Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine

Journal of Ethnopharmacology

Volumn 141, Issue 2, 2012, Pages 701-708

  Fan, Yan Fang ^a,b   Xie, Ying ^b   Liu, Liang ^b,c   Ho, Hing Man ^b   Wong, Yuen Fan ^b   Liu, Zhong Qiu ^a   Zhou, Hua ^b,c  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^c MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

Author keywords

Aconitine; Acute toxicity; Paeoniflorin; Pharmacokinetics

Indexed keywords

ACONITINE; PAEONIFLORIN;

ACCURACY; ACONITE; ACONITUM CARMICHAELI; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DEATH; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; LD 50; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PAEONIA LACTIFLORA; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ACONITINE; ACONITUM; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BENZOIC ACIDS; BRIDGED COMPOUNDS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; GLUCOSIDES; INJECTIONS, INTRAPERITONEAL; LETHAL DOSE 50; MALE; MEDICINE, CHINESE TRADITIONAL; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED ICR; PAEONIA; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

ACONITUM CARMICHAELI; ANIMALIA; MUS; PAEONIA LACTIFLORA; RATTUS;

EID: 84861189685     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.09.005     Document Type: Article

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