메뉴 건너뛰기




Volumn 20, Issue 31, 2013, Pages 3903-3922

A functional scaffold in marine alkaloid: An anticancer moiety for human

Author keywords

Anticancer agents; Anticancer mechanisms; Docking analysis; Marine alkaloids; Structure activity studies

Indexed keywords

ALKALOID; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); INDOLE ALKALOID; OXAZOLE; PALBOCICLIB; PYRAZOLE; PYRIDINE; PYRROLOQUINON; THIAZOLE; TIAZOFURIN; UNCLASSIFIED DRUG;

EID: 84887975932     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/09298673113209990186     Document Type: Article
Times cited : (14)

References (141)
  • 1
    • 4944264246 scopus 로고    scopus 로고
    • Molecules of Interest Camptothecin, over four decades of surprising findings
    • Argelia Lorence.; Craig L. Nessler. Molecules of Interest Camptothecin, over four decades of surprising findings. Phytochemistry, 2004, 65, (20), 2735-2749
    • (2004) Phytochemistry , vol.65 , Issue.20 , pp. 2735-2749
    • Argelia, L.1    Nessler, C.L.2
  • 2
    • 0035780976 scopus 로고    scopus 로고
    • ALKALOID BIOSYNTHESIS in PLANTS : BBiochemistry, Cell Biology, Molecular Regulation, and Metabolic Engineering Applications
    • Facchini. ALKALOID BIOSYNTHESIS IN PLANTS : Biochemistry, Cell Biology, Molecular Regulation, and Metabolic Engineering Applications. Annual Review of Plant Physiology and Plant Molecular Biology. 2001, 52, (1), 29-66
    • (2001) Annual Review of Plant Physiology and Plant Molecular Biology. , vol.52 , Issue.1 , pp. 29-66
    • Facchini1
  • 3
    • 77957155737 scopus 로고    scopus 로고
    • Trends for diverse production strategies of plant medicinal alkaloids
    • Yang, Liuqing.; Stèockigt.;Joachim. Trends for diverse production strategies of plant medicinal alkaloids. Natural Product Reports. 2010, 27, (10), 1469-1479
    • (2010) Natural Product Reports. , vol.27 , Issue.10 , pp. 1469-1479
    • Yang, L.1    Joachim, S.2
  • 4
    • 0029311075 scopus 로고
    • Engineering pathways for transformations of morphine alkaloids
    • Bruce. Engineering pathways for transformations of morphine alkaloids. Trends in Biotechnology. 1995, 13, (6), 200-205
    • (1995) Trends in Biotechnology. , vol.13 , Issue.6 , pp. 200-205
    • Bruce1
  • 5
    • 0027360552 scopus 로고
    • Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations
    • Jordan. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proceedings of the National Academy of Sciences-PNAS. 1993, 90, (20), 9552
    • (1993) Proceedings of the National Academy of Sciences-PNAS. , vol.90 , Issue.20 , pp. 9552
    • Jordan1
  • 6
    • 11244309692 scopus 로고    scopus 로고
    • New microtubule/tubulin-targeted anticancer drugs and novel chemotherapeutic strategies
    • Wilson. New microtubule/tubulin-targeted anticancer drugs and novel chemotherapeutic strategies. Journal of Chemotherapy. 2004, 16, 83
    • (2004) Journal of Chemotherapy. , vol.16 , pp. 83
    • Wilson1
  • 7
    • 4944264246 scopus 로고    scopus 로고
    • Camptothecin, over four decades of surprising findings
    • Lorence. Camptothecin, over four decades of surprising findings. Phytochemistry. 2004, 65, (20).
    • (2004) Phytochemistry , vol.65 , Issue.20
    • Lorence1
  • 8
    • 0031321872 scopus 로고    scopus 로고
    • Diterpenoid alkaloids as a new class of antiarrhythmic agents
    • Dzhakhangirov. Diterpenoid alkaloids as a new class of antiarrhythmic agents. Chemistry of Natural Compounds. 1997, 33, (2), 190-202.
    • (1997) Chemistry of Natural Compounds. , vol.33 , Issue.2 , pp. 190-202
    • Dzhakhangirov1
  • 9
    • 0019989148 scopus 로고
    • Belladonna alkaloids and immer rbital combination pharmaceuticals analysis I: High-performance liquid chromatographic determinations of hyoscyamine-atropine and scopolamine
    • Pennington. Belladonna alkaloids and immer rbital combination pharmaceuticals analysis I: High-performance liquid chromatographic determinations of hyoscyamine-atropine and scopolamine. Journal of Pharmaceutical Sciences. 1982, 71, (8), 951-953.
    • (1982) Journal of Pharmaceutical Sciences. , vol.71 , Issue.8 , pp. 951-953
    • Pennington1
  • 10
    • 0000331562 scopus 로고
    • Marine pyridoacridine alkaloids: Structure, synthesis, and biological chemistry
    • Molinski. Marine pyridoacridine alkaloids: structure, synthesis, and biological chemistry. Chemical Reviews. 1993, 93, (5), 1825-1838
    • (1993) Chemical Reviews. , vol.93 , Issue.5 , pp. 1825-1838
    • Molinski1
  • 11
    • 0037369126 scopus 로고    scopus 로고
    • Marine pyridoacridine alkaloids and synthetic analogues as antitumor agents
    • Delfourne. Marine pyridoacridine alkaloids and synthetic analogues as antitumor agents. Medicinal Research Reviews. 2003, 23, (2), 234-252
    • (2003) Medicinal Research Reviews. , vol.23 , Issue.2 , pp. 234-252
    • Delfourne1
  • 12
    • 14744287300 scopus 로고    scopus 로고
    • Novel antitumor agents: Marine sponge alkaloids, their synthetic analogs and derivatives
    • Dembitsky. Novel antitumor agents: Marine sponge alkaloids, their synthetic analogs and derivatives. Mini-Reviews in Medicinal Chemistry. 2005, 5, (3), 319.
    • (2005) Mini-Reviews in Medicinal Chemistry. , vol.5 , Issue.3 , pp. 319
    • Dembitsky1
  • 13
    • 0037369126 scopus 로고    scopus 로고
    • Marine pyridoacridine alkaloids and synthetic analogues as antitumor agents
    • Delfourne. Marine pyridoacridine alkaloids and synthetic analogues as antitumor agents. Medicinal Research Reviews. 2003, 23, (2), 234-252.
    • (2003) Medicinal Research Reviews. , vol.23 , Issue.2 , pp. 234-252
    • Delfourne1
  • 14
    • 0019312403 scopus 로고
    • Mycotoxins: A review of biological effects and their role in human diseases
    • Wallace Hayes. Mycotoxins: A review of biological effects and their role in human diseases. Clinical Toxicology. 1980,17, (1), 45-83.
    • (1980) Clinical Toxicology. , vol.17 , Issue.1 , pp. 45-83
    • Hayes, W.1
  • 15
    • 79251472417 scopus 로고    scopus 로고
    • Secondary metabolites of fungi from marine habitats
    • Rateb.; Mostafa E.; Ebel, Rainer. Secondary metabolites of fungi from marine habitats. Natural Product Reports. 2011, 28, (2), 290-344.
