Metal-free [3+2+1]/[2+2+1] biscyclization: Stereospecific construction with concomitant functionalization of indolizin-5(1 H)-one

Journal of Organic Chemistry

Volumn 78, Issue 22, 2013, Pages 11414-11420

  Li, Tuan Jie ^a   Liu, Zhong Qiu ^a   Yin, Hong Mei ^a   Yao, Chang Sheng ^a   Jiang, Bo ^a   Wang, Xiang Shan ^a   Tu, Shu Jiang ^a   Li, Xiu Ling ^d   Li, Guigen ^b,c  

^a JIANGSU NORMAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

^c TEXAS TECH UNIVERSITY   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

FUNCTIONALIZATIONS; QUATERNARY CARBON; STEREOCENTERS; STEREOSPECIFIC;

CHEMISTRY;

ORGANIC COMPOUNDS;

2,7 BIS(2 CHLOROPHENYL) 6 (2 HYDROXYBENZOYL) 1 PICOLINOYL 3,8A DI(PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 2,7 BIS(2,3 DIMETHOXYPHENYL) 6 (2 HYDROXYBENZOYL) 1 PICOLINOYL 3 (PYRAZIN 2 YL) 8A (PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 2,7 BIS(2,3 DIMETHOXYPHENYL) 6 (2 HYDROXYBENZOYL) 1 PICOLINOYL 3,8A DI(PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 2,7 BIS(2,3 DIMETHOXYPHENYL) 6 (2 HYDROXYBENZOYL) 8A (PYRAZIN 2 YL) 1 (PYRAZINE 2 CARBONYL) 3 (PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 2,7 BIS(2,4 DICHLOROPHENYL) 6 (2 HYDROXYBENZOYL) 1 PICOLINOYL 3,8A DI(PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 2,7 BIS(3,4 DIMETHOXYPHENYL) 6 (2 HYDROXYBENZOYL) 1 PICOLINOYL 3,8A DI(PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 2,7 BIS(4 BROMOPHENYL) 6 (2 HYDROXYBENZOYL) 8A (PYRAZIN 2 YL) 1 (PYRAZINE 2 CARBONYL) 3 (PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 2,7 BIS(4 CHLOROPHENYL) 6 (2 HYDROXY 5 METHYLBENZOYL) 1 PICOLINOYL 3,8A DI(PYRID 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 2,7 BIS(4 CHLOROPHENYL) 6 (2 HYDROXYBENZOYL) 1 PICOLINOYL 3 (PYRAZIN 2 YL) 8A (PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 2,7 BIS(4 CHLOROPHENYL) 6 (2 HYDROXYBENZOYL) 1 PICOLINOYL 3,8A DI(PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 2,7 BIS(4 CHLOROPHENYL) 6 (2 HYDROXYBENZOYL) 8A (PYRAZIN 2 YL) 1 (PYRAZINE 2 CARBONYL) 3 (PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 6 (2 HYDROXY 5 METHYLBENZOYL) 2,7 BIS(4 METHOXYPHENYL) 1 PICOLINOYL 3,8A DI(PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 6 (2 HYDROXYBENZOYL) 1 PICOLINOYL 3,8A DI(PYRIDIN 2 YL) 2,7 DI 4 TOLYLHEXAHYDROINDOLIZIN 5(1H) ONE; 6 (2 HYDROXYBENZOYL) 2,7 BIS(4 METHOXYPHENYL) 1 PICOLINOYL 3,8A DI(PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 6 (5 BROMO 2 HYDROXYBENZOYL) 1 PICOLINOYL 3,8A DI(PYRIDIN 2 YL) 2,7 DI 4 TOLYLHEXAHYDROINDOLIZIN 5(1H) ONE; 6 (5 BROMO 2 HYDROXYBENZOYL) 2,7 BIS(4 CHLOROPHENYL) 1 PICOLINOYL 3,8A DI(PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 6 (5 BROMO 2 HYDROXYBENZOYL) 2,7 BIS(4 FLUOROPHENYL) 1 PICOLINOYL 3,8A DI(PYRIDIN 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; 6 (5 BROMO 2 HYDROXYBENZOYL) 2,7 BIS(4 METHOXYPHENYL) 1 PICOLINOYL 3,8A DI(PYRID 2 YL)HEXAHYDROINDOLIZIN 5(1H) ONE; CARBON; INDOLIZIN 5(1H) ONE; INDOLIZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL BOND; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYCLIZATION; CYCLOADDITION; NUCLEOPHILICITY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME; RING OPENING; STEREOCHEMISTRY; STEREOSPECIFICITY; SYNTHESIS;

BICYCLO COMPOUNDS; CYCLIZATION; INDOLIZINES; MOLECULAR STRUCTURE; STEREOISOMERISM;

EID: 84887987310     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo401969g     Document Type: Article

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