Synthesis and antitumor characterization of pyrazolic analogues of the marine pyrroloquinoline alkaloids: Wakayin and tsitsikammamines

Journal of Medicinal Chemistry

Volumn 49, Issue 10, 2006, Pages 2979-2988

  Legentil, Laurent ^a   Benel, Laurent ^b   Bertrand, Viviane ^b   Lesur, Brigitte ^b   Delfourne, Evelyne ^a  

^a UPS)   (France)

^b Centre de Recherches   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 ETHYLAMINE INDOLE 4,7 DIONE; ALKALOID; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRROLOQUINOLINE ALKALOID; QUINOLINE DERIVATIVE; TSITSIKAMMAMINE A; TSITSIKAMMAMINE B; UNCLASSIFIED DRUG; WAKAYIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; CYCLIZATION; CYCLOADDITION; DNA SUPERCOILING; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; KIDNEY CANCER; MOUSE; NONHUMAN; PROSTATE CANCER;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLE ALKALOIDS; PYRAZOLES; PYRROLES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646747297     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051247f     Document Type: Article

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