    • (2011) Natural Product Reports. , vol.28 , Issue.2 , pp. 290-344
    • Rateb Mostafa, E.1    Ebel, R.2
  • 17
    • 79960601388 scopus 로고    scopus 로고
    • Epipolythiodioxopiperazines from Fungi: Chemistry and Bioactivities
    • Jiang, C.-S.; Guo, Y.-W. Epipolythiodioxopiperazines from Fungi: Chemistry and Bioactivities. Mini-Reviews in Medicinal Chemistry. 11, (9), 2011, 728-745.
    • (2011) Mini-Reviews in Medicinal Chemistry. , vol.11 , Issue.9 , pp. 728-745
    • Jiang, C.-S.1    Guo, Y.-W.2
  • 18
    • 79960151500 scopus 로고    scopus 로고
    • Design, Synthesis, and SAR Studies of 4-Substituted Methoxylbenzoyl-aryl- thiazoles Analogues as Potent and Orally Bioavailable Anticancer Agents
    • Lu, Y.; Li, C.-M.; Wang, Z. Design, Synthesis, and SAR Studies of 4-Substituted Methoxylbenzoyl-aryl-thiazoles Analogues as Potent and Orally Bioavailable Anticancer Agents. Journal of Medicinal Chemistry. 2011, 54 (13), 4678-4693.
    • (2011) Journal of Medicinal Chemistry. , vol.54 , Issue.13 , pp. 4678-4693
    • Lu, Y.1    Li, C.-M.2    Wang, Z.3
  • 20
    • 77249107910 scopus 로고    scopus 로고
    • Oxazole-Bridged Combretastatin A Analogues with Improved Anticancer Properties
    • Biersack, B.; Effenberger, K.; Schobert, R.; Ocker, M. Oxazole-Bridged Combretastatin A Analogues with Improved Anticancer Properties. Chemmedchem. 2010, 5 (3), 420-427.
    • (2010) Chemmedchem. , vol.5 , Issue.3 , pp. 420-427
    • Biersack, B.1    Effenberger, K.2    Schobert, R.3    Ocker, M.4
  • 21
    • 84862287729 scopus 로고    scopus 로고
    • A Selective, Orally Bioavailable 1, 2, 4-Triazolo [1, 5-a] pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779
    • Dugan, B. J.; Gingrich, D. E.; Mesaros, E. F. A Selective, Orally Bioavailable 1, 2, 4-Triazolo [1, 5-a] pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779. Journal of Medicinal Chemistry. 2012, 55 (11), 5243-5254.
    • (2012) Journal of Medicinal Chemistry. , vol.55 , Issue.11 , pp. 5243-5254
    • Dugan, B.J.1    Gingrich, D.E.2    Mesaros, E.F.3
  • 22
    • 80052946477 scopus 로고    scopus 로고
    • Synthesis, characterization of some benzazoles bearing pyridine moiety: Search for novel anticancer agents
    • Elzahabi, H. S. Synthesis, characterization of some benzazoles bearing pyridine moiety: Search for novel anticancer agents. European Journal of Medicinal Chemistry. 2011, 46(9), 4025-4034.
    • (2011) European Journal of Medicinal Chemistry. , vol.46 , Issue.9 , pp. 4025-4034
    • Elzahabi, H.S.1
  • 23
    • 77953483368 scopus 로고    scopus 로고
    • Anticancer properties of indole compounds: Mechanism of apoptosis induction and role in chemotherapy
    • Ahmad, A.; Sakr, W. A.; Rahman, K. M. W. Anticancer Properties of Indole Compounds: Mechanism of Apoptosis Induction and Role in Chemotherapy. Current Drug Targets. 2010, 11 (6), 652-666.
    • (2010) Current Drug Targets. , vol.11 , Issue.6 , pp. 652-666
    • Ahmad, A.1    Sakr, W.A.2    Rahman, K.M.W.3
  • 25
    • 1542509425 scopus 로고    scopus 로고
    • Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
    • Gompel. Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum. Bioorganic and Medicinal Chemistry Letters. 2004, 14, (7), 1703-1707.
    • (2004) Bioorganic and Medicinal Chemistry Letters. , vol.14 , Issue.7 , pp. 1703-1707
    • Gompel1
  • 26
    • 0037573393 scopus 로고    scopus 로고
    • Synthesis, StructureActivity Relationship, and Biological Studies of Indolocarbazoles as Potent Cyclin D1-CDK4 Inhibitors
    • Zhu. Synthesis, StructureActivity Relationship, and Biological Studies of Indolocarbazoles as Potent Cyclin D1-CDK4 Inhibitors. Journal of Medicinal Chemistry. 2003, 46 (11), 2027-2030.
    • (2003) Journal of Medicinal Chemistry. , vol.46 , Issue.11 , pp. 2027-2030
    • Zhu1
  • 27
    • 4344650390 scopus 로고    scopus 로고
    • Marine natural products and related compounds in clinical and advanced preclinical trials
    • Newman. Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials. Journal of Natural Products. 2004, 67, (8), 1216-1238.
    • (2004) Journal of Natural Products. , vol.67 , Issue.8 , pp. 1216-1238
    • Newman1
  • 28
    • 84860637270 scopus 로고    scopus 로고
    • A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid
    • Patel K.; Gadewar M.; Tripathi R.; Prasad S.K.; Patel D.K. A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid. Asian Pacific Journal of Tropical Biomedicine. 2012, 2, (8), 660-664.
    • (2012) Asian Pacific Journal of Tropical Biomedicine , vol.2 , Issue.8 , pp. 660-664
    • Patel, K.1    Gadewar, M.2    Tripathi, R.3    Prasad, S.K.4    Patel, D.K.5
  • 29
    • 37249089097 scopus 로고    scopus 로고
    • Bacillamides from a Hypersaline Microbial Mat Bacterium
    • Socha, A.M.; Long, R.A.; Rowley, D.C. Bacillamides from a Hypersaline Microbial Mat Bacterium. Journal of Natural Products. 2007, 70, (11), 1793-1795.
    • (2007) Journal of Natural Products. , vol.70 , Issue.11 , pp. 1793-1795
    • Socha, A.M.1    Long, R.A.2    Rowley, D.C.3
  • 30
    • 65749086659 scopus 로고    scopus 로고
    • Neobacillamide A, a Novel Thiazole-Containing Alkaloid from the Marine Bacterium Bacillus vallismortis C89, Associated with South China Sea Sponge Dysidea avara
    • Yu, L. L.; Li, Z. Y.; Peng, C. S. Neobacillamide A, a Novel Thiazole-Containing Alkaloid from the Marine Bacterium Bacillus vallismortis C89, Associated with South China Sea Sponge Dysidea avara. Helvetica Chimica Acta. 2009, 92, (3), 607-612
    • (2009) Helvetica Chimica Acta. , vol.92 , Issue.3 , pp. 607-612
    • Yu, L.L.1    Li, Z.Y.2    Peng, C.S.3
  • 31
    • 78649756003 scopus 로고    scopus 로고
    • Thiazole and oxazole alkaloids: Isolation and synthesis
    • Davyt. Thiazole and Oxazole Alkaloids: Isolation and Synthesis. Marine Drugs. 2010, 8, (11), 2755-2780.
