Potent integrin antagonists from a small library of RGD-lncluding cyclic pseudopeptides

Organic Letters

Volumn 3, Issue 7, 2001, Pages 1001-1004

  Belvisi, Laura ^a   Bernardi, Anna ^a   Checchia, Anna ^a   Manzoni, Leonardo ^a   Potenza, Donatella ^a   Scolastico, Carlo ^a   Castorina, Massimo ^b   Cupelli, Amelia ^b   Giannini, Giuseppe ^b   Carminati, Paolo ^b   Pisano, Claudio ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b Sigma Tau   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTITHROMBOCYTIC AGENT; ARGINYL-GLYCYL-ASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID; BICYCLO COMPOUND; ECHISTATIN; LACTAM; OLIGOPEPTIDE; PEPTIDE; PEPTIDE LIBRARY; VITRONECTIN RECEPTOR;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIZATION; DRUG ANTAGONISM; KINETICS; METABOLISM; PROTEIN SECONDARY STRUCTURE; RADIOASSAY; SYNTHESIS;

ANTINEOPLASTIC AGENTS; BICYCLO COMPOUNDS; CYCLIZATION; KINETICS; LACTAMS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PEPTIDE LIBRARY; PEPTIDES; PLATELET AGGREGATION INHIBITORS; PROTEIN STRUCTURE, SECONDARY; RADIOLIGAND ASSAY; RECEPTORS, VITRONECTIN;

EID: 1542353892     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.5555/ol007049u     Document Type: Article

References (19)

1. Ruoslahti, E.; Pierschbacher, M. D. Science 1987, 238, 491.
2. Mousa, S. A.; Cheresh, D. A. Drug Discovery Today 1997, 2, 187.
3. Haubner, R.; Finsinger, D.; Kessler, H. Angew. Chem., Int. Ed. Engl. 1997, 36, 1374.
4. Ojima, I.; Chakravarty, S.; Dong, Q. Bioorg. Med. Chem. 1995, 3, 337.
5. Duggan, M. E.; Hutchinson, J. H. Exp. Opin. Ther. Pat. 2000, 10, 1367.
6. Bach II, A. C.; Espina, J. R.; Jackson, S. A.; Stouten, P. F. W.; Duke, J. L.; Mousa, S. A.; DeGrado, W. F. J. Am. Chem. Soc. 1996, 118, 293.
7. Müller, G.; Gurrath, M.; Kessler, H. J. Comput.-Aided Mol. Design 1994, 8, 709.
8. Scarborough, R. M.; Naughton, M. A.; Teng, W.; Rose, J. W.; Phillips, D. R.; Nannizzi, L.; Arfsten, A.; Campbell, A. M.; Charo, I. F. J. Biol. Chem. 1993, 268, 1066.
9. Haubner, R.; Gratias, R.; Diefenbach, B.; Goodman, S. L.; Jonczyk, A.; Kessler, H. J. Am. Chem. Soc. 1996, 118, 7461.
10. Dechantsreiter, M. A.; Planker, E.; Mathä, B.; Lohof, E.; Hölzemann, G.; Jonczyk, A.; Goodman, S. L.; Kessler, H. J. Med. Chem. 1999, 42, 3033.
11. Lohof, E.; Planker, E.; Mang, C.; Burkhart, F.; Dechantsreiter, M. A.; Haubner, R.; Wester, H.-J.; Schwaiger, M.; Hölzemann, G.; Goodman, S. L.; Kessler, H. Angew. Chem. Int. Ed. 2000, 39, 2761.
12. Schumann, F.; Müller, A.; Koksch, M.; Müller, G.; Sewald, N. J. Am. Chem. Soc. 2000, 122, 12009.
13. Haubner, R.; Schmitt, W.; Hölzemann, G.; Goodman, S. L.; Jonczyk, A.; Kessler, H. J. Am. Chem. Soc. 1996, 118, 7881.
14. Angiolini, M.; Araneo, S.; Belvisi, L.; Cesarotti, E.; Checchia, A.; Crippa, L.; Manzoni, L.; Scolastico, C. Eur. J. Org. Chem. 2000, 2571.
15. Belvisi, L.; Bernardi, A.; Manzoni, L.; Potenza, D.; Scolastico, C. Eur. J. Org. Chem. 2000, 2563.
16. Mergler, M.; Tanner, R.; Gosteli, J.; Grogg, P. Tetrahedron Lett. 1988, 29, 4005.
17. Carpino, L. A. J. Am. Chem. Soc. 1993, 115, 4397.
18. Kumar, C. C.; Nie, H.; Rogers, C. P.; Malkowski, M.; Maxwell, E.; Catino, J. J.; Armstrong, L. J. Pharm. Exp. Ther. 1997, 283, 843.
19. Cheng, Y.; Prusoff, W. H. Biochem. Pharmacol. 1973, 22, 3099.