Risks of nutrigenomics and nutrigenetics? What the scientists say

Genes and Nutrition

Volumn 9, Issue 1, 2014, Pages

  Hurlimann, T ^a   Menuz, V ^a   Graham, J ^a,b   Robitaille, J ^a,c   Vohl, M C ^a,c   Godard, B ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

Benefits; Ethics; Nutrigenomics; Researchers; Risks; Survey

Indexed keywords

ARTICLE; GENOMICS; HEALTH HAZARD; HEALTH SURVEY; HUMAN; NUTRIGENETICS; NUTRIGENOMICS; NUTRITIONAL HEALTH; OPTIMISM; PERSONAL AUTONOMY; QUESTIONNAIRE; RISK ASSESSMENT; RISK FACTOR; SCIENTIST; SOCIAL STIGMA;

EID: 84888224556     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-013-0370-6     Document Type: Article

References (87)

1. Afman L, Muller M (2006) Nutrigenomics: from molecular nutrition to prevention of disease. J Am Diet Assoc 106:569-576. doi: 10.1016/j.jada.2006.01. 001
2. Aggarwal BB, Shishodia S (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71:1397-1421. doi: 10.1016/j.bcp.2006.02.009
3. Bellcross CA, Page PZ, Meaney-Delman D (2012) Direct-to-consumer personal genome testing and cancer risk prediction. Cancer J 18:293-302. doi: 10.1097/PPO.0b013e3182610e38
4. Bergmann MM, Gorman U, Mathers JC (2008) Bioethical considerations for human nutrigenomics. Annu Rev Nutr 28:447-467. doi: 10.1146/annurev.nutr.28. 061807.155344
5. Bisogni CA, Jastran M, Seligson M, Thompson A (2012) How people interpret healthy eating: contributions of qualitative research. J Nutr Educ Behav 44:282-301. doi: 10.1016/j.jneb.2011.11.009
6. Blair J, Meredith M, Plotnikoff GA (2012) Introduction to traditional Asian therapeutic diets: two enduring perspectives. Minn Med 95:45-49
7. Bloss CS, Darst BF, Topol EJ, Schork NJ (2011) Direct-to-consumer personalized genomic testing. Hum Mol Genet 20(R2):R132-141 doi: 10.1093/hmg/ddr349
8. Brand A (2011) Public health genomics - public health goes personalized? Eur J Public Health 21:2-3. doi: 10.1093/eurpub/ckq197
9. Brand A (2012) Public health genomics and personalized healthcare: a pipeline from cell to society. Drug Metabol Drug Interact 27:121-123. doi: 10.1515/dmdi-2012-0028
10. Brody H, Glenn JE, Hermer L (2012) Racial/ethnic health disparities and ethics - the need for a multilevel approach. Camb Q Healthc Ethics 21:309-319. doi: 10.1017/S0963180112000035
11. Brown RC (2013) Moral responsibility for (un) healthy behaviour. J Med Ethics. doi: 10.1136/medethics-2012-100774
12. Caspi CE, Sorensen G, Subramanian SV, Kawachi I (2012) The local food environment and diet: a systematic review. Health Pl 18:1172-1187. doi: 10.1016/j.healthplace.2012.05.006
13. Chadwick R (2004) Nutrigenomics, individualism and public health. Proc Nutr Soc 63:161-166. doi: 10.1079/PNS2003329
14. Childress JF, Faden RR, Gaare RD, Gostin LO, Kahn J, Bonnie RJ, Kass NE, Mastroianni AC, Moreno JD, Nieburg P (2002) Public health ethics: mapping the terrain. J Law Med Ethics 30:170-178
15. Dainesi SM, Goldbaum M (2012) Post-trial access to study medication: a Brazilian e-survey with major stakeholders in clinical research. J Med Ethics 38:757-762. doi: 10.1136/medethics-2011-100127
16. de Roos B (2012) Personalized nutrition: ready for practice? Proc Nutr Soc 72:48-52. doi: 10.1017/S002966511200284
17. de Vries J, Jallow M, Williams TN, Kwiatkowski D, Parker M, Fitzpatrick R (2012) Investigating the potential for ethnic group harm in collaborative genomics research in Africa: is ethnic stigmatisation likely? Soc Sci Med 75:1400-1407. doi: 10.1016/j.socscimed.2012.05.020
