New thiazole carboxamides as potent inhibitors of Akt kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 1208-1212

  Chang, Shaohua ^a,b   Zhang, Zhang ^a   Zhuang, Xiaoxi ^a   Luo, Jinfeng ^a   Cao, Xianwen ^c   Li, Honglin ^c   Tu, Zhengchao ^a   Lu, Xiaoyun ^a   Ren, Xiaomei ^a   Ding, Ke ^a  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Akt kinase; Inhibitors; Thiazole carboxamides

Indexed keywords

AMIDE; ANTINEOPLASTIC AGENT; GLYCOGEN SYNTHASE KINASE 3BETA; N (1 AMINO 3 PHENYLPROPAN 2 YL) 2 PHENYLTHIAZOLE 5 CARBOXAMIDE; PROTEIN AKT 1; PROTEIN AKT 3; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN KINASE B INHIBITOR; PROTEIN MDM2; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; PROTEIN PHOSPHORYLATION; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION;

AMIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MDM2; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84855699631     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.080     Document Type: Article

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