    • (2010) Marine Drugs. , vol.8 , Issue.11 , pp. 2755-2780
    • Davyt1
  • 33
    • 77649184195 scopus 로고    scopus 로고
    • Novel thiazole and oxazole containing cyclic hexapeptides from a waterbloom of the cyanobacterium Microcystis sp
    • Raveh A.; Carmeli S.; Moshe S.; Evron Z.; Flescher E. Novel thiazole and oxazole containing cyclic hexapeptides from a waterbloom of the cyanobacterium Microcystis sp. Tetrahedron. 2010, 66, (14), 2705-2712.
    • (2010) Tetrahedron. , vol.66 , Issue.14 , pp. 2705-2712
    • Raveh, A.1    Carmeli, S.2    Moshe, S.3    Evron, Z.4    Flescher, E.5
  • 34
    • 78650302320 scopus 로고    scopus 로고
    • Grassypeptolides A-C, Cytotoxic Bis-thiazoline Containing Marine Cyclodepsipeptides
    • Kwan, J. C.; Ratnayake, R.; Abboud, K. A.; Paul, V. J.; Luesch, H. Grassypeptolides A-C, Cytotoxic Bis-thiazoline Containing Marine Cyclodepsipeptides. Journal of Organic Chemistry. 2010, 75, (23), 8012-8023.
    • (2010) Journal of Organic Chemistry. , vol.75 , Issue.23 , pp. 8012-8023
    • Kwan, J.C.1    Ratnayake, R.2    Abboud, K.A.3    Paul, V.J.4    Luesch, H.5
  • 35
    • 77957661922 scopus 로고    scopus 로고
    • Total synthesis of grassypeptolide
    • Liu, H.; Liu, Y.; Xing, X. Total synthesis of grassypeptolide. Chemical Communications. 2010, 46, (40), 7486-7488
    • (2010) Chemical Communications. , vol.46 , Issue.40 , pp. 7486-7488
    • Liu, H.1    Liu, Y.2    Xing, X.3
  • 36
    • 80052164096 scopus 로고    scopus 로고
    • Cyclic Depsipeptides, Grassypeptolides D and e and Ibu- epidemethoxylyngbyastatin 3, from a Red Sea Leptolyngbya Cyanobacterium
    • Thornburg, C. C .; Thimmaiah, M .; Shaala, L. A .; Hau, A. M .; Malmo, J. M .; Ishmael, J. E. Cyclic Depsipeptides, Grassypeptolides D and E and Ibu-epidemethoxylyngbyastatin 3, from a Red Sea Leptolyngbya Cyanobacterium. Journal of Natural Products. 2011, 74, (8), 1677-1685.
    • (2011) Journal of Natural Products. , vol.74 , Issue.8 , pp. 1677-1685
    • Thornburg, C.C.1    Thimmaiah, M.2    Shaala, L.A.3    Hau, A.M.4    Malmo, J.M.5    Ishmael, J.E.6
  • 37
    • 23044477928 scopus 로고    scopus 로고
    • Aqueous phase synthesis of thiazoles and aminothiazoles in the presence of-cyclodextrin
    • Narender. Aqueous phase synthesis of thiazoles and aminothiazoles in the presence of-cyclodextrin. Tetrahedron Letters. 2005, 46, (35), 5953-5955.
    • (2005) Tetrahedron Letters. , vol.46 , Issue.35 , pp. 5953-5955
    • Narender1
  • 38
    • 84863850836 scopus 로고    scopus 로고
    • A Simple, Convenient, and Efficient Synthetic Route for the Preparation of (Z)-3,5-Dichloro-N-(3-(4-substitutedphenyl)-4-phenylthiazole-2(3H)-ylide) benzamide Heterocyclic Compounds from Aroyl Thiourea Derivatives via Scyclization Mechanis
    • Saeed, S.; Wong, W. T. A Simple, Convenient, and Efficient Synthetic Route for The Preparation of (Z)-3,5-Dichloro-N-(3-(4-substitutedphenyl)-4- phenylthiazole-2(3H)-ylide) benzamide Heterocyclic Compounds from Aroyl Thiourea Derivatives via Scyclization Mechanis. Journal of Heterocyclic Chemistry. 2012, 49, (3), 580-584.
    • (2012) Journal of Heterocyclic Chemistry , vol.49 , Issue.3 , pp. 580-584
    • Saeed, S.1    Wong, W.T.2
  • 40
    • 0019948293 scopus 로고
    • Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-/3-Dribofuranosylthiazole-4-carboxamide (NSC 286193)
    • Jayaram HN.; Dion RL.; Glazer RI.; Johns DG. Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-/3- Dribofuranosylthiazole-4-carboxamide (NSC 286193). Biochem Pharmacol. 1982, 31, 2371-2380
    • (1982) Biochem Pharmacol. , vol.31 , pp. 2371-2380
    • Jayaram, H.N.1    Dion, R.L.2    Glazer, R.I.3    Johns, D.G.4
  • 41
    • 0020567631 scopus 로고
    • Synthesis of thiazole-4-carboxamideadenine dinucleotide (TAD). A powerful inhibitor of IMP dehydrogenase
    • Gebeyehu G.; Marquez VE.; Kelley JA. Synthesis of thiazole-4- carboxamideadenine dinucleotide (TAD). A powerful inhibitor of IMP dehydrogenase. J Med Chem. 1983, 26, 922-925.
    • (1983) J Med Chem. , vol.26 , pp. 922-925
    • Gebeyehu, G.1    Marquez, V.E.2    Kelley, J.A.3
  • 43
    • 0035489468 scopus 로고    scopus 로고
    • PKB/AKT: Functional insights from genetic models
    • Scheid. PKB/AKT: FUNCTIONAL INSIGHTS FROM GENETIC MODELS. Nature Reviews-Molecular Cell Biology. 2001, 2, (10), 760-768.
    • (2001) Nature Reviews-Molecular Cell Biology. , vol.2 , Issue.10 , pp. 760-768
    • Scheid1
  • 44
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song. The activation of Akt/PKB signaling pathway and cell survival. Journal of Cellular and Molecular Medicine. 2005, 9, (1), 59-71.
    • (2005) Journal of Cellular and Molecular Medicine. , vol.9 , Issue.1 , pp. 59-71
    • Song1
  • 45
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase-AKT pathway in human cancer
    • Vivanco. The phosphatidylinositol 3-Kinase-AKT pathway in human cancer. Nature Reviews-Cancer. 2002, 2, 489-501.
    • (2002) Nature Reviews-Cancer. , vol.2 , pp. 489-501
    • Vivanco1
  • 46
    • 4344602002 scopus 로고    scopus 로고
    • The biology and clinical relevance of the PTEN tumor suppressor pathway
    • Sansal. The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway. Journal of Clinical Oncology. 2004, 22, (14), 2954-2963.
