Synthesis of indolizidinone analogues of cytotoxic alkaloids: Monocyclic precursors are also active

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 10, 2012, Pages 3402-3407

  Boto, Alicia ^a   Miguélez, Javier ^a   Marín, Raquel ^b,c,d   Díaz, Mario ^c,d  

^a INSTITUTO DE PRODUCTOS NATURALES Y AGROBIOLOGÍA   (Spain)

^b UNIVERSIDAD DE LA LAGUNA   (Spain)

^c Madrid Spain   (Spain)

^d UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

Alkaloid analogues; Cytotoxicity; Indolizidine alkaloids; Sequential processes; Synthetic methodology

Indexed keywords

ALKALOID DERIVATIVE; CYTOTOXIC AGENT; INDOLIZIDINE DERIVATIVE;

ALKYLATION; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; ISOMER; OXIDATION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALKALOIDS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLIZIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860478622     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.109     Document Type: Article

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