Functionally engineered nanosized particles in pharmaceutics: Improved oral delivery of poorly water-soluble drugs

Current Pharmaceutical Design

Volumn 19, Issue 35, 2013, Pages 6259-6269

  Ozeki, Tetsuya ^a   Tagami, Tatsuaki ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Carrier based oral drug delivery system; Down sizing and bottom up methods; Drug nanoparticles; Nanocomposite; Poorly watersoluble drugs; Spray dryer

Indexed keywords

ARTEMISIN; ATORVASTATIN; BETA CAROTENE; BICALUTAMIDE; CEFPODOXIME PROXETIL; CEFUROXIME AXETIL; CILOSTAZOL; FAMOTIDINE; GLIBENCLAMIDE; IBUPROFEN; INDOMETACIN; ITRACONAZOLE; MEVINOLIN; NABUMETONE; NANOCOMPOSITE; NANOPARTICLE; NAPROXEN; NITRENDIPINE; NOBILETIN; PACLITAXEL; PHENYTOIN; PRANLUKAST; PROBUCOL; QUERCETIN; RALOXIFENE; SPIRONOLACTONE; THALIDOMIDE; THEOPHYLLINE; TRANILAST; UNINDEXED DRUG;

DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG SOLUBILITY; NANOPHARMACEUTICS; PHARMACEUTICAL ENGINEERING; PRIORITY JOURNAL; REVIEW;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS; NANOPARTICLES; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; SOLUBILITY;

EID: 84887905245     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612811319350004     Document Type: Review

References (101)

1. Lobenberg R, Amidon GL. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. Eur J Pharm Biopharm 2000; 50(1): 3-12.
2. Singh A, Worku ZA, Van den Mooter G. Oral formulation strategies to improve solubility of poorly water-soluble drugs. Expert Opin Drug Deliv 2011; 8(10): 1361-78.
3. Nagarwal RC, Kumar R, Dhanawat M, Das N, Pandit JK. Nanocrystal technology in the delivery of poorly soluble drugs: an overview. Curr Drug Deliv 2011; 8(4): 398-406.
4. van Hoogevest P, Liu X, Fahr A. Drug delivery strategies for poorly water-soluble drugs: the industrial perspective. Expert Opin Drug Deliv 2011; 8(11): 1481-500.
5. Shegokar R, Muller RH. Nanocrystals: industrially feasible multifunctional formulation technology for poorly soluble actives. Int J Pharm 2010; 399(1-2): 129-39.
6. Krishnaiah YSR. Pharmaceutical technologies for enhancing oral bioavailability of poorly soluble drugs. J Bioequiv Availab 2010; 2(2): 28-36.
7. Fahr A, Liu X. Drug delivery strategies for poorly water-soluble drugs. Expert Opin Drug Deliv 2007; 4(4): 403-16.
8. Banavath H, Sivarama RK, Ansari T, Ali S, Pattnail G. Nanosuspension: an attempt to enhance bioavailability of poorly soluble drugs. International Journal of Pharmaceutical Sciences and Research 2010; 1(9): 1-11.
9. Noyes AA, Whitney WR. The rate of solution of solid substances in their ownn solutions. J Am Chem Soc 1897; 19(12): 930-934.
10. Keck CM, Muller RH. Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation. Eur J Pharm Biopharm 2006; 62(1): 3-16.
11. Bailey MM, Berkland CJ. Nanoparticle formulations in pulmonary drug delivery. Med Res Rev 2009; 29(1): 196-212.
12. Tozuka Y, Imono M, Uchiyama H, Takeuchi H. A novel application of alpha-glucosyl hesperidin for nanoparticle formation of active pharmaceutical ingredients by dry grinding. Eur J Pharm Biopharm 2011; 79(3): 559-65.
13. Niwa T, Nakanishi Y, Danjo K. One-step preparation of pharmaceutical nanocrystals using ultra cryo-milling technique in liquid nitrogen. Eur J Pharm Sci 2010; 41(1): 78-85.