    • (2004) Journal of Clinical Oncology. , vol.22 , Issue.14 , pp. 2954-2963
    • Sansal1
  • 47
    • 34447503697 scopus 로고    scopus 로고
    • Conformational entropy in molecular recognition by proteins
    • Frederick. Conformational entropy in molecular recognition by proteins. Nature. 2007, 448, 325-329.
    • (2007) Nature. , vol.448 , pp. 325-329
    • Frederick1
  • 48
    • 3242884966 scopus 로고    scopus 로고
    • High-throughput docking as a source of novel drug leads
    • Alvarez. High-throughput docking as a source of novel drug leads. Current Opinion in Chemical Biology. 2004, 8 (4), 365-370.
    • (2004) Current Opinion in Chemical Biology. , vol.8 , Issue.4 , pp. 365-370
    • Alvarez1
  • 49
    • 0029905736 scopus 로고    scopus 로고
    • Makaluvic Acids A and B: Novel Alkaloids from the Marine Sponge Zyzzya fuliginosus
    • Fu. Makaluvic Acids A and B: Novel Alkaloids from the Marine Sponge Zyzzya fuliginosus. Journal of Natural Products. 1996, 59, (11), 1104-1106.
    • (1996) Journal of Natural Products. , vol.59 , Issue.11 , pp. 1104-1106
    • Fu1
  • 50
    • 0032956510 scopus 로고    scopus 로고
    • Pyrroloquinoline and pyridoacridine alkaloids from marine sources
    • Ding. Pyrroloquinoline and pyridoacridine alkaloids from marine sources. Current Medicinal Chemistry. 1999, 6, (1), 1.
    • (1999) Current Medicinal Chemistry. , vol.6 , Issue.1 , pp. 1
    • Ding1
  • 51
    • 0000331562 scopus 로고
    • Marine pyridoacridine alkaloids: Structure, synthesis, and biological chemistry
    • Molinski. Marine pyridoacridine alkaloids: structure, synthesis, and biological chemistry. Chemical Reviews. 1993, 93, (5), 1825-1838.
    • (1993) Chemical Reviews. , vol.93 , Issue.5 , pp. 1825-1838
    • Molinski1
  • 52
    • 14844304846 scopus 로고    scopus 로고
    • Pyrroloiminoquinone and related metabolites from marine sponges
    • Antunes. Pyrroloiminoquinone and related metabolites from marine sponges. Natural Product Reports. 2005, 22, (1), 62.
    • (2005) Natural Product Reports. , vol.22 , Issue.1 , pp. 62
    • Antunes1
  • 53
    • 60549110057 scopus 로고    scopus 로고
    • Analogues of marine pyrroloiminoquinone alkaloids: Synthesis and antitumor properties
    • Delfourne, E. Analogues of Marine Pyrroloiminoquinone Alkaloids: Synthesis and Antitumor Properties. Anti-Cancer Agents in Medicinal Chemistry. 2008, 8, (8), 910-916.
    • (2008) Anti-Cancer Agents in Medicinal Chemistry. , vol.8 , Issue.8 , pp. 910-916
    • Delfourne, E.1
  • 54
    • 0036103606 scopus 로고    scopus 로고
    • Batzelline D and Isobatzelline e from the Indopacific Sponge Zyzzya f uliginosa
    • Chang. Batzelline D and Isobatzelline E from the Indopacific Sponge Zyzzya f uliginosa. Journal of Natural Products. 2002, 65, (5), 776-778.
    • (2002) Journal of Natural Products. , vol.65 , Issue.5 , pp. 776-778
    • Chang1
  • 56
    • 0028137119 scopus 로고
    • Synthetic studies of the pyrroloquinoline nucleus of the makaluvamine alkaloids. Synthesis of the topoisomerase II inhibitor makaluvamine D
    • White. Synthetic Studies of the Pyrroloquinoline Nucleus of the Makaluvamine Alkaloids. Synthesis of the Topoisomerase II Inhibitor Makaluvamine D. Journal of the American Chemical Society. 1994, 116, (5), 1831-1838.
    • (1994) Journal of the American Chemical Society , vol.116 , Issue.5 , pp. 1831-1838
    • White1
  • 57
    • 0027167775 scopus 로고
    • Novel cytotoxic topoisomerase II inhibiting pyrroloiminoquinones from Fijian sponges of the genus Zyzzya
    • Radisky. Novel cytotoxic topoisomerase II inhibiting pyrroloiminoquinones from Fijian sponges of the genus Zyzzya. Journal of the American Chemical Society. 1993, 115, (5), 1632-1638.
    • (1993) Journal of the American Chemical Society. , vol.115 , Issue.5 , pp. 1632-1638
    • Radisky1
  • 58
    • 38749095499 scopus 로고    scopus 로고
    • Regioselective synthesis and antitumor screening of some novel N-phenylpyrazole derivatives
    • Ahmad M. Faraga.; Abdelrahman S. Mayhoubb.; Saber E. Barakatb.; Ashraf H. Bayomic. Regioselective synthesis and antitumor screening of some novel N-phenylpyrazole derivatives. Bioorganic & Medicinal Chemistry. 2008, 16, (2), 881-889.
    • (2008) Bioorganic & Medicinal Chemistry , vol.16 , Issue.2 , pp. 881-889
    • Faraga, A.M.1    Mayhoubb, A.S.2    Barakatb, S.E.3    Bayomic, A.H.4
  • 59
    • 0027276902 scopus 로고
    • DNA topoisomerase i and II in cancer chemotherapy: Update and perspectives
    • Pommier. DNA topoisomerase I and II in cancer chemotherapy: update and perspectives. Cancer Chemotherapy and Pharmacology. 1993, 32, (2), 103-108.
    • (1993) Cancer Chemotherapy and Pharmacology. , vol.32 , Issue.2 , pp. 103-108
    • Pommier1
  • 60
    • 84887942927 scopus 로고    scopus 로고
    • Topoisomerase as target for antibacterial and anticancer drug discovery
    • Kathiravan. Topoisomerase as target for antibacterial and anticancer drug discovery. Journal of Enzyme Inhibition and Medicinal Chemistry. 2012, 1, 1-17.
    • (2012) Journal of Enzyme Inhibition and Medicinal Chemistry. , vol.1 , pp. 1-17
    • Kathiravan1
  • 61
    • 0035724690 scopus 로고    scopus 로고
    • DNA topoisomerases as targets for anticancer drugs
    • Topcu. DNA topoisomerases as targets for anticancer drugs. Journal of Clinical Pharmacy and Therapeutics. 2001, 26, (6), 405-416.
    • (2001) Journal of Clinical Pharmacy and Therapeutics. , vol.26 , Issue.6 , pp. 405-416
    • Topcu1
  • 62
    • 68549115137 scopus 로고    scopus 로고
    • Interactions between the nuclear matrix and an enhancer of the tryptophan oxygenase gene
    • Kaneoka H .; Miyake K .; Iijima S . Interactions between the nuclear matrix and an enhancer of the tryptophan oxygenase gene. Biochemical and Biophysical Research Communications. 2009, 387 (4), 717-722
    • (2009) Biochemical and Biophysical Research Communications , vol.387 , Issue.4 , pp. 717-722
    • Kaneoka, H.1    Miyake, K.2    Iijima, S.3
  • 63
    • 20544452797 scopus 로고    scopus 로고
    • Tracking topoisomerases activity at the single molecule level
    • Charvin. Tracking topoisomerases activity at the single molecule level. Annual Review of Biophysics. 2005, 34 (1), 201-219.
