P-glycoprotein is responsible for the poor intestinal absorption and low toxicity of oral aconitine: In vitro, in situ, in vivo and in silico studies

Toxicology and Applied Pharmacology

Volumn 273, Issue 3, 2013, Pages 561-568

  Yang, Cuiping ^a   Zhang, Tianhong ^a   Li, Zheng ^a   Xu, Liang ^a   Liu, Fei ^a   Ruan, Jinxiu ^a   Liu, Keliang ^a   Zhang, Zhenqing ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Aconitine; Caco 2 cells; In situ intestinal perfusion; MDCKII MDR1 cells; Oral absorption; P glycoprotein

Indexed keywords

ACONITINE; CYCLOSPORIN A; MULTIDRUG RESISTANCE PROTEIN; VERAPAMIL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL LINE; CELL STRAIN CACO 2; COMPUTER MODEL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; MALE; MAXIMUM PLASMA CONCENTRATION; MDCKII MDR1 CELL; NONHUMAN; RAT;

ACONITINE; CACO-2 CELLS; IN SITU INTESTINAL PERFUSION; MDCKII-MDR1 CELLS; ORAL ABSORPTION; P-GLYCOPROTEIN;

ACONITINE; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CHROMATOGRAPHY, LIQUID; CYCLOSPORINE; DRUG INTERACTIONS; HUMANS; INTESTINAL ABSORPTION; INTESTINES; MALE; P-GLYCOPROTEIN; PERMEABILITY; PLANT EXTRACTS; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; VERAPAMIL;

ACONITUM; RATTUS;

EID: 84888878106     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.09.030     Document Type: Article

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