Crystal structure of human protein kinase CK2: Insights into basic properties of the CK2 holoenzyme

EMBO Journal

Volumn 20, Issue 19, 2001, Pages 5320-5331

  Niefind, Karsten ^a   Guerra, Barbara ^b   Ermakowa, Inessa ^a   Issinger, Olaf Georg ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Casein kinase 2; CK2 holoenzyme; Constitutive activity; Protein kinase CK2; X ray crystallography

Indexed keywords

CASEIN KINASE II; HOLOENZYME;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBUNIT; HUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CASEIN KINASE II; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; HOLOENZYMES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOTION; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS;

EID: 0035476623     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.19.5320     Document Type: Article

References (48)

1. The crystal structure of the complex of Zea mays α subunit with a fragment of human β subunit provides the clue to the architecture of protein kinase CK2 holoenzyme
2. Recombinant human casein kinase II. A study with the complete set of subunits (α, α′ and β), site-directed autophosphorylation mutants and a bicistronically expressed holoenzyme
3. A-Raf kinase is a new interacting partner of protein kinase CK2β subunit
4. Reconstitution of normal and hyperactivated forms of casein kinase-2 by variably mutated β-subunits
5. Protein kinase CK2 structure-function relationship: Effects of the β subunit on reconstitution and activity
6. Structure of protein kinase CK2: Dimerization of the human β-subunit
7. Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1
8. 1NK4d
9. The free R value: A novel statistical quantity for assessing the accuracy of crystal structures
10. Crystallography and NMR system (CNS): A new software system for macromolecular structure determination
11. Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization
12. Dual specificity of casein kinase II from the yeast Yarrowia lipolytica
13. The casein kinase 2 subunit binds to Mos and inhibits Mos activity
14. Identification and characterization of protein kinase CK2 isoforms in HeLa cells
15. The CCP4 suite: Programs for protein crystallography
16. Domain movements in protein kinases
17. Crystal structure of cyclin-dependent kinase 2
18. An extensively modified version of MolScript that includes greatly enhanced coloring capabilities
19. Effect of metal ions on the activity of casein kinase II from Xenopus laevis
20. Interactions between the subunits of casein kinase II
21. A filamentous form of Drosophila casein kinase II
22. The regulatory β subunit of protein kinase CK2 mediates formation of tetrameric CK2 complexes
23. Protein kinase CK2 and its role in cellular proliferation, development and pathology
24. The regulatory subunit of protein kinase CK2 is a specific A-Raf activator
25. Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
26. Systematic analysis of domain motions in proteins from conformational change. New results on citrate synthase and T4 lysozyme
27. Characterization of the α and β subunits of casein kinase 2 by far-UV CD spectroscopy
28. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
29. Principles of protein-protein interactions
30. Improved methods for building protein models in electron density maps and the location of errors in these models
31. Interactions of protein kinase CK2 subunits
32. Interaction sites between catalytic and regulatory subunits in human protein kinase CK2 holoenzyme as indicated by chemical cross-linking and immunological investigations
33. Isolation and characterization of human cDNA clones encoding the α and the α′ subunits of casein kinase II
34. Tyrosine versus senne/threonine phosphorylation by protein kinase casein kinase-2
35. Raster3D: Photorealistic molecular graphics
36. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
37. Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 Å resolution
38. GTP plus water mimics ATP in the active site of protein kinase CK2
39. Crystallization and preliminary characterization of crystals of human protein kinase CK2
40. Processing of X-ray diffraction data collected in oscillation mode
41. Isolation, sequencing and disruption of the yeast CKA2 gene: Casein kinase II is essential for viability in Saccharomyces cerevisiae
42. Protein kinase CK2 ('casein kinase-2') and its implication in cell division and proliferation
43. Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
44. INK4a
45. Biochemical evidence that the N-terminal segments of the α subunit and the β subunit play interchangeable roles in the activation of protein kinase CK2
46. Casein kinase 2α transgene-induced murine lymphoma: Relation to Theileriosis in cattle
47. Casein kinase II catalyses tyrosine phosphorylation of the yeast nucleolar immunophilin Fpr3
48. Quaternary structures of a catalytic subunit-regulatory subunit dimeric complex and the holoenzyme of the cAMP-dependent protein kinase by neutron contrast variation