18. Dykema J, Stevenson J, Day B, Sellers SL, Bonham VL (2011) Effects of incentives and prenotification on response rates and costs in a national web survey of physicians. Eval Health Prof 34:434-447. doi: 10.1177/0163278711406113
19. Eussen SR, Verhagen H, Klungel OH, Garssen J, van Loveren H, van Kranen HJ, Rompelberg CJ (2011) Functional foods and dietary supplements: products at the interface between pharma and nutrition. Eur J Pharmacol 668(Suppl 1):S2-S9. doi: 10.1016/j.ejphar.2011.07.008
20. Fallaize R, Macready AL, Butler LT, Ellis JA, Lovegrove JA (2013) An insight into the public acceptance of nutrigenomic-based personalised nutrition. Nutr Res Rev 26:39-48. doi: 10.1017/S0954422413000024
21. Finney Rutten LJ, Gollust SE, Naveed S, Moser RP (2012) Increasing public awareness of direct-to-consumer genetic tests: health Care access, internet use, and population density correlates. J Cancer Epidemiol 2012:309109. doi: 10.1155/2012/309109
22. Food Ethics Council (2005). FEC publishing foodethicscouncil.org website. Getting personal: Shifting responsibilities for dietary health. http://www.foodethicscouncil.org/node/110. Accessed 6 June 2013
23. Gartin M (2012) Food deserts and nutritional risk in Paraguay. Am J Hum Biol 24:296-301. doi: 10.1002/ajhb.22270
24. Georgiou NA, Garssen J, Witkamp RF (2011) Pharma-nutrition interface: the gap is narrowing. Eur J Pharmacol 651:1-8. doi: 10.1016/j.ejphar.2010.11.007
25. Ghosh D (2009) Future perspectives of nutrigenomics foods: benefits vs. risks. Indian J Biochem Biophys 46:31-36
26. Godard B, Hurlimann T (2009) Nutrigenomics for global health: ethical challenges for underserved populations. CPPM 7:205-214
27. Görman U (2006) Ethical issues raised by personalized nutrition based on genetic information. Genes Nutr 1:13-22. doi: 10.1007/BF02829932
28. Görman U, Mathers JC, Grimaldi KA, Ahlgren J, Nordström K (2013) Do we know enough? A scientific and ethical analysis of the basis for genetic-based personalized nutrition. Genes Nutr. doi: 10.1007/s12263-013-0338-6
29. Gupta SC, Kim JH, Prasad S, Aggarwal BB (2010) Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev 29:405-434. doi: 10.1007/s10555-010-9235-2
30. Hesketh J (2012) Personalised nutrition: how far has nutrigenomics progressed? Eur J Clin Nutr 67:430-435. doi: 10.1038/ejcn.2012.145
31. Hurlimann T, Stenne R, Menuz V, Godard B (2011) Inclusion and exclusion in nutrigenetics clinical research: ethical and scientific challenges. J Nutrigenet Nutrigenomics 4:322-343. doi: 10.1159/000334853
32. Jaja C, Gibson R, Quarles S (2013) Advancing genomic research and reducing health disparities: what can nurse scholars do? J Nurs Scholarsh. doi: 10.1111/j.1547-5069.2012.01482.x
33. Janssens AC, van Duijn CM (2008) Genome-based prediction of common diseases: advances and prospects. Hum Mol Genet 17(R2):R166-173. doi: 10.1093/hmg/ddn250
34. Knerr S, Ramos E, Nowinski J, Dixon K, Bonham VL (2010) Human difference in the genomic era: facilitating a socially responsible dialogue. BMC Med Genomics 3:20. doi: 10.1186/1755-8794-3-20
35. Komduur RH, Korthals M, te Molder H (2009) The good life: living for health and a life without risks? On a prominent script of nutrigenomics. Br J Nutr 101:307-316. doi: 10.1017/S0007114508076253
