Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles

Acta Pharmacologica Sinica

Volumn 31, Issue 6, 2010, Pages 759-764

  Yu, Jiang Nan ^a,b   Zhu, Yuan ^a   Wang, Li ^a   Peng, Min ^a,b   Tong, Shan Shan ^a   Cao, Xia ^a   Qiu, Hui ^a   Xu, Xi Ming ^a  

^a JIANGSU UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Bioavailability; Drug delivery system; Mixed micelles; Phospholipid; Silybin; Sodium cholate

Indexed keywords

CHOLIC ACID; LIVER PROTECTIVE AGENT; PHOSPHOLIPID; SILIBININ; SILYBIN N METHYLGLUCAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; FEMALE; IN VITRO STUDY; MALE; MICELLE; NONHUMAN; PARTICLE SIZE;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; DOGS; DRUG CARRIERS; DRUG COMPOUNDING; FEMALE; MALE; MICELLES; PARTICLE SIZE; PHOSPHOLIPIDS; SILYMARIN; SODIUM CHOLATE; SOLUBILITY;

EID: 77953283333     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.55     Document Type: Article

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