An escort for GPCRs: implications for regulation of receptor density at the cell surface

Trends in Pharmacological Sciences

Volumn 29, Issue 10, 2008, Pages 528-535

  Achour, Lamia ^a,b   Labbé Jullié, Catherine ^a,b   Scott, Mark G H ^a,b   Marullo, Stefano ^a,b  

^a INSTITUT COCHIN   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; CELL SURFACE RECEPTOR; ESTROGEN RECEPTOR; FILAMIN A; G PROTEIN COUPLED RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR FOR ACTIVATED C KINASE 1;

CELL SURFACE; CELLULAR DISTRIBUTION; ENDOPLASMIC RETICULUM; HUMAN; INTRACELLULAR TRANSPORT; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN TARGETING; RECEPTOR DENSITY; REVIEW; SIGNAL TRANSDUCTION;

CELL MEMBRANE; ENDOPLASMIC RETICULUM; HUMANS; MODELS, BIOLOGICAL; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED;

EID: 53149113005     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2008.07.009     Document Type: Review

References (81)

1. Higy M., et al. Topogenesis of membrane proteins at the endoplasmic reticulum. Biochemistry 43 (2004) 12716-12722
2. Krebs M.P., et al. Quality control of integral membrane proteins. Trends Biochem. Sci. 29 (2004) 648-655
3. Ellgaard L., and Helenius A. Quality control in the endoplasmic reticulum. Nat. Rev. Mol. Cell Biol. 4 (2003) 181-191
4. Hebert D.N., and Molinari M. In and out of the ER: protein folding, quality control, degradation, and related human diseases. Physiol. Rev. 87 (2007) 1377-1408
5. Tsai B., et al. Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat. Rev. Mol. Cell Biol. 3 (2002) 246-255
6. Siffroi-Fernandez S., et al. Association of the thyrotropin receptor with calnexin, calreticulin and BiP. Effects on the maturation of the receptor. Eur. J. Biochem. 269 (2002) 4930-4937
7. Mizrachi D., and Segaloff D.L. Intracellularly located misfolded glycoprotein hormone receptors associate with different chaperone proteins than their cognate wild-type receptors. Mol. Endocrinol. 18 (2004) 1768-1777
8. Rozell T.G., et al. Association of gonadotropin receptor precursors with the protein folding chaperone calnexin. Endocrinology 139 (1998) 1588-1593
9. Morello J.P., et al. Association of calnexin with wild type and mutant AVPR2 that causes nephrogenic diabetes insipidus. Biochemistry 40 (2001) 6766-6775
10. 1 receptor. Biochem. Biophys. Res. Commun. 340 (2006) 395-402
11. 2+ regulation, and photoreceptor cell survival. Neuron 49 (2006) 229-241
12. Lu M., et al. Endoplasmic reticulum retention, degradation, and aggregation of olfactory G-protein coupled receptors. Traffic 4 (2003) 416-433
13. Fan J., et al. A point mutation in the human melanin concentrating hormone receptor 1 reveals an important domain for cellular trafficking. Mol. Endocrinol. 19 (2005) 2579-2590
14. Petaja-Repo U.E., et al. Newly synthesized human δ opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome. J. Biol. Chem. 276 (2001) 4416-4423
15. Robben J.H., et al. Characterization of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus in a polarized cell model. Am. J. Physiol. Renal Physiol. 289 (2005) F265-F272
16. Daulat A.M., et al. Purification and identification of G protein-coupled receptor protein complexes under native conditions. Mol. Cell. Proteomics 6 (2007) 835-844
17. Barlowe C. Signals for COPII-dependent export from the ER: what's the ticket out?. Trends Cell Biol. 13 (2003) 295-300
18. Dong C., et al. Endoplasmic reticulum export of adrenergic and angiotensin II receptors is differentially regulated by Sar1 GTPase. Cell. Signal. 20 (2008) 1035-1043
19. Aridor M., et al. Cargo selection by the COPII budding machinery during export from the ER. J. Cell Biol. 141 (1998) 61-70
20. Dong C., et al. Regulation of G protein-coupled receptor export trafficking. Biochim. Biophys. Acta 1768 (2007) 853-870