36. Korthals M (2011) Coevolution of nutrigenomics and society: ethical considerations. Am J Clin Nutr 94(6 Suppl):2025S-2029S. doi: 10.3945/ajcn.110.001289
37. Kussmann M, Fay LB (2008) Nutrigenomics and personalized nutrition: science and concept. Pers Med 5:447-455. doi: 10.2217/17410541.5.5.447
38. Lampe JW, Navarro SL, Hullar MA, Shojaie A (2013) Inter-individual differences in response to dietary intervention: integrating omics platforms towards personalised dietary recommendations. Proc Nutr Soc 72:207-218. doi: 10.1017/S0029665113000025
39. Lang T, Barling D (2012) Nutrition and sustainability: an emerging food policy discourse. Proc Nutr Soc 72:1-12. doi: 10.1017/S002966511200290X
40. Langford AT, Resnicow K, Roberts JS, Zikmund-Fisher BJ (2012) Racial and ethnic differences in direct-to-consumer genetic tests awareness in HINTS 2007: sociodemographic and numeracy correlates. J Genet Couns 21:440-447. doi: 10.1007/s10897-011-9478-2
41. Lee YC, Lai CQ, Ordovas JM, Parnell LD (2011) A database of gene-environment interactions pertaining to blood lipid traits, cardiovascular disease and type 2 diabetes. J Data Mining Genomics Proteomics 2:1. doi: 10.4172/2153-0602.1000106
42. Lenoir-Wijnkoop I, Jones PJ, Uauy R, Segal L, Milner J (2013) Nutrition economics - food as an ally of public health. Br J Nutr 109:777-784. doi: 10.1017/S0007114512005107
43. Lévesque L, Ozdemir V, Gremmen B, Godard B (2008) Integrating anticipated nutrigenomics bioscience applications with ethical aspects. OMICS 12:1-16. doi: 10.1089/omi.2007.0042
44. Levy DE, Byfield SD, Comstock CB, Garber JE, Syngal S, Crown WH, Shields AE (2011) Underutilization of BRCA1/2 testing to guide breast cancer treatment: black and Hispanic women particularly at risk. Genet Med 13:349-355. doi: 10.1097/GIM.0b013e3182091ba4
45. Massé R, Williams-Jones B (2012) Ethical dilemmas in health promotion practice. In: Rootman I, Dupéré S, Pederson A, O'Neill M (eds) Health promotion in Canada. Canadian Scholars' Press Inc, Toronto, pp 241-253
46. McBride CM, Bryan AD, Bray MS, Swan GE, Green ED (2012) Health behavior change: can genomics improve behavioral adherence? Am J Public Health 102:401-405. doi: 10.2105/AJPH.2011.300513
47. McClellan KA, Avard D, Simard J, Knoppers BM (2012) Personalized medicine and access to health care: potential for inequitable access? Eur J Hum Genet 21:143-147. doi: 10.1038/ejhg.2012.149
48. Minihane AM (2012) The genetic contribution to disease risk and variability in response to diet: where is the hidden heritability? Proc Nutr Soc 72:40-47. doi: 10.1017/S0029665112002856
49. Mitroi N, Mota M (2008) Nutrigenomics/nutrigenetics. Rom J Intern Med 46:295-304
50. Mullany B, Neault N, Tsingine D, Powers J, Lovato V, Clitso L, Massey S, Talgo A, Speakman K, Barlow A (2013) Food insecurity and household eating patterns among vulnerable American-Indian families: associations with caregiver and food consumption characteristics. Public Health Nutr 16:752-760. doi: 10.1017/S136898001200300X
51. Nazmi A, Monteiro C (2013) The nutrition transition: the same, but different. Public Health Nutr 16:571-572. doi: 10.1017/S1368980013000372
52. Nielsen DE, El-Sohemy A (2012) A randomized trial of genetic information for personalized nutrition. Genes Nutr 7:559-566. doi: 10.1007/s12263-012-0290-x
53. NIH (2008) Strategic vision for the future: from curative to pre-emptive medicine. U.S. Department of Health and Human Services Publishing NIH.gov website. http://www.nih.gov/strategicvision.htm. Accessed 6 June 2013