    • (2005) Annual Review of Biophysics. , vol.34 , Issue.1 , pp. 201-219
    • Charvin1
  • 64
    • 33646747297 scopus 로고    scopus 로고
    • Synthesis and antitumor characterization of pyrazolic analogues of the marine pyrroloquinoline alkaloids: Wakayin and tsitsikammamines
    • Legentil. Synthesis and Antitumor Characterization of Pyrazolic Analogues of the Marine Pyrroloquinoline Alkaloids: Wakayin and Tsitsikammamines. Journal of Medicinal Chemistry. 2006, 49(10), 2979-2988.
    • (2006) Journal of Medicinal Chemistry. , vol.49 , Issue.10 , pp. 2979-2988
    • Legentil1
  • 66
    • 34247334648 scopus 로고    scopus 로고
    • Analogs of the marine alkaloid makaluvamines: Synthesis,topoisomerase II inhibition, and anticancer activity
    • Bidhan A.;,Shinkre.; Kevin P. Raisch.; Analogs of the marine alkaloid makaluvamines: Synthesis,topoisomerase II inhibition, and anticancer activity. Bioorganic & Medicinal Chemistry Letters. 2007, 17, 2890-2893.
    • (2007) Bioorganic & Medicinal Chemistry Letters , vol.17 , pp. 2890-2893
    • Shinkre, B.A.1    Raisch, K.P.2
  • 67
    • 0025738516 scopus 로고
    • Tetrazolium-based assays for cellular viability: A critical examination of selected parameters affecting formazan production
    • Vistica. Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production. Cancer Research. 1991, 51 (10), 2515.
    • (1991) Cancer Research. , vol.51 , Issue.10 , pp. 2515
    • Vistica1
  • 68
    • 66149180566 scopus 로고    scopus 로고
    • In vitro and in vivo Anticancer Activity of Novel Synthetic Makaluvamine Analogues
    • Wei Wang. In vitro and In vivo Anticancer Activity of Novel Synthetic Makaluvamine Analogues. Clinical Cancer Research. 2009, 15 (10), 1078-0432.
    • (2009) Clinical Cancer Research. , vol.15 , Issue.10 , pp. 1078-0432
    • Wang, W.1
  • 69
    • 0023619677 scopus 로고
    • A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity
    • Twentyman. A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity. British Journal of Cancer. 1987, 56 (3), 279.
    • (1987) British Journal of Cancer , vol.56 , Issue.3 , pp. 279
    • Twentyman1
  • 70
    • 0035418619 scopus 로고    scopus 로고
    • The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells
    • Jacob. The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells. Cancer Research. 2001, 61 (17) 6555.
    • (2001) Cancer Research. , vol.61 , Issue.17 , pp. 6555
    • Jacob1
  • 71
    • 0031906084 scopus 로고    scopus 로고
    • The role of DNA mismatch repair in drug resistance
    • Fink. The role of DNA mismatch repair in drug resistance. Clinical Cancer Research. 1998, 4 (1), 1078-0432.
    • (1998) Clinical Cancer Research. , vol.4 , Issue.1 , pp. 1078-0432
    • Fink1
  • 72
    • 61449199502 scopus 로고    scopus 로고
    • Muscarine, imidazole, oxazole and thiazole alkaloids
    • Jin, Zhong. Muscarine, imidazole, oxazole and thiazole alkaloids. Natural Product Reports. 2009, 26, (3), 382-445.
    • (2009) Natural Product Reports. , vol.26 , Issue.3 , pp. 382-445
    • Jin, Z.1
  • 73
    • 34247142390 scopus 로고    scopus 로고
    • Neopeltolide, a Macrolide from a Lithistid Sponge of the Family Neopeltidae
    • Wright. Neopeltolide, a Macrolide from a Lithistid Sponge of the Family Neopeltidae. Journal of Natural Products. 2007, 70, (3), 412-416.
    • (2007) Journal of Natural Products. , vol.70 , Issue.3 , pp. 412-416
    • Wright1
  • 74
    • 54749110587 scopus 로고    scopus 로고
    • Total synthesis of the marine macrolide (+)-neopeltolide
    • Paterson, Ian; Miller, Natalie A. Total synthesis of the marine macrolide (+)-neopeltolide. Chemical Communications. 2008, 39, 4708-4710.
    • (2008) Chemical Communications. , vol.39 , pp. 4708-4710
    • Paterson, I.1    Miller, N.A.2
  • 75
    • 55449094954 scopus 로고    scopus 로고
    • Taumycins A and B, Two Bioactive Lipodepsipeptides from the Madagascar Sponge Fascaplysinopsis sp
    • Bishara, A.; Rudi, A.; Aknin, M.; Neumann, D.; Ben-Califa, N.; Kashman, Y. Taumycins A and B, Two Bioactive Lipodepsipeptides from the Madagascar Sponge Fascaplysinopsis sp. Organic Letters 2008, 10, (19), 4307-4310.
    • (2008) Organic Letters , vol.10 , Issue.19 , pp. 4307-4310
    • Bishara, A.1    Rudi, A.2    Aknin, M.3    Neumann, D.4    Ben-Califa, N.5    Kashman, Y.6
  • 77
    • 66149172044 scopus 로고    scopus 로고
    • Total Synthesis of Siphonazoles by the Use of a Conjunctive Oxazole Building Block
    • Zhang, J.; Ciufolini, M. A. Total Synthesis of Siphonazoles by the Use of a Conjunctive Oxazole Building Block. Organic Letters. 2009, 11, (11), 2389-2392.
    • (2009) Organic Letters. , vol.11 , Issue.11 , pp. 2389-2392
    • Zhang, J.1    Ciufolini, M.A.2
  • 78
    • 3042518847 scopus 로고    scopus 로고
    • Recent Studies on Natural Products as Anticancer Agents
    • G Ravelo. Recent Studies on Natural Products as Anticancer Agents. Current Topics in Medicinal Chemistry. 2004, 4, (2), 241-265.
    • (2004) Current Topics in Medicinal Chemistry. , vol.4 , Issue.2 , pp. 241-265
    • Ravelo, G.1
  • 79
    • 0035985177 scopus 로고    scopus 로고
    • Identification of genes periodically expressed in the human cell cycle and their expression in tumors
    • Whitfield. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Molecular Biology of the Cell. 2002, 13, (6), 1977.
    • (2002) Molecular Biology of the Cell. , vol.13 , Issue.6 , pp. 1977
    • Whitfield1
  • 80
    • 0034957287 scopus 로고    scopus 로고
    • Individual Expression of Recombinant-and-Tubulin from Haemonchus contortus: Polymerization and Drug Effects
    • Oxberry. Individual Expression of Recombinant-and-Tubulin from Haemonchus contortus: Polymerization and Drug Effects. Protein Expression and Purification. 2001, 21, (1), 30-39.
