Nanonization of itraconazole by high pressure homogenization: Stabilizer optimization and effect of particle size on oral absorption

Journal of Pharmaceutical Sciences

Volumn 100, Issue 8, 2011, Pages 3365-3373

  Sun, Wei ^a   Mao, Shirui ^a   Shi, Yi ^b   Li, Luk Chiu ^b   Fang, Liang ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Central composite design; Dissolution; Itraconazole; Multiple stabilizer system; Nanosuspensions; Oral absorption

Indexed keywords

DODECYL SULFATE SODIUM; ITRACONAZOLE; POLOXAMER;

ANIMAL EXPERIMENT; ARTICLE; DISSOLUTION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG STABILITY; DRUG SYNTHESIS; IN VITRO STUDY; MALE; NANOPHARMACEUTICS; NONHUMAN; PARTICLE SIZE; RAT; SURFACE PROPERTY; ZETA POTENTIAL;

EID: 79958811057     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22587     Document Type: Article

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