The omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of PGE 2-dependent cell motility

British Journal of Pharmacology

Volumn 166, Issue 5, 2012, Pages 1724-1737

  Hawcroft, G ^a   Volpato, M ^a   Marston, G ^a   Ingram, N ^a   Perry, S L ^a   Cockbain, A J ^a   Race, A D ^b   Munarini, A ^c   Belluzzi, A ^c   Loadman, P M ^b   Coletta, P L ^a   Hull, M A ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

COX; eicosapentaenoic acid; EP4 receptor; omega 3 polyunsaturated fatty acid; PG

Indexed keywords

ALCOHOL; BROXURIDINE; CYCLOOXYGENASE 2; FATTY ACID; ICOSAPENTAENOIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OMEGA 3 FATTY ACID; PROSTAGLANDIN E2; PROSTAGLANDIN E3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET THERAPY; DIETARY INTAKE; DISEASE MODEL; ECHOGRAPHY; ENZYME PHOSPHORYLATION; FEMALE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INHIBITION KINETICS; LIVER METASTASIS; LIVER WEIGHT; MICROVASCULATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; TUMOR VOLUME;

ALPROSTADIL; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; DINOPROSTONE; EICOSAPENTAENOIC ACID; FEMALE; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; TUMOR BURDEN;

EID: 84862742394     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01882.x     Document Type: Article

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