    • (2001) Protein Expression and Purification. , vol.21 , Issue.1 , pp. 30-39
    • Oxberry1
  • 81
    • 0031172760 scopus 로고    scopus 로고
    • Microtubule dynamics: Treadmilling comes around again
    • Waterman-Storer. Microtubule dynamics: Treadmilling comes around again. Current Biology. 1997, 7, (6), R369-R372.
    • (1997) Current Biology. , vol.7 , Issue.6
    • Waterman-Storer1
  • 82
    • 65349097586 scopus 로고    scopus 로고
    • Tubulin-Interactive Natural Products as Anticancer Agents
    • Kingston, D. G. I. Tubulin-Interactive Natural Products as Anticancer Agents. Journal of Natural Products 2009, 72, (3), 507-515.
    • (2009) Journal of Natural Products , vol.72 , Issue.3 , pp. 507-515
    • Kingston, D.G.I.1
  • 83
    • 31344448309 scopus 로고    scopus 로고
    • Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines
    • Ouyang. Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines. Bioorganic and Medicinal Chemistry Letters. 2006, 16, (5), 1191-1196.
    • (2006) Bioorganic and Medicinal Chemistry Letters. , vol.16 , Issue.5 , pp. 1191-1196
    • Ouyang1
  • 85
    • 0036829930 scopus 로고    scopus 로고
    • The antiproliferative activity of resveratrol results in apoptosis in MCF-7 but not in MDA-MB-231 human breast cancer cells: Cell-specific alteration of the cell cycle
    • Pozo-Guisado. The antiproliferative activity of resveratrol results in apoptosis in MCF-7 but not in MDA-MB-231 human breast cancer cells: cell-specific alteration of the cell cycle. Biochemical Pharmacology. 2002, 64 (9), 1375-1386.
    • (2002) Biochemical Pharmacology. , vol.64 , Issue.9 , pp. 1375-1386
    • Pozo-Guisado1
  • 90
    • 14744287300 scopus 로고    scopus 로고
    • Novel antitumor agents: Marine sponge alkaloids, their synthetic analogs and derivatives
    • Dembitsky. Novel antitumor agents: Marine sponge alkaloids, their synthetic analogs and derivatives. Mini-Reviews in Medicinal Chemistry. 2005, 5, (3), 319.
    • (2005) Mini-Reviews in Medicinal Chemistry. , vol.5 , Issue.3 , pp. 319
    • Dembitsky1
  • 91
    • 0034815454 scopus 로고    scopus 로고
    • In Vitro Effect of Alkaloids on Bloodstream Forms of Trypanosoma brucei and T
    • Merschjohann. In Vitro Effect of Alkaloids on Bloodstream Forms of Trypanosoma brucei and T. congolense. Planta Medica. 2001, 67, (7), 623-627.
    • (2001) Congolense. Planta Medica. , vol.67 , Issue.7 , pp. 623-627
    • Merschjohann1
  • 92
    • 0035960054 scopus 로고    scopus 로고
    • Synthesis and Characterization of the Antitumor Activities of Analogues of Meridine, a Marine Pyridoacridine Alkaloid
    • Delfourne. Synthesis and Characterization of the Antitumor Activities of Analogues of Meridine, a Marine Pyridoacridine Alkaloid. Journal of Medicinal Chemistry. 2001, 44, (20), 3275-3282.
    • (2001) Journal of Medicinal Chemistry. , vol.44 , Issue.20 , pp. 3275-3282
    • Delfourne1
  • 93
    • 0002137946 scopus 로고    scopus 로고
    • 3-Alkylpyridines III. Total synthesis of both enantiomers of the antineoplastic marine alkaloid niphatesine D
    • Bracher. 3-Alkylpyridines III. Total synthesis of both enantiomers of the antineoplastic marine alkaloid niphatesine D. Monatshefte Für Chemie. 1996, 127, (1), 91-95.
    • (1996) Monatshefte Für Chemie. , vol.127 , Issue.1 , pp. 91-95
    • Bracher1
  • 94
    • 37049080289 scopus 로고
    • Niphatesines A-D, new antineoplastic pyridine alkaloids from the okinawan marine sponge Niphates sp
    • Jun'ichi Kobayashi.; Tetsuya Murayama. Niphatesines A-D, new antineoplastic pyridine alkaloids from the okinawan marine sponge Niphates sp. J. Chem. Soc.Perkin Trans. 1990, 1, 3301-3303
    • (1990) J. Chem. Soc.Perkin Trans. , vol.1 , pp. 3301-3303
    • Kobayashi, J.1    Murayama, T.2
  • 95
    • 0024454033 scopus 로고
    • Antitumor activity and nucleic acid binding properties of dercitin, a new acridine alkaloid isolated from a marine Dercitus species sponge
    • Burres. Antitumor activity and nucleic acid binding properties of dercitin, a new acridine alkaloid isolated from a marine Dercitus species sponge. Cancer Research. 1989, 49, (19), 5267.
    • (1989) Cancer Research. , vol.49 , Issue.19 , pp. 5267
    • Burres1
  • 97
    • 0033625587 scopus 로고    scopus 로고
    • An antimicrobial C14 acetylenic acid from a marine sponge Oceanapia species
    • Matsugana, S.; Okada, Y.; Fusetani, N. An antimicrobial C14 acetylenic acid from a marine sponge Oceanapia species. J. Nat. Prod. 2000, 63, 690-691.
    • (2000) J. Nat. Prod. , vol.63 , pp. 690-691
    • Matsugana, S.1    Okada, Y.2    Fusetani, N.3
  • 98
    • 37749032421 scopus 로고    scopus 로고
    • Mechanisms of Toxicity of 3-Alkylpyridinium Polymers from Marine Sponge Reniera sarai
    • Turk. Mechanisms of Toxicity of 3-Alkylpyridinium Polymers from Marine Sponge Reniera sarai. Marine Drugs. 2007, 5, (4), 157-167.
    • (2007) Marine Drugs. , vol.5 , Issue.4 , pp. 157-167
    • Turk1
  • 99
    • 34347258181 scopus 로고    scopus 로고
    • Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand
    • Anake Kijjoa.; Rawiwan Wattanadilok. Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand. Mar. Drugs. 2007, 5, 6-22.
    • (2007) Mar. Drugs. , vol.5 , pp. 6-22
    • Kijjoa, A.1    Wattanadilok, R.2
  • 100
    • 39049126024 scopus 로고    scopus 로고
    • Inhibitors of cyclin dependent kinases: Useful targets for cancer treatment
    • Sharma, P. S.; Sharma, R.; Tyagi, R. Inhibitors of Cyclin Dependent Kinases: Useful Targets for Cancer Treatment. Current Cancer Drug Targets. 2008, 8, (1), 53-75.