54. NIH Office of Extramural Research (2011) Glossary and acronym list. U.S. Department of Health and Human Services Publishing NIH.gov website. http://grants.nih.gov/grants/glossary.htm. Accessed 6 June 2013
55. Nordström K, Coff C, Jönsson H, Nordenfelt L, Görman U (2013) Food and health: individual, cultural, or scientific matters? Genes Nutr. doi: 10.1007/s12263-013-0336-8
56. OMICS-ETHICS Research Group (2012) Ethics and nutrigenomics research: preliminary results. OMICS-ETHICS Research Group publishing. http://omics-ethics.org/en/NGX-research-index. Accessed 6 June 2013
57. OMICS-ETHICS Research Group (2013) Scientific and ethical challenges in nutrigenomics/nutrigenetics research: a survey of researchers' perceptions. Final report. OMICS-ETHICS Research Group publishing. http://omics-ethics.org/ docs/Report2-Nutrigenomics-Omics-Ethics-2013.pdf. Accessed 25 Nov 2013
58. OPHG-CDC (Office of Public Health Genomics, Centers for Disease Control and Prevention) (2010) Genomic testing - ACCE model for evaluating genetic tests. CDC Publishing. http://www.cdc.gov/genomics/gtesting/ACCE/index.htm. Accessed 6 June 2013
59. OPHG-CDC (Office of Public Health Genomics, Centers for Disease Control and Prevention) (2013). Genomic testing. CDC publishing. http://www.cdc.gov/ genomics/gtesting/. Accessed 6 June 2013
60. Ordovas JM, Corella D (2004) Nutritional genomics. Annu Rev Genomics Hum Genet 5:71-118. doi: 10.1146/annurev.genom.5.061903.180008
61. Ortiz AP, Lopez M, Flores LT, Soto-Salgado M, Finney Rutten LJ, Serrano-Rodriguez RA, Hesse BW, Tortolero-Luna G (2011) Awareness of direct-to-consumer genetic tests and use of genetic tests among Puerto Rican adults, 2009. Prev Chronic Dis 8:A110. http://www.cdc.gov/pcd/issues/2011/sep/ 10-0220.htm. Accessed 18 June 2013
62. Otlowski M, Taylor S, Bombard Y (2012) Genetic discrimination: international perspectives. Annu Rev Genomics Hum Genet 13:433-454. doi: 10.1146/annurev-genom-090711-163800
63. Penders B, Horstman K, Saris WHM, Vos R (2007) From individuals to groups: a review of the meaning of 'personalized' in nutrigenomics. Trends Food Sci Technol 18:333-338. doi: 10.1016/j.tifs.2007.02.004
64. Phillips CM (2013) Nutrigenetics and metabolic disease: current status and implications for personalised nutrition. Nutrients 5:32-57. doi: 10.3390/nu5010032
65. Qi L (2012) Gene-diet interactions in complex disease: current findings and relevance for public health. Curr Nutr Rep 1:222-227. doi: 10.1007/s13668-012-0029-8
66. Reilly PR, Debusk RM (2008) Ethical and legal issues in nutritional genomics. J Am Diet Assoc 108:36-40. doi: 10.1016/j.jada.2007.10.016
67. Rich LE, Ashby MA (2013) From personal misfortune to public liability: the ethics, limits, and politics of public health saving ourselves from ourselves. J Bioeth Inq 10:1-5. doi: 10.1007/s11673-013-9427-x
68. Ries NM, Castle D (2008) Nutrigenomics and ethics interface: direct-to-consumer services and commercial aspects. OMICS 12:245-250. doi: 10.1089/omi.2008.0049
69. Ronteltap A, van Trijp H (2007) Consumer acceptance of personalised nutrition. Genes Nutr 2:85-87. doi: 10.1007/s12263-007-0003-z
70. Ronteltap A, van Trijp H, Renes RJ (2007) Expert views on critical success and failure factors for nutrigenomics. Trends Food Sci Technol 18:189-200. doi: 10.1016/j.tifs.2006.12.007