14. Merisko-Liversidge E, Liversidge GG. Nanosizing for oral and parenteral drug delivery: a perspective on formulating poorly-water soluble compounds using wet media milling technology. Adv Drug Deliv Rev 2011; 63(6): 427-40.
15. Merisko-Liversidge EM, Liversidge GG. Drug nanoparticles: formulating poorly water-soluble compounds. Toxicol Pathol 2008; 36(1): 43-8.
16. Patel DJ, Patel JK, Pandya VM. Improvement in the dissolution of poorly water solluble drug using media milling technique. Thai J Pharm Sci 2010; 34: 155-64.
17. Tanaka Y, Inkyo M, Yumoto R, Nagai J, Takano M, Nagata S. Nanoparticulation of probucol, a poorly water-soluble drug, using a novel wet-milling process to improve in vitro dissolution and in vivo oral absorption. Drug Dev Ind Pharm 2011.
18. Singh SK, Srinivasan KK, Gowthamarajan K, Singare DS, Prakash D, Gaikwad NB. Investigation of preparation parameters of nanosuspension by top-down media milling to improve the dissolution of poorly water-soluble glyburide. Eur J Pharm Biopharm 2011; 78(3): 441-6.
19. Liu P, Rong X, Laru J, et al. Nanosuspensions of poorly soluble drugs: preparation and development by wet milling. Int J Pharm 2011; 411(1-2): 215-22.
20. Onoue S, Uchida A, Takahashi H, et al. Development of highenergy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability. J Pharm Sci 2011; 100(9): 3793-801.
21. Kawabata Y, Yamamoto K, Debari K, Onoue S, Yamada S. Novel crystalline solid dispersion of tranilast with high photostability and improved oral bioavailability. Eur J Pharm Sci 2010; 39(4): 256-62.
22. Patel VR, Agrawal YK. Nanosuspension: An approach to enhance solubility of drugs. J Adv Pharm Technol Res 2011; 2(2): 81-7.
23. Sun W, Mao S, Shi Y, Li LC, Fang L. Nanonization of itraconazole by high pressure homogenization: stabilizer optimization and effect of particle size on oral absorption. J Pharm Sci 2011; 100(8): 3365-73.
24. Li W, Yang Y, Tian Y, et al. Preparation and in vitro/in vivo evaluation of revaprazan hydrochloride nanosuspension. Int J Pharm 2011; 408(1-2): 157-62.
25. Uchiyama H, Tozuka Y, Asamoto F, Takeuchi H. alpha-Glucosyl hesperidin induced an improvement in the bioavailability of pranlukast hemihydrate using high-pressure homogenization. Int J Pharm 2011; 410(1-2): 114-7.
26. Arunkumar N, Deecaraman M, Rani C, Mohanraj KP, Venkateskumar K. Formulation development and in vitro evaluation of nanosuspentions loaded with Atorvastatin calcium. Asian Journal of Pharmaceutics 2010; 4(1): 28-33.
27. Sahoo NG, Kakran M, Shaal LA, et al. Preparation and characterization of quercetin nanocrystals. J Pharm Sci 2011; 100(6): 2379-90.
28. Gao Y, Qian S, Zhang J. Physicochemical and pharmacokinetic characterization of a spray-dried cefpodoxime proxetil nanosuspension. Chem Pharm Bull (Tokyo) 2010; 58(7): 912-7.
29. Hahn A, Barcikowski S, Chichkov BN. Influences on nanoparticle production during pulsed laser ablation. journal of laser micro/nanoengineering 2008; 3(2): 73-77.
30. Kabashin AV, Mounior M. Synthesis of colloidal nanoparticles during femtosecond laser ablation of gold in water. Journal of Applied Physics 2003; 94: 7941.
31. Sylvestre JP, Kabashin AV, Sacher E, Meunier M. Femtosecond laser ablation of gold in water: influence of the laser-produced plasma on the nanoparticle size distribution. Appl. Phys. A 2005; 80: 753-758.