21. Appenzeller-Herzog C., and Hauri H.P. The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function. J. Cell Sci. 119 (2006) 2173-2183
22. Tisdale E.J. Rab2 interacts directly with atypical protein kinase C (aPKC) ι/λ and inhibits aPKCι/λ-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation. J. Biol. Chem. 278 (2003) 52524-52530
23. Moyer B.D., et al. Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis-Golgi tethering. Traffic 2 (2001) 268-276
24. Wu G., et al. Distinct pathways for the trafficking of angiotensin II and adrenergic receptors from the endoplasmic reticulum to the cell surface: Rab1-independent transport of a G protein-coupled receptor. J. Biol. Chem. 278 (2003) 47062-47069
25. Dong C., and Wu G. Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases. Cell. Signal. 19 (2007) 2388-2399
26. Trucco A., et al. Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments. Nat. Cell Biol. 6 (2004) 1071-1081
27. Pfeffer S.R. Unsolved mysteries in membrane traffic. Annu. Rev. Biochem. 76 (2007) 629-645
28. Arvan P., et al. Secretory pathway quality control operating in Golgi, plasmalemmal, and endosomal systems. Traffic 3 (2002) 771-780
29. Petaja-Repo U.E., et al. Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human δ opioid receptor. J. Biol. Chem. 275 (2000) 13727-13736
30. Jordens I., et al. Rab proteins, connecting transport and vesicle fusion. Traffic 6 (2005) 1070-1077
31. Shetty K.M., et al. Rab6 regulation of rhodopsin transport in Drosophila. J. Biol. Chem. 273 (1998) 20425-20430
32. Dong C., and Wu G. Regulation of anterograde transport of α2-adrenergic receptors by the N termini at multiple intracellular compartments. J. Biol. Chem. 281 (2006) 38543-38554
33. Bulenger S., et al. Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation. Trends Pharmacol. Sci. 26 (2005) 131-137
34. B receptor heterodimerization. Neuron 27 (2000) 97-106
35. Gething M.J., and Sambrook J. Protein folding in the cell. Nature 355 (1992) 33-45
36. Hein L., et al. Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. J. Biol. Chem. 269 (1994) 27719-27726
37. 1 receptors to the plasma membrane. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 5573-5578
38. Holtback U., et al. Receptor recruitment: a mechanism for interactions between G protein-coupled receptors. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 7271-7275
39. 1 receptors in dendritic spines by NMDA receptor activation. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 1661-1664
40. Kruse M.S., et al. Recruitment of renal dopamine 1 receptors requires an intact microtubulin network. Pflugers Arch. 445 (2003) 534-539
41. Cahill C.M., et al. Trafficking of δ-opioid receptors and other G-protein-coupled receptors: implications for pain and analgesia. Trends Pharmacol. Sci. 28 (2007) 23-31
42. Cahill C.M., et al. Immunohistochemical distribution of δ opioid receptors in the rat central nervous system: evidence for somatodendritic labeling and antigen-specific cellular compartmentalization. J. Comp. Neurol. 440 (2001) 65-84
43. Kieffer B.L. Opioids: first lessons from knockout mice. Trends Pharmacol. Sci. 20 (1999) 19-26
44. Cahill C.M., et al. Prolonged morphine treatment targets δ opioid receptors to neuronal plasma membranes and enhances δ-mediated antinociception. J. Neurosci. 21 (2001) 7598-7607
45. Morinville A., et al. Regulation of δ-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from μ-opioid receptor knock-out mice. J. Neurosci. 23 (2003) 4888-4898
46. Saito H., et al. RTP family members induce functional expression of mammalian odorant receptors. Cell 119 (2004) 679-691
47. Janovick J.A., et al. Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy. J. Biol. Chem. 281 (2006) 8417-8425
48. 1D-adrenergic receptors. J. Pharmacol. Exp. Ther. 313 (2005) 16-23
