disease. Am J Gastroenterol 90: 76-80, 1995.
42. Chiba M, Fukushima T, Horie Y, Iizuka M, Masamune O. No Mycobacterium paratuberculosis detected in intestinal tissue, including Peyer's patches and lymph follicles, of Crohn's disease. J Gastroenterol 33: 482-487, 1998.
43. Kanazawa K, Haga Y, Funakoshi O, Nakajima H, Munakata A, Yoshida Y. Absence of Mycobacterium paratuberculosis DNA in intestinal tissues from Crohn's disease by nested polymerase chain reaction. J Gastroenterol 34: 200-206, 1999.
44. Suenaga K, Yokoyama Y, Nishimori I, et al. Serum antibodies to Mycobacterium paratuberculosis in patients with Crohn's disease. Dig Dis Sci 44: 1202-1207, 1999.
45. Imler JL, Hoffmann JA. Toll and Toll-like proteins: an ancient family of receptors signaling infection. Rev Immunogenet 2: 294-304, 2000.
46. Chaudhary PM, Ferguson C, Nguyen V, et al. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. Blood 91: 4020-4027, 1998.
47. O'Neill LA, Greene C. Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants. J Leukoc Biol 63: 650-657, 1998.
48. Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF. A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA. 95: 588-593, 1998.
49. Heumann D, Roger T. Initial responses to endotoxins and Gram-negative bacteria. Clin Chim Acta 323: 59-72, 2002.
50. Hoshino K, Takeuchi O, Kawai T, et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 3749-3752, 1999.
51. Shimazu R, Akashi S, Ogata H, et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 189: 1777-1782, 1999.
52. Takeuchi O, Hoshino K, Kawai T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-451, 1999.
53. Aliprantis AO, Yang RB, Mark MR, et al. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285: 736-739, 1999.
54. Underhill DM, Ozinsky A, Smith KD, Aderem A. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc Natl Acad Sci USA 96: 14459-14463, 1999.
55. Hayashi F, Smith KD, Ozinsky A, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410: 1099-1103, 2001.
56. Hemmi H, Takeuchi O, Kawai T, et al. A Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745, 2000 (Erratum in: Nature 409: 646, 2001).
57. Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A. The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med 187: 2097-2101, 1998.
58. Jobin C, Sartor RB. NF-κB signaling proteins as therapeutic targets for inflammatory bowel disease. Inflamm Bowel Dis 6: 206-213, 2000.
59. Hausmann M, Kiessling S, Mestermann S, et al. Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology 122: 1987-2000, 2002.
60. Inohara N, Ogura Y, Chen FF, Muto A, Nunez G. Human Nod1 confers responsiveness to bacterial lipopolysaccharides. J Biol Chem 276: 2551-2554, 2001.
61. Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411: 599-603, 2001.
62. Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411: 603-606, 2001.
63. Hampe J, Cuthbert A, Croucher PJ, et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 357: 1925-1928, 2001, (Erratum in: Lancet 360: 806, 2002).
64. Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 276: 4812-4818, 2001.
65. Inoue N, Tamura K, Kinouchi Y, et al. Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology 123: 86-91, 2002.
66. Blumberg RS, Strober W. Prospects for research in inflammatory bowel disease. JAMA 285: 643-647, 2001.
67. Ohkusa T, Miwa H, Kobayashi O, et al. Antibiotic combination therapy in patients with chronic ulcerative colitis. Gastroenterology 124 (Suppl 1): A68 (Abstract 544), 2003.