32. Kenth S, Sylvestre JP, Fuhrmann K, Meunier M, Leroux JC. Fabrication of paclitaxel nanocrystals by femtosecond laser ablation and fragmentation. J Pharm Sci 2011; 100(3): 1022-30.
33. Nanjwade BK, Derkar GK, Bechra HM, Nanjwade V, Mani FV. Design and characterization of nanocrystals of for solubility and dissolution enhancement. J Nanomedic and Nanotechnol 2011; 2(2): doi: 10. 4172/2157-7439. 1000107.
34. Kakran M, Sahoo NG, Li L, Judeh Z. Fabrication off quercetin nanoparticles by anti-solvent precipitation method for enhanced dissolution. Powder Technology 2011: corrected proof.
35. Mansouri M, Pouretedal HR, Vosoughi V. Preparation and characterization of ibuprofen nanoparticles by using solvent/antisolvent precipitation. The Open Conference Proceeding journal 2011; 2: 88-94.
36. Miao X, Sun C, Jiang T, Zheng L, Wang T, Wang S. Investigation of nanosized crystalline form to improve the oral bioavailability of poorly water soluble cilostazol. J Pharm Pharm Sci 2011; 14(2): 196-214.
37. Rezaei MA, Kebriaee ZA, Keshavarz M, Ahmadi A, Mohtat B. Preparation and in-vitro evaluation of indomethacin nanoparticles. DARU Journal of Pharmaceutical Sciences 2010; 18(3): 185-192.
38. Salem H, Abdelrahim M, Eid KA, Sharaf M. Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler. Int J Nanomedicine 2011; 6: 311-20.
39. Xia D, Cui F, Piao H, et al. Effect of crystal size on the in vitro dissolution and oral absorption of nitrendipine in rats. Pharm Res 2010; 27(9): 1965-76.
40. Min S, Yan G, Yan P, et al. Development of nanosuspention formulation for oral delivery of quercetin. Journal of Biomedical Nanotechnology 2010; 6(4): 325-332.
41. Li C, Le Y, Chen JF. Formation of bicalutamide nanodispersion for dissolution rate enhancement. Int J Pharm 2011; 404(1-2): 257-63.
42. Suthar AK, Solanki SS, Dhanwani RK. Enhancement of dissolution of poorly water soluble raloxifene hydrochloride by preparation nanoparticles. Journal of Advanced Pharmacy Education and Research 2011; 2: 189-194.
43. Dong Y, Ng WK, Hu J, Shen S, Tan RB. A continuous and highly effective static mixing process for antisolvent precipitation of nanoparticles of poorly water-soluble drugs. Int J Pharm 2010; 386(1-2): 256-61.
44. Zhang QX, Xu LM, Zhou Y, Wang JX, Chen JF. Preparation of drug nanoparticles using a T-junction microchannel system. Ind Eng Chem Res 2011; 50(24): 13805-13812.
45. Kakran M, Sahoo NG, Li L, et al. Fabrication of drug nanoparticles by evaporative precipitation of nanosuspension. Int J Pharm 2010; 383(1-2): 285-92.
46. Zhu Z, Margulis-Goshen K, Magdassi S, Talmon Y, Macosko CW. Polyelectrolyte stabilized drug nanoparticles via flash nanoprecipitation: a model study with beta-carotene. J Pharm Sci 2010; 99(10): 4295-306.
47. Chow AH, Tong HH, Chattopadhyay P, Shekunov BY. Particle engineering for pulmonary drug delivery. Pharm Res 2007; 24(3): 411-37.
48. Turk M, Bolten D. Formation of submicron poorly water-soluble drugs by rapid expansion of supercritical solution (RESS): Results for Naproxen. The Journal of Supercritical Fluids 2010; 55(2): 778-785.
