Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 9, 2008, Pages 4932-4953

  Jacquemard, Ulrich ^a   Dias, Nathalie ^b   Lansiaux, Amélie ^b   Bailly, Christian ^b   Logé, Cédric ^c   Robert, Jean Michel ^c   Lozach, Olivier ^d   Meijer, Laurent ^d   Mérour, Jean Yves ^a   Routier, Sylvain ^a  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d CNRS   (France)

Author keywords

Anticancer agent; CDK inhibitors; Cytotoxicity; Indole; Pyridine

Indexed keywords

1 (2 DIMETHYLAMINOETHYL) 2 [5 (5 HYDROXY 1H INDOL 2 YL)PYRIDIN 3 YL] 5 HYDROXY 1H INDOLE; 1 (2 DIMETHYLAMINOETHYL) 2 [5 [4 (3 DIMETHYLAMINOPROPOXY)PHENYL]PYRIDIN 3 YL] 5 HYDROXY 1H INDOLE; 1 (3 DIMETHYLAMINOPROPYL) 2 [5 (5 HYDROXY 1H INDOL 2 YL)PYRIDIN 3 YL] 5 HYDROXY 1H INDOLE; 1 PHENYLSULFONYL 2 (5 BROMOPYRIDIN 3 YL) 1H INDOLE; 1 PHENYLSULFONYL 2 TRIBUTYLSTANNYL 1H INDOLE; 1 PHENYLSULFONYL 5 BENZYLOXY 2 (5 BROMOPYRIDIN 3 YL) 1H INDOLE; 1 PHENYLSULFONYL 5 BENZYLOXY 2 TRIBUTYLSTANNYL 1H INDOLE; 2 [5 (4 HYDROXYPHENYL) PYRIDIN 3 YL] 5 HYDROXY 1H INDOLE; 2 [5 [4 (2 DIMETHYLAMINOETHOXY)PHENYL]PYRIDIN 3 YL] 1 (2 DIMETHYLAMINOETHYL) 5 HYDROXY 1H INDOLE; 2 [5 [4 (2 DIMETHYLAMINOETHOXY)PHENYL]PYRIDIN 3 YL] 1 (3 DIMETHYLAMINOPROPYL) 5 HYDROXY 1H INDOLE; 2 [5 [4 (2 DIMETHYLAMINOETHOXY)PHENYL]PYRIDIN 3 YL] 5 HYDROXY 1H INDOLE; 2 [5 [4 (3 DIMETHYLAMINOPROPOXY)PHENYL]PYRIDIN 3 YL] 5 HYDROXY 1H INDOLE; 3 [(2 INDOLYL) 5 PHENYL] PYRIDINE; 3,5 BIS(1 PHENYLSULFONYL 5 BENZYLOXY 1H INDOLE) PYRIDINE; 3,5 BIS(1 PHENYLSULFONYL 5 HYDROXY 1H INDOL) PYRIDINE; 3,5 BIS(2 INDOLYL)PYRIDINE; 3,5 BIS(5 BENZYLOXY 1H INDOLE)PYRIDINE; 3,5 BIS(5 HYDROXY 1H INDOL)PYRIDINE; 3,5 BIS[1 (2 DIMETHYLAMINOETHYL) 5 HYDROXY 1H INDOL]PYRIDINE; 3,5 BIS[1 (3 DIMETHYLAMINOPROPYL) 5 HYDROXY 1H INDOL]PYRIDINE; [2 [4 [5 (1H INDOL 2 YL)PYRIDIN 3 YL]PHENOXY]ETHYL]DIMETHYL AMINE; [3 (2 [5 [4 (2 DIMETHYLAMINOETHOXY)PHENYL]PYRIDIN 3 YL]INDOL 1 YL]PROPYL]DIMETHYLAMINE; [3 (4 [5 [1 (2 DIMETHYLAMINOETHYL) 1H INDOL 2 YL]PYRIDIN 3 YL]PHENOXY]PROPYL]DIMETHYLAMINE; [3 (4 [5 [1 (3 DIMETHYLAMINOPROPYL) 1H INDOL 2 YL]PYRIDIN 3 YL]PHENOXY]PROPYL]DIMETHYLAMINE; [3 [4 [5 (1H INDOL 2 YL)PYRIDIN 3 YL]PHENOXY]PROPYL]DIMETHYLAMINE; CYCLIN DEPENDENT KINASE INHIBITOR; CYTOTOXIC AGENT; INDOLE DERIVATIVE; PYRIDINE DERIVATIVE; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS COUPLING REACTION; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ASSAY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; MOUSE; NONHUMAN; STILLE REACTION; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; WILLIAMSON REACTION;

AMINO ACID SEQUENCE; CDC2 PROTEIN KINASE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRIDINES; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 43049170147     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.034     Document Type: Article

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