71. Ronteltap A, van Trijp H, Renes RJ (2008) Making nutrigenomics work - integrating expert stakeholder opinions and consumer preferences. Trends Food Sci Technol 19:390-398. doi: 10.1016/j.tifs.2008.01.012
72. Ronteltap A, van Trijp H, Berezowska A, Goossens J (2012) Nutrigenomics-based personalised nutritional advice: in search of a business model? Genes Nutr 8:153-163. doi: 10.1007/s12263-012-0308-4
73. Rubio-Aliaga I, Kochhar S, Silva-Zolezzi I (2012) Biomarkers of nutrient bioactivity and efficacy: a route toward personalized nutrition. J Clin Gastroenterol 46:545-554. doi: 10.1097/MCG.0b013e3182548df2
74. Saukko P (2013) State of play in direct-to-consumer genetic testing for lifestyle-related diseases: market, marketing content, user experiences and regulation. Proc Nutr Soc 72:53-60. doi: 10.1017/S0029665112002960
75. Savard J (2013) Personalised medicine: a critique on the future of health care. J Bioeth Inq. doi: 10.1007/s11673-013-9429-8
76. Schubert L, Gallegos D, Foley W, Harrison C (2012) Re-imagining the 'social' in the nutrition sciences. Public Health Nutr 15:352-359. doi: 10.1017/S1368980011001297
77. Slashinski MJ, McCurdy SA, Achenbaum LS, Whitney SN, McGuire AL (2012) "Snake-oil," "quack medicine," and "industrially cultured organisms": biovalue and the commercialization of human microbiome research. BMC Med Ethics 13:28. doi: 10.1186/1472-6939-13-28
78. Stenne R, Hurlimann T, Godard B (2012) Are research papers reporting results from nutrigenetics clinical research a potential source of biohype? Account Res 19:285-307. doi: 10.1080/08989621.2012.718681
79. Stenne R, Hurlimann T, Godard B (2013) Benefits associated with nutrigenomics research and their reporting in the scientific literature: researchers' perspectives. Account Res 20:167-183. doi: 10.1080/08989621.2013. 788381
80. Sung B, Prasad S, Yadav VR, Lavasanifar A, Aggarwal BB (2011) Cancer and diet: how are they related? Free Radic Res 45:864-879. doi: 10.3109/10715762. 2011.582869
81. Szarc vel Szic K, Ndlovu MN, Haegeman G, Berghe WV (2010) Nature or nurture: let food be your epigenetic medicine in chronic inflammatory disorders. Biochem Pharmacol 80:1816-1832. doi: 10.1016/j.bcp.2010.07.029
82. Tremblay J, Hamet P (2013) Role of genomics on the path to personalized medicine. Metabolism 62(Suppl 1):S2-S5. doi: 10.1016/j.metabol.2012.08.023
83. Vernarelli JA (2012) Impact of genetic risk assessment on nutrition-related lifestyle behaviours. Proc Nutr Soc 72:153-159. doi: 10.1017/S0029665112002741
84. Viera AJ, Edwards T (2012) Does an offer for a free on-line continuing medical education (CME) activity increase physician survey response rate? A randomized trial. BMC Res Notes 5:129. doi: 10.1186/1756-0500-5-129
85. Wilson CP, McNulty H, Ward M, Strain JJ, Trouton TG, Hoeft BA, Weber P, Roos FF, Horigan G, McAnena L, Scott JM (2013) Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial. Hypertension 61:1302-1308. doi: 10.1161/HYPERTENSIONAHA.111.01047
86. Zeba AN, Delisle HF, Renier G, Savadogo B, Baya B (2012) The double burden of malnutrition and cardiometabolic risk widens the gender and socio-economic health gap: a study among adults in Burkina Faso (West Africa). Public Health Nutr 15:2210-2219. doi: 10.1017/S1368980012000729
87. Zenk SN, Schulz AJ, Israel BA, Mentz G, Miranda PY, Opperman A, Odoms-Young AM (2013) Food shopping behaviours and exposure to discrimination. Public Health Nutr. doi: 10.1017/S136898001300075X