49. Tozuka Y, Miyazaki Y, Takeuchi H. A combinational supercritical CO2 system for nanoparticle preparation of indomethacin. Int J Pharm 2010; 386(1-2): 243-8.
50. Jin H, Hemingway M, Gupta RB, Xia F, Zhao Y. Preparation of thalidomide nano-flakes by supercritical antisolvent with enhanced mass transfer. Particuology 2012; 10(1): 17-23.
51. Ignatious F, Sun L, Lee CP, Baldoni J. Electrospun nanofibers in oral drug delivery. Pharm Res 2010; 27(4): 576-88.
52. Yu DG, Branford-White C, White K, Li XL, Zhu LM. Dissolution improvement of electrospun nanofiber-based solid dispersions for acetaminophen. AAPS PharmSciTech 2010; 11(2): 809-17.
53. Yu DG, Gao LD, White K, Branford-White C, Lu WY, Zhu LM. Multicomponent amorphous nanofibers electrospun from hot aqueous solutions of a poorly soluble drug. Pharm Res 2010; 27(11): 2466-77.
54. Yu DG, Branford-White C, Shen XX, Zhang XF, Zhu LM. Solid dispersions of Ketoprofen in drug-loaded electrospun nanofibers. Journal of Dispersion Sciences and Technology 2010; 31(7): 902-908.
55. Yu DG, Yang JM, Branford-White C, Lu P, Zhang L, Zhu LM. Third generation solid dispersions of ferulic acid in electrospun composite nanofibers. Int J Pharm 2010; 400(1-2): 158-64.
56. Hu J, Ng WK, Dong Y, Shen S, Tan RB. Continuous and scalable process for water-redispersible nanoformulation of poorly aqueous soluble APIs by antisolvent precipitation and spray-drying. Int J Pharm 2011; 404(1-2): 198-204.
57. Kho K, Hadinoto K. Effects of excipient formulation on the morphology and aqueous re dispersiibility of dry-powder silica nanoaggregates. Colloids and Surface A: Physicochemical and Engineering Aspects 2010; 359(1-3): 71-81.
58. Ozeki T, Beppu S, Mizoe T, Takashima Y, Yuasa H, Okada H. Preparation of two-drug composite microparticles to improve the dissolution of insoluble drug in water for use with a 4-fluid nozzle spray drier. J Control Release 2005; 107(3): 387-94.
59. Mizoe T, Beppu S, Ozeki T, Okada H. One-step preparation of drug-containing microparticles to enhance the dissolution and absorption of poorly water-soluble drugs using a 4-fluid nozzle spray drier. J Control Release 2007; 120: 205-210.
60. Ozeki T, Beppu S, Mizoe T, Takashima Y, Yuasa H, Okada H. Preparation of polymeric submicron particle-containing microparticles using a 4-fluid nozzle spray dryer. Pharm Res 2006; 23(1): 177-182.
61. Mizoe T, Ozeki T, Okada H. Preparation of drug nanoparticlecontaining microparticles using a 4-fluid nozzle spray drier for oral, pulmonary, and injection dosage forms. J Control Release 2007; 122(1): 10-5.
62. Mizoe T, Ozeki T, Okada H. Application of a four-fluid nozzle spray drier to prepare inhalable rifampicin-containing mannitol microparticles. AAPS PharmSciTech 2008; 9(3): 755-61.
63. Ohashi K, Kabasawa T, Ozeki T, Okada H. One-step preparation of rifampicin/poly(lactic-co-glycolic acid) nanoparticle-containing mannitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosis. J Control Release 2009; 135(1): 19-24.
64. Bunjes H. Lipid nanoparticles for the delivery of poorly watersoluble drugs. J Pharm Pharmacol 2010; 62(11): 1637-45.
65. Fricker G, Kromp T, Wendel A, et al. Phospholipids and lipidbased formulations in oral drug delivery. Pharm Res 2010; 27(8): 1469-86.
