Hydrophilic pyrazine dyes as exogenous fluorescent tracer agents for real-time point-of-care measurement of glomerular filtration rate

Journal of Medicinal Chemistry

Volumn 54, Issue 14, 2011, Pages 5048-5058

  Rajagopalan, Raghavan ^a   Neumann, William L ^a,b   Poreddy, Amruta R ^a   Fitch, Richard M ^a   Freskos, John N ^a   Asmelash, Bethel ^a   Gaston, Kimberly R ^a   Galen, Karen P ^a   Shieh, Jeng Jong ^a   Dorshow, Richard B ^a  

^a MEDTRONIC INC   (United States)

^b SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,6 BIS(2,3 DIHYDROXYPROPYLAMINO)PYRAZINE 2,5 DICARBOXAMIDE; 3,6 BIS[[2,2 DIMETHYL 1,3 DIOXOLAN 4 YL]METHYLAMINO]PYRAZINE 2,5 DICARBOXAMIDE; 3,6 DIAMINO N2,N5 BIS(1,3 DIHYDROXY 1 OXOPROPAN 2 YL)PYRAZINE 2,5 DICARBOXAMIDE; 3,6 DIAMINO N2,N5 BIS(2 HYDROXYETHYL)PYRAZINE 2,5 DICARBOXAMIDE; 3,6 DIAMINO N2,N5 BIS(2 TERT BUTOXYETHYL)PYRAZINE 2,5 DICARBOXAMIDE; 3,6 DIAMINO N2,N5 BIS(2,3 DIHYDROXYPROPYL]PYRAZINE 2,5 DICARBOXAMIDE; 3,6 DIAMINO N2,N5 BIS[(2,2 DIMETHYL 1,3 DIOXOLAN 4 YL)METHYL]PYRAZINE 2,5 DICARBOXAMIDE; 3,6 DIAMINO N2,N5 BIS[1 (BENZYLOXY) 3 HYDROXY 1 OXOPROPAN 2 YL]PYRAZINE 2,5 DICARBOXAMIDE; 3,6 DIAMINO N2,N5 BIS[1,2 (DIBENZYLOXYCARBONYL)ETHYL]PYRAZINE 2,5 DICARBOXAMIDE; 3,6 DIAMINO N2,N5 BIS[1,2 (DICARBOXY)ETHYL]PYRAZINE 2,5 DICARBOXAMIDE; DEXTRO SERINE; FLUORESCENT DYE; IOTALAMIC ACID; MERTIATIDE TC 99M; N2,N5 BIS(1,3 DIHYDROXY 1 OXOPROPAN 2 YL) 3,6 BIS(2,3 DIHYDROXYPROPYLAMINO)PYRAZINE 2,5 DICARBOXAMIDE; N2,N5 BIS(1,3 DIHYDROXY 1 OXOPROPAN 2 YL) 3,6 BIS(PROPYLAMINO)PYRAZINE 2,5 DICARBOXAMIDE; N2,N5 BIS(2,3 DIHYDROXYPROPYL) 3,6 BIS(2,3 DIHYDROXYPROPYLAMINO)PYRAZINE 2,5 DICARBOXAMIDE; N2,N5 BIS[(2,2 DIMETHYL 1,3 DIOXOLAN 4 YL)METHYL] 3,6 BIS[(2,2 DIMETHYL 1,3 DIOXOLAN 4 YL)METHYLAMINO]PYRAZINE 2,5 DICARBOXAMIDE; N2,N5 BIS[1 (BENZYLOXY) 3 HYDROXY 1 OXOPROPAN 2 YL] 3,6 BIS(PROPYLAMINO)PYRAZINE 2,5 DICARBOXAMIDE; N2,N5 BIS[1 (BENZYLOXY) 3 HYDROXY 1 OXOPROPAN 2 YL] 3,6 BIS[(2,2 DIMETHYL 1,3 DIOXOLAN 4 YL)METHYLAMINO]PYRAZINE 2,5 DICARBOXAMIDE; PROBENECID; PYRAZINE DERIVATIVE; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; GLOMERULUS FILTRATION RATE; GOLD STANDARD; IN VITRO STUDY; IN VIVO STUDY; KIDNEY TUBULE EXCRETION; MALE; MONITORING; NONHUMAN; PHYSICAL CHEMISTRY; PLASMA CLEARANCE; PLASMA PROTEIN BINDING; POINT OF CARE TESTING; RAT; REAL TIME POINT OF CARE MEASUREMENT; URINARY EXCRETION;

ANIMALS; BLOOD PROTEINS; FLUORESCENT DYES; GLOMERULAR FILTRATION RATE; MALE; MICE; POINT-OF-CARE SYSTEMS; PROTEIN BINDING; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960641795     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200257k     Document Type: Article

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