Pharmacokinetics of aconitine as the targeted marker of Fuzi (Aconitum carmichaeli) following single and multiple oral administrations of Fuzi extracts in rat by UPLC/MS/MS

Journal of Ethnopharmacology

Volumn 141, Issue 2, 2012, Pages 736-741

  Tang, Lan ^a   Gong, Yun ^a   Lv, Chang ^a   Ye, Ling ^a   Liu, Liang ^b   Liu, Zhongqiu ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

Aconitine; Fuzi extract; Pharmacokinetics; UPLC MS MS

Indexed keywords

ACONITINE; FUZI EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ACONITE; ACONITUM CARMICHAELI; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG ELIMINATION; DRUG HALF LIFE; DRUG PROTEIN BINDING; EQUILIBRIUM DIALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LD 50; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; REPEATED DRUG DOSE; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ACONITINE; ACONITUM; ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG ADMINISTRATION SCHEDULE; DRUGS, CHINESE HERBAL; HALF-LIFE; MALE; MEDICINE, CHINESE TRADITIONAL; METABOLIC CLEARANCE RATE; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

ACONITUM CARMICHAELI; RATTUS;

EID: 84861194660     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.08.070     Document Type: Article

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