66. Das S, Chaudhury A. Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS Pharm-SciTech 2011; 12(1): 62-76.
67. Shah M, Pathak K. Development and statistical optimization of solid lipid nanoparticles of simvastatin by using 2(3) full-factorial design. AAPS PharmSciTech 2010; 11(2): 489-96.
68. Seenivasan A, Panda T, Theodore T. Lovastatin nanoparticle synthesis and characterization for better drug delivery. The Open Biotechnology Journal 2011; 5: 28-32.
69. Dodiya SS, Chavhan SS, Sawant KK, Korde AG. Solid lipid nanoparticles and nanosuspension formulation of Saquinavir: preparation, characterization, pharmacokinetics and biodistribution studies. J Microencapsul 2011; 28(6): 515-27.
70. Hu L, Xing Q, Meng J, Shang C. Preparation and enhanced oral bioavailability of cryptotanshinone-loaded solid lipid nanoparticles. AAPS PharmSciTech 2010; 11(2): 582-7.
71. Kheradmandnia S, Vasheghani-Farahani E, Nosrati M, Atyabi F. Preparation and characterization of ketoprofen-loaded solid lipid nanoparticles made from beeswax and carnauba wax. Nanomedicine 2010; 6(6): 753-9.
72. Zhang Z, Bu H, Gao Z, Huang Y, Gao F, Li Y. The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats. Int J Pharm 2010; 394(1-2): 147-53.
73. Aji Alex MR, Chacko AJ, Jose S, Souto EB. Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting. Eur J Pharm Sci 2011; 42(1-2): 11-8.
74. Nanjwade BK, Patel DJ, Udhani RA, Manvi FV. Functions of Lipids for Enhancement of Oral Bioavailability of Poorly Water-Soluble Drugs. Sci Pharm 2011; 79(4): 705-727.
75. Ahmad J, Kohli K, Mir SR, Amin S. Formulation of selfnanoemulsifying drug delivery system for telmisartan with improved dissolution and oral bioavailability. Journal of Dispersion Sciences and Technology 2011; 32(7): 958-968.
76. Ghai D, Sinha VR. Nanoemulsions as self-emulsified drug delivery carriers for enhanced permeability of the poorly water-soluble selective beta(1)-adrenoreceptor blocker Talinolol. Nanomedicine 2011.
77. Patel J, Patel A, Raval M, Sheth N. Formulation and development of a self-nanoemulsifying drug delivery system of irbesartan. J Adv Pharm Technol Res 2011; 2(1): 9-16.
78. Mahesh RD, Milan DL, Navin RS. Preparation and in vivo evaluation of self-nanoemulsifying drug delivery system (SNEDDS) containing Ezetimide. Current Nanoscience 2011; 7(4): 616-627.
79. Bandivadeka MM, Pancholi SS, Kaul-Ghanekar R, Choudhali A, Koppikar S. Self-microemulsifying smaller molecular volume oil (Capmul MCM) using non-ionic surfactant: a delivery system for poorly water-soluble drug. Drug Development and Industrial Pharmacy 2011: doi: 10. 3109/03639045. 2011. 631548.
80. Zhang J, Peng Q, Shi S, et al. Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin-phospholipid complex. Int J Nanomedicine 2011; 6: 3405-14.
81. Yang YQ, Zheng LS, Guo XD, Qian Y, Zhang LJ. pH-Sensitive micelles self-assembled from amphiphilic copolymer brush for delivery of poorly water-soluble drugs. Biomacromolecules 2011; 12(1): 116-22.
82. Chiappetta DA, Hocht C, Taira C, Sosnik A. Efavirenz-loaded polymeric micelles for pediatric anti-HIV pharmacotherapy with significantly higher oral bioavailability [corrected]. Nanomedicine (Lond) 2010; 5(1): 11-23.
83. Yu JN, Zhu Y, Wang L, et al. Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles. Acta Pharmacol Sin 2010; 31(6): 759-64.