    • (2008) Current Cancer Drug Targets. , vol.8 , Issue.1 , pp. 53-75
    • Sharma, P.S.1    Sharma, R.2    Tyagi, R.3
  • 102
    • 0346993724 scopus 로고    scopus 로고
    • Cell cycle inhibitors for the treatment of cancer
    • Kong. Cell cycle inhibitors for the treatment of cancer. Drugs of the Future. 2003, 28 (9), 881
    • (2003) Drugs of the Future , vol.28 , Issue.9 , pp. 881
    • Kong1
  • 103
    • 21644456228 scopus 로고    scopus 로고
    • Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors
    • Ian Collins.; Michelle D Garrett. Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. Current Opinion in Pharmacology. 2005, 5(4), 366-373.
    • (2005) Current Opinion in Pharmacology. , vol.5 , Issue.4 , pp. 366-373
    • Ian, Collins.1    Garrett, M.D.2
  • 104
    • 21244450397 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitors: A survey of the recent patent literature
    • Pevarello. Cyclin-dependent kinase inhibitors: a survey of the recent patent literature. Expert Opinion on Therapeutic Patents. 2005, 15, (6), 675-70.
    • (2005) Expert Opinion on Therapeutic Patents. , vol.15 , Issue.6 , pp. 675-70
    • Pevarello1
  • 105
    • 9444228344 scopus 로고    scopus 로고
    • Specific inhibition of cyclindependent kinase 4/6 by PD 0332991 and associated antitumour activity in human tumor xenografts
    • D.W. Fry.; P.J. Harvey.; P.R. Keller. Specific inhibition of cyclindependent kinase 4/6 by PD 0332991 and associated antitumour activity in human tumor xenografts. Mol Cancer Ther. 2004, 3, 1427-1437
    • (2004) Mol Cancer Ther. , vol.3 , pp. 1427-1437
    • Fry, D.W.1    Harvey, P.J.2    Keller, P.R.3
  • 108
    • 0033559197 scopus 로고    scopus 로고
    • Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells
    • Cover. Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells. Cancer Research. 1999, 59, (6), 1244.
    • (1999) Cancer Research. , vol.59 , Issue.6 , pp. 1244
    • Cover1
  • 109
    • 0035476623 scopus 로고    scopus 로고
    • Crystal structure of human protein kinase CK2: Insights into basic properties of the CK2 holoenzyme
    • Niefind. Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme. EMBO Journal, 2001, 20, (19), 5320-5331.
    • (2001) EMBO Journal , vol.20 , Issue.19 , pp. 5320-5331
    • Niefind1
  • 110
    • 0344809977 scopus 로고    scopus 로고
    • ATP-site directed inhibitors of cyclin-dependent kinases
    • Gray. ATP-site directed inhibitors of cyclin-dependent kinases. Current Medicinal Chemistry. 1999, 6 (9), 859
    • (1999) Current Medicinal Chemistry. , vol.6 , Issue.9 , pp. 859
    • Gray1
  • 111
    • 0030954172 scopus 로고    scopus 로고
    • A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
    • Tong. A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nature Structural Biology. 1997, 4, (4), 311-316.
    • (1997) Nature Structural Biology , vol.4 , Issue.4 , pp. 311-316
    • Tong1
  • 112
    • 31544459273 scopus 로고    scopus 로고
    • AZ703, an Imidazo[1,2-a]Pyridine Inhibitor of Cyclin-Dependent Kinases 1 and 2, Induces E2F-1-Dependent Apoptosis Enhanced by Depletion of Cyclin-Dependent Kinase 9
    • Cai. AZ703, an Imidazo[1,2-a]Pyridine Inhibitor of Cyclin-Dependent Kinases 1 and 2, Induces E2F-1-Dependent Apoptosis Enhanced by Depletion of Cyclin-Dependent Kinase 9. Cancer Research. 2006, 66, (1), 435-444.
    • (2006) Cancer Research. , vol.66 , Issue.1 , pp. 435-444
    • Cai1
  • 113
    • 12444260278 scopus 로고    scopus 로고
    • 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: Highly potent 2,6-Difluorophenacyl analogues
    • Misra. 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorganic and Medicinal Chemistry Letters. 2003, 13 (14), 2405-2408.
    • (2003) Bioorganic and Medicinal Chemistry Letters , vol.13 , Issue.14 , pp. 2405-2408
    • Misra1
  • 114
    • 21644456228 scopus 로고    scopus 로고
    • Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors
    • Collins. Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. Current Opinion in Pharmacology. 2005, 5, (4), 366-373.
    • (2005) Current Opinion in Pharmacology. , vol.5 , Issue.4 , pp. 366-373
    • Collins1
  • 116
    • 0037242334 scopus 로고    scopus 로고
    • Anti-cancer agents
    • P. Furet. Anti-Cancer Agents. Curr. Med. Chem. 2003, 3, 15-23.
    • (2003) Curr. Med. Chem. , vol.3 , pp. 15-23
    • Furet, P.1
  • 119
    • 27844463013 scopus 로고    scopus 로고
    • Indole alkaloid marine natural products: An established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases
    • Gul. Indole alkaloid marine natural products: An established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases. Life Sciences. 2005, 78, (5), 442-453.
    • (2005) Life Sciences. , vol.78 , Issue.5 , pp. 442-453
    • Gul1
  • 120
    • 0027260378 scopus 로고
    • Makaluvamine G, a cytotoxic pigment from an an Indonesian Sponge Histodermella sp
    • Carney. Makaluvamine G, a cytotoxic pigment from an an Indonesian Sponge Histodermella sp. Tetrahedron. 1993, 49, (38), 8483-8486.
    • (1993) Tetrahedron. , vol.49 , Issue.38 , pp. 8483-8486
    • Carney1
  • 121
    • 0023791166 scopus 로고
    • Dragmacidin, a new cytotoxic bis(indole) alkaloid from a deep water marine sponge, Dragmacidon sp
    • Kohmoto. Dragmacidin, a new cytotoxic bis(indole) alkaloid from a deep water marine sponge, Dragmacidon sp. Journal of Organic Chemistry. 1988, 53, (13), 3116-3118.
    • (1988) Journal of Organic Chemistry. , vol.53 , Issue.13 , pp. 3116-3118
    • Kohmoto1
  • 122
    • 0037184886 scopus 로고    scopus 로고
    • Preparing functional bis(indole) pyrazine by stepwise cross-coupling reactions: An efficient method to construct the skeleton of Dragmacidin D
    • Yang. Preparing Functional Bis(indole) Pyrazine by Stepwise Cross-coupling Reactions: An Efficient Method to Construct the Skeleton of Dragmacidin D. Journal of Organic Chemistry. The 2002, 67, (26), 9392-9396.
    • (2002) Journal of Organic Chemistry. the , vol.67 , Issue.26 , pp. 9392-9396
    • Yang1
  • 123
    • 0031775783 scopus 로고    scopus 로고
    • Dragmacidins: New Protein Phosphatase Inhibitors from a Southern Australian Deep-Water Marine Sponge, Spongosorites sp
    • Capon. Dragmacidins: New Protein Phosphatase Inhibitors from a Southern Australian Deep-Water Marine Sponge, Spongosorites sp. Journal of Natural Products. 1998, 61, (5), 660-662.
    • (1998) Journal of Natural Products. , vol.61 , Issue.5 , pp. 660-662
    • Capon1
  • 124
    • 27844463013 scopus 로고    scopus 로고
    • Hamann Indole alkaloid marine natural products: An established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases
    • Waseem Gul.; Mark T. Hamann Indole alkaloid marine natural products: An established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases. Life Sciences. 2005, 5(22), 442-453.