49. Pietila E.M., et al. Inefficient maturation of the rat luteinizing hormone receptor. A putative way to regulate receptor numbers at the cell surface. J. Biol. Chem. 280 (2005) 26622-26629
50. Herrmann J.M., et al. Out of the ER-outfitters, escorts and guides. Trends Cell Biol. 9 (1999) 5-7
51. Baker E.K., et al. The cyclophilin homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin. EMBO J. 13 (1994) 4886-4895
52. Ferreira P.A., et al. Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin. Nature 383 (1996) 637-640
53. Chapple J.P., and Cheetham M.E. The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation. J. Biol. Chem. 278 (2003) 19087-19094
54. Westhoff B., et al. HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome. Curr. Biol. 15 (2005) 1058-1064
55. Parameswaran N., and Spielman W.S. RAMPs: the past, present and future. Trends Biochem. Sci. 31 (2006) 631-638
56. Horn F., et al. GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res. 26 (1998) 275-279
57. McLatchie L.M., et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393 (1998) 333-339
58. Bouschet T., et al. Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma membrane. J. Cell Sci. 118 (2005) 4709-4720
59. Dwyer N.D., et al. Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein. Cell 93 (1998) 455-466
60. Behrens M., et al. Members of RTP and REEP gene families influence functional bitter taste receptor expression. J. Biol. Chem. 281 (2006) 20650-20659
61. Loconto J., et al. Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules. Cell 112 (2003) 607-618
62. Olson R., et al. MHC homologs in the nervous system - they haven't lost their groove. Curr. Opin. Neurobiol. 16 (2006) 351-357
63. Metherell L.A., et al. Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. Nat. Genet. 37 (2005) 166-170
64. Cooray S.N., et al. The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line. Endocrinology 149 (2008) 1935-1941
65. 1B receptor function by p11 in depression-like states. Science 311 (2006) 77-80
66. Donato R. Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Biochim. Biophys. Acta 1450 (1999) 191-231
67. 1 receptor by a new membrane-associated ER protein. Nat. Cell Biol. 3 (2001) 492-498
68. Leclerc P.C., et al. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology 143 (2002) 4702-4710
69. Dupre D.J., et al. Dopamine receptor-interacting protein 78 acts as a molecular chaperone for Gγ subunits before assembly with Gβ. J. Biol. Chem. 282 (2007) 13703-13715
70. Wruck C.J., et al. Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 57-64
71. 2. Traffic 9 (2008) 394-407
72. Chen C., et al. GEC1 interacts with the κ opioid receptor and enhances expression of the receptor. J. Biol. Chem. 281 (2006) 7983-7993
73. Tai A.W., et al. Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1. Cell 97 (1999) 877-887
74. Ango F., et al. Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation. J. Neurosci. 20 (2000) 8710-8716
75. 3 receptors are linked to the actin cytoskeleton via interaction with filamin A. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 5258-5263
76. Luo W., et al. p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. J. Biol. Chem. 282 (2007) 30246-30255
77. Yamamoto A., et al. Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. Cell 120 (2005) 223-235
78. Couturier C., et al. Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 19476-19481
79. Dupre D.J., et al. Seven transmembrane receptor core signaling complexes are assembled prior to plasma membrane trafficking. J. Biol. Chem. 281 (2006) 34561-34573
80. Conn P.M., et al. G protein-coupled receptor trafficking in health and disease: lessons learned to prepare for therapeutic mutant rescue in vivo. Pharmacol. Rev. 59 (2007) 225-250
81. Bernier V., et al. Pharmacological chaperone action on G-protein-coupled receptors. Curr. Opin. Pharmacol. 4 (2004) 528-533