84. Kadam Y, Yerramilli U, Bahadur A, Bahadur P. Micelles from PEO-PPO-PEO block copolymers as nanocontainers for solubilization of a poorly water soluble drug hydrochlorothiazide. Colloids Surf B Biointerfaces 2011; 83(1): 49-57.
85. Zhang Y, Zhi Z, Jiang T, Zhang J, Wang Z, Wang S. Spherical mesoporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartan. J Control Release 2010; 145(3): 257-63.
86. Zhang Y, Zhang J, Jiang T, Wang S. Inclusion of the poorly watersoluble drug simvastatin in mesocellular foam nanoparticles: drug loading and release properties. Int J Pharm 2011; 410(1-2): 118-24.
87. Zhang Y, Jiang T, Zhang Q, Wang S. Inclusion of telmisartan in mesocellular foam nanoparticles: drug loading and release property. Eur J Pharm Biopharm 2010; 76(1): 17-23.
88. Lim LH, Tan A, Simovic S, Prestidge CA. Silica-lipid hybrid microcapsules: influence of lipid and emulsifier type on in vitro performance. Int J Pharm 2011; 409(1-2): 297-306.
89. Tan A, Simovic S, Davey AK, Rades T, Boyd BJ, Prestidge CA. Silica nanoparticles to control the lipase-mediated digestion of lipid-based oral delivery systems. Mol Pharm 2010; 7(2): 522-32.
90. Tan A, Davey AK, Prestidge CA. Silica-lipid hybrid (SLH) versus non-lipid formulations for optimising the dose-dependent oral absorption of celecoxib. Pharm Res 2011; 28(9): 2273-87.
91. Simovic S, Hui H, Song Y, Davey AK, Rades T, Prestidge CA. An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles. J Control Release 2010; 143(3): 367-73.
92. Salustio PJ, Pontes P, Conduto C, et al. Advanced technologies for oral controlled release: cyclodextrins for oral controlled release. AAPS PharmSciTech 2011; 12(4): 1276-92.
93. Bhise S. Effect of Hydroxyypropyl beta-cyclodextrin inclusion complexation on solubility of fenofibrate. International journal of research in pharmaceutical and biomedical sciences 2011; 2(2): 596-604.
94. Yano H, Kleinebudde P. Improvement of dissolution behavior for poorly water-soluble drug by application of cyclodextrin in extrusion process: comparison between melt extrusion and wet extrusion. AAPS PharmSciTech 2010; 11(2): 885-93.
95. Ji JG, Hao SL, Dong J, Zhang JF, Li JJ, Xu Y. Preparation of chitosan/cyclodextrin/trisodium citrate nanoparticles for the poor-water drug carrier material. Advanced Materials Research 2011; 152-153: 1356-1359.
96. Vyas A, Saraf S, Saraf S. Encapsulation of cyclodextrin comlexed simvastatin in chitosan nanocarriers: A novel technique for oral delivery. Journal of inclusion phenomena and macrocyclic chemistry 2010; 66(3-4): 251-259.
97. Reul R, Renette T, Bege N, Kissel T. Nanoparticles for paclitaxel delivery: a comparative study of different types of dendritic polyes ters and their degradation behavior. Int J Pharm 2011; 407(1-2): 190-6.
98. Sahoo NG, Bao H, Pan Y, et al. Functionalized carbon nanomaterials as nanocarriers for loading and delivery of a poorly watersoluble anticancer drug: a comparative study. Chem Commun (Camb) 2011; 47(18): 5235-7.
99. Das S, Chaudhury A. Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS Pharm-SciTech 2011; 12(1): 62-76.
100. Harde H, Das M, Jain S. Solid lipid nanoparticles: an oral bioavailability enhancer vesicle. Expert Opin Drug Deliv 2011; 8(11): 1407-24.
101. Cai Z, Wang Y, Zhu LJ, Liu ZQ, Nanocarriers: a general strategy for enhancement of oral bioavailability of poorly absorbed or presystemically metabolized drugs. Curr Drug Metab 2010 11(2) 197-207.