Synthesis, anticancer activities and molecular modeling studies of novel indole retinoid derivatives

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 346-354

  Selen Gurkan Alp, A ^a   Mumcuoglu, Mine ^b   Andac, Cenk A ^c   Dayanc, Emre ^b   Cetin Atalay, Rengul ^b   Buyukbingol, Erdem ^a  

^a ANKARA UNIVERSITY   (Turkey)

^b BILKENT UNIVERSITY   (Turkey)

^c DICLE UNIVERSITY   (Turkey)

Author keywords

Indole; MDA MB 231; Molecular dynamics; Retinoid; T47D

Indexed keywords

3 (1H INDOL 3 YL) 1 (5,5,8,8 TETRAMETHYL 5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 2 EN 1 ONE; 3 (5 BROMO 1H INDOL 3 YL) 1 (5,5,8,8 TETRAMETHYL 5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 2 EN 1 ONE; 3 (5 CHLORO 1H INDOL 3 YL) 1 (5,5,8,8 TETRAMETHYL 5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 2 EN 1 ONE; 3 (5 METHOXY 1H INDOL 3 YL) 1 (5,5,8,8 TETRAMETHYL 5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 2 EN 1 ONE; 3 [3 OXO 3 (5,5,8,8 TETRAMETHYL 5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROP 1 ENYL] 1H INDOLE 5 CARBOXYLIC ACID; ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; RETINOID DERIVATIVE; RETINOID X RECEPTOR ALPHA; RETINOID X RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL PROLIFERATION; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MOLECULAR DYNAMICS;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; RETINOIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; TUMOR CELLS, CULTURED;

EID: 84868451623     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.10.013     Document Type: Article

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