An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles

Journal of Controlled Release

Volumn 143, Issue 3, 2010, Pages 367-373

  Simovic, Spomenka ^a   Hui, He ^a   Song, Yunmei ^a   Davey, Andrew K ^a   Rades, Thomas ^b   Prestidge, Clive A ^a  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

In vitro dissolution; In vivo pharmacokinetics; Indomethacin; Lipid based oral delivery; Poorly soluble drugs

Indexed keywords

IN-VITRO DISSOLUTION; IN-VIVO; INDOMETHACIN; LIPID-BASED ORAL DELIVERY; POORLY SOLUBLE DRUGS;

ABSORPTION; BIOCHEMISTRY; DRUG PRODUCTS; DYES; ELECTROSTATICS; EMULSIFICATION; ENCAPSULATION; MICROCRYSTALS; PHARMACOKINETICS; SILICA; SPRAY DRYING; SUSPENSIONS (FLUIDS);

DISSOLUTION;

INDOMETACIN; LIPID EMULSION; NANOCARRIER; OIL; SILICON DIOXIDE;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; COACERVATION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; GASTROINTESTINAL TRACT; IN VITRO STUDY; IN VIVO STUDY; LIPOLYSIS; LIPOPHILICITY; MALE; MAXIMUM PLASMA CONCENTRATION; MICROCAPSULE; NANOFABRICATION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; POROSITY; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SPRAY DRYING; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CATIONS; DRUG CARRIERS; EMULSIONS; INDOMETHACIN; LIPIDS; MALE; NANOPARTICLES; RATS; RATS, SPRAGUE-DAWLEY; SILICON DIOXIDE;

EID: 77952237639     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.01.008     Document Type: Article

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