    • (2005) Life Sciences. , vol.5 , Issue.22 , pp. 442-453
    • Waseem, G.1    Mark, T.2
  • 125
    • 28944443244 scopus 로고    scopus 로고
    • Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC)
    • Balamurugan. Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC). Molecular Biosystems. 2005, 1, (1), 36.
    • (2005) Molecular Biosystems. , vol.1 , Issue.1 , pp. 36
    • Balamurugan1
  • 126
    • 33645349584 scopus 로고    scopus 로고
    • Synthetic immer of indole-3-carbinol: Second generation diet derived anti-cancer agent in hormone sensitive prostate cancer
    • Garikapaty. Synthetic immer of indole-3-carbinol: Second generation diet derived anti-cancer agent in hormone sensitive prostate cancer. Prostate. 2006, 66 (5), 453-462
    • (2006) Prostate. , vol.66 , Issue.5 , pp. 453-462
    • Garikapaty1
  • 127
    • 34547590883 scopus 로고    scopus 로고
    • Computer-Aided Rational Drug Design: A Novel Agent (SR13668) Designed to Mimic the Unique Anticancer Mechanisms of Dietary Indole-3-Carbinol to Block Akt Signaling
    • Chao. Computer-Aided Rational Drug Design: A Novel Agent (SR13668) Designed to Mimic the Unique Anticancer Mechanisms of Dietary Indole-3-Carbinol to Block Akt Signaling. Journal of Medicinal Chemistry. 2007, 50, (15), 3412-3415.
    • (2007) Journal of Medicinal Chemistry. , vol.50 , Issue.15 , pp. 3412-3415
    • Chao1
  • 128
    • 84887890178 scopus 로고    scopus 로고
    • Absorption-enhanced 3,3-Diindolylmethane: Human use in HPV-related, benign and precancerous conditions
    • Zeligs MA.; Sepkovic DW. Absorption-enhanced 3,3-Diindolylmethane: human use in HPV-related, benign and precancerous conditions. American Association of Cancer Research. 2002, 42.
    • (2002) American Association of Cancer Research , pp. 42
    • Zeligs, M.A.1    Sepkovic, D.W.2
  • 129
    • 0031777837 scopus 로고    scopus 로고
    • Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis
    • Rosen CA.; Woodson GE.; Thompson JW. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg. 1998, 118(6), 810.
    • (1998) Otolaryngol Head Neck Surg. , vol.118 , Issue.6 , pp. 810
    • Rosen, C.A.1    Woodson, G.E.2    Thompson, J.W.3
  • 130
    • 0024494430 scopus 로고
    • Effects of immunosuppressive chemicals on lymphoid development in foetal thymus organ cultures
    • d'Argy R.; Bergman J.; Dencker L.; Effects of immunosuppressive chemicals on lymphoid development in foetal thymus organ cultures. Pharmacol Toxicol. 1989, 64(1), 33.
    • (1989) Pharmacol Toxicol , vol.64 , Issue.1 , pp. 33
    • D'argy, R.1    Bergman, J.2    Dencker, L.3
  • 131
    • 80051715729 scopus 로고    scopus 로고
    • Phytoestrogens and their Putative Effects on the Aryl Hydrocarbon Receptor
    • Medjakovic. Phytoestrogens and their Putative Effects on the Aryl Hydrocarbon Receptor. Current Bioactive Compounds. 2011, 7, (3), 136-155.
    • (2011) Current Bioactive Compounds. , vol.7 , Issue.3 , pp. 136-155
    • Medjakovic1
  • 132
    • 0035977882 scopus 로고    scopus 로고
    • Molecular biology of the Ah receptor and its role in carcinogenesis
    • Safe. Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicology Letters. 2001,120, 1-7.
    • (2001) Toxicology Letters. , vol.120 , pp. 1-7
    • Safe1
  • 133
    • 25444449603 scopus 로고    scopus 로고
    • Molecular targets and anticancer potential of indole-3-carbinol and its derivatives
    • Aggarwal. Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives. Cell Cycle. 2005, 4, (9), 1201-1215.
    • (2005) Cell Cycle. , vol.4 , Issue.9 , pp. 1201-1215
    • Aggarwal1
  • 134
  • 136
    • 40649107590 scopus 로고    scopus 로고
    • Indole-3-carbinol as a chemopreventive and anti-cancer agent
    • Weng J.-R.; Tsai C.-H.; Kulp S. K.; Chen C.-S. Indole-3-carbinol as a chemopreventive and anti-cancer agent. Cancer Letters. 2008, 262, (2), 153-163.
    • (2008) Cancer Letters. , vol.262 , Issue.2 , pp. 153-163
    • Weng, J.-R.1    Tsai, C.-H.2    Kulp, S.K.3    Chen, C.-S.4
  • 137
    • 12844279940 scopus 로고    scopus 로고
    • Targets for indole-3-carbinol in cancer prevention
    • Kim. Targets for indole-3-carbinol in cancer prevention. Journal of Nutritional Biochemistry. 2005, 16, (2), 65-73.
    • (2005) Journal of Nutritional Biochemistry. , vol.16 , Issue.2 , pp. 65-73
    • Kim1
  • 138
    • 77955856301 scopus 로고    scopus 로고
    • Pharmacological Exploitation of Indole-3-Carbinol to Develop Potent Antitumor Agents
    • Weng, J.-R.; Omar, H. A.; Kulp, S. K.; Chen, C.-S. Pharmacological Exploitation of Indole-3-Carbinol to Develop Potent Antitumor Agents. Mini-Reviews in Medicinal Chemistry. 2010, 10, (5), 398-404.
    • (2010) Mini-Reviews in Medicinal Chemistry. , vol.10 , Issue.5 , pp. 398-404
    • Weng, J.-R.1    Omar, H.A.2    Kulp, S.K.3    Chen, C.-S.4
  • 139
    • 34547590883 scopus 로고    scopus 로고
    • Computer-Aided Rational Drug Design: A Novel Agent (SR13668) Designed to Mimic the Unique Anticancer Mechanisms of Dietary Indole-3-Carbinol to Block Akt Signaling
    • Chao. Computer-Aided Rational Drug Design: A Novel Agent (SR13668) Designed to Mimic the Unique Anticancer Mechanisms of Dietary Indole-3-Carbinol to Block Akt Signaling. Journal of Medicinal Chemistry. 2007, 50 (15), 12-3415
    • (2007) Journal of Medicinal Chemistry. , vol.50 , Issue.15 , pp. 12-3415
    • Chao1
  • 140
    • 79955876707 scopus 로고    scopus 로고
    • Phase 0 clinical chemoprevention trial of the akt inhibitor SR13668
    • Reid. Phase 0 Clinical Chemoprevention Trial of the Akt Inhibitor SR13668. Cancer Prevention Research. 2011, 4, (3), 347-353.
    • (2011) Cancer Prevention Research. , vol.4 , Issue.3 , pp. 347-353
    • Reid1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.