Seven cases of fatal aconite poisoning: Forensic experience in China

Forensic Science International

Volumn 212, Issue 1-3, 2011, Pages

  Liu, Qian ^a   Zhuo, Luo ^a   Liu, Liang ^a   Zhu, Shaohua ^a   Sunnassee, Ananda ^a   Liang, Man ^a   Zhou, Lan ^a   Liu, Yan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Aconitine; Aconitum; Caowu; Chuanwu; Fatal poisoning

Indexed keywords

ACONITUM EXTRACT; ALKALOID;

ABDOMINAL PAIN; ACONITE; ACONITE POISONING; ACUTE TOXICITY; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPSY; CAUSE OF DEATH; CHINA; CHINESE MEDICINE; CLINICAL ARTICLE; CONTROLLED STUDY; DIZZINESS; ELECTROCARDIOGRAPHY; FATALITY; FORENSIC PATHOLOGY; FORENSIC TOXICOLOGY; FORMICATION; HEART PALPITATION; HEART VENTRICLE TACHYCARDIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTOXICATION; LEG CRAMP; MALE; MOUSE; NONHUMAN; PARESTHESIA; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY; VOMITING; WEAKNESS;

EID: 80052325864     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2011.05.009     Document Type: Article

References (29)

1. Singhuber J., Zhu M., Prinz S. Aconitum in traditional Chinese medicine-a valuable drug or an unpredictable risk?. J. Ethnopharmacol. 2009, 126:18-30.
2. Liu Q., Zhou L., Zheng N., Zhuo L., Liu Y., Liu L. Poisoning deaths in China: type and prevalence detected at the Tongji Forensic Medical Center in Hubei. Forensic Sci. Int. 2009, 193:88-94.
3. Fu H.L. An overview of aconitum medicinal plants in China. Zhong Yao Cai 2004, 27:149-152.
4. Van Landeghem A.A., De Letter E.A., Lambert W.E., Van Peteghem C.H., Piette M.H. Aconitine involvement in an unusual homicide case. Int. J. Legal Med. 2007, 121:214-219.
5. Xiao P., Wang F., Gao F., Yan L., Chen D., Liu Y. A pharmacophylogenteic study of Aconitum L. (Ranunculaceae) from China. Acta Phytotaxon. Sin. 2006, 44:1-46.
6. Chan T.Y.K. Incidence of herb-induced aconitine poisoning in Hong Kong-impact of publicity measures to promote awareness among the herbalists and the public. Drug Safety 2002, 25:823-828.
7. Weijters B.J., Verbunt R.J.A.M., Hoogsteen J., Visser R.F. Salade malade: malignant ventricular arrhythmias due to an accidental intoxification with Aconitum napellus. Neth. Heart J. 2008, 16:96-99.
8. Elliott S.P. A case of fatal poisoning with the aconite plant: quantitative analysis in biological fluid. Sci. Justice 2002, 42:111-115.
9. Ito K., Tanaka S., Funayama M., Mizugaki M. Distribution of Aconitum alkaloids in body fluids and tissues in a suicidal case of aconite ingestion. J. Anal. Toxicol. 2000, 24:348-353.
10. Mizugaki M., Ito K., Ohyama Y., Konishi Y., Tanaka S., Kurasawa K. Quantitative analysis of Aconitum alkaloids in the urine and serum of a male attempting suicide by oral intake of aconite extract. J. Anal. Toxicol. 1998, 22:336-340.
11. Tai Y.T., But P.P.H., Young K., Lau C.P. Cardiotoxicity after accidental herb-induced aconite poisoning. Lancet 1992, 340:1254-1256.
12. Colombo M.L., Bugatti C., Davanzo F., Persico A., Ballabio C., Restani P. Analytical aspects of diterpene alkaloid poisoning with monkshood. Nat. Prod. Commun. 2009, 4:1551-1552.
13. Sørensen B. Poisoning with Aconitum napellus (monkshood). Ugeskr. Laeger. 2003, 165:2109-2110.
14. Pullela R., Young L., Gallagher B., Avis S.P., Randell E.W. A case of fatal aconitine poisoning by Monkshood ingestion. J. Forensic Sci. 2008, 53:491-494.
15. He Y.T. Aconitum poisoning in different dosages and combinations. Zhejiang Zhong Yi Za Zhi 1983, 18:87.
16. He X.D. Aconitum poisoning. Beijing Zhong Yi Xue Yuan Xue BAO 1991, 14:49-51.
17. Xu W., Hu B.W. Effects of alcohol on the pharmacokinetic of Aconitine. Fa Yi Xue Za Zhi 1994, 10:66-70.
18. Chan T.Y.K. Aconite poisoning. Clin. Toxicol. 2009, 47:279-285.
19. Chan T.Y.K., Chan J.C.N., Tomlinson B., Critchley J.A.J.H. Poisoning by Chinese herbal medicines in Hong Kong: a hospital based study. Vet. Hum. Toxicol. 1994, 36:546-547.
20. Chan T.Y.K., Tomlinson B., Tse L.K.K., Chan J.C.N., Chan W.W.M., Critchley J.A.J.H. Aconitine poisoning due to Chinese herbal medicines: a review. Vet. Hum. Toxicol. 1994, 36:452-455.
21. Ameri A. The effects of Aconitum alkaloids on the central nervous system. Prog. Neurobiol. 1998, 56:211-235.
22. Friese J., Gleitz J., Gutser U.T., Heubach J.F., Matthiesen T., Wilffert B., Selve N. Aconitum sp. alkaloids: the modulation of voltage-dependent Na+-channels, toxicity and antinociceptive properties. Eur. J. Pharmacol. 1997, 337:165-174.
23. Zhang S.W., Liu Y., Huang G.Z., Liu L. Aconitine alters connexin43 phosphorylation status and [Ca2+] oscillation patterns in cultured ventricular myocytes of neonatal rats. Toxicol. In Vitro 2007, 21:1476-1485.
24. Chan T.Y.K. Aconite poisoning presenting as hypotension and bradycardia. Hum. Exp. Toxicol. 2009, 28:795-797.
25. Qin T.C. Retrospective study of 108 acute aconitine poisoning cases. Intern. Med. China 2008, 3:209-211.
26. Smith S.W., Shah R.R., Herzog C.A. Bidirectional ventricular tachycardia resulting from herbal aconite poisoning. Ann. Emerg. Med. 2005, 45:100-101.
27. Yim K.M., Tse M.L., Lau F.L. Reversible intraventricular conduction defect in aconitine poisoning. Singapore Med. J. 2009, 50:E302-E305.
28. Matsuyama K., Tatsukawa S., Kakiuchi N. The effect of planting depth, disbudding, and root pruning on root weight and aconite alkaloid content of the tuberous root of aconite. J. Nat. Med. 2007, 61:127-130.
29. Liu L. Forensic toxicology 2009, People's Medical Publishing House, Beijing, China, p. 212. 4th ed.