Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 7, 2004, Pages 1703-1707

  Gompel, Marie ^a   Leost, Maryse ^a   Bal De Kier Joffe, Elisa ^b   Puricelli, Lydia ^b   Hernandez Franco, Laura ^b   Palermo, Jorge ^b   Meijer, Laurent ^a  

^a STATION BIOLOGIQUE   (France)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Cancer; CDK; Cyclin dependent kinase; Glycogen synthase kinase; Glycogen synthase kinase 3; GSK 3; Kinase inhibitor; MEM; Meridianin; Modified Eagle Medium; MTT; Neurodegenerative diseases; Protein kinase

Indexed keywords

CASEIN KINASE I; CYCLIC NUCLEOTIDE DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE; DISCODERMINDOL; GLYCOGEN SYNTHASE KINASE 3; ISOMERIDIANIN C; ISOMERIDIANIN G; MERIDIANIN; MERIDIANIN A; MERIDIANIN B; MERIDIANIN C; MERIDIANIN D; MERIDIANIN E; MERIDIANIN F; MERIDIANIN G; PROTEIN KINASE INHIBITOR; PSAMMOPEMMIN A; PSAMMOPEMMIN B; PSAMMOPEMMIN C; UNCLASSIFIED DRUG; VARIOLIN B;

APLIDIUM MERIDIANUM; APOPTOSIS; ARTICLE; ASCIDIACEA; CELL DEATH; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PHARMACODYNAMICS;

AMINOPYRIDINES; ANIMALS; CELL DIVISION; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INDOLE ALKALOIDS; MICE; PROTEIN KINASE INHIBITORS; UROCHORDATA;

APLIDIUM; APLIDIUM MERIDIANUM; ASCIDIA; CICONIIFORMES;

EID: 1542509425     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.01.050     Document Type: Article

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